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  • Diagnostics and Epidemiolog... Diagnostics and Epidemiology of Colorectal Cancer
    Kolligs, Frank T. Visceral medicine, 06/2016, Volume: 32, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Colorectal cancer is one of the leading causes of cancer-related morbidity and mortality. Main risk factors include advanced age, family history, male sex, and lifestyle factors. Screening can reduce ...
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  • A key role for E-cadherin i... A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation
    Schneider, Marlon R; Dahlhoff, Maik; Horst, David ... PloS one, 12/2010, Volume: 5, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function. ...
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  • E-cadherin's role in develo... E-cadherin's role in development, tissue homeostasis and disease: Insights from mouse models
    Schneider, Marlon R.; Kolligs, Frank T. BioEssays, March 2015, Volume: 37, Issue: 3
    Journal Article
    Peer reviewed

    Recent studies uncovered critical roles of the adhesion protein E‐cadherin in health and disease. Global inactivation of Cdh1, the gene encoding E‐cadherin in mice, results in early embryonic ...
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  • Tivantinib for second-line ... Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study
    Santoro, Armando, MD; Rimassa, Lorenza, Dr; Borbath, Ivan, MD ... Lancet oncology/Lancet. Oncology, 2013, January 2013, 2013-Jan, 2013-01-00, 20130101, Volume: 14, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Summary Background Tivantinib (ARQ 197), a selective oral inhibitor of MET, has shown promising antitumour activity in hepatocellular carcinoma as monotherapy and in combination with sorafenib. We ...
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  • Comprehensive analysis of β... Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling
    Herbst, Andreas; Jurinovic, Vindi; Krebs, Stefan ... BMC genomics, 01/2014, Volume: 15, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Deregulation of Wnt/β-catenin signaling is a hallmark of the majority of sporadic forms of colorectal cancer and results in increased stability of the protein β-catenin. β-catenin is then shuttled ...
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  • Risk of advanced colorectal... Risk of advanced colorectal neoplasia according to age and gender
    Kolligs, Frank T; Crispin, Alexander; Munte, Axel ... PloS one, 05/2011, Volume: 6, Issue: 5
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    Peer reviewed
    Open access

    Colorectal cancer (CRC) is one of the leading causes of cancer related morbidity and death. Despite the fact that the mean age at diagnosis of CRC is lower in men, screening by colonoscopy or fecal ...
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  • E‐cadherin's role in develo... E‐cadherin's role in development, tissue homeostasis and disease: Insights from mouse models: Tissue‐specific inactivation of the adhesion protein E‐cadherin in mice reveals its functions in health and disease
    Schneider, Marlon R; Kolligs, Frank T BioEssays, 03/2015, Volume: 37, Issue: 3
    Journal Article
    Peer reviewed

    Recent studies uncovered critical roles of the adhesion protein E‐cadherin in health and disease. Global inactivation of Cdh1, the gene encoding E‐cadherin in mice, results in early embryonic ...
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  • Screening for Colorectal Cancer Is Associated With Lower Disease Stage: A Population-Based Study
    Kubisch, Constanze H; Crispin, Alexander; Mansmann, Ulrich ... Clinical gastroenterology and hepatology, 11/2016, Volume: 14, Issue: 11
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    Peer reviewed

    Screening for colorectal cancer (CRC) using fecal occult blood tests (FOBT) is associated with reduced CRC incidence and mortality. Population-based FOBT screening has led to identification of CRCs ...
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  • Circulating cell-free methy... Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer
    Philipp, Alexander B; Nagel, Dorothea; Stieber, Petra ... BMC cancer, 04/2014, Volume: 14, Issue: 1
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    Open access

    Hypermethylation of DNA is an epigenetic alteration commonly found in colorectal cancer (CRC) and can also be detected in blood samples of cancer patients. Methylation of the genes helicase-like ...
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  • Prognosis of patients with ... Prognosis of patients with hepatocellular carcinoma. Validation and ranking of established staging-systems in a large western HCC-cohort
    op den Winkel, Mark; Nagel, Dorothea; Sappl, Julia ... PloS one, 10/2012, Volume: 7, Issue: 10
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    Peer reviewed
    Open access

    HCC is diagnosed in approximately half a million people per year, worldwide. Staging is a more complex issue than in most other cancer entities and, mainly due to unique geographic characteristics of ...
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