Nanoinsecticides of plant origin have advantages in the resistance of Aedes aegypti, vectors of infectious diseases. The objective of this study was to evaluate the insecticidal potential of Ayapana ...triplinervis essential oil nano-emulsions using in silico and in vivo assays in an Aedes aegypti model. Molecular docking showed that minority compounds present in the morphotype A essential oil have a more significant binding affinity to inhibit acetylcholinesterase and juvenile hormone receptors. Aedes aegypti adults were susceptible to A. triplinervis at 150 µg.mL-1 in a diagnostic time of 15 min for morphotype A essential oil nano-emulsion and 45 min for morphotype B essential oil nano-emulsion. The evaluation of toxicity in Swiss albino mice indicated that the nano-emulsions had low acute dermal toxicity and presented LD50 greater than 2000 mg.Kg−1. Thus, it is possible to conclude that nano-emulsions have the potential to be used in the chemical control of A. aegypti.
Este trabalho buscou estabelecer um primeiro panorama dos pressupostos Freireanos na produção acadêmica do ensino Ciência Tecnologia e Sociedade, CTS, no Brasil, por meio da análise das principais ...palavras-chave e referenciais teóricos mais recorrentes pelos pesquisadores da área. Os treze artigos analisados na pesquisa foram retirados no banco de dados do Grupo CTS e Educação do CEFET/RJ, que reúne 244 artigos sobre CTS, de 1996 a 2016, em 31 periódicos. O critério de seleção foi encontrar no título, resumo ou palavras-chave dos artigos, termos relacionados à pedagogia freireana. Num primeiro momento, investiu-se na análise de Rede Social, por meio das palavras-chaves e autores citados. Posteriormente, foi realizada uma leitura analítica nos artigos com objetivo de identificar como os saberes relacionados à abordagem desde Freire foram relacionados com o enfoque CTS. A discussão realizada no presente trabalho pode auxiliar no entendimento de como os principais campos teóricos de Paulo Freire são representados na abordagem CTS. Os resultados obtidos apresentaram evidências que levam à necessidade de análises teóricas mais profundas, mas mostram que as inter-relações entre Freire e CTS se fazem de maneira superficial e sem aprofundamento teórico.
Transient global amnesia (TGA) is characterized by abrupt transient loss of anterograde memory, lasting up to 24 hours, and no other focal neurological signs. We report the case of a right-handed ...71-year-old female patient who presented temporal-spatial disorientation 5 minutes after ingestion of 1000 ml of iodinated contrast. The patient had mild temporal-spatial disorientation, with significant deficit in anterograde memory. After 12 hours under observation, the patient progressed to gradual improvement and was discharged. A reevaluation after 15 days showed normal cortical functions, score on mini-mental state exam of 30, and unaffected working and recall memory. MRI performed 48 hours after the event showed hypersignal in the diffusion sequence in the anterior portion of the cingulate gyrus, with hypointense signal in MAP/ADC, confirming a finding consistent with TGA. No previous reports in the literature have described the location affected in this patient, rendering it a novel site consistent with this diagnosis.
This study evaluated the larvicidal activity of Origanum majorana Linnaeus essential oil, identified the chemical composition, evaluated the antimicrobial, cytotoxic and antioxidant potential. The ...larvicidal activity was evaluated against larvae of the third stage of Aedes aegypti Linaeus, whereas the chemical composition was identified by gas chromatography coupled to mass spectrometer, the antimicrobial activity was carried out against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus auereus, the antioxidant activity was evaluated from of 2.2-diphenyl-1-picryl-hydrazila sequestration and Artemia salina Leach cytotoxicity. Regarding to the results, the larvicidal activity showed that O. majorana L. essential oil caused high mortality in A. aegypti L. larvae. In the chromatographic analysis, the main component found in O. majorana L. essential oil was pulegone (57.05%), followed by the other components verbenone (16.92%), trans-p-menthan-2-one (8.57%), iso-menthone (5.58%), piperitone (2.83%), 3-octanol (2.35%) and isopulegol (1.47%). The antimicrobial activity showed that E. coli and P. aeruginosa bacteria were more sensitive to oil than S. aureus, which was resistant at all concentrations. Essential oil did not present antioxidant activity, but it has high cytotoxic activity against A. salina L.
