Sialon ceramics were prepared by the nitridation of Si, Al and Al
2
O
3
powders with the transition metals (Fe, Co, Ni) catalysts. The phase composition, microstructure and mechanical properties of ...specimens were studied. Compared with the catalyst-free specimen, the addition of Fe, Co and Ni greatly promoted the nitridation process of Sialon ceramics and improved the weight gain rate and mechanical properties of specimens. With the increased content of catalysts, the apparent porosity of the products decreased first and then increased, contrary to flexural strength and compressive strength. The specimen with 2.5 wt% Fe had the highest flexural strength 145.8 MPa, and it exhibited the highest compressive strength of 594.6 MPa when Co content was 2.5 wt%, whereas they were 71.9 and 78.7 MPa, respectively, when without catalyst.
Graphic abstract
This paper proposes a new measure for recommendation through integrating Triangle and Jaccard similarities. The Triangle similarity considers both the length and the angle of rating vectors between ...them, while the Jaccard similarity considers non co-rating users. We compare the new similarity measure with eight state-of-the-art ones on four popular datasets under the leave-one-out scenario. Results show that the new measure outperforms all the counterparts in terms of the mean absolute error and the root mean square error.
Tetrahydroxy stilbene glycoside (TSG) is a main active compound in Polygonum multiflorum. Acetaminophen (APAP) is a well‐known analgesic and antipyretic drug. It is considered to be safe within a ...therapeutic range, in case of acute intoxication hepatotoxicity occurs. This present study aims to observe TSG‐provided alleviation on APAP‐induced hepatoxicity in C57BL/6 mice. APAP performs extensive necrosis and dissolves nucleus suggesting liver damage from hepatic histopathology. Serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase analysis and liver histological evaluation showed that TSG reduced the hepatotoxicity induced by a toxic dose of APAP. Moreover, TSG alone had no hepatotoxicity. TSG eliminated hepatic glutathione depletion and cysteine adducts formation. It also reduced the expression of interleukin‐10 and lowered the production of reactive oxygen species in liver tissues. Luminex was used to detect cytokine production in different groups. Herein, we used an untargeted metabolomics approach by performing ultrahigh‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry on treated mice to identify metabolic disruptions under APAP and TSG. Major alterations were observed for purine metabolism, amino acid metabolism, and fatty acid metabolism. These data provide metabolic evidence and biomarkers in the liver that the ABC transporters, Glycine serine and threonine metabolism, and Choline metabolism in cancer changed the most. These targets of metabolites have the potential to improve our understanding of homeostatic. Meanwhile, these metabolites revealed that TSG can alleviate inflammation caused by APAP and promote the activity of intrinsic antioxidants. In summary, TSG can regulate lipid metabolism, promote the production of antioxidant enzymes, and decrease the inflammatory response.
Tetrahydroxy stilbene glycoside can regulate lipid metabolism, promote the production of antioxidant enzymes, and decrease the inflammatory response.
Cellular angiolipoma is a rare subtype of angiolipoma, with vascular density approaching 95%. This case report describes a 55-year-old female that presented for treatment of a mass in her left breast ...that had been tender to slightly painful on palpation for nearly 2 years The patient underwent surgical excision of the mass, which was pathologically confirmed as a cellular angiolipoma. As of the 3-year follow-up, the patient reported no recurrence of the lesion. It is important to report this case and refresh knowledge of this and similar lesions to raise awareness of this diagnosis and treatment and improve future management of cellular angiolipoma cases.
Granular computing and acquisition of IF-THEN rules are two basic issues in knowledge representation and data mining. A rough set approach to knowledge discovery in incomplete multi-scale decision ...tables from the perspective of granular computing is proposed in this paper. The concept of incomplete multi-scale information tables in the context of rough sets is first introduced. Information granules at different levels of scales in incomplete multi-scale information tables are then described. Lower and upper approximations with reference to different levels of scales in incomplete multi-scale information tables are also defined and their properties are examined. Optimal scale selection with various requirements in incomplete multi-scale decision tables are further discussed. Relationships among different notions of optimal scales in incomplete multi-scale decision tables are presented. Finally, knowledge acquisition in the sense of rule induction in consistent and inconsistent incomplete multi-scale decision tables are explored.
This article outlines the basic principles of OFDM-IDMA. Comparisons with other alternative technologies such as OFDM-CDMA and OFDMA are provided. Some attractive features of OFMD-IDMA are explained, ...including low-cost iterative multi-user detection, flexible rate adaptation, frequency diversity, and significant advantages regarding spectral and power efficiency.
Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of ...these associations is still lacking.
