Introduction: Aspirin is a non-selective COX inhibitor and is widely used for its anti-platelet effect but also has anti-inflammatory effect for which its use is extended in both acute and chronic ...inflammatory conditions. Acute pancreatitis is a potentially lethal acute abdominal condition that carries significant risk of mortality especially increased with severe acute pancreatitis (SAP) and is one of the most common causes of hospitalization secondary to gastrointestinal etiology. Adjusted odds ratio (OR) and confidence intervals (CI) at 99% were reported.
Odds ratios (OR) and confidence intervals (CI) at 99% were reported. The odds of cirrhosis were significantly higher among Native Americans 13.3%, Hispanics 7.4%, and Whites 5.2% (OR 2.43 CI ...2.10-2.82; OR 2.20 CI 1.65-2.95; OR 2.40 CI 1.14-5.06, respectively). The prevalence of IgA nephropathy in cirrhotic patients increased with age till age 65 and is more common in Native Americans, Hispanics, and Whites.Table 1 Variable IgA nephropathy % no IgA nephropathy P-value Cirrhosis 0.1 99.9 0.01 Age, years ± SE 56.3 ± 0.7 60.0 ± 0.2 0.01 Age group, years 0.03 18-35 1.4 0.3 36-50 6.1 2.6 51-65 9.8 4.4 >65 3.0 1.7 Sex 0.02 Female 5.7 3.2 Male 3.7 1.5 Race White 5.2 2.2 0.01 Black 1.9 1.6 0.49 Hispanics 7.4 3.5 0.01 Asian 2.6 1.6 0.16 Native American 13.3 6.0 0.03 Medical Coverage 0.01 Medicare 4.6 2.2 Medicaid 6.9 3.1 Private Insurance 4.8 1.6 Self-pay 7.7 3.0 Median Household Income 0.01 0-25th percentile 6.5 2.6 26th to 50th percentile (median) 4.5 2.3 51th to 75th percentile 4.1 2.1 76th to 100th percentile 4.6 1.8 Tobacco use 6.8 3.6 0.01 Obesity 5.3 2.1 0.01 LOS, days, mean ± SE 8.5 ± 0.6 6.1 ± 0.1 0.02 Hospital charges, $, mean ± SE 87,449.6 ± 6,982.7 66,606.6 ± 210.2 0.01 Liver Transplant 1.7 0.8 0.08 Mortality 4.5 5.9 0.38 Abbreviations: *LOS; length of stay.
Obese patients with complicated small bowel diverticulitis were more likely to die during the hospital stay (2.4, 1.8-3.2), and incurred more charges compared to non-obese patients with complicated ...small bowel diverticulitis ($24,042, 17,366-30,718). A similar trend was observed in obese patients with simple large bowel diverticulitis (Table 1). Conclusion: We found that hospitalized obese patients with complicated small bowel diverticulitis were more likely to die during that hospitalization, and to incurred higher hospital charges compared to non-obese patients with diverticulitis. Hospital Outcomes in Obese Patients with Diverticular Disease Variable In hospital mortality, % (OR, CI) Length of stay, days (mean difference, CI) Total charges, $ (mean difference, CI) Diverticular disease with vs without obesity 1.6 vs 1.4 (1.2, 1.1-1.2) 5.3 vs 4.8 (0.5, 0.1-0.6) 57,560 vs 54,831 (2,729, 153 – 2,334) Small bowel simple diverticulitis with vs without obesity 1.6 vs 1.3 (1.2, 0.7-1.9) 5.2 vs 4.8 (-0.4, -0.9 to 0.1) 57,577 vs 51,727 (5849, -2,046 to 13,745) Small bowel complicated diverticulitis with vs without obesity 3.2 vs 1.3 (2.4, 1.8-3.2) 7.9 vs 4.8 (3.2, 0.2-2.6) 81,616 vs 57,573 (24,042, 17366-30718) Large bowel simple diverticulitis with vs without obesity 1.4 vs 0.7 (1.8, 1.7-2.0) 4.8 vs 4.4 (0.4, 0.4-0.5) 57,650 vs 43,380 (14270, 13636 – 14904) Large bowel complicated diverticulitis with vs without obesity 1.6 vs 1.4 (1.2, 0.7-1.9) 5.2 vs 4.8 (0.3, -0.1 to 0.8) 57,824 vs 51,728 (3060, -13991 to 1800) Author Notes *Presenter
