Estomatitis Asociada a Metotrexato: Un Reto Diagnóstico Sánchez-Romero, María Luisa; Cepeda-Bravo, Juan Antonio; Tejeda-Nava, Francisco Javier ...
International journal of odontostomatology,
12/2020, Volume:
14, Issue:
4
Journal Article
Open access
RESUMEN: Las úlceras orales (UO) son uno de los signos de toxicidad por metotrexato (Mtx) aún en pacientes con esquemas de dosis bajas para el control de artritis reumatoide (AR). En estos casos ...establecer un diagnóstico correlacionando UO con el medicamento puede ser un reto. Presentamos 2 casos clínicos de pacientes con AR en tratamiento con Mtx, las cuales desarrollaron UO. En los dos casos, interesantemente los pacientes fueron evaluados tanto por especialistas del área médica y oral sin tener un resultado satisfactorio después de múltiples tratamientos. Las UO resolvieron posterior a la suspensión del medicamento. Se estableció el diagnóstico de Estomatitis por Metotrexato (EMtx) por un especialista en medicina oral. El manejo multidisciplinario en estos casos es clave para el establecimiento de un diagnóstico y tratamiento oportuno.
Estomatitis Asociada a Metotrexato: Un Reto Diagnóstico Sánchez-Romero, María Luisa; Cepeda-Bravo, Juan Antonio; Tejeda-Nava, Francisco Javier ...
International journal of odontostomatology,
12/2020, Volume:
14, Issue:
4
Journal Article
Objetivo: Describir el conocimiento existente sobre las alteraciones del MBO y la presencia LO en pacientes con LLA. Materiales y Métodos: Se realizó una búsqueda electrónica en las bases de datos ...PubMed, Scielo y Google académico y se incluyeron artículos descriptivos, analíticos, observacionales sobre MBO, LO y LLA. Se evaluaron 642, se eliminaron artículos duplicados, reporte de caso y aquellos donde solo reportaran los cambios durante o después del tratamiento quimioterapéutico. Resultados: Se evaluaron 10 artículos, publicados entre 1997 y 2021, 4 artículos coincidieron que el MBO de pacientes con LLA se encuentra en disbiosis mostrando un aumento significativo de firmicutes, bacillus, y bacterias oportunistas como Moraxella spp, Klebsiella spp , Pseudomona spp ,Enterobacter spp , Acinetobacter spp y E . coli, las LO más frecuentes reportadas en 5 artículos fueron sangrado gingival espontáneo, gingivitis y úlceras. Conclusiones: La cavidad oral de los pacientes con LLA se encuentra en disbiosis y se identifican LO asociadas. Es necesario establecer estrategias preventivas con un enfoque nicho-ecológico para restablecer el MBO, con la finalidad de disminuir el riesgo de infecciones oportunistas y otras LO durante el tratamiento de quimioterapia.
Introduction of a novel influenza virus into the human population leads to the occurrence of pandemic events, such as the one caused by pandemic influenza A (H1N1) 2009 virus. The severity of ...infections caused by this virus in young adults was greater than that observed in patients with seasonal influenza. Fatal cases have been associated with an abnormal innate, proinflammatory immune response. A critical role for natural killer cells during the initial responses to influenza infections has been suggested. In this study, we assessed the association of killer-cell immunoglobulin-like receptors (KIRs) with disease severity by comparing KIR gene content in patients with mild and severe pandemic influenza virus infections to a control group. We found that activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes, encoded in group B haplotypes containing the cB01, cB03 and tB01 motifs, are associated with severe pandemic influenza A (H1N1) 2009 infections. Better understanding of how genetic variability contributes to influenza virus pathogenesis may help to the development of immune intervention strategies aiming at controlling the severity of disease.
