The development of photocurable compositions is in high demand for the manufacture of functional materials for electronics, optics, medicine, energy, etc. The properties of the final photo-cured ...material are primarily determined by the initial mixture, which needs to be tuned for each application. In this study we propose to use simple systems based on di(meth)acrylate, polyimide and photoinitiator for the preparation of new photo-curable compositions. It was established that a fluorinated cardo copolyimide (FCPI) based on 2,2-
-(3,4-dicarboxydiphenyl)hexafluoropropane dianhydride, 9,9-
-(4-aminophenyl)fluorene and 2,2-
-(4-aminophenyl)hexafluoropropane (1.00:0.75:0.25 mol) has excellent solubility in di(met)acrylates. This made it possible to prepare solutions of FCPI in such monomers, to study the effect of FCPI on the kinetics of their photopolymerization in situ and the properties of the resulting polymers. According to the obtained data, the solutions of FCPI (23 wt.%) in 1,4-butanediol diacrylate (BDDA) and FCPI (15 wt.%) in tetraethylene glycol diacrylate were tested for the formation of the primary protective coatings of the silica optical fibers. It was found that the new coating of poly(BDDA-FCPI
) can withstand prolonged annealing at 200 °C (72 h), which is comparable or superior to the known most thermally stable photo-curable coatings. The proposed approach can be applied to obtain other functional materials.
The article considers the methods for predicting the technological settlements of buildings in the zone of influence of the construction of deep pit fences in the form of a cut-off wall of the trench ...type, borehole and bored-secant piles, jacked and vibro-driven sheet piles. The results of studies that allow predicting certain types of technological settlements in various engineering and geological conditions, including soil bases composed of water-saturated weak clay soils and loose sands, are presented.
To determine the frequency of prescribing and the main therapeutic targets of Teraligen in the treatment of Schizotypal disorder (STD) in childhood and adolescence.
The sample consisted of 151 ...patients aged 7 to 16 years with a diagnosis of STD (F 21), of which 31.1% (
47) of female patients and 68.9% (
104) of male patients who received inpatient or outpatient treatment at the FSBI NCPZ from 2008 to 2020. The study was conducted by clinical-psychopathological, clinical-catamnestic, and statistical methods.
Teraligen was prescribed by psychiatrists to patients with STD in 74.2% of cases, of which in 46.4% of cases patients received Teraligen even before the diagnosis of STD in connection with complaints of neurotic disorders (anxiety, fears and sleep disorders) (
30), as well as in connection with autistic-like behavior (
22). At the time of follow-up, 55% (
83) of patients received Teraligen, of which 63.9% (
53) of patients were prescribed it for the first time. The applied schemes of prescribing Teraligen for the treatment of anxiety-phobic, depressive and behavioral syndromes within the framework of the STD in a relatively age-related aspect are presented.
The high frequency of prescribing Teraligen by psychiatrists and neurologists to children and adolescents with STD at different stages of observation is shown, which reflects the confidence of specialists in this drug. Teraligen has demonstrated a multidimensional pharmacological effect, including a mild antipsychotic effect, providing reduction of a wide range of psychopathological symptoms, with good tolerability and drug interaction. The study of the possibilities of Teraligen, both for monotherapy and for augmentation of the treatment of mental pathology in childhood, remains relevant.
Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can be avoided for these patients ...if the nodules are reliably diagnosed as benign without surgery.
To determine the diagnostic accuracy of a multigene classifier (GC) test (ThyroSeq v3) for cytologically indeterminate thyroid nodules.
Prospective, blinded cohort study conducted at 10 medical centers, with 782 patients with 1013 nodules enrolled. Eligibility criteria were met in 256 patients with 286 nodules; central pathology review was performed on 274 nodules.
A total of 286 FNA samples from thyroid nodules underwent molecular analysis using the multigene GC (ThyroSeq v3).
The primary outcome was diagnostic accuracy of the test for thyroid nodules with Bethesda III and IV cytology. The secondary outcome was prediction of cancer by specific genetic alterations in Bethesda III to V nodules.