The zebrafish (
Danio rerio
) has been proposed as a low-cost and simple alternative to the use of higher vertebrates in laboratory research on novel compounds with antinociceptive potential. In this ...study, we tested adult zebrafish (
Danio rerio
) as an alternative behavioral model of formalin-induced nociception. We evaluated the nociceptive effect of 0.1% formalin (3 or 5 μL; intramuscularly i.m.), applied into the tail or lips, on locomotor activity, using as parameter the number of times the fish crossed the lines between the quadrants of a glass Petri dish during the neurogenic stage (0–5 min) and the inflammatory stage (15–30 min). The behavioral model was validated by testing the antinociceptive effect of morphine and indomethacin (standard analgesic drugs used in the formalin test of rodents). We also tested whether the effect of morphine could be modulated by naloxone, an opioid antagonist. The effect of morphine and indomethacin on zebrafish locomotor behavior was evaluated with the open field test. The white/black test was used to rule out the anxiolytic effect of 0.1% formalin injected into the tail on adult zebrafish. Formalin (0.1%; 3 and 5 μL injected into the tail) increased significantly the nociceptive behavior of the adult zebrafish in both stages (
p
< 0.001 vs. control). Morphine and indomethacin (both 0.2 mg/mL; 20 μL; intraperitoneally i.p.) significantly inhibited nociception induced with formalin (5 μL injected i.m. into the tail) in both stages (
p
< 0.001). Naloxone blocked the antinociceptive effect of morphine. No influence on locomotion was observed. Locally administered formalin (injected into the tail) induced nociception, but not anxiety. The results suggest that the adult zebrafish behavioral model is a feasible alternative to more conventional laboratory models used in research on novel compounds with antinociceptive potential.
This paper sought to establish a first overview of the Freirean assumptions in the academic production of Science, Technology and Society (STS) education in Brazil, though the analysis of the main ...recurring keywords and theoretical references by researchers in the field.The thirteen articles analyzed in the survey were taken from the STS and Education Group database of CEFET / RJ, which gathers 244 articles on STS, from 1996 to 2016, in 31 journals. The selection criterion was to find in the title, abstract or keywords of the articles, terms related to Freirean pedagogy. At first, it was invested in the analysis of Social Network, through the mentioned keywords and authors. Subsequently an analytical reading was carried out in the articles in order to identify how the knowledge related to the Freire approach was related to the STS approach. The discussion carried out in the present work can help in the understanding of how the main theoretical fields of Paulo Freire are represented in the CTS approach. The results obtained presented evidences that lead to the need of deeper theoretical analyzes, but show that the interrelationships between Freire and CTS are made superficially and without theoretical deepening.
Este trabalho buscou estabelecer um primeiro panorama dos pressupostos Freireanos na produção acadêmica do ensino Ciência Tecnologia e Sociedade, CTS, no Brasil, por meio da análise das principais palavras-chave e referenciais teóricos mais recorrentes pelos pesquisadores da área. Os treze artigos analisados na pesquisa foram retirados no banco de dados do Grupo CTS e Educação do CEFET/RJ, que reúne 244 artigos sobre CTS, de 1996 a 2016, em 31 periódicos. O critério de seleção foi encontrar no título, resumo ou palavras-chave dos artigos, termos relacionados à pedagogia freireana. Num primeiro momento, investiu-se na análise de Rede Social, por meio das palavras-chaves e autores citados. Posteriormente, foi realizada uma leitura analítica nos artigos com objetivo de identificar como os saberes relacionados à abordagem desde Freire foram relacionados com o enfoque CTS. A discussão realizada no presente trabalho pode auxiliar no entendimento de como os principais campos teóricos de Paulo Freire são representados na abordagem CTS. Os resultados obtidos apresentaram evidências que levam à necessidade de análises teóricas mais profundas, mas mostram que as inter-relações entre Freire e CTS se fazem de maneira superficial e sem aprofundamento teórico.
