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  • dbPTM in 2019: exploring di... dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications
    Huang, Kai-Yao; Lee, Tzong-Yi; Kao, Hui-Ju ... Nucleic acids research, 01/2019, Volume: 47, Issue: D1
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    Open access

    Abstract The dbPTM (http://dbPTM.mbc.nctu.edu.tw/) has been maintained for over 10 years with the aim to provide functional and structural analyses for post-translational modifications (PTMs). In ...
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  • Identification of subtypes ... Identification of subtypes of anticancer peptides based on sequential features and physicochemical properties
    Huang, Kai-Yao; Tseng, Yi-Jhan; Kao, Hui-Ju ... Scientific reports, 06/2021, Volume: 11, Issue: 1
    Journal Article
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    Anticancer peptides (ACPs) are a kind of bioactive peptides which could be used as a novel type of anticancer drug that has several advantages over chemistry-based drug, including high specificity, ...
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  • dbPTM 2016: 10-year anniver... dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins
    Huang, Kai-Yao; Su, Min-Gang; Kao, Hui-Ju ... Nucleic acids research, 01/2016, Volume: 44, Issue: D1
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    Open access

    Owing to the importance of the post-translational modifications (PTMs) of proteins in regulating biological processes, the dbPTM (http://dbPTM.mbc.nctu.edu.tw/) was developed as a comprehensive ...
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  • Dysregulation of miRNAs-COU... Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
    Lin, Shih-Chieh; Kao, Chung-Yang; Lee, Hui-Ju ... Nature communications, 04/2016, Volume: 7, Issue: 1
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    Although early detection and treatment of prostate cancer (PCa) improves outcomes, many patients still die of metastatic PCa. Here, we report that metastatic PCa exhibits reduced levels of the ...
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  • Elevated COUP-TFII expressi... Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction
    Kao, Chung-Yang; Xu, Mafei; Wang, Leiming ... PLoS genetics, 06/2020, Volume: 16, Issue: 6
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    Parkinson's disease (PD) is a neurodegenerative disorder featuring progressive loss of midbrain dopaminergic (DA) neurons that leads to motor symptoms. The etiology and pathogenesis of PD are not ...
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  • iDPGK: characterization and... iDPGK: characterization and identification of lysine phosphoglycerylation sites based on sequence-based features
    Huang, Kai-Yao; Hung, Fang-Yu; Kao, Hui-Ju ... BMC bioinformatics, 12/2020, Volume: 21, Issue: 1
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    Protein phosphoglycerylation, the addition of a 1,3-bisphosphoglyceric acid (1,3-BPG) to a lysine residue of a protein and thus to form a 3-phosphoglyceryl-lysine, is a reversible and non-enzymatic ...
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  • Dysregulation of nuclear re... Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development
    Lee, Hui-Ju; Kao, Chung-Yang; Lin, Shih-Chieh ... Scientific reports, 06/2017, Volume: 7, Issue: 1
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    Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) has been shown to inhibit myogenesis and skeletal muscle metabolism in vitro. However, its precise role and in vivo function in ...
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  • Characterization and identi... Characterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites
    Huang, Kai-Yao; Kao, Hui-Ju; Hsu, Justin Bo-Kai ... BMC bioinformatics, 02/2019, Volume: 19, Issue: Suppl 13
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    Glutarylation, the addition of a glutaryl group (five carbons) to a lysine residue of a protein molecule, is an important post-translational modification and plays a regulatory role in a variety of ...
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  • Adaptable interaction betwe... Adaptable interaction between aquaporin‐1 and band 3 reveals a potential role of water channel in blood CO2 transport
    Hsu, Kate; Lee, Ting‐Ying; Periasamy, Ammasi ... The FASEB journal, October 2017, Volume: 31, Issue: 10
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    ABSTRACT Human CO2 respiration requires rapid conversion between CO2 and HCO3−. Carbonic anhydrase II facilitates this reversible reaction inside red blood cells, and band 3 anion exchanger 1 (AE1) ...
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  • Goat Milk Consumption Enhan... Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice
    Kao, Hui-Fang; Wang, Yu-Chin; Tseng, Hsiu-Ying ... Frontiers in immunology, 02/2020, Volume: 11
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    Goat milk (GM), as compared to cow milk (CM), is easier for humans to digest. It also has antioxidant and anti-inflammatory effects and can improve minor digestive disorders and prevent allergic ...
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