As particularidades clínicas da otite média Nogueira, Flamaryon Ribeiro; Faria, Jessica Pagan; De Campos, Matheus Henrique Ferreira ...
Brazilian Journal of Development,
12/2022, Volume:
8, Issue:
12
Journal Article
A otite média é um processo inflamatório de evolução abrupta, acompanhado pelo quadro clínico típico de inflamação na orelha média, sendo sua incidência prevalente em crianças, culminando em leves ...repercussões clínicas, mas que deve ser adequadamente diagnosticada e tratada. Este evento clínico pode ser agudo, subagudo ou crônico com aparições típicas, evolução e manejo clínico diferenciados. O seguinte artigo é uma revisão narrativa de literatura que visa analisar a respeito das principais particularidades clínicas da Otite Média. Diante das informações coletadas, pode se elucidar que a otite média é o fator causal para implicações negativas e antibioticoterapia em crianças, logo é essencial medidas para diagnose precoce para evitar repercussões na saúde destes.
In the state of Paraná, Brazil, calcined sewage sludge (biosolid) without remediation is used as a fertilizer in different crops, such as soybeans and corn. Evaluated the chemical composition, ...pathogenic potential, and toxic potential to plants and
E. fetida
of biosolid produced in the state. The analysis of metals and pathogens, based on the Brazilian Resolution 498/2020 of the National Council for the Environment (CONAMA), classified the residue as suitable for incorporation into crop soils in Brazil. However, all concentrations of the biosolid (6.25, 25, 50, and 100%) caused phytotoxicity to
Lactuca sativa
,
Allium cepa
,
Cucumis sativus,
and
Triticum aestivum
.
A. cepa
meristematic cells exposed to the residue revealed division disruption, including clastogenic damage to chromosomes, and death. All concentrations promoted swelling in onion roots, drastic inhibition of ascorbate peroxidase and superoxide dismutase, activation of guaiacol peroxidase, and lipid peroxidation in their meristems. Studies with
Eisenia fetida
showed biosolid has strong repellent effects and higher concentrations caused 100% mortality. In surviving animals, catalase and guaiacol peroxidase showed higher tissue levels of activity, suggesting a response to increased environmental free radicals, including reactive oxygen species. Therefore, in Paraná, the current and recurring incorporation of biosolids, without adequate remediation, into cropping soils has the potential to trigger extensive oxidative stress in plants and animals, representing an environmental risk. Furthermore, this study brings important elements that advance the understanding of how biosolids trigger phytotoxicity and cellular toxicity in different organisms.
Methylparaben, chloro-methylparaben, and dichloro-methylparaben were evaluated in
Allium cepa
at 5, 10, 50, and 100 μg/L and in
Eisenia fetida
at 10 and 100 μg/L. In
A. cepa
roots, 100 μg/L ...methylparaben and 50 and 100 μg/L chlorinated methylparabens reduced cell proliferation, caused cellular changes, and reduced cell viability in meristems, which caused a reduction in root growth. Furthermore, they caused drastic inhibition of catalase, ascorbate peroxidase, and superoxide dismutase; activated guaiacol peroxidase and promoted lipid peroxidation in meristematic root cells. In earthworms, after 14 days exposure to the three compounds, there were no deaths, and catalase, ascorbate peroxidase, and superoxide dismutase were not inhibited. However, guaiacol peroxidase activity and lipid peroxidation were observed in animals exposed to dichloro-methylparaben. Soils with dichloro-methylparaben also caused the escape of earthworms. It is inferred that the recurrent contamination of soils with these methylparabens, with emphasis on chlorinated derivatives, can negatively impact different species that depend directly or indirectly on soil to survive.
Ketamine, also called ‘K-powder’ by abusers, an analog of phencyclidine, primarily acts as an antagonist of N-methyl-D-aspartic acid (NMDA) receptors, therapeutically used as an anesthetic agent. ...Ketamine also stimulates the limbic system, inducing hallucinations and dissociative effects. At sub-anesthetic doses, ketamine also displays hallucinatory and dissociative properties, but not loss of consciousness. These behavioral consequences have elicited its recreational use worldwide, mainly at rave parties. Ketamine is generally a drug of choice among teenagers and young adults; however, the harmful consequences of its recreational use on adolescent central nervous systems are poorly explored. Thus, the aim of the present study was to characterize the behavioral and biochemical consequences induced by one binge-like cycle of ketamine during the early withdrawal period in adolescent female rats. Adolescent female Wistar rats (n = 20) received intraperitoneally administered ketamine (10 mg/kg/day) for 3 consecutive days. Twenty-four hours after the last administration of ketamine, animals were submitted to behavioral tests in an open field, elevated plus-maze, and forced swimming test. Then, animals were intranasally anesthetized with 2% isoflurane and euthanized to collect prefrontal cortex and hippocampus to assess lipid peroxidation, antioxidant capacity against peroxyl radicals, reactive oxygen species, reduced glutathione, and brain-derived neurotrophic factor (BDNF) levels. Our results found that 24 h after recreational ketamine use, emotional behavior disabilities, such as anxiety- and depression-like profiles, were detected. In addition, spontaneous ambulation was reduced. These negative behavioral phenotypes were associated with evidence of oxidative stress on the prefrontal cortex and hippocampus.