Purpose: The objective was to evaluate the antagonistic effect of Lactobacillus and Bifidobacterium recovered from five commercial probiotics on the growth of C. albicans. Study design: The ...Lactobacillus and Bifidobacterium strains of five commercial probiotics were recovered and grown: Probio Hp+®, ProBiseis®, Lactipan®, Liolactil®, and Lacteol Fort®; 50 mg of each was hydrated and grown in Lactobacilli MRS (De Man, Rogosa and Sharpe) broth and incubated at 37°C with stirring (120 RPM) for 24 hours. Serial dilutions of 10−1 to 10−7 were made and viability was verified and quantified. For the antagonism tests, a suspension/inoculum of Lactobacillus strains recovered from each commercial preparation (4–30 × 109) and C. albicans ATCC 90028 (1.5–8 × 108) was prepared in MRS broth and incubated for 48 hours at 36°C, then plated on Dextrose Sabouraud Agar with Chloramphenicol and Rogosa Agar and the colony-forming units (CFU) were quantified. Additionally, viability was evaluated using the LIVE/DEAD® Yeast and Bacterial Viability kit. Results: The probiotic that produced the highest acidity of the medium was Lactipan®, followed by Probiseis® and Liolactil®, while Probio Hp+® showed the least change. Probiseis® was determined to have the highest growth of probiotic bacteria and the highest inhibition on C. albicans, followed by Lactipan®; Liolactil® and ProbioHp+® showed the least effect. In fluorescence tests, ProBiseis® showed the best effect, followed by Liolactil® and Lactipan®; Probio Hp+® had less of an effect. Conclusions: Two commercial products (ProBiseis and Lactipan) whose formulations have L. acidophilus, L. casei, L. rhamnosus, L. plantarum, B. infantis, and S. thermophilus have a greater inhibitory effect on C. albicans ATCC 90028
Abstract Background The colonization of the surfaces of dental prostheses by Candida albicans is associated with the development of denture stomatitis. In this context, the use of fluconazole has ...been proposed, but its disadvantage is microbial resistance. Meanwhile, the oil of Allium sativum has shown an effect in controlling biofilm formation by C. albicans. Aims The objective of this study was to determine the antifungal activities of the essential oil of A. sativum and fluconazole against clinical isolates of Candida species obtained from rigid, acrylic-based partial or total dentures and to compare these agents’ effects on both biofilm and planktonic cells. Methods A total of 48 clinical isolates obtained from the acrylic surface of partial or complete dentures were examined, and the following species were identified: C. albicans , Candida glabrata , Candida tropicalis , and Candida krusei . For each isolate, the antifungal activities of the essential oil of A. sativum and fluconazole against both biofilm and planktonic cells were evaluated using the Clinical & Laboratory Standards Institute (CLSI) M27-A3 method. The isolates were also evaluated by semiquantitative XTT reduction. Results All planktonic Candida isolates were susceptible to the essential oil of A. sativum , whereas 4.2% were resistant to fluconazole. Regarding susceptibilities in biofilms, 43.8% of biofilms were resistant to A. sativum oil, and 91.7% were resistant to fluconazole. Conclusions All planktonic cells of the different Candida species tested are susceptible to <1 mg/ml A. sativum oil, and the majority are susceptible to fluconazole. Susceptibility decreases in biofilm cells, with increased resistance to fluconazole compared with A. sativum oil. The essential oil of A. sativum is thus active against clinical isolates of Candida species obtained from dentures, with effects on both biofilm and planktonic cells in vitro.
Las infecciones odontogénicas (IO) son la principal causa de atención en la consulta dental, representan un número importante de ingresos hospitalarios en urgencias y unidades de cuidados intensivos, ...por lo que es pertinente la revisión de la literatura para sustentar la mayor evidencia científica, analizar y proponer acciones o principios para definir, diagnosticar y resolver efectivamente las infecciones odontogénicas, otorgando atención precisa que devuelva las funciones al sistema estomatólogico y que evite el uso inapropiado o indiscriminado de antibióticos. Está revisión se realizó entre el año 2006 y el 2018, incluye artículos de revisión, documentos de consenso y distintas guías clínicas, con base en ello, se proponen condiciones que identifican oportunamente la presencia de infecciones odontogénicas, factores asociados (clínicos y/o sistémicos) que pueden influir en el juicio del profesional para su manejo y las pautas de control y tratamiento de las infecciones odontogénicas.
Highlights • Oral candidiasis increased with age of 13.2% to 33.3% between 60 and >80 years. • Frequency of colonizing the oral cavity increased with age. • The frequency of oral colonization by ...multi-species of Candida increases with age. • The oral Candida albicans isolates shows increased resistance to fluconazole with increasing age range in older mexican women.
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