En Das Passagen-Werk Benjamin vuelve sobre el concepto de Ursprung, esta vez como salto genuino de lo que ha sido, como vuelco dialéctico en el instante del Jetztzeit del materialista histórico, ...instante de legibilidad, pero también como parada e interrupción Stillstand de este despliegue, donde la fuerza dialéctica queda suspendida por un instante, en el ahora de su cognoscibilidad. Para llegar a esto, el berlinés ha hecho un recorrido reflexivo, crítico y contundente, el cual comienza a definirse más intensamente desde el prólogo Epistemocrítico de su Trauerspiel. Rastrearemos el recorrido en ambas obras y en las construcciones problemáticas de sus textos y fragmentos anteriores, especialmente en la tensión de la mediación, relación y conexión entre la obra de arte y el arte como despliegue teórico; sobre todo la tensión existente entre los primeros Románticos y Goethe, en la dialéctica entre la forma pura Idee y el contenido ideal Ideale del arte. También nos inmiscuiremos en las tesis Sobre el concepto de historia y Parque central y algunos fragmentos sobre Baudelaire. Nuestro objetivo principal es mostrar el despliegue de la imagen Bild en la escritura filosófica benjaminiana, en medio Mittel de los extremos de idea y fenómeno, de verdad y conocimiento, por tanto en la misma construcción conceptual, cuando nombrar y contemplar la realidad histórica, la realidad material debía ser comentada, interpretada y leída en su eterna caducidad ewige Vergängnis o hundimiento Untergang, como exposición Darstellung de una experiencia histórica configurada por determinadas constelaciones imaginales.
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that is diagnosed for the first time during pregnancy. The objective of this study is to know the glucose tolerance ...status after 15 years of pregnancy in patients diagnosed with gestational diabetes and to assess the long-term effect of GDM on the circulating miRNA profile of these women. To answer these, 30 randomly selected women diagnosed with GDM during 2005-2006 were included in the study, and glucose tolerance was measured using the National Diabetes Data Group criteria. Additionally, four miRNAs (hsa-miR-1-3p, hsa-miR-24-3p, hsa-miR-329-3p, hsa-miR-543) were selected for their analysis in the plasma of women 15 years after the diagnosis of GDM. In our study we discovered that, fifteen years after the diagnosis of GDM, 50% of women have some degree of glucose intolerance directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed a significantly increased level of circulating hsa-miR-24-3p. Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
The Ilopango caldera is the source of the large Tierra Blanca Joven (TBJ) eruption that occurred about 1.5 ka years ago, between ca. AD270 and AD535. The eruption dispersed volcanic ash over much of ...the present territory of El Salvador, and pyroclastic density currents (PDCs) extended 40 km from the volcano. In this study, we document the physical characteristics of the deposits from all over El Salvador to further constrain the eruption processes and the intensity and magnitude of the different phases of the eruption. The succession of deposits generated by the TBJ eruption is made of 8 units. The eruption started with PDCs of hydromagmatic origin (Unit A0), followed by fallout deposits (Units A and B) that are <15 cm thick and exposed in sections close to the Ilopango caldera (within 10–15 km). The eruption, then, transitioned into a regime that generated further PDCs (Units C–F), these range from dilute to dense and they filled the depressions near the Ilopango caldera with thicknesses up to 70 m. Deposits from the co-ignimbrite plume (Unit G) are the most widespread, the deposits are found in Guatemala, Honduras, Nicaragua, Costa Rica and the Pacific Ocean and cm-thick across El Salvador. Modelling of the deposits suggests that column heights were 29 km and 7 km for the first two fallout phases, and that the co-ignimbrite phoenix plume rose up to 49 km. Volumes estimated for the fallout units are 0.15, 0.8 and 16 km3 dense rock equivalent (DRE) for Unit A, B and G respectively. The PDCs deposits volumes were estimated to be ~0.5, ~3.3, ~0.3 and ~9.1 km3 DRE for Units C, D, E and F, respectively. The combined volume of TBJ deposits is ~30 km3 DRE (~58 km3 bulk rock), indicating that it was one of largest Holocene eruptions from Central America. This eruption occurred while Mayan populations were living in the region and it would have had a significant impact on the areas within tens of kilometres of the vent for many years to decades after the eruption.
