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► The well-dispersed PTA in both medium and large cavities of MIL-101. ► About three Keggin polyanions are allocated to per cavity of MIL-101. ► The adjacent lattice planes of MIL-101 ...are larger due to the addition of PTA. ► The dominant crystal shapes of high loading PTA@MIL-101 are a monolithic. ► The reactivity of ODS follows the order DBT>4,6-DMDBT>BT using PTA@MIL-101.
Successful encapsulation of phosphotungstic acid (PTA) within the nanocages of MIL-101 has been achieved via “bottle around ship” approach under static condition. XRD, FT-IR, 31P MAS NMR, N2 adsorption, SEM–EDS and XRF confirm the incorporation and well-distribution of PTA in both middle and large cavities of the MIL-101. SEM, XRD and TEM reveal the dominant crystal shapes of high loading PTA@MIL-101 are a monolithic and the adjacent lattice planes of MIL-101 are larger due to the addition of PTA. The host–guest composite materials PTA@MIL-101 containing 17–50wt.% of PTA have been obtained and demonstrate an excellent catalytic performance in the oxidative desulfurization process of the refractory sulfur-containing compounds. This is the first example of the application of MIL-101 or PTA@MIL-101 composite materials in oxidative desulfurization. The reactivity of the sulfur-containing compounds follows the order DBT>4,6-DMDBT>BT. In four consecutive reaction cycles, the catalyst recovery is in excess of 71%, while the DBT conversion slightly decreases.
This study aimed to explore the clinical efficacy of ultrasound-guided interventional therapy in patients with benign ovarian cysts through meta-analysis. A literature search was performed on PubMed, ...Web of Science, Embase, CNKI, and WanFang databases to obtain clinical randomized controlled trials on ultrasound-guided interventional therapy for benign ovarian cysts published between 2010 and 2022. A total of 1395 studies were initially retrieved, and finally 12 studies were included for meta-analysis. The results showed that the observation group (ultrasound-guided interventional therapy) had higher treatment effective rate than the control group (conventional laparotomy or laparoscopic cyst resection), but the incidence of adverse reactions was markedly lower. Additionally, the length of hospital stay, intraoperative blood loss, and operation time showed significant lower levels in the observation group. In terms of ovarian function, postoperative luteinizing hormone and follicle-stimulating hormone levels in the observation group were lower than the control group, while oestradiol levels were higher. In conclusion, compared with conventional surgical treatment, ultrasound-guided interventional therapy can significantly improve the clinical effective rate, shorten the hospital stay and reduce intraoperative blood loss. Such therapy can protect ovarian reserve, with high value of clinical promotion.
IMPACT STATEMENT
What is already known on this subject? Main surgical methods for ovarian cysts consist of laparotomy, laparoscopic surgery, and interventional therapy.
What the results of this study add? With the advancement of surgical techniques and instruments, many minimally invasive surgeries have been applied to treat ovarian cysts with good clinical results. However, there is no exact evidence to prove its clinical efficacy. Given the lack in this field, we conducted a meta-analysis of all clinical studies of ultrasound-guided interventional therapy for ovarian cysts to evaluate its efficacy and safety.
What the implications are of these findings for clinical practice and/or further research? Compared with conventional laparotomic or laparoscopic cyst resection, ultrasound-guided interventional therapy for ovarian cysts significantly improves the treatment effectiveness, shortens the hospital stay and reduces intraoperative blood loss. This therapy with good clinical efficacy also has advantages of small wound, rapid recovery and less adverse reactions, and can protect ovarian reserve. This safe and effective surgical method for ovarian cysts is worth promoting clinically.
Abstract
Background
Immature ovarian teratoma is one of the three common malignant ovarian germ cell tumors. However, immature ovarian teratoma in pregnancy is very rare. Due to the rare occurrence, ...there is little evidence regarding its diagnosis, optimal management, and prognosis. Hence, we present a case of immature teratoma diagnosed during pregnancy, and analyze its clinicopathological features, management and prognosis.
Case presentation
A 28-year-old woman underwent a sonographic examination revealed no abnormality in the bilateral adnexal area before 29 weeks gestational age (WGA). At 29 WGA, ultrasound demonstrated a 9.7 × 8.5 × 6.4 cm complex structure in the left adnexal area. At 30 WGA, repeated ultrasound revealed rapid growth of tumor mass, measuring 25.0 × 15.0 × 13.7 cm. An elective cesarean section combined with exploratory laparotomy was performed at 33 WGA. Intraoperative frozen pathological examination suggested left ovarian immature teratoma. Then, she underwent a complete staging surgery. Subsequently, the patient received 4 cycles of bleomycin-etoposide-cisplatin (BEP) chemotherapy. After 18 months of follow-up, there is no sign of tumor recurrence till now.