We searched PubMed, Web of Science, Embase, Scopus, Cochrane, and several regional databases from their inception until Feb 16, 2024, with the aim of identifying systematic reviews with meta-analyses of observational studies exploring associations between ABO and Rh blood groups and diverse health outcomes. For each association, we calculated the summary effect sizes, corresponding 95% confidence intervals, 95% prediction interval, heterogeneity, small-study effect, and evaluation of excess significance bias. The evidence was evaluated on a grading scale that ranged from convincing (Class I) to weak (Class IV). We assessed the certainty of evidence according to the Grading of Recommendations Assessment, Development, and Evaluation criteria (GRADE). We also evaluated the methodological quality of included studies using the A Measurement Tool to Assess Systematic Reviews (AMSTAR). AMSTAR contains 11 items, which were scored as high (8-11), moderate (4-7), and low (0-3) quality. We have gotten the registration for protocol on the PROSPERO database (CRD42023409547).
The current umbrella review included 51 systematic reviews with meta-analysis articles with 270 associations. We re-calculated each association and found only one convincing evidence (Class I) for an association between blood group B and type 2 diabetes mellitus risk compared with the non-B blood group. It had a summary odds ratio of 1.28 (95% confidence interval: 1.17, 1.40), was supported by 6870 cases with small heterogeneity (I
= 13%) and 95% prediction intervals excluding the null value, and without hints of small-study effects (P for Egger's test > 0.10, but the largest study effect was not more conservative than the summary effect size) or excess of significance (P < 0.10, but the value of observed less than expected). And the article was demonstrated with high methodological quality using AMSTAR (score = 9). According to AMSTAR, 18, 32, and 11 studies were categorized as high, moderate, and low quality, respectively. Nine statistically significant associations reached moderate quality based on GRADE.
Our findings suggest a potential relationship between ABO and Rh blood groups and adverse health outcomes. Particularly the association between blood group B and type 2 diabetes mellitus risk.
In this paper, knowledge acquisition in the sense of deriving IF-THEN rules in multi-scale information systems with multi-scale decision attributes is investigated. Specifically, the concept of a ...generalized multi-scale information system with a multi-scale decision attribute, called generalized multi-scale decision information table (GMDIT for short), is first introduced. Such a system is a multi-scale decision table in which each condition or decision attribute at each object can take different values under different scales. The notion of scale selections for a GMDIT, which is mainly used to determine individual decision tables, is then defined. Information granules and their properties with different scale selections in GMDITs are also described. Optimal scale selections which are used to determine proper decision tables for final decision in inconsistent GMDITs are further formulated. Local optimal scale selections to obtain more concise decision rules for different objects are presented. Finally, attribute reducts based on optimal scale selections are derived and decision rules hidden in inconsistent GMDITs are unraveled.
AMPA receptors are tetrameric ionic glutamate receptors, which mediate 90% fast excitatory synaptic transmission induced by excitatory glutamate in the mammalian central nervous system through the ...activation or inactivation of ion channels. The alternation of synaptic AMPA receptor number and subtype is thought to be one of the primary mechanisms that involve in synaptic plasticity regulation and affect the functions in learning, memory, and cognition. The increasing of surface AMPARs enhances synaptic strength during long-term potentiation, whereas the decreasing of AMPARs weakens synaptic strength during the long-term depression. It is closely related to the AMPA receptor as well as its subunits assembly, trafficking, and degradation. The dysfunction of any step in these precise regulatory processes is likely to induce the disorder of synaptic transmission and loss of neurons, or even cause neuropsychiatric diseases ultimately. Therefore, it is useful to understand how AMPARs regulate synaptic plasticity and its role in related neuropsychiatric diseases via comprehending architecture and trafficking of the receptors. Here, we reviewed the progress in structure, expression, trafficking, and relationship with synaptic plasticity of AMPA receptor, especially in anxiety, depression, neurodegenerative disorders, and cerebral ischemia.
Abstract
Objective
Exploring the correlation between bone turnover marks (BTMs) with lumbar BMD in middle-aged populations.
Methods
The cross-sectional analysis fetched data came from NHANES. The ...level of serum bone alkaline phosphatase (sBAP) and urinary N-telopeptide (uNTx) were regarded as representative of bone turnover. Lumbar BMD was the outcome of the study. Multivariable linear regression models were utilized to detect the correlation of sBAP and uNTx with Lumbar BMD.
Results
The level of sBAP and uNTx was negatively correlated with lumbar BMD in every multivariable linear regression. For sBAP, this inverse correlation was stable in both men and women (
P
< 0.01). uNTx indicated a negative association after all relevant covariables were adjusted (
P
< 0.01). The men group remained the negative correlation in gender subgroup analysis (
P
< 0.01).
Conclusion
This study indicated that the increased level of sBAP and uNTx associated with lumbar BMD decreased among middle-aged adults. This correlation could prompt researchers to explore further the relationship between bone turnover rate and BMD, which may provide information for the early detection of BMD loss and provide a new strategy for clinical practice.
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