Background: Multiple factors affect the growth response to recombinant
human growth hormone (rhGH) in children with idiopathic short stature
(ISS). Aim: To evaluate the growth responses of children ...with ISS
treated with rhGH, aiming to identify the predictors of growth
response. Materials and Methods: We studied 120 cases, 90 males (75%),
with a mean age of 13.8±2.7 years and 30 females (25%), with a
mean age of 12.3±2.5 years. All patients received rhGH with a
standard dose of 20 IU /m2 /week. The calculated dose per week was
divided into six days and given subcutaneous at night. Results: A
significant positive trend was detected in the delta changes of all
anthropometric data. For the first year, the growth response was
positively correlated to CA and BA delay and negatively correlated to
height, weight and IGF-1 SDSs. For the second year, the growth response
was correlated positively to first year growth velocity, BA, triceps
skin fold thickness SDS and deviation from target height, and
negatively correlated to weight, IGFBP3 SDS and target height SDS. For
the third year, the growth response was positively correlated to five
variables namely target height, 2nd year growth velocity, IGF-1 SDS,
weight SDS and triceps skin fold thickness SDS. For the fourth year,
growth response was positively correlated to 2nd and 3rd year growth
velocity, BA, deviation from target height and weight/ height SDS.
Conclusion: Our study showed multiplicity of predictors that is
responsible for response in ISS children treated with rhGH, and BA was
an important predictor.
Background and Objectives: Recombinant human growth hormone (rhGH) is
approved for use in children with Turner′s syndrome (TS) in most
industrialized countries and is recommended in the recently ...issued
guidelines. We determined the growth responses of girls who are treated
with rhGH for TS, with an aim to identify the predictors of growth
response. Materials and Methods: Fifty-six prepubertal girls with TS,
documented by peripheral blood karyotype, were enrolled. All the
patients received biosynthetic growth hormone therapy with a standard
dose of 30 IU/m 2 /week. The calculated dose per week was divided for 6
days and given subcutaneously at night. Results: This study showed that
rhGH therapy provides satisfactory auxological results. Bone age delay
is to be considered as a predictive factor which may negatively
influence the effect of rhGH therapy on final height. The growth
velocity in the preceding year is the most important predictor of rhGH
therapy response. Conclusion: These observations help us to guide rhGH
prescription, to reduce the risks and costs.
γ-Ray irradiation of pre-sowing seeds of tomato did not trigger the formation of the phytoalexin “rishitin” in either leaves or fruits of tomato plants through different growth seasons. Application ...of copper sulfate initiated rishitin formation in both leaves and fruits. Increasing of γ-ray dose was accompanied by decreasing rishitin accumulation in the presence of copper sulfate. Rishitin of tomato leaves was found to be reduced significantly, concomitant with increasing the disease incidence for late and early blight, andFusarium wilt disease, after applying γ-irradiation, in the case of biotic initiatorsPhytophthora infestans, Alternaria solani orFusarium oxysporum alone or together with the abiotic inducer copper sulfate. Shelf-extending γ-ray doses of 1.0, 1.5 and 2.0 kGy decreased rishitin amounts in tomato fruits treated with copper sulfate alone or infected withPhytophthora infestans. Also, the amount of formed rishitin was reduced by extending the storage period.
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