This phase 3 trial of patisiran, a small interfering RNA that targets hepatic production of the transthyretin protein, showed efficacy in treating transthyretin-mediated (ATTR) cardiac amyloidosis.
Purpose
We sought to identify breast magnetic resonance imaging (MRI) criteria capable of influencing the differential diagnosis between radial scars related to benign proliferative disease and those ...associated with breast cancer with a view to proposing breast MRI as a promising and cost-effective modality to be carried out between mammography and surgical biopsy.
Materials and methods
From 1998 to June 2006, we studied 20 patients with a focal architectural distortion on mammography. All patients underwent contrast-enhanced breast MRI with a T1 Philips Gyroscan scanner and the acquisition of T1-weighted fast field echo, echo planar imaging (FFE EPI) axial dynamic sequences with a slice thickness of 3 mm. During postprocessing, subtracted images were assessed for morphological features, pattern of contrast enhancement, time-intensity curve and lesion enhancement rate.
Results
Breast MRI depicted 27 lesions between 7 mm and 30 mm in size. Fifteen of the 27 breast lesions showed benign features, eight showed malignant features and four were classified as suspicious. Pathological examination confirmed the benignity of all 15 lesions showing benign MRI features and revealed the benign nature of the four lesions classified as suspicious.
Conclusions
Evaluation of breast MRI showed that enhancement rate and time-intensity curve were useful only in the differential diagnosis between benign and malignant breast lesions. Our experience confirmed that breast MRI has very high sensitivity and, in particular, a negative predictive value of 100%. Breast MRI could thus be considered a useful diagnostic tool that can guide the choice between follow-up or surgical excision of radial scars.
...the infectious-like onset of PMR suggests a precipitating environmental factor as one of the causes, and a close temporal relationship between epidemics of Mycoplasma pneumoniae, Chlamydia ...pneumoniae, and parvovirus B19 and peaks of cases of PMR/GCA has been reported. 1, 2 However, reports of material with an infectious origin in temporal arteries have not been corroborated, 8, 9 and Peris found no relationship between the onset of PMR and parvovirus B19 infection. 6 Secondly, some authors have reported seasonal variation of the immune system and inflammatory responsiveness. 10 These seasonal changes, when associated with several unknown infectious agents, may increase the susceptibility to develop some diseases, including PMR.
Nocturnal Melatonin Patterns in Children Salti, R; Galluzzi, F; Bindi, G ...
The journal of clinical endocrinology and metabolism,
06/2000, Volume:
85, Issue:
6
Journal Article
Peer reviewed
Open access
Time patterns in nocturnal concentrations of circulating melatonin of
children are quantified in 8 girls and 8 boys, 8.7–16.8 yr of age,
classified by Tanner pubertal stage. Between 1900 and 0700 h, ...each
provided blood samples at 30-min intervals for melatonin RIA.
Associations with gender, body mass index, and chronological and
pubertal age determined by multiple linear regression and ANOVA reveal
that the area under the curve of 12-h melatonin concentrations was
affected by pubertal rather than chronological age, an effect to which
data collected during darkness contributed the most. Each data series
was also analyzed by a least squares spectrum at frequencies of 1–20
cycles/day. Ultradian changes with periods of 3.4 and 1.5 h,
putatively associated with rapid eye movement sleep cycles,
characterize nocturnal melatonin in boys and girls.
The Data Processor system of EUSO-SPB1 Scotti, V.; Bayer, J.; Cafagna, F. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2019, Volume:
916
Journal Article
Peer reviewed
In this paper we present the Data Processor (DP) and the flight software of the EUSO-SPB1 mission. The EUSO-SPB1 experiment is a pathfinder mission of the EUSO program whose main objective is to ...detect Ultra-High Energy Cosmic Rays (UHECR) by measuring, for the first time from space, the fluorescence and the Cerenkov Ultra-Violet light produced by Extensive Air Shower. The instrument is a small telescope mounted on an unpressurized gondola of a super pressure balloon. Since a super pressure balloon could remain airborne up to 100 days, the requirements on the electronics and data handling are quite severe. The DP is the component of the electronics system performing the data handling, the monitoring, and the control of the instrument from ground through the interface with the telemetry system. EUSO-SPB1 was launched from Wanaka Airport (New Zealand) on the 24th of April 2017, at 22:51 UTC and the flight lasted for 12 days.
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