Electrostatic analyzers of different designs have been used since the earliest days of the space age, beginning with the very earliest solar-wind measurements made by Mariner 2 en route to Venus in ...1962. The Parker Solar Probe (PSP) mission, NASA's first dedicated mission to study the innermost reaches of the heliosphere, makes its thermal plasma measurements using a suite of instruments called the Solar Wind Electrons, Alphas, and Protons (SWEAP) investigation. SWEAP's electron PSP Analyzer (Solar Probe ANalyzer-Electron (SPAN-E)) instruments are a pair of top-hat electrostatic analyzers on PSP that are capable of measuring the electron distribution function in the solar wind from 2 eV to 30 keV. For the first time, in situ measurements of thermal electrons provided by SPAN-E will help reveal the heating and acceleration mechanisms driving the evolution of the solar wind at the points of acceleration and heating, closer than ever before to the Sun. This paper details the design of the SPAN-E sensors and their operation, data formats, and measurement caveats from PSP's first two close encounters with the Sun.
Occult hypovolaemia is a key factor in the aetiology of postoperative morbidity and may not be detected by routine heart rate and arterial pressure measurements. Intraoperative gut hypoperfusion ...during major surgery is associated with increased morbidity and postoperative hospital stay. We assessed whether using intraoperative oesophageal Doppler guided fluid management to minimize hypovolaemia would reduce postoperative hospital stay and the time before return of gut function after colorectal surgery.
This single centre, blinded, prospective controlled trial randomized 128 consecutive consenting patients undergoing colorectal resection to oesophageal Doppler guided or central venous pressure (CVP)-based (conventional) intraoperative fluid management. The intervention group patients followed a dynamic oesophageal Doppler guided fluid protocol whereas control patients were managed using routine cardiovascular monitoring aiming for a CVP between 12 and 15 mm Hg.
The median postoperative stay in the Doppler guided fluid group was 10 vs 11.5 days in the control group P<0.05. The median time to resuming full diet in the Doppler guided fluid group was 6 vs 7 for controls P<0.001. Doppler patients achieved significantly higher cardiac output, stroke volume, and oxygen delivery. Twenty-nine (45.3%) control patients suffered gastrointestinal morbidity compared with nine (14.1%) in the Doppler guided fluid group P<0.001, overall morbidity was also significantly higher in the control group P=0.05.
Intraoperative oesophageal Doppler guided fluid management was associated with a 1.5-day median reduction in postoperative hospital stay. Patients recovered gut function significantly faster and suffered significantly less gastrointestinal and overall morbidity.
ABSTRACT We present the discovery of a transiting exoplanet candidate in the K2 Field-1 with an orbital period of 9.1457 hr: K2-22b. The highly variable transit depths, ranging from ∼0% to 1.3%, are ...suggestive of a planet that is disintegrating via the emission of dusty effluents. We characterize the host star as an M-dwarf with Teff 3800 K. We have obtained ground-based transit measurements with several 1-m class telescopes and with the GTC. These observations (1) improve the transit ephemeris; (2) confirm the variable nature of the transit depths; (3) indicate variations in the transit shapes; and (4) demonstrate clearly that at least on one occasion the transit depths were significantly wavelength dependent. The latter three effects tend to indicate extinction of starlight by dust rather than by any combination of solid bodies. The K2 observations yield a folded light curve with lower time resolution but with substantially better statistical precision compared with the ground-based observations. We detect a significant "bump" just after the transit egress, and a less significant bump just prior to transit ingress. We interpret these bumps in the context of a planet that is not only likely streaming a dust tail behind it, but also has a more prominent leading dust trail that precedes it. This effect is modeled in terms of dust grains that can escape to beyond the planet's Hill sphere and effectively undergo "Roche lobe overflow," even though the planet's surface is likely underfilling its Roche lobe by a factor of 2.
The Solar Probe Cup on the Parker Solar Probe Case, A. W.; Kasper, Justin C.; Stevens, Michael L. ...
The Astrophysical journal. Supplement series,
02/2020, Volume:
246, Issue:
2
Journal Article
Peer reviewed
Open access
Solar Probe Cup (SPC) is a Faraday cup instrument on board NASA's Parker Solar Probe (PSP) spacecraft designed to make rapid measurements of thermal coronal and solar wind plasma. The spacecraft is ...in a heliocentric orbit that takes it closer to the Sun than any previous spacecraft, allowing measurements to be made where the coronal and solar wind plasma is being heated and accelerated. The SPC instrument was designed to be pointed directly at the Sun at all times, allowing the solar wind (which is flowing primarily radially away from the Sun) to be measured throughout the orbit. The instrument is capable of measuring solar wind ions with an energy between 100 and 6000 V (protons with speeds from 139 to 1072 km s−1). It also measures electrons with an energy/charge between 100 and 1500 V. SPC has been designed to have a wide dynamic range that is capable of measuring protons and alpha particles at the closest perihelion (9.86 solar radii from the center of the Sun) and out to 0.25 au. Initial observations from the first orbit of PSP indicate that the instrument is functioning well.
Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture and release of multiple infective merozoites, parasitised RBC (pRBC) ...can reach very high numbers in vivo, a process that correlates with disease severity in humans and experimental animals. Thus, controlling pRBC numbers can prevent or ameliorate malaria. In endemic regions, circulating parasite-specific antibodies associate with immunity to high parasitemia. Although in vitro assays reveal that protective antibodies could control pRBC via multiple mechanisms, in vivo assessment of antibody function remains challenging. Here, we employed two mouse models of antibody-mediated immunity to malaria, P. yoelii 17XNL and P. chabaudi chabaudi AS infection, to study infection-induced, parasite-specific antibody function in vivo. By tracking a single generation of pRBC, we tested the hypothesis that parasite-specific antibodies accelerate pRBC clearance. Though strongly protective against homologous re-challenge, parasite-specific IgG did not alter the rate of pRBC clearance, even in the presence of ongoing, systemic inflammation. Instead, antibodies prevented parasites progressing from one generation of RBC to the next. In vivo depletion studies using clodronate liposomes or cobra venom factor, suggested that optimal antibody function required splenic macrophages and dendritic cells, but not complement C3/C5-mediated killing. Finally, parasite-specific IgG bound poorly to the surface of pRBC, yet strongly to structures likely exposed by the rupture of mature schizonts. Thus, in our models of humoral immunity to malaria, infection-induced antibodies did not accelerate pRBC clearance, and instead co-operated with splenic phagocytes to block subsequent generations of pRBC.
Abstract This study investigated viruses in bovine respiratory disease (BRD) cases in feedlots, including bovine herpesvirus-1 (BoHV-1), bovine viral diarrhea virus (BVDV), bovine respiratory ...syncytial virus (BRSV), bovine coronaviruses (BoCV) and parainfluenza-3 virus (PI3V). Nasal swabs were collected from 114 cattle on initial BRD treatment. Processing included modified live virus (MLV) vaccination. Seven BRD necropsy cases were included for 121 total cases. Mean number of days on feed before first sample was 14.9 days. Swabs and tissue homogenates were tested by gel based PCR (G-PCR), quantitative-PCR (qPCR) and quantitative real time reverse transcriptase PCR (qRT-PCR) and viral culture. There were 87/114 (76.3%) swabs positive for at least one virus by at least one test. All necropsy cases were positive for at least one virus. Of 121 cases, positives included 18/121 (14.9%) BoHV-1; 19/121 (15.7%) BVDV; 76/121 (62.8%) BoCV; 11/121 (9.1%) BRSV; and 8/121 (6.6%) PI3V. For nasal swabs, G-PCR (5 viruses) detected 44/114 (38.6%); q-PCR and qRT-PCR (4 viruses) detected 81/114 (71.6%); and virus isolation detected 40/114 (35.1%). Most were positive for only one or two tests, but not all three tests. Necropsy cases had positives: 5/7 G-PCR, 5/7 q-PCR and qRT-PCR, and all were positive by cell culture. In some cases, G-PCR and both real time PCR were negative for BoHV-1, BVDV, and PI3V in samples positive by culture. PCR did not differentiate field from vaccines strains of BoHV-1, BVDV, and PI3V. However based on sequencing and analysis, field and vaccine strains of culture positive BoHV-1, BVDV, and PI3V, 11/18 (61.1%) of BoHV-1 isolates, 6/17 (35.3%) BVDV isolates, and 1/10 (10.0%) PI3V identified as vaccine. BRSV was only identified by PCR testing. Interpretation of laboratory tests is appropriate as molecular based tests and virus isolation cannot separate field from vaccine strains. Additional testing using sequencing appears appropriate for identifying vaccine strains.
Abstract
The Solar Probe ANalyzer for Ions (SPAN-I) onboard NASA’s Parker Solar Probe spacecraft is an electrostatic analyzer with time-of-flight capabilities that measures the ion composition and ...three-dimensional distribution function of the thermal corona and solar-wind plasma. SPAN-I measures the energy per charge of ions in the solar wind from 2 eV to 30 keV with a field of view of 247.°5 × 120° while simultaneously separating H
+
from He
++
to develop 3D velocity distribution functions of individual ion species. These observations, combined with reduced distribution functions measured by the Sun-pointed Solar Probe Cup, will help us further our understanding of the solar-wind acceleration and formation, the heating of the corona, and the acceleration of particles in the inner heliosphere. This paper describes the instrument hardware, including several innovative improvements over previous time-of-flight sensors, the data products generated by the experiment, and the ground calibrations of the sensor.
This study examined responses of male broilers during a 49-d production cycle to 4 placement densities in 2 trials. Trials were pooled because no treatment x trial interaction occurred. In each ...trial, 1,488 male chicks were randomly placed into 32 floor pens to simulate final densities of 30 (37 chicks/pen), 35 (43 chicks/pen), 40 (50 chicks/pen), and 45 (56 chicks/pen) kg of BW/m2 of floor space based on a projected final BW of 3.29 kg. Growth rate and nutrient utilization were similar (P greater than or equal to 0.05) among the treatments from 1 to 32 d of age. From 1 to 49 d, BW gain (P = 0.011) and feed consumption (P = 0.029) were adversely affected by increasing the placement density from 30 to 45 kg of BW/m2 of floor space. The reduction in cumulative BW gain due to placement density can be partially explained by less feed consumption as evidenced by 95.4% of the sums of squares of BW gain being attributable to feed consumption. Litter moisture content (P = 0.025) and foot pad lesion score (P = 0.001) increased linearly with increasing placement density. Upon processing, whole carcass and breast meat yields relative to BW were not affected (P greater than or equal to 0.05) as density increased from 30 to 45 kg/m2. The proportion of whole carcasses with scratches, but not tears, on the back and thighs increased (P = 0.021) as density increased. These results indicate that increasing the density beyond 30 kg/m2 elicited some negative effects on live performance of heavy broilers.
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