The canalicular domain‐specific glycoprotein gp110, which recently has been shown to function as an ATP‐dependent taurocholate transporter, has been purified 1800‐fold from rat liver plasma ...membranes. gp110 has been characterised as an integral plasma membrane protein with Mr of 100000–115000 and pI of 2.5–3.5 and possesses a highly glycosylated and negatively charged extra‐cellular domain. The broad range of Mr and pI values results from the existence of numerous glycoforms composed of sialylated N‐glycans. After deglycosylation, the polypeptide has Mr 48000 and pI 5.0. In primary cultures of rat hepatocytes, gp110 is synthesised with Mr 110000, while in the presence of tunicamycin the non‐glycosylated form has Mr 48000. In the presence of 1‐deoxymannojirimycin, two forms of Mr 83000 and Mr 91000 were found, which were converted by endo‐β‐N‐acetylglucosaminidase H into a single 52000‐Mr band, indicating the existence of two basic glycoforms at the ollgomannosyl stage of biosynthesis. gp110 was phosphorylated at serine residues in primary cultures of hepatocytes. The sequences of ten internal peptides of gp110 were identical to the sequence of the high‐Mr form of ecto‐ATPase, but ecto‐ATPase activity from plasmamembrane extracts was not depleted by anti‐(gp110) serum. In contrast, Fab fragments of these antibodies inhibit the aggregation of freshly isolated hepatocytes.
To characterize plaque morphologic characteristics of transplant coronary artery disease early and late after cardiac transplantation, 72 patients were studied with intravascular ultrasonography ...during routine coronary angiography (group 1, 25 patients ≤2 months after surgery; group 2, 47 patients ≥12 months after surgery). Both groups had comparable baseline characteristics. Three hundred fifty-one segments were imaged in 127 coronary arteries (4.9 ± 1.8 segments per patient). By intravascular ultrasonography, relevant intimal thickening (>0.3 mm) was found in the majority of patients (68% for group 1 and 72% for group 2). Angiography detected abnormal findings in only 16% and 32% for groups 1 and 2, respectively. Mean intimal index was higher in patients late after transplantation (27% ± 12% vs 17% ± 12%, respectively;
p < 0.01). Maximal and mean plaque thickness were comparable in both groups, whereas a higher mean plaque circumference was found in group2 (278 ± 66 degrees vs 211 ± 75 degrees, respectively;
p < 0.002). The lesions were more eccentric in patients early after transplantation (mean eccentricity index 95% ± 7% vs 77% ± 15%, respectively;
p < 0.0001). Diffuse, concentric intimal thickening was not a common pattern. Maximal plaque thickness correlated with donor age (
r = 0.50,
p < 0.0001). Coronary lesions were frequent even early after transplantation, with predominantly eccentric plaque morphologic characteristics indicative of preexisting atherosclerosis. Later after transplantation, a more homogeneous plaque distribution was seen, partly with diffuse concentic intimal thickening. Late transplant coronary artery disease appears to be a combination of preexisting native and acquired immune-mediated coronary artery disease. (Am Heart J 1997;133:29-35.)
Provider: - Institution: Österreichische Nationalbibliothek - Austrian National Library - Data provided by Europeana Collections- Maler: Beischlag, Johann Christoph
Stecher: Kilian, Philipp- All ...metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Österreichische Nationalbibliothek - Austrian National Library - Data provided by Europeana Collections- Maler: Beischlag, Johann Christoph
Stecher: Kilian, Philipp- All ...metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Österreichische Nationalbibliothek - Austrian National Library - Data provided by Europeana Collections- Maler: Beischlag, Johann Christoph
Stecher: Kilian, Philipp- All ...metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Österreichische Nationalbibliothek - Austrian National Library - Data provided by Europeana Collections- Maler: Beischlag, Johann Christoph
Stecher: Kilian, Philipp- All ...metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Österreichische Nationalbibliothek - Austrian National Library - Data provided by Europeana Collections- Maler: Beischlag, Johann Christoph
Stecher: Kilian, Philipp- All ...metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Wie viele unentdeckte Schätze die Wissenschaftliche Bibliothek in Dessau noch birgt und wie wichtig es ist, die wissenschaftliche Aufarbeitung historischer Bibliotheken als einen kontinuierlichen ...Prozess der permanenten Wissensanreicherung zu begreifen, durfte eine Gruppe von Leipziger Studierenden live erleben, die im Sommersemester 2019 an einem Kolloquium unter dem Titel „Neuentdeckte Dessauer Handschriftenfragmente gemeinsam erforschen“ teilnahmen.