Of the 286 cytologically indeterminate nodules, 206 (72%) were benign, 69 (24%) malignant, and 11 (4%) noninvasive follicular thyroid neoplasms with papillary-like nuclei (NIFTP). A total of 257 (90%) nodules (154 Bethesda III, 93 Bethesda IV, and 10 Bethesda V) had informative GC analysis, with 61% classified as negative and 39% as positive. In Bethesda III and IV nodules combined, the test demonstrated a 94% (95% CI, 86%-98%) sensitivity and 82% (95% CI, 75%-87%) specificity. With a cancer/NIFTP prevalence of 28%, the negative predictive value (NPV) was 97% (95% CI, 93%-99%) and the positive predictive value (PPV) was 66% (95% CI, 56%-75%). The observed 3% false-negative rate was similar to that of benign cytology, and the missed cancers were all low-risk tumors. Among nodules testing positive, specific groups of genetic alterations had cancer probabilities varying from 59% to 100%.
In this prospective, blinded, multicenter study, the multigene GC test demonstrated a high sensitivity/NPV and reasonably high specificity/PPV, which may obviate diagnostic surgery in up to 61% of patients with Bethesda III to IV indeterminate nodules, and up to 82% of all benign nodules with indeterminate cytology. Information on specific genetic alterations obtained from FNA may help inform individualized treatment of patients with a positive test result.
New non-crystallizable low-dispersity star-shaped polydimethylsiloxanes (PDMS) containing stereoregular
-tetra(organo)(dimethylsiloxy)cyclotetrasiloxanes containing methyl-, tolyl- and ...phenyl-substituents at silicon atoms and the mixture of four stereoisomers of tetraphenyl(dimethylsiloxy)cyclotetrasiloxane as the cores were synthesized. Their thermal and viscous properties were studied. All synthesized compounds were characterized by a complex of physicochemical analysis methods: nuclear magnetic resonance (NMR), FT-IR spectroscopy, gel permeation chromatography (GPC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), viscometry in solution, rheometry, and Langmuir trough study.
In this work, we studied lead(II) and cobalt(II) complexation of derivatives 2-B10H9O(CH2)2O(CH2)2N32− and 2-B10H9O(CH2)5N32− of the closo-decaborate anion containing pendant azido groups in the ...presence of 1,10-phenanthroline and 2,2′-bipyridyl. Mononuclear PbL2{An} and binuclear Pb2L4(NO3)2{An} lead complexes (where {An} is the N3-substituted boron cluster) were isolated and studied by IR spectroscopy and elemental analysis. The mononuclear lead(II) complex Pb(phen)2B10H9O(CH2)2O(CH2)2N3 and the binuclear lead(II) complex Pb2(phen)4(NO3)2B10H9O(CH2)5)N3 were determined by single-crystal X-ray diffraction. In complex Pb2(phen)4(NO3)2B10H9O(CH2)5)N3, the boron cluster is coordinated by the metal atom only via the 3c2e MHB bonds. In complex Pb(phen)2B10H9O(CH2)2O(CH2)2N3, the coordination environment of the metal includes BH groups of the boron cluster and the oxygen atom of the exo-polyhedral substituent. When the reaction was performed in a CH3CN/water mixture, the binuclear lead(II) complex (Pb(bipy)NO3)(Pb(bipy)2NO3)(B10H9O(CH2)2O(CH2)2N3)·CH3CN·H2O was isolated, where the boron cluster acts as a bridging ligand between lead atoms coordinated by the boron cage via the O atoms of the substituent and/or the BH groups. In the course of cobalt(II) complexation, the starting compound (Ph4P)2B10H9O(CH2)5N3 was isolated and its structure was also determined by X-ray diffraction. Although a number of lead(II) complexes with coordinated N3 are known from the literature, no complexes with the boron cluster coordinated by the pendant N3 group involved in the metal coordination have been isolated.
