The aim of this study was to verify the impact of periodontitis in the course of chronic obstructive pulmonary disease (COPD) in C57Bl/6J mice.
The animals were randomly divided into four groups ...(n = 8): Basal, Periodontitis (P), COPD and COPD+P. COPD was induced by orotracheal instillation of 30 μl of cigarette extract 3 times/week for 7 weeks. Periodontitis was induced by ligation technique for 22 days. Euthanasia was performed on 51st day. The analyzes were total/differential cells and cytokines recovered from bronchoalveolar lavage (BAL), total/differential blood cell count, platelets, total marrow cell count, airway collagen deposition, alveolar enlargement analyzed by mean linear intercept (Lm), mucus and bone crest reabsorption. One-way ANOVA followed by the Student-Newman-Keuls was used.
The association COPD+P decreased macrophages (p = 0,0351), TNF-α (p = 0,0071) and INF-γ (p = 0,0004) in BAL, when compared to the COPD group maintaining emphysema levels by alveolar enlargement (p < .05) reorganization of collagen fibers (p = .001) and also mean linear intercept (lm) (p = .001) and mucus (p = .0001). The periodontitis group caused TNF-α increase (p = 0, 0001) in BAL.
Periodontitis, per se, does not alter any of the parameters analyzed, except for increased TNF-α in BAL. However, its association with COPD caused macrophages TNF-α and INF-γ alterations, when compared to the COPD group maintaining emphysema levels by alveolar enlargement and reorganization of collagen fibers. It seems that periodontitis is influencing the course of Th1 profile cell, and cytokines and pulmonary alterations. Further studies are needed to clarify the regulatory process underlying these two diseases.
O presente estudo buscou avaliar a flexibilidade de dois tipos de limas: tipo K e Flexofile® de diferentes números, submetidas ou não a um tratamento térmico recristalizador. Para tanto, ...utilizaram-se 144 limas que foram submetidas ao ensaio de flexão em um troptômetro e uma célula de carga. Os resultados evidenciaram que o tratamento térmico recristalizador foi capaz de provocar a redução na resistência à flexão das limas tipo K de 56,78 a 82,06%. Nas limas Flexofile®, a diminuição da resistência à flexão foi da ordem de 1,94 a 50,60%, quando comparadas com as Flexofile® não-tratadas. Concluiu-se que o tratamento térmico recristalizador, como o proposto, reduz a resistência à flexão das limas tipo K de forma significativa, e das limas tipo Flexofile® de maneira pouco sensível.
The aim of this study was to evaluate the bending resistance of 2 types of files: K and Flexofile®, from different numbers submitted or not to a recrystallizing thermal treatment. A hundred and forty-four files were submitted to the bending test in a torquemeter with a scale. The results made evident that the recrystallizing thermal treatment was able to cause a decrease on the bending resistance of the K type files between 56.78 and 82.06% (alpha = 0.05%). The Flexofile® files presented a decrease on the bending resistance between 1.94 and 50.60% (alpha = 0.05%), in comparison with non-treated Flexofile® files, except for number 25. In conclusion, the recrystallizing thermal treatment, as proposed, reduces the bending resistance of K type files in a significant way, and of Flexofile® files in a less marked way.
O presente estudo buscou avaliar a flexibilidade de dois tipos de limas: tipo K e Flexofile® de diferentes números, submetidas ou não a um tratamento térmico recristalizador. Para tanto, ...utilizaram-se 144 limas que foram submetidas ao ensaio de flexão em um troptômetro e uma célula de carga. Os resultados evidenciaram que o tratamento térmico recristalizador foi capaz de provocar a redução na resistência à flexão das limas tipo K de 56,78 a 82,06%. Nas limas Flexofile®, a diminuição da resistência à flexão foi da ordem de 1,94 a 50,60%, quando comparadas com as Flexofile® não-tratadas. Concluiu-se que o tratamento térmico recristalizador, como o proposto, reduz a resistência à flexão das limas tipo K de forma significativa, e das limas tipo Flexofile® de maneira pouco sensível.
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