Quality control can decrease variations in the performance of colonoscopists and improve the effectiveness of colonoscopy to prevent colorectal cancers. Unfortunately, routine quality control is ...difficult to carry out because a practical method is lacking. The aim of this study was to develop an automatic quality control system (AQCS) and assess whether it could improve polyp and adenoma detection in clinical practice.
First, we developed AQCS based on deep convolutional neural network models for timing of the withdrawal phase, supervising withdrawal stability, evaluating bowel preparation, and detecting colorectal polyps. Next, consecutive patients were prospectively randomized to undergo routine colonoscopies with or without the assistance of AQCS. The primary outcome of the study was the adenoma detection rate (ADR) in the AQCS and control groups.
A total of 659 patients were enrolled and randomized. A total of 308 and 315 patients were analyzed in the AQCS and control groups, respectively. AQCS significantly increased the ADR (0.289 vs 0.165, P < .001) and the mean number of adenomas per procedure (0.367 vs 0.178, P < .001) compared with the control group. A significant increase was also observed in the polyp detection rate (0.383 vs 0.254, P = .001) and the mean number of polyps detected per procedure (0.575 vs 0.305, P < .001). In addition, the withdrawal time (7.03 minutes vs 5.68 minutes, P < .001) and adequate bowel preparation rate (87.34% vs 80.63%, P = .023) were superior for the AQCS group.
AQCS could effectively improve the performance of colonoscopists during the withdrawal phase and significantly increase polyp and adenoma detection. (Clinical trial registration number: NCT03622281.)
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The duration of the accumulation rate (physical image) is a key factor in analysis of counterintuitive phenomena involving relative timescales on multiplex networks. Typically, the relative ...timescales are represented by multiplying any layer by the same factor. However, researchers often overlook the changes in the relative timescales caused by local parameters, resulting in incomplete analysis of phenomena. This paper examines the survival time of stifler individuals in the information-epidemic model on multiplex networks. The relative timescales can be affected by the survival time (only one parameter), reversing the monotonically increasing phenomenon into a monotonically decreasing one, that is, a counterintuitive phenomenon under incomplete analysis. Additionally, the relative timescales can influence the epidemic threshold, which is different from the previous studies. Our work suggests that considering the physical image of relative timescales is crucial when analyzing multiplex networks, even when only one parameter is altered.
•Relative timescales are essential for coevolutionary dynamics on multiplex networks.•Changing just one parameter can significantly change the relative timescales.•Epidemic threshold in information-epidemic model is affected by relative timescales.•Reducing the survival time of stifler individuals is a “double-edged sword”.
Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor ...molecules that also activate different intracellular signalling pathways. Here we reveal that TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), stimulates acute catecholamine secretion through coupling with the transient receptor potential cation channel subfamily C 3 (TRPC3). We show that TRV120027 promotes the recruitment of TRPC3 or phosphoinositide-specific phospholipase C (PLCγ) to the AT1R-β-arrestin-1 signalling complex. Replacing the C-terminal region of β-arrestin-1 with its counterpart on β-arrestin-2 or using a specific TAT-P1 peptide to block the interaction between β-arrestin-1 and PLCγ abolishes TRV120027-induced TRPC3 activation. Taken together, our results show that the GPCR-arrestin complex initiates non-desensitized signalling at the plasma membrane by coupling with ion channels. This fast communication pathway might be a common mechanism of several cellular processes.
