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  • Oxytocin in the anterior ci... Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
    Li, Xu-Hui; Matsuura, Takanori; Xue, Man ... Cell reports (Cambridge), 07/2021, Volume: 36, Issue: 3
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    Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and ...
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  • Opposite trends of glycosid... Opposite trends of glycosides and alkaloids in Dendrobium nobile of different age based on UPLC‐Q/TOF‐MS combined with multivariate statistical analyses
    Lu, An‐jing; Jiang, Yuan; Wu, Jia ... Phytochemical analysis, June 2022, Volume: 33, Issue: 4
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    Introduction Alkaloids and glycosides are the active ingredients of the herb Dendrobium nobile, which is used in traditional Chinese medicine. The pharmacological effects of alkaloids include ...
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  • Basolateral amygdala astroc... Basolateral amygdala astrocytes modulate diabetic neuropathic pain and may be a potential therapeutic target for koumine
    Lu, Jing‐Shan; Yang, Lan; Chen, Jian ... British journal of pharmacology, 20/May , Volume: 180, Issue: 10
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    Background and Purpose New remedies are required for the treatment of diabetic neuropathic pain (DNP) due to insufficient efficacy of available therapies. Here, we used chemogenetic approaches ...
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  • Dendrobium nobile Lindl alk... Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25‐35 in hippocampus neurons in vitro
    Li, Li‐Sheng; Lu, Yan‐Liu; Nie, Jing ... CNS neuroscience & therapeutics, April 2017, Volume: 23, Issue: 4
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    Summary Aims Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid‐β (Aβ) peptide deposition. Growing evidence indicates that ...
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  • Dendrobium nobile Lindl. al... Dendrobium nobile Lindl. alkaloids regulate metabolism gene expression in livers of mice
    Xu, Yun‐Yan; Xu, Ya‐Sha; Wang, Yuan ... Journal of pharmacy and pharmacology, October 2017, Volume: 69, Issue: 10
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    Objectives In our previous studies, Dendrobium nobile Lindl. alkaloids (DNLA) has been shown to have glucose‐lowering and antihyperlipidaemia effects in diabetic rats, in rats fed with high‐fat ...
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  • Dendrobium nobile Lindl. Al... Dendrobium nobile Lindl. Alkaloids Decreases the Level of Intracellular β-Amyloid by Improving Impaired Autolysosomal Proteolysis in APP/PS1 Mice
    Nie, Jing; Jiang, Lin-Shan; Zhang, Yu ... Frontiers in pharmacology, 12/2018, Volume: 9
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    As the major degradation pathway for long-lived proteins and organelles, macroautophagy is a decisive factor for the survival and longevity of cells. The existing evidence indicates that the ...
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  • Cyclic AMP‐dependent positi... Cyclic AMP‐dependent positive feedback signaling pathways in the cortex contributes to visceral pain
    Liu, Shui‐bing; Wang, Xin‐shang; Yue, Jiao ... Journal of neurochemistry, April 2020, Volume: 153, Issue: 2
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    Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less ...
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  • Pharmacokinetics and tissue... Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
    Hu, Wen-juan; Chang, Lu; Yang, Ying ... Acta pharmacologica Sinica, 07/2021, Volume: 42, Issue: 7
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    Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent ...
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  • Neuroprotective effect of r... Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats
    Jin, Feng; Wu, Qin; Lu, Yuan-Fu ... European journal of pharmacology, 12/2008, Volume: 600, Issue: 1
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    The present study was undertaken to investigate the neuroprotective effects of resveratrol on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease in rats. 6-OHDA-induced Parkinson's disease rat ...
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  • Creep-Based Reliability Eva... Creep-Based Reliability Evaluation of Turbine Blade-Tip Clearance with Novel Neural Network Regression
    Zhang, Chun-Yi; Wei, Jing-Shan; Wang, Ze ... Materials, 10/2019, Volume: 12, Issue: 21
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    To reveal the effect of high-temperature creep on the blade-tip radial running clearance of aeroengine high-pressure turbines, a distributed collaborative generalized regression extremum neural ...
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