•Detailed stratigraphy of the TBJ (Tierra Blanca Joven) eruption•Transport/depositional mechanisms, eruption dynamics and physical parameters•Modelling of the dispersion of products•Local and regional impact on Maya civilization
The systemic response to exercise is dose‐dependent and involves a complex gene expression regulation and cross‐talk between tissues. This context ARISES the need for analyzing the influence of ...exercise dose on the profile of circulating microRNAs (c‐miRNAs), as emerging posttranscriptional regulators and intercellular communicators. Thus, we hypothesized that different exercise doses will determine specific c‐miRNA signatures that will highlight its potential as exercise dose biomarker. Nine active middle‐aged males completed a 10‐km race (10K), a half‐marathon (HM), and a marathon (M). Blood samples were collected immediately before and after races. Plasma RNA was extracted, and a global screening of 752 microRNAs was analyzed using RT‐qPCR. Three different c‐miRNA profiles were defined according to the three doses. In 10K, 14 c‐miRNAs were found to be differentially expressed between pre‐ and post‐exercise, 13 upregulated and 1 downregulated. Regarding HM, 13 c‐miRNAs were found to be differentially modulated, in all the cases upregulated. A total of 28 c‐miRNAs were found to be differentially expressed in M, 21 overexpressed and 7 repressed after this race. We had also found 3 common c‐miRNAs between 10K and M and 2 common c‐miRNAs between 10K and HM. In silico analysis supported a close association between exercise dose c‐miRNA profiles and cellular pathways linked to energy metabolism and cell cycle. In conclusion, we have observed that different exercise doses induced specific c‐miRNA profiles. So, our results point to c‐miRNAs as emerging exercise dose biomarkers and as one of regulatory mechanisms modulating the response to endurance exercise.
Cancer is one of the leading causes of premature death and constitutes a challenge for both low- and high-income societies. Previous evidence supports a close association between modifiable risk ...factors, including dietary habits, and cancer risk. Investigation of molecular mechanisms that mediate the pro-oncogenic and anti-oncogenic effects of diet is therefore fundamental. MicroRNAs (miRNAs) have received much attention in the past few decades as crucial molecular elements of human physiology and disease. Aberrant expression patterns of these small noncoding transcripts have been observed in a wide array of cancers. Interestingly, human miRNAs not only can be modulated by bioactive dietary components, but it has also been proposed that diet-derived miRNAs may contribute to the pool of human miRNAs. Results from independent groups have suggested that these exogenous miRNAs may be functional in organisms. These findings open the door to novel and innovative approaches to cancer therapy. Here, we provide an overview of the biology of miRNAs, with a special focus on plant-derived dietary miRNAs, summarize recent findings in the field of cancer, address the possible applications to clinical practice and discuss obstacles and challenges in the field.
A sedentary lifestyle and Olympic participation are contrary risk factors for global mortality and incidence of cancer and cardiovascular disease. Extracellular vesicle miRNAs have been described to ...respond to exercise. No molecular characterization of young male sedentary people versus athletes is available; so, our aim was to identify the extracellular vesicle miRNA profile of chronically trained young endurance and resistance male athletes compared to their sedentary counterparts. A descriptive case–control design was used with 16 sedentary young men, 16 Olympic male endurance athletes, and 16 Olympic male resistance athletes. Next‐generation sequencing and RT‐qPCR and external and internal validation were performed in order to analyze extracellular vesicle miRNA profiles. Endurance and resistance athletes had significant lower levels of miR‐16‐5p, miR‐19a‐3p, and miR‐451a compared to sedentary people. Taking all together, exercise‐trained miRNA profile in extracellular vesicles provides a differential signature of athletes irrespective of the type of exercise compared to sedentary people. Besides, miR‐25‐3p levels were specifically lower in endurance athletes which defines its role as a specific responder in this type of athletes. In silico analysis of this profile suggests a role in adaptive energy metabolism in this context that needs to be experimentally validated. Therefore, this study provides for the first time basal levels of circulating miRNA in extracellular vesicles emerge as relevant players in intertissue communication in response to chronic exercise exposure in young elite male athletes.
