To explore the characteristics of Helicobacter pylori resistance in China and the association between antibiotic resistance and several clinical factors.
H. pylori strains were collected from ...patients in 13 provinces or cities in China between 2010 and 2016. Demographic data including type of disease, geographic area, age, gender and isolation year were collected to analyse their association with antibiotic resistance. Antibiotic resistance was detected using the Etest test and the Kirby-Bauer disc diffusion method.
H. pylori were successfully cultured from 1117 patients. The prevalence of metronidazole, clarithromycin (CLA), azithromycin, levofloxacin (LEV), moxifloxacin, amoxicillin (AMO), tetracycline and rifampicin resistance was 78.2, 22.1, 23.3, 19.2, 17.2, 3.4, 1.9 and 1.5%, respectively. No resistance to furazolidone was observed. The resistance rates to LEV and moxifloxacin were higher in strains isolated from patients with gastritis compared to those with duodenal ulcer and among women. Compared to patients ≥40 years old, younger patients exhibited lower resistance rates to CLA, azithromycin, LEV and moxifloxacin. The resistance rates to CLA and AMO were higher in strains isolated more recently, and we also found that the prevalence of resistance to metronidazole, CLA, azithromycin and AMO were significantly different among different regions of China.
The resistance rates to metronidazole, CLA and LEV were high in China. Patient age, gender, disease and location were associated with the resistance of H. pylori to some antibiotics. Furazolidone, AMO and tetracycline are better choices for H. pylori treatment in China.
Galeruca daurica (Joannis) is a new outbreak pest in the Inner Mongolia grasslands in northern China. Heat shock protein 10 and 60 (Hsp10 and Hsp60) genes of G. daurica, designated as GdHsp10 and ...GdHsp60, were cloned by rapid amplification of cDNA ends techniques. Sequence analysis showed that GdHsp10 and GdHsp60 encoded polypeptides of 104 and 573 amino acids, respectively. Sequence alignment and phylogenetic analysis clearly revealed that the amino acids of GdHsp10 and GdHsp60 had high homology and were clustered with other Hsp10 and Hsp60 genes in insects which are highly relative with G. daurica based on morphologic taxonomy. The mRNA expression analysis by real-time PCR revealed that GdHsp10 and GdHsp60 were expressed at all development stages and in all tissues examined, but expressed highest in eggs and in adults' abdomen; both heat and cold stresses could induce mRNA expression of GdHsp10 and GdHsp60 in the 2nd instar larvae; the two Hsp genes were expressed from high to low with the extension of treatment time in G. daurica eggs exposed to freezing point. Overall, our study provides useful information to understand temperature stress responses of Hsp60 and Hsp10 in G. daurica, and provides a basis to further study functions of Hsp60/Hsp10 relative to thermotolerance and cold hardiness mechanism.
Organizations and other groups often recognize the importance of members treating each other in a fair (dignified, unbiased) manner. This type of treatment is key to fostering individuals' sense of ...belonging in the group. However, while a sense of belonging is important, individuals also need to be shown that they have some distinct value to the group-enabling them to not only "fit in" but also "stand out." Building from research on fair treatment, we explicate another form, distinctive treatment, whereby others show interest and appreciation for an individual's more distinguishing, group-relevant qualities. In six studies using multiple methods (e.g., experimental, longitudinal) and in multiple types of groups (work organizations, student communities, racial/ethnic minority groups), we show that fair and distinctive treatment play fundamentally different roles-shaping individuals' perceived belonging versus intragroup standing, respectively-and with downstream benefits for mental health (less anxiety, fewer depressive symptoms). Overall, this illustrates that promoting fair treatment in groups is important, but not sufficient. Experiencing distinctive treatment is also key. Each type of treatment provides unique social evaluative information that fosters a healthy sense of self. This research further indicates that distinctive treatment may be a vital yet overlooked element to promoting diversity and inclusion in groups, as it provides a path for recognizing and appreciating, and thus encouraging, a diversity of ideas, insights, knowledge and skills that individuals bring to the group.