The core@shell nanostructures were obtained in the process of transformation of ferrocene Fe(C5H5)2 at high pressure (HP) of 8 GPa and high temperature (HT) of 900 °C with an isothermal exposure time ...t varying from 10 to 10000 s. At t > 300 s, the iron carbide o-Fe7C3 nanoparticles with an orthorhombic crystal structure (sp.gr. Pnma) can be created, which are dispersed in highly defective carbon matrix. After opening the high-pressure cell, a series of redox reactions occurs, leading to a formation of iron oxides on the surface of the iron carbide core. When the size of Fe7C3 nanoparticle is less than critical one the nanoparticle is fully oxidized, while in the larger particle an amorphous iron oxide shell is formed. A sequential increase in t initiates crystallization processes both in the iron carbide subsystem and in the carbon subsystem, resulting in the formation of core@shell Fe7C3/FexOy/C structures. Iron oxides with a cubic spinel-type structure (Fe3O4/γ-Fe2O3) appear in the shell. However, under oxygen reduction, part of magnetite can be transformed into wüstite FeO. The magnetic properties of magnetite and wüstite are radically different, and by varying the thickness of these layers, structures with the desired functional properties can be obtained.
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Genes crucial for cancer development can be mutated via various mechanisms, which may reflect the nature of the mutagen. In thyroid papillary carcinomas, mutations of genes coding for effectors along ...the MAPK pathway are central for transformation. BRAF point mutation is most common in sporadic tumors. By contrast, radiation-induced tumors are associated with paracentric inversions activating the receptor tyrosine kinases RET and NTRK1. We report here a rearrangement of BRAF via paracentric inversion of chromosome 7q resulting in an in-frame fusion between exons 1-8 of the AKAP9 gene and exons 9-18 of BRAF. The fusion protein contains the protein kinase domain and lacks the autoinhibitory N-terminal portion of BRAF. It has elevated kinase activity and transforms NIH3T3 cells, which provides evidence, for the first time to our knowledge, of in vivo activation of an intracellular effector along the MAPK pathway by recombination. The AKAP9-BRAF fusion was preferentially found in radiation-induced papillary carcinomas developing after a short latency, whereas BRAF point mutations were absent in this group. These data indicate that in thyroid cancer, radiation activates components of the MAPK pathway primarily through chromosomal paracentric inversions, whereas in sporadic forms of the disease, effectors along the same pathway are activated predominantly by point mutations.
The specificity of the most plant carbohydrate-binding proteins (CBP), many of which are known only through bioinformatic analysis of the genome, has either not been studied at all or characterized ...to a limited extent. The task of deciphering the carbohydrate specificity of the proteins can be solved using glycoarrays composed of many tens or even hundreds of glycans immobilized on a glass surface. Plant carbohydrates are the most significant natural ligands for plant proteins; this work shows that plant polysaccharides without additional modification can be immobilized on the surface, bearing N-hydroxysuccinimide activated carboxyl groups. As a result, an array of 113 well-characterized polysaccharides isolated from various plant cell walls, 23 mono- and oligosaccharides – components of polysaccharides, and glycans – ligands for widely known plant lectins was designed. Upon chemical immobilization of polysaccharides, their functional activity was preserved, which was confirmed by the results of interaction with antibodies and the plant lectin ricin. Using the constructed array, a previously unknown ability of ricin to bind polysaccharides was found, which significantly expands the knowledge of its specificity, and it was also found that a large variety of antibodies to plant polysaccharides are present in human peripheral blood.
In this work, polycarboranosiloxanes (
M
n
= 25.5-31.3 kDa) with well-defined structures and a varying content of the carborane moiety (2-15 wt%) were obtained. TGA and DSC methods were used to study ...their thermal properties and the rheological behavior of melts was studied. It was found that as the content of carboranes in the structure of these polymers exceeds 9 wt%, the crystallization of the siloxane chain is suppressed. Data of rheological studies indicate that phase separation occurs in such hybrid carboranosiloxane systems.
In this work, polycarboranosiloxanes with well-defined structures and a varying content of the carborane moiety (2-15 wt%) were obtained. Data of rheological studies indicate that phase separation occurs in such hybrid carboranosiloxane systems.
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