Provider: - Institution: - Data provided by Europeana Collections- "Der Bund verfolgt das Ziel, für alle Menschen hierzulande die gleichen Chancen zu bieten, gesund zu sein bzw. das eigene ...Gesundheitspotenzial voll auszuschöpfen. Verschiedene Studien geben Hinweise darauf, dass bei Teilen der Migrationsbevölkerung diese Chancengleichheit beeinträchtigt ist. Das Nationale Programm Migration und Gesundheit (2008-2013 umfasst Massnahmen und Projekte in den Bereichen Prävention, Gesundheitsversorgung, Bildung und Forschung. Das Programm soll zum Abbau gesundheitlicher Benachteiligungen von Personen mit Migrationshintergrund in der Schweiz beitragen und die Voraussetzungen verbessern, so dass diese dieselbe Chance wie Einheimische haben, ihr Gesundheitspotenzial zu entfalten. Im Bereich der Forschung hat das BAG im Jahr 2004 ein Gesundheitsmonitoring der Migrationsbevölkerung (GMM) in der Schweiz in Auftrag gegeben, das erstmals repräsentative Daten zu den erwähnten Gesundheitsdeterminanten ausgewählter Gruppen erhoben hat. Um die Datengrundlage weiter zu vertiefen, hat sich das BAG entschieden, eine zweite Gesundheitsbefragung bei Personen mit Migrationshintergrund in Auftrag zu geben (GMM II). Im Rahmen dieses Forschungsauftrags sollten folgende drei Hauptfragestellungen geklärt werden: Welches sind die wichtigsten gesundheitlichen Unterschiede zwischen der einheimischen Bevölkerung und Personen mit Migrationshintergrund in der Schweiz hinsichtlich ihres Gesundheitszustands, ihres Gesundheitsverhaltens, ihrer Gesundheitskompetenz und ihres Zugangs zum Gesundheitssystem? Welche Gruppen innerhalb der Migrationsbevölkerung in der Schweiz sind in gesundheitlicher Hinsicht am vulnerabelsten? Welches sind die wichtigsten Determinanten der eruierten gesundheitlichen Unterschiede und wie stark sind deren Einflüsse (Geschlecht, Alter, Arbeit/Einkommen, Bildung, soziale Integration, Migrationshintergrund)?" (Autorenreferat)- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
A high proportion of people with severe mental health problems are unemployed but would like to work. Individual Placement and Support(IPS) offers a promising approach to establishing people in paid ...employment. In a randomized controlled trial across six European countries, we investigated the economic case for IPS for people with severe mental health problems compared to standard vocational rehabilitation. Individuals (n5312) were randomized to receive either IPS or standard vocational services and followed for 18 months. Service use and outcome data were collected. Cost-effectiveness analysis was conducted with two primary outcomes: additional days worked in competitive settings and additional percentage of individuals who worked at least 1 day. Analyses distinguished country effects. A partial cost-benefit analysis was also conducted. IPS produced better outcomes than alternative vocational services at lower cost overall to the health and social care systems. This pattern also held in disaggregated analyses for five of the six European sites. The inclusion of imputed values for missing cost data supported these findings. IPS would be viewed as more cost-effective than standard vocational services. Further analysis demonstrated cost-benefit arguments for IPS. Compared to standard vocational rehabilitation services, IPS is, therefore, probably cost-saving and almost certainly more cost-effective as a way to help people with severe mental health problems into competitive employment.
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