AbstractBamboo is increasingly recognized for its potential as an environmentally friendly and sustainable building material, but the knowledge of its combustion properties and the safety of bamboo ...building construction are very limited. In this study, experiments were conducted to obtain the combustion behaviors of glue-laminated bamboo (GluBam or glubam) boards by using a cone calorimeter. The tests were carried out at five levels of heat flux: 15, 25, 35, 50, and 70 kW/m2. The measured results are compared with those of fir plywood. Glubam generally behaves better than plywood under the same heat flux. A further comparison of the investigation in this study with some measured results in published papers indicates that glubam is less flammable than the laminated bamboo materials and several wood species. The fire safety assessment of glubam is also studied based on fire hazard indices, the charring rate, and fire endurance time. From flammability considerations, glubam has the potential as a substitute for untreated plywood in structural and lining applications and should further be evaluated according to building codes to define its end-use.
•Impact between a uniform elastic rod and a linear elastic or bilinear inelastic spring supported by a fix rigid wall is studied.•The spring may represent, e.g., the stiffness of a small elastic ...cylinder with flat ends or the inelastic bit-rock interaction in percussive drilling.•Acceleration of the rod to its impact momentum by a force generates pre-impact waves in the rod.•Such waves have significant effect on the coefficient of restitution (COR) if the duration of the force is short relative to the wave transit time through the rod.•A mechanism leading to super rebounds with COR up to 1.4261 is described in terms of pre-impact waves.
The effect of pre-impact waves on the coefficient of restitution (COR) in longitudinal impact of a uniform elastic rod on a linear elastic or bilinear inelastic spring supported by a fix rigid wall is studied. The spring models may represent the quasi-static response of, e.g., a small elastic cylinder or the inelastic bit-rock interaction in percussive drilling. The rod is accelerated to its impact momentum either by a force of relatively short duration which generates significant pre-impact waves in the rod (pre-impact wave case) or by a force of long duration which does not generate such waves (reference case). Analytical and numerical results based on the 1D wave equation are presented in dimensionless form. It is shown that the work performed by the accelerating force is much larger in the pre-impact wave case than in the reference case, and that the COR generally depends on spring stiffness, elasticity parameter, initial rod-spring separation, and wave transit time. In the pre-impact wave case, the COR may be significantly larger or smaller than in the reference case. It may also be significantly larger or smaller than unity. A pre-impact wave mechanism leading to super rebounds with COR up to 1.4261 is described.
To explore the application value of serum Gal-13, GLP-1 and VEGF in the prevention and guidance of adverse pregnancy outcomes in gestational diabetes (GDM). A retrospective study with case-control ...method was used to select 1 012 GDM patients from Haikou Maternal and Child Health Hospital from January 2019 to December 2022 as the study objects, and they were divided into poor pregnancy outcome group (
=342) and good pregnancy outcome group (
=670) according to whether they had adverse pregnancy outcomes. The medical records of 521 healthy women with normal glucose metabolism were selected as the control group. Serum Gal-13 and GLP-1 were detected by enzyme-linked immunosorbent assay and VEGF was determined by IAMMGE specific protein analyzer. After comparing the differences of the above factors among the three groups, multivariate logistic regression model was used to analyze the influencing factors of adverse pregnancy outcomes in GDM patients, and ROC curve was drawn to analyze the predictive value of serum
To Compare the effects and safety of lumen reshaping after thoracic endovascular aortic repair (TEVAR) for Stanford B type aortic dissection (AD) at different intervention times.
A retrospective ...analysis was conducted on the clinical data of 189 patients with Stanford type B aortic dissection treated with TEVAR at the Affiliated Hospital of Chengde Medical College from January 2016 to December 2020.Based on the time from onset to surgery, patients were divided into an early intervention group (≤14 days,
=127) and a delayed intervention group (>14 days,
=62).The diameters of the total aorta, true lumen and false lumen at different times and planes (S
plane: at the bifurcation of the pulmonary artery; S
plane: at the lower edge of the left atrium; S
plane: at the upper edge of the celiac trunk) post-surgery were compared between the two groups, and the rate of change in diameters of true and false lumens across these planes was calculated. The patients were followed until December 1
, 2023, and the median follo
More Than a Feeling Osborne, Danny; Smith, Heather J.; Huo, Yuen J.
