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  • Th17 cell based vaccines in... Th17 cell based vaccines in mucosal immunity
    Kumar, Pawan; Chen, Kong; Kolls, Jay K Current opinion in immunology, 06/2013, Volume: 25, Issue: 3
    Journal Article
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    Open access

    Highlights • Th17 responses show protection against both bacterial and fungal pathogens. • Mucosal and systemic vaccines can elicit protective Th17 responses. • Th17 responses can mediate serotype ...
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  • Host defenses against bacte... Host defenses against bacterial lower respiratory tract infection
    Eddens, Taylor; Kolls, Jay K Current opinion in immunology, 08/2012, Volume: 24, Issue: 4
    Journal Article
    Peer reviewed
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    Highlights ► Pattern recognition receptors respond to a wide variety of bacterial pathogens in the lung. ► IL-23 stimulates innate production of IL-17 and IL-22 which increase lung defenses. ► CD4+ T ...
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  • Microbiological Laboratory ... Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline
    Hage, Chadi A; Carmona, Eva M; Epelbaum, Oleg ... American journal of respiratory and critical care medicine, 09/2019, Volume: 200, Issue: 5
    Journal Article
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    Open access

    Fungal infections are of increasing incidence and importance in immunocompromised and immunocompetent patients. Timely diagnosis relies on appropriate use of laboratory testing in susceptible ...
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  • The role of Th17 cytokines ... The role of Th17 cytokines in primary mucosal immunity
    Kolls, Jay K; Khader, Shabaana A Cytokine & growth factor reviews, 12/2010, Volume: 21, Issue: 6
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    Open access

    Abstract The T helper type 17 (Th17) lineage of CD4+ T-cells produce several effector molecules including IL-17A, IL-17F, IL-21, and IL-22. In addition to CD4+, αβ T-cells, these cytokines can be ...
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  • MCPIP1 Endoribonuclease Act... MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation
    Garg, Abhishek V.; Amatya, Nilesh; Chen, Kong ... Immunity (Cambridge, Mass.), 09/2015, Volume: 43, Issue: 3
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    Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We demonstrate that the signaling ...
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  • Spelunking in Sputum: Singl... Spelunking in Sputum: Single-Cell RNA Sequencing Sheds New Insights into Cystic Fibrosis
    Iwanaga, Naoki; Kolls, Jay K American journal of respiratory and critical care medicine, 11/2020, Volume: 202, Issue: 10
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    Iwanaga and Kolls discuss the study by Schupp et al who performed a single-cell RNAseq analyses in sputum between nine cystic fibrosis (CF) subjects and five healthy control subjects. The authors ...
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  • An Emerging Role of B Cell ... An Emerging Role of B Cell Immunity in Susceptibility to Pneumocystis Pneumonia
    Kolls, Jay K American journal of respiratory cell and molecular biology, 03/2017, Volume: 56, Issue: 3
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    Importantly, they chose a 14-day time point after Pneumocystis inoculation, as this time point coincided with the induction of adaptive immune responses that are just initializing clearance, yet ...
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  • Multi-omic comparisons betw... Multi-omic comparisons between CFBE41o- cells stably expressing wild-type CFTR and F508del-mutant CFTR
    Lu, Shiping; Kolls, Jay K. Journal of cystic fibrosis, January 2023, 2023-01-00, 20230101, Volume: 22, Issue: 1
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    •Polarization of cells dramatically increases cytokine secretion in bronchial epithelial cells.•CFTR F508del mutation itself is sufficient to significantly alter the epigenome and transcriptome of ...
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