ObjectivesFurazolidone containing regimen is effectivefor Helicobacter pylori (H. pylori) infection, but its safetyremains controversial. To assess the safety of furazolidone containing regimenin H. ...pylori infection.DesignA systematic review and meta-analysis.Data sourcesPubMed, Embase, Cochrane Library, Web of Science and Scopus databases were systematically searched for eligible randomised controlled trials.Eligibility criteriaStudies comparing furazolidone with non-furazolidone-containing regimen, variable durations or doses of furazolidone were included.Data extraction and synthesisTwo reviewers independently selected studies and extracted data. Primary outcomes were the risk of total adverse events (AEs), serious AEs and severe AEs, expressed as relative risk (RR) with 95% CI. Secondary outcomes contained the incidence of individual adverse symptoms, AE-related treatment discontinuation and compliance.ResultsTwenty-six articles were identified from 2039 searched records, of which 14 studies (n=2540) compared furazolidone with other antibiotics. The eradication rates of furazolidone-containing regimen were higher than those of other antibiotics in both intention-to-treat (RR 1.06, 95% CI 1.01 to 1.12) and per-protocol analysis (RR 1.05, 95% CI 1.00 to 1.10). Only two serious AEs were reported in furazolidone group (2/1221, 0.16%). No significant increased risk was observed for the incidence of total AEs (RR 1.04, 95% CI 0.89 to 1.21) and severe AEs (RR 1.81, 95% CI 0.91 to 3.60). Twelve studies (n=3139) compared different durations of furazolidone, and four studies (n=343) assessed variable doses. Elevated risk of total AEs and severe AEs were only found in a high daily dose of furazolidone rather than prolonged duration. The incidence of AE-related treatment discontinuation and compliance of patients were all similar, irrespective of dose and duration adjustments.ConclusionFurazolidone-containing regimen has a similar risk of AEs and compliance as non-furazolidone-containing regimen. A low daily dose of 200 mg is well-tolerated for 14 day regimen and should be first considered.PROSPERO registration numberCRD42019137247
Patterns emerging through self-organization in nature have sparked considerable interest across various disciplines, owing to their significance in comprehending collective behaviors. The ...anti-coordination phenomenon is widespread in both social systems and ecosystems. However, within the context of the SnowDrift Game (SDG), considered as a typical anti-coordination game, the occurrence of anti-coordination patterns is surprisingly rare. In this work, we introduce a model called the Two-Agent, Two-Action Reinforcement Learning Evolutionary Game (2 × 2 RLEG), and utilize it in the SDG on different regular lattices. We unveil intriguing phenomena represented by Anti-Coordinated domains (AC-domains) within spatial patterns, which hold a significant sway over the cooperation preference within populations. The frustration contributes substantially to the diversity of AC-domains within parameter space. To comprehend the underlying mechanism, we have developed a perturbation theory to analyze the stability of different AC-domains comprising action patterns and identify continuous phase transitions within parameter space. Our theory effectively partitions the parameter space into several areas, each characterized by unique features of domains that determine the cooperation preferences within the population. Our work offers insights into the emergence of spatial patterns and their impact on cooperation in nature, contributing to the development of theories that analyze their structural complexities.
•Anti-coordinated patterns naturally emerge in snowdrift game by reinforcement learning.•A perturbation theory is successfully developed.•The effect of memory and frustration greatly influence these patterns and collective preferences.
Cooperation is the foundation of ecosystems and the human society, and the reinforcement learning provides crucial insight into the mechanism for its emergence. However, most previous work has mostly ...focused on the self-organization at the population level, the fundamental dynamics at the individual level remains unclear. Here, we investigate the evolution of cooperation in a two-agent system, where each agent pursues optimal policies according to the classical Q-learning algorithm in playing the strict prisoner’s dilemma. We reveal that a strong memory and long-sighted expectation yield the emergence of Coordinated Optimal Policies (COPs), where both agents act like “Win-Stay, Lose-Shift” (WSLS) to maintain a high level of cooperation. Otherwise, players become tolerant toward their co-player’s defection and the cooperation loses stability in the end where the policy “all Defection” (All-D) prevails. This suggests that tolerance could be a good precursor to a crisis in cooperation. Furthermore, our analysis shows that the Coordinated Optimal Modes (COMs) for different COPs gradually lose stability as memory weakens and expectation for the future decreases, where agents fail to predict co-player’s action in games and defection dominates. As a result, we give the constraint to expectations of future and memory strength for maintaining cooperation. In contrast to the previous work, the impact of exploration on cooperation is found not be consistent, but depends on composition of COMs. By clarifying these fundamental issues in this two-player system, we hope that our work could be helpful for understanding the emergence and stability of cooperation in more complex scenarios in reality.
