This article presents research that explored the ways that systemic and family therapists might approach the support of families living with dementia. A constructivist grounded theory methodology was ...used to interpret interviews with four systemic family therapists working in the United Kingdom. All participants had professional and/or lived experience of dementia. Transcript analysis and theoretical sampling led to the development of five categories, each related to different aspects of considering systemic therapy in a dementia context. These categories were further developed into a ‘systemically informed dementia orienteering’ conceptual framework, which is presented in this paper as a learning resource. Findings are related to existing literature, and recommendations for future research are made.
This note reviews new approaches to topics in economic history that have come into practice in the last 20 years or so. The three main approaches are cliodynamics, big history and deep history. All ...three extend the time scale of economic history investigations to beyond that of written history and involve a variety of disciplines other than economics and history. Cliodynamics and big history are essentially quantitative. They use models to interpret historical phenomena and test hypotheses derived from the models. An example of a research topic is provided for each of the three new approaches. These new areas offer many opportunities for the student of economic history.
This paper seeks to develop and apply a simple yardstick based on remaining life expectancy to assess whether specific health policies unfairly discriminate against people on the basis of their age. ...This reveals that the COVID‐19 vaccine prioritization policies of several countries have discriminated against older people. Conversely, the exclusion of older people from COVID‐19 vaccine testing is shown to be non‐discriminatory, as is some degree of age prioritization for limited acute COVID‐19 care. Age discrimination in vaccine prioritization is shown to be embedded in wider ageist attitudes in health policy, which give the lives of older people a lower social value than the lives of people at younger ages.
The reduction by a third of premature non-communicable disease (NCD) mortality by 2030 is the ambitious target of Sustainable Development Goal (SDG) 3.4. However, the indicator is narrowly defined, ...including only four major NCDs (cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases) and only for people aged 30–70 years. This study focuses on premature avertable mortality from NCDs—premature deaths caused by NCDs that could be prevented through effective public policies and health interventions or amenable to high-quality health care—to assess trends at global, regional, and national levels using estimates from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2017.
We reviewed existing lists of NCD causes of death that are either preventable through public health policies and interventions or amenable to health care to create a list of avertable NCD causes of death, which was mapped to the GBD cause list. We estimated age-standardised years of life lost (YLL) per 100 000 population due to premature avertable mortality from NCDs, avertable NCD cause clusters, and non-avertable NCD causes by sex, location, and year and reported their 95% uncertainty intervals (UIs). We examined trends in age-standardised YLL due to avertable and non-avertable NCDs, assessed the progress of premature avertable mortality from NCDs in achieving SDG 3.4, and explored specific avertable NCD cause clusters that could make a substantial contribution to overall trends in premature mortality.
Globally, premature avertable mortality from NCDs for both sexes combined declined −1·3% (95% UI −1·4 to −1·2) per year, from 12 855 years (11 809 to 14 051) in 1990 to 9008 years (8329 to 9756) in 2017. However, the absolute number of avertable NCD deaths increased 49·3% (95% UI 47·3 to 52·2) from 23·1 million (22·0–24·1) deaths in 1990 to 34·5 million (33·4 to 35·6) in 2017. Premature avertable mortality from NCDs reduced in every WHO region and in most countries and territories between 1990 and 2017. Despite these reductions, only the Western Pacific and European regions and 25 countries (most of which are high-income countries) are on track to achieve SDG target 3.4. Since 2017, there has been a global slowdown in the reduction of premature avertable mortality from NCDs. In 2017, high premature avertable mortality from NCDs was clustered in low-income and middle-income countries, mainly in the South-East Asia region, Eastern Mediterranean region, and African region. Most countries with large annual reductions in such mortality between 1990 and 2017 had achieved low levels of premature avertable mortality from NCDs by 2017. Some countries, the most populous examples being Afghanistan, the Central African Republic, Uzbekistan, Haiti, Mongolia, Turkmenistan, Pakistan, Ukraine, Laos, and Egypt, reported both an upward trend and high levels of premature avertable mortality from NCDs. Cardiovascular diseases, cancers, and chronic respiratory diseases have been the main drivers of the global and regional reduction in premature avertable mortality from NCDs, whereas premature mortality from substance use disorders, chronic kidney disease and acute glomerulonephritis, and diabetes have been increasing.
