It has not been fully elucidated whether antihypertensive medication adherence affects blood pressure (BP) control in hypertension cases.
To investigate the association of adherence to ...antihypertensive drug regimens and BP control using data from the Combination Pill of Losartan Potassium and Hydrochlorothiazide for Improvement of Medication Compliance Trial (COMFORT) study.
An observational analysis from a randomized controlled trial.
A total of 203 hypertensive subjects were randomly assigned to a daily regimen of a combination pill (losartan 50 mg/hydrochlorothiazide 12.5 mg) or two pills, an angiotensin II receptor blocker and a thiazide diuretic. Medication adherence calculated based on pill counts and BPs was evaluated at 1, 3 and 6 months after randomization.
The subjects were divided into three groups according to their adherence, i.e. relatively low-adherence (<90%; n = 19), moderate-adherence (90-99%; n = 71) and high-adherence (100%; n = 113) groups. Clinical characteristics of the subjects including BP, sex, randomized treatments and past medical history did not differ significantly among the three groups. Achieved follow-up BPs over the 6-month treatment period, which were adjusted for age, sex, baseline BP and randomized treatment, were significantly higher in the low-adherence group (135/78 mmHg) compared with the high-adherence (130/74 mmHg; P = 0.02/0.02) and the moderate-adherence (128/74 mmHg; P = 0.003/0.02) groups.
Low adherence to an antihypertensive-drug regimen was associated with poor BP control.
An enzyme activity introducing an alkali-labile site at 2-hydroxyadenine (2-OH-A) in double-stranded oligonucleotides was detected in nuclear extracts of Jurkat cells. This activity co-eluted with ...activities toward adenine paired with guanine and 8-oxo-7,8-dihydroguanine (8-oxoG) as a single peak corresponding to a 55 kDa molecular mass on gel filtration chromatography. Further co-purification was then done. Western blotting revealed that these activities also co-purified with a 52 kDa polypeptide which reacted with antibodies against human MYH (anti-hMYH). Recombinant hMYH has essentially similar activities to the partially purified enzyme. Thus, hMYH is likely to possess both adenine and 2-OH-A DNA glycosylase activities. In nuclear extracts from Jurkat cells, a 52 kDa polypeptide was detected with a small amount of 53 kDa polypeptide, while in mitochondrial extracts a 57 kDa polypeptide was detected using anti-hMYH. With amplification of the 5'-regions of the hMYH cDNA, 10 forms of hMYH transcripts were identified and subgrouped into three types, each with a unique 5' sequence. These hMYH transcripts are likely to encode multiple authentic hMYH polypeptides including the 52, 53 and 57 kDa polypeptides detected in Jurkat cells.
The spin-lattice relaxation times
T
1
of an unstable nucleus
19
O (
T
1/2
= 26.9 s,
I
= 5/2) implanted into Y
2
O
3
stabilized ZrO
2
(YSZ), which is a solid oxide fuel cell material, were measured at
...T
= 278 − 333 K by means of the
β
-NMR technique, using a highly spin polarized
19
O beam produced via the heavy ion reaction. The motional correlation times
τ
c
for oxygen motion derived from the
T
1
data are on the same straight line on the Arrhenius plot as those derived from the previous
17
O-NMR data at above the room temperature. This indicates that
19
O ions implanted into YSZ from outside seem to exhibit the same behavior as oxygen ions in the host YSZ material.
We have developed a new and compact β-nuclear magnetic resonance (NMR) system using beta-radioactive nuclei. By using a Halbach array permanent magnet to create a static magnetic field, and a ...scintillating fiber as a detector, we succeeded in significantly reducing the size and weight of the entire system. The performance of the new spectrometer was tested and evaluated by observing an NMR spectrum of
19
O (
T
1/2
= 26.9 s,
I
= 5/2) in TiO
2
.
It is well known that the enhancement of halo neutron removal cross sections in neutron halo nuclei. This is one of the evidence for the neutron halo structure. Because the valence neutron of the ...isomeric state in
16
N is considered to be mainly occupying in the
s
-orbital, we studied the nuclear structure of
16
N as a candidate for neutron halo nucleus. In this study, we measured one-neutron removal cross sections
σ
-
1
n
using secondary beams of
16
N with a mixture of ground and isomeric states. We used two types of primary beams,
15
N and
18
O, to produce
16
N beams with different isomeric ratios (8.7, 24.2a
16
N beam with a large isomeric ratio is large compared to that obtained with another beam with a small isomeric state. This result suggests that the
16
N isomeric state is considered to have a neutron-halo-like structure.
We review major experiments and results obtained by the on-line low temperature nuclear orientation method at the NICOLE facility at ISOLDE, CERN since the year 2000 and highlight their general ...physical impact. This versatile facility, providing a large degree of controlled nuclear polarization, was used for a long-standing study of magnetic moments at shell closures in the region Z = 28, N = 28-50 but also for dedicated studies in the deformed region around A ∼ 180. Another physics program was conducted to test symmetry in the weak sector and constrain weak coupling beyond V-A. Those two programs were supported by careful measurements of the involved solid state physics parameters to attain the full sensitivity of the technique and provide interesting interdisciplinary results. Future plans for this facility include the challenging idea of measuring the beta-gamma-neutron angular distributions from polarized beta delayed neutron emitters, further test of fundamental symmetries and obtaining nuclear structure data used in medical applications. The facility will also continue to contribute to both the nuclear structure and fundamental symmetry test programs.
238U projectile fragments have been created at the entrance of the fragment separator FRS, spatially separated in flight within 0.45 μs and injected into the storage-cooler ring ESR at 7.9 Tm ...corresponding to about 70% light velocity. Accurate new mass values and lifetime information of the stored exotic nuclei in the element range from platinum to uranium have been obtained with single-particle Schottky spectrometry. In this experiment the new isotopes of 236Ac, 224At, 221Po, 222Po, and 213Tl were discovered. The isotopes were unambiguously identified and their masses measured. In addition, the time-correlated data have provided information on the lifetime of the new nuclides. The discovery of isotopes along with accurate mass measurement has been achieved for the first time at the FRS-ESR facility. The results will contribute to the knowledge of the decay products from the r-process nuclei and enable a crucial test of the predictive power of modern nuclear mass and half-life models.
A 410 MeV/u 238U projectile beam was used to create cadmium isotopes via abrasion-fission in a beryllium target placed at the entrance of the in-flight separator FRS at GSI. The fission fragments ...were separated by the FRS and injected into the isochronous storage ring ESR for mass measurements. Isochronous Mass Spectrometry (IMS) was performed under two different experimental conditions, with and without Bρ-tagging at the high-resolution central focal plane of the FRS. In the experiment with Bρ-tagging the magnetic rigidity of the injected fragments was determined with an accuracy of 2⋅10−4. A new method of data analysis, which uses a correlation matrix for the combined data set from both experiments, has provided experimental mass values of 25 rare isotopes for the first time. The high sensitivity and selectivity of the method have given access to nuclides detected with a rate of a few atoms per week. In this letter we present for the 129,130,131Cd isotopes mass values directly measured for the first time. The experimental mass values of cadmium as well as for tellurium and tin isotopes show a pronounced shell effect towards and at N=82. Shell quenching cannot be deduced from a single new mass value, nor by a better agreement with a theoretical model which explicitly takes into account a quenching feature. This is in agreement with the conclusion from γ-ray spectroscopy and confirms modern shell-model calculations.
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