Conclusions
This case report suggests that the benefits and risks of timely treatment for patients and fetuses should be fully assessed by a multidisciplinary team. The early diagnosis, the timing of surgery and chemotherapy, the choice of chemotherapy for BEP will determine the prognosis. Surgery and combination chemotherapy with BEP play an important role in the treatment of immature teratomas in pregnancy, and could gain successful and satisfactory outcomes for mother and fetus.
Objective
Peri-implantitis is characterized by peri-implant mucositis and alveolar bone resorption. This study investigated cholecystokinin (CCK) expression and the mechanism underlying its ...involvement in peri-implantitis.
Methods
mRNA sequencing was performed using the Gene Expression Omnibus database GSE106090. Human bone marrow mesenchymal stem cells (hBMSCs) were pretreated with various concentrations of CCK (0, 10, 30, or 100 nM) for 1 hour before induction in osteogenic differentiation medium for 2 weeks. Alkaline phosphatase (ALP) activity was determined, and the cells were stained with alizarin red. The expression levels of TNFα and the osteogenic markers ALP, RUNX2, and OCN were measured using quantitative real-time PCR. TNFα, phosphorylated P65, and total P65 levels were determined by western blot.
Results
Compared with healthy individuals, 262 and 215 genes were up- and down-regulated, respectively, in the periodontal tissues of patients with peri-implantitis. CCK expression was significantly upregulated in patients with peri-implantitis. CCK reduced ALP activity, osteogenic differentiation, and levels of the osteogenic markers ALP, RUNX2, and OCN. Moreover, CCK promoted levels of TNFα and phosphorylated P65, which is a marker of activation for the NF-κB inflammatory pathway.
Conclusions
CCK regulates osteogenic differentiation through the TNFα/NF-κB axis in peri-implantitis.
Background Acute myocardial infarctions are increasingly common among young adults. We investigated sex and racial differences in the evaluation of chest pain (CP) among young adults presenting to ...the emergency department. Methods and Results Emergency department visits for adults aged 18 to 55 years presenting with CP were identified in the National Hospital Ambulatory Medical Care Survey 2014 to 2018, which uses stratified sampling to produce national estimates. We evaluated associations between sex, race, and CP management before and after multivariable adjustment. We identified 4152 records representing 29 730 145 visits for CP among young adults. Women were less likely than men to be triaged as emergent (19.1% versus 23.3%, respectively,
<0.001), to undergo electrocardiography (74.2% versus 78.8%, respectively,
=0.024), or to be admitted to the hospital or observation unit (12.4% versus 17.9%, respectively,
<0.001), but ordering of cardiac biomarkers was similar. After multivariable adjustment, men were seen more quickly (hazard ratio HR, 1.15 95% CI, 1.05-1.26) and were more likely to be admitted (adjusted odds ratio, 1.40 95% CI, 1.08-1.81;
=0.011). People of color waited longer for physician evaluation (HR, 0.82 95% CI, 0.73-0.93;
<0.001) than White adults after multivariable adjustment, but there were no racial differences in hospital admission, triage level, electrocardiography, or cardiac biomarker testing. Acute myocardial infarction was diagnosed in 1.4% of adults in the emergency department and 6.5% of admitted adults. Conclusions Women and people of color with CP waited longer to be seen by physicians, independent of clinical features. Women were independently less likely to be admitted when presenting with CP. These differences could impact downstream treatment and outcomes.
•A two-center study showed that deep learning radiomics analysis of pre- and post-nCRT CT images could improve the pCR prediction of patients with ESCC.•The combined model was superior to the ...clinical and radiomics models in predicting pCR in locally advanced ESCC and the LR classifier performed best in the current study.•Decision curves demonstrated that the novel predictive model based on deep learning and handcrafted radiomics features combined with hematological parameters has great clinical utility.
To evaluate and validate CT-based models using pre- and posttreatment deep learning radiomics features and hematological biomarkers for assessing esophageal squamous cell carcinoma (ESCC) pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT).
This retrospective study recruited patients with biopsy-proven ESCC who underwent nCRT from two Chinese hospitals between May 2017 and May 2022, divided into a training set (hospital I, 111 cases), an internal validation set (hospital I, 47 cases), and an external validation set (hospital II, 33 cases). We used minimum redundancy maximum relevance (mRMR) and least absolute shrinkage and selection operator (LASSO) as feature selection methods and three classifiers as model construction methods. The assessment of models was performed using area under the receiver operating characteristic (ROC) curve (AUC) and decision curve analysis (DCA).