Este trabajo tuvo como objetivo establecer una primera visión general de los supuestos freireanos en la producción académica de la educación en ciencia, tecnología y sociedad (CTS) en Brasil, a través del análisis de las principales palabras clave recurrentes y referenciales teóricos de investigadores en el campo. Los trece artículos analizados en la encuesta fueron encontrados en el banco de datos del Grupo CTS y Educación delCEFET / RJ, que reúne 244 artículos sobre CTS, de 1996 a 2016, en 31 revistas. El criterio de selección fue encontrar en el título, resumen o palabras clave de los artículos, términos relacionados a la pedagogía freireana. En un primer momento, estudiamos la Red Social, por medio de las palabras clave y autores citados. Posteriormente se realizó una lectura analítica en los artículos con el objetivo de identificar cómo lossaberes relacionados con el enfoque desde Freire se relacionaron con el enfoque CTS. La discusión realizada en el presente trabajo puede ayudar a la comprensión de cómo los principales campos teóricos de Paulo Freire están representados en el enfoque CTS. Los resultados obtenidos presentaron evidencias que llevan a la necesidad de análisis teóricos más profundos, pero muestran que las interrelaciones entre Freire y CTS sehacen de manera superficial y sin profundización teórica.
Limbic encephalitis is a syndrome characterised by irritability, depression, sleeping disturbance, convulsion, hallucination and short-period memory loss that is commonly associated with a malignancy ...even if there is no evidence of it by the time of presentation. Most reported cases of limbic encephalitis as a paraneoplastic syndrome are associated with small-cell lung cancer and lymphoma. This article is a case report of a patient with limbic encephalitis associated with an oesophageal adenocarcinoma. The patient is a middle-aged man who presented apathy and unstable mood. After months, developed diplopia, reduced visual acuity and involuntary movements. Later, gait disability, disorientation, memory loss and aggressive behaviour were detected, associated with seizures. After investigation, limbic encephalitis was diagnosed and, as the patient developed dysphagia, oesophageal adenocarcinoma was detected. Oesophageal carcinoma usually does not have neurological symptoms associated.
This study evaluated the larvicidal activity of Origanum majorana Linnaeus essential oil, identified the chemical composition, evaluated the antimicrobial, cytotoxic and antioxidant potential. The ...larvicidal activity was evaluated against larvae of the third stage of Aedes aegypti Linaeus, whereas the chemical composition was identified by gas chromatography coupled to mass spectrometer, the antimicrobial activity was carried out against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus auereus, the antioxidant activity was evaluated from of 2.2-diphenyl-1-picryl-hydrazila sequestration and Artemia salina Leach cytotoxicity. Regarding to the results, the larvicidal activity showed that O. majorana L. essential oil caused high mortality in A. aegypti L. larvae. In the chromatographic analysis, the main component found in O. majorana L. essential oil was pulegone (57.05%), followed by the other components verbenone (16.92%), trans-p-menthan-2-one (8.57%), iso-menthone (5.58%), piperitone (2.83%), 3-octanol (2.35%) and isopulegol (1.47%). The antimicrobial activity showed that E. coli and P. aeruginosa bacteria were more sensitive to oil than S. aureus, which was resistant at all concentrations. Essential oil did not present antioxidant activity, but it has high cytotoxic activity against A. salina L.
Este trabalho buscou estabelecer um primeiro panorama dos pressupostos Freireanos na produçao acadêmica do ensino Ciência Tecnologia e Sociedade, CTS, no Brasil, por meio da análise das principais ...palavras-chave e referenciais teóricos mais recorrentes pelos pesquisadores da área. Os treze artigos analisados na pesquisa foram retirados no banco de dados do Grupo CTS e Educaçao do CEFET/RJ, que reúne 244 artigos sobre CTS, de 1996 a 2016, em 31 periódicos. O critério de seleçao foi encontrar no título, resumo ou palavras-chave dos artigos, termos relacionados à pedagogia freireana. Num primeiro momento, investiu-se na análise de Rede Social, por meio das palavras-chaves e autores citados. Posteriormente, foi realizada uma leitura analítica nos artigos com objetivo de identificar como os saberes relacionados à abordagem desde Freire foram relacionados com o enfoque CTS. A discussao realizada no presente trabalho pode auxiliar no entendimento de como os principais campos teóricos de Paulo Freire sao representados na abordagem CTS. Os resultados obtidos apresentaram evidências que levam à necessidade de análises teóricas mais profundas, mas mostram que as inter-relaçoes entre Freire e CTS se fazem de maneira superficial e sem aprofundamento teórico.
PDF