although it is a rare disease, common variable immunodeficiency (CVID) stands out as the most frequent primary symptomatic immunodeficiency. Carriers are prone to a variety of recurrent bacterial ...infections, in addition to the risk of developing autoimmune diseases and neoplasms including gastric cancer (GC). Despite the recognized risk, there are no specific standardized protocols for the management of GC in these patients, so the reported oncological results are varied. Thus, this study aims to describe the clinicopathological characteristics and prognosis of patients with CVID undergoing surgical treatment of GC.
all patients with GC undergoing surgical treatment between 2009 and 2020 were retrospectively evaluated. Later, patients diagnosed with CVID were identified and this group was compared with the remaining patients without any immunodeficiency.
among the 1101 patients with GC evaluated in the period, 10 had some type of immunodeficiency, and 5 were diagnosed with CVID. Patients with CVID had younger age, lower BMI, and smaller lesions compared to those without CVID. Four patients underwent curative gastrectomy and one patient underwent jejunostomy. Two patients died (1 palliative and 1 curative) and one patient had disease recurrence. There was no statistically significant difference regarding the incidence of postoperative complications and survival between the evaluated groups.
the CVID incidence in patients with GC undergoing surgical treatment was 0.5%, occurring at a less advanced age, but with no difference regarding surgical and oncological results.
During the pandemic of COVID-19, the Brazilian Health Ministry declared that 2-week postnatal women are a high-risk population that demands special assistance. Considering that women at the postnatal ...period are more susceptible to anxiety and stress symptoms, our objective is to present a digital psychoeducational booklet analyzing its validity to help this target population to cope with the stress from the new coronavirus crisis. Based on the dispositional coping theory and positive psychology, this proposal was developed as a digital booklet to promote the maternal mental health and well-being based on informational and psychoeducational approaches. Information about the COVID-19, as well as coping strategies and positive practices, were presented to provide support for the coping with pandemic stressors. To validate the booklet, 12 women answered a Google Form via WhatsApp that included a free and informed consent form, a general data protocol, and a questionnaire with validity criteria (clarity of written, practical pertinence, theoretical relevance, and presentation). Content validity coefficients (CVC) were calculated for all criteria. The participants were on average 30 years old (A.V.=23–43), and half of them had a high school degree; 50% of them self-declared white and 25% black, and 2 of them declared themselves brown and 1 yellow. All CVC were ≥ 0.96. These findings confirmed that our booklet can be considered a viable, useful, and efficient tool to help puerperium women during the pandemic, providing support for a resilient coping face to this new and critical moment.
Objective: to evaluate the prevalence of calcifications in the soft tissues of the cervical-facial region using cone beam computed tomography (CBCT) images. Material and Methods: two hundred and ten ...CBCT exames was analyzed by 01 examiner previously trained, with fild of view (FOV) of 16 x 13 cm and voxel of 0.25 mm, in ICAT Vision software (Imaging Science International, Hatfield, PA, USA) in coronal, axial and sagittal sections. The following calcifications were evaluated: tonsiloliths, sialolites, calcification of the styloid complex, calcified carotid atheromas, calcifications in laryngeal cartilages, calcified lymph nodes and osteoma cutis. The findings were tabulated according to the total of the sample, related to the gender, age group of the individuals. Results: Calcification of the styloid complex was the most frequent in the sample studied in both genres (39.04%), followed by the presence of tonsiloliths (19.52%), and calcified lymph nodes (6,67%). Conclusion: calcifications are frequent radiographic findings in CBCT and important for the diagnosis of some possible pathologies that do not present clinical symptoms.KEYWORDSCone-beam computed tomography; Prevalence; Soft tissue calcification.
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