Laterally oriented single-walled carbon nanotubes (SWCNTs) were grown by chemical vapor deposition (CVD) from cobalt nanoparticles that were produced by flow-limited field-injection electrostatic ...spray (FFESS). The FFESS system allowed simultaneous generation and deposition of cobalt nanoparticles uniformly over a large area. The population and diameter of the nanoparticles could be controlled by the FFESS system, which in turn allowed for the control of the diameter and length of the SWCNTs. Chiral angle, and consequently chiral vector and diameter, were determined using nanoarea electron diffraction.
Copper nanowires (CuNWs) were grown by chemical vapor deposition using Cu(etac)P(OEt)3|2 as the precursor. The structure of the CuNWs was a five-fold twinned crystal with a pentagonal-pyramid edge ...tip. The length of the CuNWs was around 5-10 mum and the diameter was in the range of 100-200 nm depending on the growth conditions. The phosphite ligands passivated the (001) side faces of the CuNWs and only the (111) faces grew, resulting in 1-dimensional copper wires.
Gelatin nanoparticles coated with Cathepsin D-specific peptides were developed as a vehicle for the targeted delivery of the cancer drug doxorubicin (DOX) to treat breast malignancy. Cathepsin D, a ...breast cancer cell secretion enzyme, triggered the release of DOX by digesting the protective peptide-coating layer of nanoparticles. Fabricated nanoparticles were successfully detected with ultrasound imaging in both in vitro conditions and in vivo mouse cancer models. Cell viability experiments were conducted to determine the efficacy of biomarker activation specific to breast cancer cell lines. These experimental results were compared with the outcome of a viability experiment conducted on noncancerous cells. Viability decreased in human MCF7 mammary adenocarcinoma and mouse 4T1 mammary carcinoma cells, while that of noncancerous 3T3 fibroblast cells remained unaffected. Next, a real-time video of nanoparticle flow in mouse models was obtained using in vivo ultrasound imaging. The fluorescent profile of DOX was used as a means to examine nanoparticle localization in vivo. Results show the distribution of nanoparticles concentrated primarily within bladder and tumor sites of subject mice bodies. These findings support the use of biomarker coated nanoparticles in target specific therapy for breast cancer treatment.
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