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  • Recommendations for crushin... Recommendations for crushing Circadin® (melatonin) tablets for safe and reliable delivery via pediatric nasogastric tubes
    Swedrowska, Magda; Ingham, Steve; Tomlin, Stephen ... International journal of pharmaceutics, 02/2021, Volume: 594
    Journal Article
    Peer reviewed

    Display omitted Melatonin is an important drug in pediatric medicine which often requires delivery through a narrow bore nasogastric tube (e.g. FR6; 1300 µm internal diameter) for patients that ...
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  • Psilocybin with psychologic... Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study
    Carhart-Harris, Robin L; Bolstridge, Mark; Rucker, James ... The Lancet. Psychiatry, 07/2016, Volume: 3, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Psilocybin is a serotonin receptor agonist that occurs naturally in some mushroom species. Recent studies have assessed the therapeutic potential of psilocybin for various conditions, including ...
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  • Human respiratory epithelia... Human respiratory epithelial cell culture for drug delivery applications
    Forbes, Ben; Ehrhardt, Carsten European journal of pharmaceutics and biopharmaceutics, 07/2005, Volume: 60, Issue: 2
    Journal Article
    Peer reviewed

    Recent developments in delivering drugs to the lung are driving the need for in vitro methods to evaluate the fate of inhaled medicines. Constraints on experimentation using animals have promoted the ...
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  • A Comparison of Drug Transp... A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture
    Bosquillon, Cynthia; Madlova, Michaela; Patel, Nilesh ... Pharmaceutical research, 12/2017, Volume: 34, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Purpose To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo . Method The ...
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  • Double Optimization of Riva... Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters
    Cunha, Sara; Costa, Cláudia Pina; Loureiro, Joana A ... Pharmaceutics, 06/2020, Volume: 12, Issue: 7
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    Peer reviewed
    Open access

    Rivastigmine is a drug commonly used in the management of Alzheimer's disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers ...
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  • In Silico and in Vitro Scre... In Silico and in Vitro Screening for P‑Glycoprotein Interaction with Tenofovir, Darunavir, and Dapivirine: An Antiretroviral Drug Combination for Topical Prevention of Colorectal HIV Transmission
    Swedrowska, Magda; Jamshidi, Shirin; Kumar, Abhinav ... Molecular pharmaceutics, 08/2017, Volume: 14, Issue: 8
    Journal Article
    Peer reviewed

    The aim of the study was to use in silico and in vitro techniques to evaluate whether a triple formulation of antiretroviral drugs (tenofovir, darunavir, and dapivirine) interacted with ...
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  • Imaging drugs, metabolites ... Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis
    Dexter, Alex; Steven, Rory T.; Patel, Aateka ... Analytical and bioanalytical chemistry, 12/2019, Volume: 411, Issue: 30
    Journal Article
    Peer reviewed
    Open access

    Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a ...
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  • PPAR Gamma Receptor: A Nove... PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies
    Victor, Suresh; Forbes, Ben; Greenough, Anne ... Pharmaceuticals, 10/2023, Volume: 16, Issue: 11
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    Open access

    Worldwide, three-quarters of a million babies are born extremely preterm (<28 weeks gestation) with devastating outcomes: 20% die in the newborn period, a further 35% develop bronchopulmonary ...
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  • Triggered-release nanocapsu... Triggered-release nanocapsules for drug delivery to the lungs
    Chana, Jasminder, PhD; Forbes, Ben, PhD; Jones, Stuart A., PhD Nanomedicine, 2015, January 2015, 2015-Jan, 2015-01-00, 20150101, Volume: 11, Issue: 1
    Journal Article
    Peer reviewed

    Abstract This study demonstrated the feasibility of trigger-responsive inhaled delivery of medicines using soft solid shelled nanocapsules. The delivery system was a 50 nm sized lipid rich capsule ...
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  • Using Polar Ion-Pairs to Co... Using Polar Ion-Pairs to Control Drug Delivery to the Airways of the Lungs
    Dutton, Bridie; Woods, Arcadia; Sadler, Robyn ... Molecular pharmaceutics, 05/2020, Volume: 17, Issue: 5
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    Peer reviewed
    Open access

    The rapid absorptive clearance of drugs delivered to the airways of the lungs means that many inhaled medicines have a short duration of action. The aim of this study was to investigate whether ...
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