Personality & social psychology bulletin,
05/2012, Volume:
38, Issue:
5
Journal Article
Peer reviewed
A key insight from investigations of individual relative deprivation (IRD) is that people can experience objective disadvantages differently. In this study, university faculty (N = 953) who reported ...greater IRD in response to a mandatory furlough (i.e., involuntary pay reductions) were more likely to (a) voice options designed to improve the university (voice), (b) consider leaving their job (exit), and (c) neglect their work responsibilities (neglect), but were (d) less likely to express loyalty to the university (loyalty). Consistent with the emotions literature, (a) anger mediated the relationship between IRD and voice, (b) fear between IRD and exit, (c) sadness between IRD and neglect, and (d) gratitude between IRD and loyalty. IRD was inversely associated with self-reported physical and mental health via these different emotional pathways. These results show how discrete emotions can explain responses to IRD and, in turn, contribute to organizational viability and the health of its members.
Using the Andersen behavioral model, we examined the complex relationships among geographic access to care, financial disadvantage, patient-centered care factors, and access to care outcomes.
This ...was a retrospective, cross-sectional study of the US civilian non-institutionalized population.
Our analytic sample included 15,787 US adults aged 18 years or older who had health insurance coverage for a full year in Medical Expenditure Panel Survey 2014–2015. Structural equation modeling was used to determine the associations among usual source of care, travel time to provider, financial disadvantage, patient-centered care factors (perceived interaction with health provider, shared decision-making, and value of health care), and access to care (perceived access to care and unmet need of health services).
Our analysis showed that patient-centered care factors were associated with improved perceived access to care (β = 0.03 to 0.56, P = .002) and reduced unmet needs of health care (β = −0.03 to −0.17, P = .03 to < .001). Although longer travel time to provider and having financial disadvantage of paying medical bills had negative effects on access to care outcomes, these associations were mediated by patient-centered care quality factors.
Our findings suggest that better patient-centered care factors are associated with enhanced patient access to care. Efforts that focus on improving patient experience could be an effective approach along with coverage expansion to enhance access to quality care.
•Under the Affordable Care Act, considerable disparities in access to care still exist in the US.•Having health insurance may not guarantee the use of needed health services.•Patient-centered care factors were associated with better patient experience with care.•These associations, in turn, had positive effects on continuity of care or receipt of needed health services.•Improving patient experience could be effective to enhance access to quality care.
Abstract Osthole, a bioactive simple coumarin derivative extracted from many medicinal plants such as Cnidium monnieri (L.) Cusson, exerts a broad spectrum of pharmacological activities and is ...considered to have potential therapeutic applications. The aim of this study was to investigate the potential neuroprotective role of osthole against ischemic injury in vitro , as well as the potential mechanism. Cultured cortical neurons were exposed to oxygen and glucose deprivation (OGD) for 4 h followed by a 24 h reperfusion. Osthole exhibited remarkable neuroprotection in a dose-dependent manner and the effect required presence of osthole during both OGD and reperfusion phases. Western blot was used to examine the activation of three members of mitogen-activated protein kinases (MAPKs): extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 kinase (p38). We found that osthole prolonged activation of ERK1/2 and prevented activation of JNK. Furthermore, we investigated the effects of MAPKs inhibitors on osthole-induced protection. The results demonstrated that the protection of osthole was partly reversed by PD98059, a selective inhibitor of ERK1/2, but further enhanced by the JNK inhibitor SP600125. In addition, osthole-induced reduction of neuronal apoptosis was abrogated by the ERK1/2 inhibitor PD98059, whereas the total neuronal death was further decreased by the JNK inhibitor SP600125. In summary, these data suggested that osthole had neuroprotective effect against ischemic injury in vitro , and the protection possibly was associated with prolonged activation of ERK1/2 and suppression of JNK activity.
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