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  • Dickkopf-related protein 1 ... Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer
    D'Amico, Lucia; Mahajan, Sahil; Capietto, Aude-Hélène ... The Journal of experimental medicine, 05/2016, Volume: 213, Issue: 5
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    Tumor-stroma interactions contribute to tumorigenesis. Tumor cells can educate the stroma at primary and distant sites to facilitate the recruitment of heterogeneous populations of immature myeloid ...
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  • Nuclear receptor expression... Nuclear receptor expression atlas in BMDCs: Nr4a2 restricts immunogenicity of BMDCs and impedes EAE
    Saini, Ankita; Mahajan, Sahil; Gupta, Pawan European Journal of Immunology, August 2016, Volume: 46, Issue: 8
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    The nuclear receptor (NR) superfamily of transcription factors regulates various key aspects of physiological processes; however, their role(s) in immune cells’ function are just beginning to ...
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  • Obesity-associated microbio... Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils
    Shantaram, Dharti; Hoyd, Rebecca; Blaszczak, Alecia M. ... Nature communications, 06/2024, Volume: 15, Issue: 1
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    Abstract Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains more ...
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  • Contemporary Outcomes Follo... Contemporary Outcomes Following Endovascular Therapy of Coarctation of Aorta- Experience from a Tertiary Care Centre in India
    Mahajan, Sahil; Anandaraj, Arpudh Michael; Varghese, Lijo ... Journal of clinical and diagnostic research, 09/2019, Volume: 13, Issue: 9
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    Introduction: Since 1980s, endovascular therapy has evolved as an important therapeutic strategy for Coarctation of the Aorta (CoA). Aim: This study sought to present a comprehensive contemporary ...
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  • Trifluoroethanol stabilizes... Trifluoroethanol stabilizes the molten globule state and induces non-amyloidic turbidity in stem bromelain near its isoelectric point
    Dave, Sandeep; Mahajan, Sahil; Chandra, Vemika ... International journal of biological macromolecules, 11/2011, Volume: 49, Issue: 4
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    Stem bromelain (SBM) is a therapeutic protein that has been studied for alkaline denaturation in the intestines, the principal site of its absorption. In this study, we investigated fluorinated ...
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  • Diacylglycerol Kinase ζ Reg... Diacylglycerol Kinase ζ Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models
    Mahajan, Sahil; Mellins, Elizabeth D; Faccio, Roberta The Journal of immunology (1950), 01/2020, Volume: 204, Issue: 1
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    Dysregulation of monocyte and macrophage responses are often observed in children with systemic juvenile idiopathic arthritis (sJIA) and cytokine storm syndrome (CSS), a potentially fatal ...
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  • Nuclear Receptor Nr4a2 Prom... Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis
    Mahajan, Sahil; Saini, Ankita; Chandra, Vemika ... Journal of biological chemistry/˜The œJournal of biological chemistry, 07/2015, Volume: 290, Issue: 30
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    The orphan nuclear receptor Nr4a2 is known to modulate both inflammatory and metabolic processes, but the mechanism by which it regulates innate inflammatory homeostasis has not been adequately ...
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  • Phospholipase Cγ1 (PLCγ1) C... Phospholipase Cγ1 (PLCγ1) Controls Osteoclast Numbers via Colony-stimulating Factor 1 (CSF-1)-dependent Diacylglycerol/β-Catenin/CyclinD1 Pathway
    Yang, Zhengfeng; Kim, Seokho; Mahajan, Sahil ... Journal of biological chemistry/˜The œJournal of biological chemistry, 01/2017, Volume: 292, Issue: 4
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    Phospholipases Cγ (PLCγ) 1 and 2 are a class of highly homologous enzymes modulating a variety of cellular pathways through production of inositol 1,4,5-trisphosphate and diacylglycerol (DAG). Our ...
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  • Macrophage dependent pathwa... Macrophage dependent pathways modulate the pathogenesis of cytokine storm syndrome
    Mahajan, Sahil; Decker, Corinne; Mellins, Elizabeth ... The Journal of immunology (1950), 05/2018, Volume: 200, Issue: 1_Supplement
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    Abstract Cytokine storm syndromes (CSS) are life-threatening conditions characterized by excessive activation of T cells, accumulation of well-differentiated macrophages in various organs and ...
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