This paper reports a novel mode-localized resonant accelerometer, which can keep high sensitivity even over a wide range. To improve the adjustability of sensitivity, a new four degree of freedom ...(4-DoF) series-parallel resonator array is proposed. Three sensing resonators are mechanically coupled together in series by folding beams and the fourth sensitivity-tuning resonator is electrically coupled in parallel with the sensing system. When the stiffness perturbation caused by acceleration occurs, a change of modal amplitude ratio due to the mode localization phenomenon can be detected. By tuning the voltage on the sensitivity-tuning resonator, the sensitivity of the accelerometer can be altered to keep the amplitude ratio within a reasonable range. The theoretical model of the accelerometer is established and analyzed by numerical method. To confirm the feasibility of the design, a device fabricated by SOI-MEMS technology is tested under open-loop circuit. The measured amplitude ratio sensitivity varies from 1.14/g to 23.37/g with the change of the tuning voltage, and the sensitivity adjustment range reaches 2050%.
Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report ...that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53-mediated myocardin transcription. Myocardin expression is upregulated upon H
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and ischemia/reperfusion, and knockdown of myocardin inhibits autophagy and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases.
A polymer solar cell-thermoelectric (PSC–TE) hybrid energy-harvesting system was designed and fabricated, which realizes harvesting electricity from solar light and solar heat simultaneously. A ...series of measurements has been performed to study the relationship between the PSC–TE hybrid system and individual devices. The PSC–TE system improved the total power output compared with individual PSCs when a temperature gradient across TE module was introduced. The physical process that determines the overall power generation of the PSC–TE hybrid system was also studied and analyzed. The optimal power output of PSC–TE hybrid system is given, which can act as a guideline for further optimizing the hybrid energy-harvesting system. Interestedly, we demonstrate that the hybrid system can drive a commercial light-emitting diode by effectively utilizing solar energy, while it cannot be realized by an individual device. The hybrid system is proved to be a more efficient way for obtaining electricity by integrating multiple devices with different functions.
Arabidopsis mutants produced by constitutive overexpression of the CRISPR/Cas9 genome editing system are usually mosaics in the T1 generation. In this study, we used egg cell-specific promoters to ...drive the expression of Cas9 and obtained non-mosaic T1 mutants for multiple target genes with high efficiency. Comparisons of 12 combinations of eight promoters and two terminators found that the efficiency of the egg cell-specific promoter-controlled CRISPR/Cas9 system depended on the presence of a suitable terminator, and the composite promoter generated by fusing two egg cell-specific promoters resulted in much higher efficiency of mutation in the T1 generation compared with the single promoters.
Molecular doping, a fascinating technique to modulate the electrical property of organic solids by importing additional charges, has been one of the focal points of active research over the last ...three decades. Due to the potential applications in clean energy and artificial intelligence, molecular doping is experiencing a second golden stage by virtue of its compatibility with solution‐processed organic functional devices. The central challenge at present promoting the doping efficiency. This perspective starts with revisiting the basic concepts in doping process and discusses the recent progress in efficiency improvements. Based on the journey of molecular doping, it is concluded that molecular doping can be as efficient as atomic doping is in inorganic semiconductors; future directions to achieve this goal are shared.
Aiming to enhance the doping efficiency, basic knowledge on the molecular doping process and promotion strategies including the energy level control, morphology modification, counter ion engineering, and dopant activation are introduced. Based on the achievable high‐efficiency doping process, future directions and outlooks are presented.
