AIM： To investigate the influence of CO2-insufflation pressure on adhesion, invasion and metastatic potential of colon cancer cells based on adhesion molecules expression. METHODS： With an/n vitro ...artificial pneumoperitoneum model, SW1116 human colon carcinoma cells were exposed to CO2-insufflation in 5 different pressure groups： 6 mmHg, 9 mmHg, 12 mmHg, 15 mmHg and control group, respectively for 1 h. Expression of E-cadherin, ICAM-I, CD44 and E-selectin was meas- ured at 0, 12, 24, 48 and 72 h after CO2-insufflation using flow cytometry. The adhesion and invasion capacity of SW1116 cells before and after exposure to CO2-insufflation was detected by cell adhesion/invasion assay in vitro. Each group of cells was injected intraperitoneally into 16 BALB/C mice. The number of visible abdominal cavity tumor nodules, visceral metas-tases and survival of the mice were recorded in each group. RESULTS： The expression of E-cadherin, ICAM-1, CD44 and E-selectin in SWl116 cells were changed significantly following exposure to CO2 insufflation at different pressures （P 〈 0.05）. The expression of E-cadherin, CD44 and ICAM-1 decreased with increasing CO2-insufflation pressure. The adhesive/ invasive cells also decreased gradually with increasing pressure as determined by the adhesion/invasion assay. In animal experiments, the number of abdominal cavity tumor nodules in the 15 mmHg group was also significantly lower than that in the 6 mmHg group （29.7± 9.91 vs 41.7±14.90, P = 0.046）. However, the survival in each group was not statistically different. CONCLUSION： CO2-insufflation induced a temporary change in the adhesion and invasion capacity of cancer cells in vitro. Higher CO2-insufflation pressure inhibited adhesion, invasion and metastatic potential in vitro and in vivo, which was associated with reduced expression of adhesion molecules.
To treat technical problems of data acquisition,alarm management, and historical data archiving of radiation protection control system in Thorium Molten Salt Reactor, a network prototype system was ...designed based on experimental physics and industrial control system.Radiation level of many locations in Jiading campus of Shanghai Institute of Applied Physics is being continuously monitored, and boundaries of accelerator facilities and radiochemical areas are defined by the access control system. In this paper, we introduce the control system design,including human–machine interfaces, alarm system, historical data archiving system, and the software for access control. The software development followed the standard of Capability Maturity Model Integration（CMMIò） Level3, and the software had passed a third-party test, which indicated that the functionality and the reliability could fulfill the requirements of the radiation protection system.
Combined with the parameters of the production process of a steel factory, numerical simulations for a new ladle from preheating to turnover are conducted using the finite element analysis system ...software （ANSYS）. The measured data proved that the simulated results are reliable. The effects of preheating time, thermal cycling times, and empty package time on steel temperature are calculated, an ideal preheating time is provided, besides, based on the analysis of a single factor and use the nonlinear analysis method, a steel temperature compensating model with di- versified coupling factors is proposed, with the largest error of the present coupling model at 1. 462 ~C, and the er- rors between actual and target steel temperature in tundish after the model is applied to practical production are basi- cally controlled within -4-6 ~C, which can meet the accuracy of the manufacturer and has a practical guiding significance for the production in steelmaking workshops.
Dense depth perception is critical for autonomous driving and other robotics applications. However, modern LiDAR sensors only provide sparse depth measurement. It is thus necessary to complete the ...sparse LiDAR data, where a synchronized guidance RGB image is often used to facilitate this completion. Many neural networks have been designed for this task. However, they often naïvely fuse the LiDAR data and RGB image information by performing feature concatenation or element-wise addition. Inspired by the guided image filtering, we design a novel guided network to predict kernel weights from the guidance image. These predicted kernels are then applied to extract the depth image features. In this way, our network generates content-dependent and spatially-variant kernels for multi-modal feature fusion. Dynamically generated spatially-variant kernels could lead to prohibitive GPU memory consumption and computation overhead. We further design a convolution factorization to reduce computation and memory consumption. The GPU memory reduction makes it possible for feature fusion to work in multi-stage scheme. We conduct comprehensive experiments to verify our method on real-world outdoor, indoor and synthetic datasets. Our method produces strong results. It outperforms state-of-the-art methods on the NYUv2 dataset and ranks 1st on the KITTI depth completion benchmark at the time of submission. It also presents strong generalization capability under different 3D point densities, various lighting and weather conditions as well as cross-dataset evaluations. The code will be released for reproduction.
A new class of chiral macrocyclic arene composed of three chiral 2,6‐dihydroxyltriptycene subunits bridged by methylene groups was designed and synthesized. Structural studies showed that the ...macrocyclic molecule adopts a hex‐nut‐like structure with a helical chiral cavity and highly fixed conformation. Efficient resolution was achieved through the introduction of chiral auxiliaries to give a couple of enantiopure macrocycles, which exhibited high enantioselectivity towards three pairs of chiral compounds containing a trimethylamino group.
Go nuts! A novel triptycene‐based chiral macrocyclic host with a hex‐nut‐like structure and highly fixed conformation was synthesized. Efficient resolution was achieved through the introduction of chiral auxiliaries to give a couple of enantiopure macrocycles, which exhibited highly enantioselective recognition of three pairs of chiral compounds containing a trimethylamino group.
