This work aimed to describe the synthesis and characterisation of two anionic Ru(III) complexes of the general formula NaRuCl2(N-4-Cl-Ph-salim)2 and NaRuCl2(N-3-Br-Ph-salim)2, their associated ...ligands, and determine their antioxidant activity. The ligands N-4-Cl-phenylsalicylidenimine (N-4-Cl-Ph-salimH, HLa) and N-3-Br-phenylsalicylidenimine (N-3-Br-Ph-salimH, HLb), Schiff bases, were synthesised from salicylaldehyde and chloroaniline or bromoaniline. The compounds were characterised using IR spectroscopy and ESI ToF mass spectrometry. The following was confirmed: coordination of ligands on the Ru(III) centre, the molecular formulas, and the corresponding M– ions: C26H18N2O2Cl4Ru− ion, (m/z: 631.9173) and C26H18N2O2Cl2Br2Ru– ion, (m/z: 719.8283). The antioxidant activity was determined by the ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. In contrast to the ligands, both complexes proved to be strong scavengers of the ABTS and DPPH radicals with IC50 (half maximal inhibitory concentration) values comparable to those of Trolox. As such, they present valuable candidates for further research related to their biological properties.
Ovaj rad je imao cilj opisati sintezu i karakterizaciju dvaju anionskih Ru(III) kompleksa općenite formule NaRuCl2(N-4-Cl-Ph-salim)2 i NaRuCl2(N-3-Br-Ph-salim)2, njihove pridružene ligande i odrediti ...njihovu antioksidacijsku aktivnost. Ligandi N-4-Cl-fenilsalicilidenimin (N-4-Cl-Ph-salimH, HLa) i N-3-Br-fenilsalicilidenimin (N-3-Br-Ph-salimH, HLb), Schiffove baze, sintetizirani su iz salicilaldehida i kloranilina ili bromoanilina. Spojevi su karakterizirani primjenom IR spektroskopije i ESI ToF spektrometrije masa. Potvrđena je koordinacija liganada na Ru(III) centru, molekulske formule i odgovarajući M– ioni: C26H18N2O2Cl4Ru–</sup ion (m/z: 631.9173) i
C26H18N2O2Cl2Br2Ru– ion (m/z: 719.8283). Antioksidacijska aktivnost određena je metodama ABTS (2,2’-azino-bis(3-etilbenzotiazolin-6-sulfonska kiselina) i DPPH (1,1-difenil-2-pikrilhidrazil). Za razliku od liganda, oba kompleksa pokazala su se jakim hvatačima ABTS i DPPH radikala s IC50 vrijednostima (koncentracija koja postiže 50% inhibicije) usporedivim s onima od Troloxa. Kao takvi, vrijedni su kandidati za daljnja istraživanja vezana uz njihova biološka svojstva.