Highlights
An extracellular vesicle miRNA profile defined by next‐generation sequencing differentiates athletes compared to sedentary young males.
Extracellular vesicle miR‐16‐5p, miR‐19a‐3p, and miR‐451a were lower in athletes irrespective of their sport disciplines compared to sedentary young males.
Extracellular vesicle miR‐25‐3p was specifically lower in endurance athletes compared to sedentary young males.
Energy metabolism and structural pathways are the main regulated ones based on extracellular vesicle miRNA profile.
The Fontan procedure (FP) is the standard surgical treatment for Univentricular heart diseases. Over time, the Fontan system fails, leading to pathologies such as protein-losing enteropathy (PLE), ...plastic bronchitis (PB), and heart failure (HF). FP should be considered as a transitional step to the final treatment: heart transplantation (HT). This systematic review and meta-analysis aims to establish the risk of death following HT according to the presence of FP complications. There was a total of 691 transplanted patients in the 18 articles, immediate survival 88% (
= 448), survival from 1 to 5 years of 78% (
= 427) and survival from 5.1 to 10 years of 69% (
= 208), >10 years 61% (
= 109). The relative risk (RR) was 1.12 for PLE (95% confidence interval CI = 0.89-1.40,
= 0.34), 1.03 for HF (0.7-1.51,
= 0.88), 0.70 for Arrhythmias (0.39-1.24,
= 0.22), 0.46 for PB (0.08-2.72,
= 0.39), and 5.81 for CKD (1.70-19.88,
= 0.005). In patients with two or more failures, the RR was 1.94 (0.99-3.81,
= 0.05). After FP, the risk of death after HT is associated with CKD and with the presence of two or more failures.
Coccoloba uvifera is a Mayan medicinal plant, and these leaves are used as antidiarrheal and diuretic agents. In the present work, we develop in-vitro, ex-vivo, in-vivo, and in-silico strategies to ...evaluate several aqueous extracts of C. uvifera leaves. In vitro tests showed that decoction extract (CuDe) presented the best yield and chlorophyll, phenol, and flavonoid content; however, CuDe showed low antioxidant activity (DPPH model). All aqueous extracts exert spasmolytic and vasorelaxant activity in a concentration-dependent manner (ex vivo), and in vivo tests showed that CuDe exerts the best antiperistaltic and diuretic effects. The in-silico analysis suggests that C. uvifera triterpenes act as a ligand of GPCR, and β-sitosterol could act as an antagonist of muscarinic acetylcholine receptor subtype 3 (m3AChR). In the context of aqueous extracts of C. uvifera, β-sitosterol and their heterosides were identified by FTIR and 1H-NMR spectroscopy. The concerted binding of β-sitosterol and other triterpenes within the m3AChR binding site may be relevant for the induction of relaxant effects at the gastrointestinal smooth muscle level. In this context, C. uvifera is a high-value plant species that requires analytical and pharmacological studies to confirm traditional medicinal use.
Abstract
Background
Advances in life expectancy have led to an increase in the number of elderly people with end-stage renal disease (ESRD). Scarce information is available on the outcomes of kidney ...transplantation (KT) in extremely elderly patients based on an allocation policy prioritizing donor–recipient age matching.