Layered oxide cathodes usually exhibit high compositional diversity, thus providing controllable electrochemical performance for Na‐ion batteries. These abundant components lead to complicated ...structural chemistry, closely affecting the stacking preference, phase transition and Na+ kinetics. With this perspective, we explore the thermodynamically stable phase diagram of various P2/O3 composites based on a rational biphasic tailoring strategy. Then a specific P2/O3 composite is investigated and compared with its monophasic counterparts. A highly reversible structural evolution of P2/O3–P2/O3/P3–P2/P3–P2/Z/O3′–Z/O3′ based on the Ni2+/Ni3.5+, Fe3+/Fe4+ and Mn3.8+/Mn4+ redox couples upon sequential Na extraction/insertion is revealed. The reduced structural strain at the phase boundary alleviates the phase transition and decreases the lattice mismatch during cycling, endowing the biphasic electrode a large reversible capacity of 144 mAh g−1 with the energy density approaching 514 Wh kg−1.
A rational biphasic tailoring strategy to prepare layered composite cathodes with the desired phase ratio is proposed. Benefiting from the reversible phase transition within transition metal slabs and the decreased structure strain at the phase boundary of the intergrowth structure during Na extraction and insertion, the Com‐NaNMFT composite material demonstrates excellent electrochemical performance.
Angiosperms are by far the most species-rich clade of land plants, but their origin and early evolutionary history remain poorly understood. We reconstructed angiosperm phylogeny based on 80 genes ...from 2,881 plastid genomes representing 85% of extant families and all orders. With a well-resolved plastid tree and 62 fossil calibrations, we dated the origin of the crown angiosperms to the Upper Triassic, with major angiosperm radiations occurring in the Jurassic and Lower Cretaceous. This estimated crown age is substantially earlier than that of unequivocal angiosperm fossils, and the difference is here termed the 'Jurassic angiosperm gap'. Our time-calibrated plastid phylogenomic tree provides a highly relevant framework for future comparative studies of flowering plant evolution.
Herein we describe a mild method for the dual C(sp3)−H bond functionalization of saturated nitrogen‐containing heterocycles through a sequential visible‐light photocatalyzed dehydrogenation/2+2 ...cycloaddition procedure. As a complementary approach to the well‐established use of iminium ion and α‐amino radical intermediates, the elusive cyclic enamine intermediates were effectively generated by photoredox catalysis under mild conditions and efficiently captured by acetylene esters to form a wide array of bicyclic amino acid derivatives, thus enabling the simultaneous functionalization of two vicinal C(sp3)−H bonds.
A great team: A dual C(sp3)−H bond functionalization strategy was developed by merging dehydrogenation under visible‐light photocatalysis with a 2+2 cycloaddition reaction in a sequential process. This method enabled cyclobutene rings to be fused to various saturated nitrogen‐containing heterocycles to produce a series of cyclic amino acid derivatives.
Wearable touch panels, a typical flexible electronic device, can recognize and feed back the information of finger touch and movement. Excellent wearable touch panels are required to accurately and ...quickly monitor the signals of finger movement as well as the capacity of bearing various types of deformation. High‐performance thermistor materials are one of the key functional components, but to date, a long‐standing bottleneck is that inorganic semiconductors are typically brittle while the electrical properties of organic semiconductors are quite low. Herein, a high‐performance flexible temperature sensor is reported by using plastic Ag2S with ultrahigh temperature coefficient of resistance of −4.7% K−1 and resolution of 0.05 K, and rapid response/recovery time of 0.11/0.11 s. Moreover, the temperature sensor shows excellent durability without performance damage or loss during force stimuli tests. In addition, a fully flexible intelligent touch panel composed of a 16 × 10 Ag2S‐film‐based temperature sensor array, as well as a flexible printed circuit board and a deep‐learning algorithm is designed for perceiving finger touch signals in real‐time, and intelligent feedback of Chinese characters and letters on an app. These results strongly show that high‐performance flexible inorganic semiconductors can be widely used in flexible electronics.
A fully flexible intelligent thermal touch panel based on the intrinsically plastic Ag2S semiconductor can well perceive finger touch signals in real‐time and displays intelligent feed back of Chinese characters and letters on an app.
Poly(ethylene oxide)‐based polymer all‐solid‐state LiS battery is a promising candidate due to its high specific energy, good processability, and low cost. However, the poor room temperature ionic ...conductivity limits its further development. Here an innovative photothermal battery technology is proposed to realize the normal operation at room temperature. This design places the 3D Cu substrate with Cu/Si core‐shell structures between Li anode and outer encapsulation glass, so that the light can come in and generate heat efficiently by utilizing the carrier nonradiative recombination of Si nano shell, then the heat quickly transfers to the battery system through Cu core. Once simulated sunlight irradiates, the battery achieves a fast reaction kinetics and superior photothermal conversion, thus realizing a lifespan of over 20 cycles with a capacity of 1089.9 mAh g−1 at 0.2 C. Even on the actual sunlight irradiation, a high discharge/charge capacity of 1065.2/1036.5 mAh g−1 is also reached, indicating an excellent reversible electrochemical process. Moreover, the 3D nanostructure can accommodate the fatal volume variation of lithium and reduce the effective current density, thus suppressing the dendrite nucleation and growth. This study will open the avenue to develop a room temperature polymer all‐solid‐state LiS battery using photothermal technology.
A novel photothermal battery, which possess fast reaction kinetics and superior photothermal conversion, is proposed to achieve the normal operation of poly(ethylene oxide)‐based all‐solid‐state LiS battery at room temperature. The battery delivers a high discharge/charge capacity of 1065.2/1036.5 mAh g−1 on the actual sunlight irradiation, indicating an excellent reversible electrochemical process and a potential application prospect.
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