Objectives
To develop guidelines describing a standardised approach to patient preparation and acquisition protocols for magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound (US) ...of the small bowel and colon, with an emphasis on imaging inflammatory bowel disease.
Methods
An expert consensus committee of 13 members from the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Paediatric Radiology (ESPR) undertook a six-stage modified Delphi process, including a detailed literature review, to create a series of consensus statements concerning patient preparation, imaging hardware and image acquisition protocols.
Results
One hundred and fifty-seven statements were scored for agreement by the panel of which 129 statements (82 %) achieved immediate consensus with a further 19 (12 %) achieving consensus after appropriate modification. Nine (6 %) statements were rejected as consensus could not be reached.
Conclusions
These expert consensus recommendations can be used to help guide cross-sectional radiological practice for imaging the small bowel and colon.
Key points
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Cross
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sectional imaging is increasingly used to evaluate the bowel
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Image quality is paramount to achieving high diagnostic accuracy
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Guidelines concerning patient preparation and image acquisition protocols are provided
Background
Among low-flow vascular malformations, venous malformations are relatively frequent. The pathological patterns vary in severity and are generally characterized by dilated vessels and ...low-flow blood that over time can organize into phleboliths. Sometimes small capillary and/or lymphatic vessels may be associated, micro- and/or macro-shunts may form alone or in different combinations, and finally adipose tissue may be interposed between the malformed vessels. Magnetic resonance imaging (MRI) is a crucial examination for confirming venous malformations because it can accurately identify different features of the lesions.
Objective
The aim of our study was to compare MRI and histopathological findings of venous malformations in children to assess the possibilities and limitations of MRI.
Materials and methods
In a retrospective study, two observers independently evaluated the contrast-enhanced MRI of 26 children with venous malformations. Several radiological parameters were considered and compared with histopathological findings. The agreement between the interobserver radiological evaluation and between histopathological and radiological diagnosis was verified using Cohen’s kappa.
Results
MRI interobserver agreement was excellent for micro-shunts and good for the remaining findings. The radiological-pathological agreement was perfect for the presence/absence of phleboliths and of macro-shunts and almost perfect for the presence of intralesional adipose tissue, lymphatic component, and micro-shunts.
Conclusion
MRI in venous malformations can detect the presence of phleboliths, adipose tissue, and lymphatic components with excellent accuracy and good to excellent interobserver agreement. Furthermore, MR angiography can detect micro-shunts in simple and combined venous malformations with substantial agreement with histopathological findings.
Despite numerous reports on the interactions of G-quadruplexes (G4s) with helicases, systematic analysis addressing the selectivity and specificity of each helicase towards a variety of G4 topologies ...are scarce. Among the helicases able to unwind G4s are those containing an iron-sulphur (FeS) cluster, including both the bacterial DinG (found in E. coli and several pathogenic bacteria) and the medically important eukaryotic homologues (XPD, FancJ, DDX11 and RTEL1). We carried out a detailed study of the interactions between the E. coli DinG and a variety of G4s, by employing physicochemical and biochemical methodologies. A series of G4-rich sequences from different genomic locations (promoter and telomeric regions), able to form unimolecular G4 structures with diverse topologies, were analyzed (c-KIT1, KRAS, c-MYC, BCL2, Tel
, T30695, Zic1). DinG binds to most of the investigated G4s with little discrimination, while it exhibits a clear degree of unwinding specificity towards different G4 topologies. Whereas previous reports suggested that DinG was active only on bimolecular G4s, here we show that it is also able to bind to and resolve the more physiologically relevant unimolecular G4s. In addition, when the G4 structures were stabilized by ligands (Pyridostatin, PhenDC3, BRACO-19 or Netropsin), the DinG unwinding activity decreased and in most cases was abolished, with a pattern that is not simply explained by a change in binding affinity. Overall, these results have important implications for the biochemistry of helicases, strongly suggesting that when analysing the G4 unwinding property of an enzyme, it is necessary to investigate a variety of G4 substrates.