•Strong memory and long-sighted expectations yield “win-stay, lose-shift” and high cooperation.•Tolerance of exploitation could be a good precursor to a crisis in cooperation.•The impact of exploration on cooperation nonmonotonically depends on the composition of the coordinated optimal modes.
Two isostructural ionic cobalt(ii) halides, trimethylchloromethyl ammonium tetrachlorocobalt(ii) (1, Me3NCH2Cl2CoCl4) and trimethylbromomethyl ammonium tetrabromocobalt(ii) (2, Me3NCH2Br2CoBr4), have ...been discovered as new high-temperature phase transition materials. 1 exhibits two successive structural phase transitions from P212121 to P21/c at 252 K and then to Pnma at 335 K, accompanied by step-like dielectric anomalies. The two-step sequential reversible phase transitions of 1 derive from the order-disorder transformation of CoCl4 anions and organic Me3NCH2Cl cations, respectively. Its analogue 2 also crystallizes in P21/c at 293 K by changing the halogen atoms of both cations and anions of 1. Unlike 1, 2 displays only one structural phase transition with a much higher transition temperature at 387 K, which is mainly influenced by intermolecular interactions and more energy is required to provide the freedom of the motion. All the findings in the present work indicate that the phase transition temperature and properties of materials can be tuned by using halogens in this series of compounds, which could open a new way to design and assemble novel high-temperature phase transition materials.
Purpose:
Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs that regulate gene expression through the competitive endogenous RNA (ceRNA) mechanism. CircRNA-associated-ceRNA ...networks are closely related to oxidative stress–related diseases. Oxidative stress–induced dysfunction of the corneal endothelium (CE) is a major pathological feature in many corneal diseases. This study was aimed to analyze circRNA-associated-ceRNA networks in oxidative stress–induced CE dysfunction.
Methods:
A CE dysfunction model was established using human corneal endothelial cells (HCECs) treated with H
2
O
2
at a concentration of 250 μM for 4 hours at 37°C. High-throughput sequencing was conducted to determine the expression profiles of circRNA, miRNA, and mRNA. Bioinformatic analyses, including Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes analysis, were conducted to identify the potential biological modules and pathologic pathways of dysregulated circRNAs. CircRNA-associated-ceRNA networks were established based on the data of sequencing and bioinformatic analyses.
Results:
We obtained 108 differentially expressed circRNAs, including 77 upregulated and 31 downregulated circRNAs. GO analysis suggested that dysregulated circRNAs were mainly targeted to protein quality control for misfolded or incompletely synthesized proteins (biologic process), nuclear chromatin (cellular component), and ubiquitin protein ligase binding (molecular function). GO terms related to CE functions responding to oxidative stress were also identified. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that dysregulated circRNAs were mostly enriched in the adherens junction pathway. Network analysis identified several potential therapeutic targets for CE dysfunction.
Conclusions:
CircRNAs are significantly dysregulated in HCECs under oxidative stress. The circRNA-associated-ceRNA networks are closely related to HCEC functions. Targeting these networks might provide novel therapies for CE dysfunction.
Purpose
To report atypical clinical features and diagnosis of stromal herpes simplex keratitis (HSK) and to evaluate the diagnostic efficiency of tear HSV-sIgA in atypical HSK.
Study design
...Prospective observational study.
Methods
Records of keratitis’ patients with tear herpes simplex virus (HSV)-sIgA test results acquired between May 2019 and November 2021 were evaluated retrospectively. Positive tear HSV-sIgA test was used to identify herpes simplex virus (HSV) infection. Patients with typical presentations and histories of HSV keratitis (HSK) were excluded.
Results
Eleven eyes of 11 patients initially diagnosed as keratitis caused by other etiology were confirmed as having HSV infection by positive results of tear HSV-sIgA. Clinical features of atypical stromal HSK were variable. Antiviral treatment was effective in all patients.
Conclusion
The appearance of an atypical stromal HSK represents a diagnostic challenge. Tear HSV-sIgA test could help provide a quick diagnosis.
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