Uranium is a key resource for the development of the nuclear industry, and extracting uranium from the natural seawater is one of the most promising ways to address the shortage of uranium resources. ...Herein, a semiconducting covalent organic framework (named NDA‐TN‐AO) with excellent photocatalytic and photoelectric activities was synthesized. The excellent photocatalytic effect endowed NDA‐TN‐AO with a high anti‐biofouling activity by generating biotoxic reactive oxygen species and promoting photoelectrons to reduce the adsorbed UVI to insoluble UIV, thereby increasing the uranium extraction capacity. Owing to the photoinduced effect, the adsorption capacity of NDA‐TN‐AO to uranium in seawater reaches 6.07 mg g−1, which is 1.33 times of that in dark. The NDA‐TN‐AO with enhanced adsorption capacity is a promising material for extracting uranium from the natural seawater.
Photoelectric and photocatalytic effects endow the covalent organic framework NDA‐TN‐AO with good anti‐biofouling activity. This occurs by generating biotoxic reactive oxygen species and promoting photoelectrons to reduce the adsorbed UVI to insoluble UIV, thereby improving the uranium adsorption capacity.
Dysregulated autophagy is associated with many pathological disorders such as cardiovascular diseases. Emerging evidence has suggested that circular RNAs (circRNAs) have important roles in some ...biological processes. However, it remains unclear whether circRNAs participate in the regulation of autophagy. Here we report that a circRNA, termed autophagy-related circular RNA (ACR), represses autophagy and myocardial infarction by targeting Pink1-mediated phosphorylation of FAM65B. ACR attenuates autophagy and cell death in cardiomyocytes. Moreover, ACR protects the heart from ischemia/reperfusion (I/R) injury and reduces myocardial infarct sizes. We identify Pink1 as an ACR target to mediate the function of ACR in cardiomyocyte autophagy. ACR activates Pink1 expression through directly binding to Dnmt3B and blocking Dnmt3B-mediated DNA methylation of Pink1 promoter. Pink1 suppresses autophagy and Pink1 transgenic mice show reduced myocardial infarction sizes. Further, we find that FAM65B is a downstream target of Pink1 and Pink1 phosphorylates FAM65B at serine 46. Phosphorylated FAM65B inhibits autophagy and cell death in the heart. Our findings reveal a novel role for the circRNA in regulating autophagy and ACR-Pink1-FAM65B axis as a regulator of autophagy in the heart will be potential therapeutic targets in treatment of cardiovascular diseases.
Organic electrochemical transistors (OECTs) hold promise for developing a variety of high‐performance (bio‐)electronic devices/circuits. While OECTs based on p‐type semiconductors have achieved ...tremendous progress in recent years, n‐type OECTs still suffer from low performance, hampering the development of power‐efficient electronics. Here, it is demonstrated that fine‐tuning the molecular weight of the rigid, ladder‐type n‐type polymer poly(benzimidazobenzophenanthroline) (BBL) by only one order of magnitude (from 4.9 to 51 kDa) enables the development of n‐type OECTs with record‐high geometry‐normalized transconductance (gm,norm ≈ 11 S cm−1) and electron mobility × volumetric capacitance (µC* ≈ 26 F cm−1 V−1 s−1), fast temporal response (0.38 ms), and low threshold voltage (0.15 V). This enhancement in OECT performance is ascribed to a more efficient intermolecular charge transport in high‐molecular‐weight BBL than in the low‐molecular‐weight counterpart. OECT‐based complementary inverters are also demonstrated with record‐high voltage gains of up to 100 V V−1 and ultralow power consumption down to 0.32 nW, depending on the supply voltage. These devices are among the best sub‐1 V complementary inverters reported to date. These findings demonstrate the importance of molecular weight in optimizing the OECT performance of rigid organic mixed ionic–electronic conductors and open for a new generation of power‐efficient organic (bio‐)electronic devices.
n‐Type organic electrochemical transistors (OECTs) underperform compared to p‐type OECTs. By tuning the molecular weight of the rigid ladder‐type poly(benzimidazobenzophenanthroline), n‐type OECTs with record‐high figures of merit are reported. OECT‐based complementary inverters are also demonstrated with high voltage gains of up to 100 V V−1 and ultralow power consumption down to 0.32 nW, depending on the supply voltage.
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