A total 190 patients were included in our study (60.8 ± 7.08 years, 133 men), and seventy-seven of them (40.5 %) achieved pCR. The logistic regression (LR)-based combined model incorporating neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, albumin, and radscores performed well both in the internal and external validation sets with AUCs of 0.875 and 0.857 (95 % CI, 0.776–0.964; 0.731–0.984, P <0.05), respectively. DCA demonstrated that nomogram was useful for pCR prediction and produced clinical net benefits.
The incorporation of radscores and hematological biomarkers into LR-based model improved pCR prediction after nCRT in ESCC. Enhanced pCR predictability may improve patients selection before surgery, providing clinical application value for the use of active surveillance.
The function characteristics and the realization modes of dynamics modeling based on virtual assembly for integrated transmission are analyzed. On this basis, the system architecture and analysis ...process of dynamics modeling system for the dynamics modeling based on virtual assembly for integrated transmission are proposed. According to the architecture, the system is divided into the human-computer interaction, functional implementation, core analysis and data supporting layer, and the complete system architecture is established. The dynamics modeling process is divided into the modeling of multi-attribute parts, system modeling based on assembly features, dynamics modeling and system implementation stage from the analysis process. These can provide the systematic, integrated and practical basis for the dynamics modeling and establishment for modeling platform.
Due to their capability of reversibly accepting multi lithium ions, polyoxometalates (POMs) have been widely regarded as promising candidates for electrochemical lithium storage. Nevertheless, the ...insulating nature of POMs hinders fast migration kinetics of lithium within the bulk of these materials. Herein, we propose the introduction of a local electric field surrounding the POM nanoparticles consisting of Mn and V where the concomitant Coulomb forces can accelerate the migration of lithium ions. After rationally hybridizing POMs with MXene nanosheets, the imbalanced charge distribution emerging at their interface produces the local electric field, thereby leading to a 250-fold increase of lithium diffusion coefficient. In this regard, a capacitive contribution as high as 81.7% at 1.0 mV s
−1
is observed. Moreover, the POM nanoparticles could densely assemble on the surface of MXene nanosheets, offering highly packed electrodes and thus high volumetric capacities. Due to the improved lithiumion transfer kinetics, the POMs/MXenes composites are paired with activated carbon to produce lithium-ion capacitors which could offer a high energy density of 195.5 W h kg
−1
and a large power capability of 3800 W kg
−1
. The findings in this work could build a clear relationship between materials with different conductivities for designing electrode materials.
In advanced lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutation, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have an excellent and ...long-lasting therapeutic response; however, virtually all patients eventually develop drug resistance and experience disease progression. The use of immunotherapy after EGFR-TKIs may be a successful therapeutic option for individuals who are resistant to them. It is still unclear if EGFR-TKIs can be administered again after immunotherapy has failed. We describe a case of a 37-year-old woman who was found to have T4N3M1a stage IVa lung adenocarcinoma. Amplification refractory mutation system PCR (ARMS-PCR) genetic testing suggested EGFR exon 19 deletion. The patient was initially treated with a regimen of icotinib (125 mg tid) combined with anlotinib (8 mg qd d1-d14) with an optimal efficacy rating of partial response (PR) and was granted a PFS of 7 months. In second-line treatment, the patient received three cycles of a KN046 (KN046 is a bispecific antibody inhibitor of PD-L1 and CTLA-4) 295 mg d1, pemetrexed 800 mg d1, plus carboplatin 750 mg d1 regimen, with an optimal efficacy rating of stable disease (SD) on CT. The third-line therapy was chosen to be afatinib with docetaxel, and the patient was evaluated for PR on CT. Up to 15 August 2022, the patient had a progression free survival (PFS) of 14 months. The successful treatment of this patient is a reminder that EGFR-TKI rechallenge in EGFR exon 19 deletion patients with EGFR-TKI resistance, in which immunotherapy has failed, may be effective.
Mg-MOF-74 has adsorption capacity while less research is about its luminescent properties. In this work, the fluorescent properties of Mg-MOF-74 were studied and characterized. The results show that ...Mg-MOF-74 exhibits excellent fluorescent properties and, most strikingly, selective sensing detection for nitroaromatic compounds(NACs), 2,4,6-trinitrophenol(PA) in particular, making it a promising PA-selective luminescent probe. This work demonstrates the application of MOFs in the detection of NACs with good selectivity.
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