Methods
We included recipients ≥75 years that underwent KT from similarly aged deceased donors at our institution between 2002 and 2015. Determinants of death-censored graft and patient survival were assessed by Cox regression.
Results
We included 138 recipients with a median follow-up of 38.8 months. Median (interquartile range) age of recipients and donors was 77.5 (76.3–79.7) and 77.0 years (74.7–79.0), with 22.5% of donors ≥80 years. Primary graft non-function occurred in 8.0% (11/138) of patients. Cumulative incidence rates for post-transplant infection and biopsy-proven acute rejection (BPAR) were 70.3% (97/138) and 15.2% (21/138), respectively. One- and 5-year patient survival were 82.1 and 60.1%, respectively, whereas the corresponding rates for death-censored graft survival were 95.6 and 93.1%. Infection was the leading cause of death (46.0% of fatal cases). The occurrence of BPAR was associated with lower 1-year patient survival hazard ratio (HR) = 4.21, 95% confidence interval (CI) 1.64–10.82; P = 0.003. Diabetic nephropathy was the only factor predicting 5-year death-censored graft survival (HR = 4.82, 95% CI 1.08–21.56; P = 0.040).
Conclusions
ESRD patients ≥75 years can access KT and remain dialysis free for their remaining lifespan by using grafts from extremely aged deceased donors, yielding encouraging results in terms of recipient and graft survival.
The productivity of mangrove ecosystems is associated with litterfall production, which continuously contributes large quantities of organic matter, in the form of detritus, to the food web via ...adjacent ecosystems. However, the degree of deterioration of mangrove ecosystems worldwide has been increasing due to anthropogenic activities, leading to the loss of vegetation cover and changes in hydrological patterns, the chemical conditions of interstitial water and soil, and the litterfall degradation rate and, thus, the integration of organic matter into the ecosystem. In this study, we investigate the relationship between leaf degradation and interstitial water chemistry in two mangrove forests located in Oaxaca, Mexico, that are characterized by differences in environmental conditions, species, and anthropogenic activity. Forty-two 10 cm × 20 cm nylon mesh bags were installed in the Rhizophora mangle forest along two flood-associated lines (21 per line), and twenty-one bags were installed centrally in the Avicennia germinans forest because of the flood conditions in this area. Three bags per line were collected each month. This material was then dried and calcined for determination of the decomposition rate (k). The in situ redox potential and interstitial water salinity of mangrove forests were measured using a HACH HQ40d multiparametric probe and A&O refractometer, and the sulfate concentration was determined by ion chromatography. The results show that daily average decomposition rates were higher in the Salina lagoon (k = 0.01 g·day−1) than in the Chacahua lagoon (k = 0.004 g·day−1). The degradation model was Y = 66.054e−0.010t, R2 = 0.89, p ≤ 0.05, for the Salina lagoon and Y = 67.75e−0.004t, R2 = 0.76, p ≤ 0.05, for the Chacahua lagoon. Leaf decomposition rates differed between the Salina and Chacahua lagoons (F1,206 = 4.8, p < 0.03). In the Salina lagoon, dominated by A. germinans, an inverse relationship was established between the percentage of degraded biomass with respect to salinity concentration (R2 = 0.82, p < 0.013) and redox potential (R2 = 0.89, p < 0. 015), and for the Chacahua lagoon, dominated by R. mangle, the percentage of degraded litter biomass was found to be inversely correlated with redox potential (R2 = 0.94, p < 0.005) and sulfate concentration (R2 = 0.88, p < 0.017). Based on the results obtained in this study, we conclude that variations in the chemical conditions of interstitial water and hydrological patterns can affect the process of mangrove leaf degradation based on species and the integration of organic matter in the soil and in adjacent ecosystems. These findings are potentially useful for mangrove management because they advance understanding of the dynamics of organic matter in mangroves and the importance of maintaining the health of these ecosystems, which is necessary for the maintenance of coastal fishing production.
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