Worldwide, there has been a substantial reduction in premature avertable mortality from NCDs, but progress has been uneven across populations. Countries vary substantially in current levels and trends and, hence, the extent to which they are on track to achieve SDG 3.4. By accounting for premature avertable mortality while avoiding arbitrary age cutoffs, premature avertable mortality from NCDs is a robust, comprehensive, and actionable indicator for quantifying and monitoring global and national progress towards NCD prevention and control.
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Models of consciousness are usually developed within physical monist or dualistic frameworks, in which the structure and dynamics of the mind are derived from the workings of the physical brain. ...Little attention has been given to modelling consciousness within a mental monist framework, deriving the structure and dynamics of the mental world from primitive mental constituents only—with no neural substrate. Mental monism is gaining attention as a candidate solution to Chalmers’ Hard Problem on philosophical grounds, and it is therefore timely to examine possible formal models of consciousness within it. Here, I argue that the austere ontology of mental monism places certain constraints on possible models of consciousness, and propose a minimal set of hypotheses that a model of consciousness (within mental monism) should respect. From those hypotheses, it would be possible to construct many formal models that permit universal computation in the mental world, through cellular automata. We need further hypotheses to define transition rules for particular models, and I propose a transition rule with the unusual property of deep copying in the time dimension.
This paper reviews the history of tariffs imposed by the six Australian colonies during the nineteenth century. In each of the colonies, we identify the starting dates for the first tariffs, first ...preferences, and other features, and the turning points in the levels of tariffs. We then construct a time series of the average tariff levels in the individual colonies and an average for all six colonies combined. The conclusion notes general features of the pattern of tariffs and how the main features of colonial tariffs, such as the favourable treatment of intermediate inputs, the complex differentiation of tariff rates within industries, and the protection implicit in the excise tax system all carried over to the Commonwealth Customs Tariff in the twentieth century.
Big Economic History Lloyd, Peter J.
Australian economic history review,
March 2021, 2021-03-00, 20210301, Volume:
61, Issue:
1
Journal Article
Peer reviewed
Open access
This paper reviews the history of human economic activity from the time Homo sapiens appeared to the present. The first aim is to provide a coherent narrative of the economic history of this period. ...The second aim is to quantify economic activities where time series data is available and to use economic theory to explain the trends and turning points. It examines the history of three central time series – the aggregate human population, output per capita and human‐induced species extinctions. It concludes with some brief observations on the contribution of Big Economic History to Big Human History.
Inflammatory processes are prominent in various types of human and experimental pulmonary hypertension (PH) and are increasingly recognized as major pathogenic components of pulmonary vascular ...remodeling. Macrophages, T and B lymphocytes, and dendritic cells are present in the vascular lesions of PH, whether in idiopathic pulmonary arterial hypertension (PAH) or PAH related to more classical forms of inflammatory syndromes such as connective tissue diseases, human immunodeficiency virus (HIV), or other viral etiologies. Similarly, the presence of circulating chemokines and cytokines, viral protein components (e.g., HIV-1 Nef ), and increased expression of growth (such as vascular endothelial growth factor and platelet-derived growth factor) and transcriptional (e.g., nuclear factor of activated T cells or NFAT) factors in these patients are thought to contribute directly to further recruitment of inflammatory cells and proliferation of smooth muscle and endothelial cells. Other processes, such as mitochondrial and ion channel dysregulation, seem to convey a state of cellular resistance to apoptosis; this has recently emerged as a necessary event in the pathogenesis of pulmonary vascular remodeling. Thus, the recognition of complex inflammatory disturbances in the vascular remodeling process offers potential specific targets for therapy and has recently led to clinical trials investigating, for example, the use of tyrosine kinase inhibitors. This paper provides an overview of specific inflammatory pathways involving cells, chemokines and cytokines, cellular dysfunctions, growth factors, and viral proteins, highlighting their potential role in pulmonary vascular remodeling and the possibility of future targeted therapy.