We review the pivotal role of the stromal derived factor (SDF)-1 chemokine in tissue ischaemia and how it orchestrates the rapid revascularization of injured, ischaemic, and regenerating tissues via ...the CXC chemokine receptors CXCR4 and CXCR7. Furthermore, we discuss the effects of preconditioning (PC), which is a well-known protective phenomenon for tissue ischaemia. The positive effect of both hypoxic and acidic PC on progenitor cell therapeutic potential is reviewed, while stressing the role of the SDF-1/CXCR4 axis in this process.
Why do some people struggle with self-control (colloquially called willpower) whereas others are able to sustain it during challenging circumstances? Recent research showed that a person's implicit ...theories of willpower-whether they think self-control capacity is a limited or nonlimited resource-predict sustained self-control on laboratory tasks and on goal-related outcomes in everyday life. The present research tests the Implicit Theory of Willpower for Strenuous Mental Activities Scale (or ITW-M) Scale for measurement invariance across samples and gender within each culture, and two cultural contexts (the U.S. and Switzerland/Germany). Across a series of multigroup confirmatory factor analyses, we found support for the measurement invariance of the ITW-M scale across samples within and across two cultures, as well as across men and women. Further, the analyses showed expected patterns of convergent (with life-satisfaction and trait-self-control) and discriminant validity (with implicit theory of intelligence). These results provide guidelines for future research and clinical practice using the ITW-M scale for the investigation of latent group differences, for example, between gender or cultures.
Public Significance Statement
A person's implicit theories of willpower-whether they think self-control is a limited or nonlimited resource-predict self-control assessed with laboratory tasks and in everyday life. This study demonstrates that a six-item scale invariantly measures a person's implicit theory of willpower for strenuous mental activities across 10 data sets, two cultural contexts, and men and women.
Full text
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CEKLJ, FFLJ, NUK, ODKLJ, PEFLJ
Aim
There is a paucity of data on the clinical presentation and management of cancer patients with acquired haemophilia (AH), we here report a systematic literature review on acquired haemophilia in ...the context of cancer.
Methods
Treatment outcomes of AH were defined as complete response (CR), partial response (PR) or no response (NR), based on inhibitor eradication, coagulation factor VIII levels and bleeding control. Reported deaths were either related to cancer or bleeding.
Results
Overall, 105 cases were collected and analyzed according to classification of cancer and efficacy of treatments for inhibitor and malignancy. The mean age was 68 years for both males (range 37‐86 years) and females (range 43‐89 years), 39 patients were female subjects and 66 were males. A solid cancer was diagnosed in 60 subjects, while 45 patients suffered a haematological malignancy. Solid cancers affected mainly males; however, the incidence of solid tumours vs haematological malignancies was not statistically significant (P = .09). Not all patients were treated for their underlying cancer, bleeding and/or inhibitor, in two cases outcome is unavailable. CR was reported in 62.1% (64/103) cases, PR in 9.7% (10/103) cases, NR with or without death was reported in 28.1% (29/103) cases.
Conclusion
CR was best achieved when successful and complete elimination of autoantibodies occurred contemporaneously with the successful treatment of the underlying malignancy. In some cases, recurrent autoantibodies were harbingers of relapsed cancer. Type of cancer, inhibitor titer, treatments administered for bleeding control and inhibitor eradication did not significantly affect clinical outcome of analyzed cases.
The role of Volunteered Geographic Information (VGI) to integrate, update or complement authoritative datasets released by governments has become increasingly important. This work analyses the ...contribution of OpenStreetMap (OSM), the most popular VGI project, as one of the input sources that the Military Geographic Institute (IGM), one of the Italian governmental mapping agencies, has used for producing the National Summary Database (DBSN). This database, which was recently released for 12 out of the 20 Italian regions, has a schema organised into a hierarchical structure composed of 10 layers, 30 themes and 93 classes, where each geospatial object carries information on the specific data source it was derived from. For each DBSN layer and theme, we first calculated the fraction of objects derived from OSM in all the Italian regions and related provinces. We found a heterogeneous picture with OSM contribution generally being limited, with the exception of few regions and layers/themes where the DBSN was almost exclusively derived from OSM. An in-depth comparison between the DBSN and OSM building datasets showed that OSM building completeness is varying across Italian regions and provinces, but in all regions there are buildings in OSM that are not included in the DBSN. The work shed light on the opportunities and obstacles for OSM to become a primary input source for the production of governmental datasets.
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