The goal of this study was to verify an association between both diseases, explore the burden of HS on IBD including in-hospital mortality, length of stay (LOS), total costs and complications, and ...establish baseline comorbidities of IBD patients with HS. Despite no difference in in-hospital mortality between IBD and IBD-HS groups, IBD-HS patients were more likely to be septic (OR 1.75 CI 1.35 – 2.28) and had a longer hospital LOS (6.28 vs 5.31 days, P=0.02), compared to IBD only patients (Table 1). Factors associated with IBD-HS Parameter IBD-HS vs IBD (odds ratio) Confidence interval, 95%, P< 0.05 Female vs male 1.38 1.13 – 1.69 Age, years, mean 39.56 vs 53.24 11.84 – 15.51 Inpatient dead 0.32 0.08 – 1.27 Hospital LOS, mean days 6.28 vs 5.31 -1.76 to -0.34 Hospital total charges, $ 54291.04 vs 52834.63 -10261.90 to +7349.07 Black vs other races 7.88 6.50 – 9.57 Median household income (%) P< 0.01 < 25th percentile 40.0 25th to 50th percentile 25.2 51st to 75th percentile 16.9 >75th percentile 17.4 Diabetes 2.53 1.04 – 6.12 Coronary artery disease 0.50 0.27 – 0.94 Obesity 1.94 1.44 – 2.62 Chronic kidney disease 0.53 0.36 – 0.77 Chronic obstructive pulmonary disease 0.54 0.34 – 0.85 Chronic heart failure 0.63 0.34 – 1.14 Chronic liver disease 0.16 0.02 – 1.17 Clostridiodes difficile infection 1.04 0.65 – 1.66 Sepsis 1.75 1.35 – 2.28 Osteoporosis 0.39 0.19 – 0.82 Blood transfusion 0.70 0.42 – 1.15 Colorectal cancer 0.26 0.04 – 1.85 Ulcerative colitis 0.30 0.23 – 0.40 Crohn’s disease 3.28 2.50 – 4.30 Author Notes *Presenter
In this study we aim to study the factors affecting the outcomes (morality, LOS, total hospital charges) associated with acute pancreatitis. Adjusted odds ratio (OR) and confidence intervals (CI) at ...99% were reported. F 51.9 vs 48.1 Length of stay, days, mean±SE 5.43±0.02 Total charges, $, mean±SE 56092±287 Aspirin use 8.6 Race White 61.8 Black 15.5 Hispanic 12.9 Asian or Pacific Islander 2.3 Native American 0.9 Insurance Medicare 34.2 Medicaid 23.6 Private insurance 30.2 Self-pay 8.1 Etiologies of acute pancreatitis Idiopathic 2.9 Biliary 19.7 Alcohol 20.2 Drug induced 1.5 b. Variable Mortality, % Length of stay, days Total hospital charges, $ Acute pancreatitis Age, reference 18-35 years 36-50 1.53, 1.22 – 1.93 -0.11, -0.20 to 0.18 1352, -1734 to 4439 51-65 3.15, 2.55 – 3.90 0.41, 0.12 – 0.69 10052, 5434 - 14671 >65 5.31, 4.20 – 6.71 0.57, 0.13 – 0.99 17252, 10211 - 24292 Aspirin use vs No aspirin use 0.49, 0.41 – 0.58 -1.05, -1.21 to -0.88 -14412, -17120 to -11704 Male vs Female 1.30, 1.29 – 1.32 -0.38, -0.48 to -0.29 -7016, -8508 to -5523 Race White vs Black 1.08, 1.07 - 1.10 0.12, -0.01 to 0.25 -705, -2817 to 1406 White vs Hispanic 0.94, 0.92 – 0.96 -0.17, -0.31 to -0.03 13084, 10793 - 15376 White vs Asian & pacific Islander 1.21, 1.17 – 1.25 0.58, 0.28 – 0.89 29799, 24770 - 34829 White vs Native American 1.26, 1.17 – 1.35 -0.05, -0.53 to 0.44 -3807, -11620 to 4005 Insurance, Medicare is reference group Medicaid 1.18, 1.15 – 1.21 0.15, 0.01 – 0.29 1255, -1126 to 3636 Private insurance 1.01, 0.99 – 1.03 -0.43, -0.56 to -0.29 -2409, -4584 to -235 Self-pay 1.47, 1.42 – 1.52 -0.54, -0.74 to -0.35 -8186, -11359 to -5013 Comorbidities (reference is ≤ 2 comorbidities) 3 to 4 comorbidities 1.60, 1.80 – 2.39 0.45, 0.35 – 1.10 1354, -1237 to 2564 5 to 6 comorbidities 1.98, 1.85 – 2.46 1.35, 1.12 – 2.35 4567, 4256 - 4898 ≥7 comorbidities 2.20, 1.82 – 2.62 1.67, 1.45 – 3.12 7345, 6852 - 8547 Author Notes *Presenter
The impact of these hospitalizations poses a great burden on the US health care system, with a direct cost estimated at $5 billion in 2018. ...information on age, sex, race/ethnicity, insurance type ...and geographic region, hospital type were also obtained. Cocaine use and Non-variceal Upper GI Bleed Parameter NVUGIB, counts (%) P-value Cocaine Yes 9342 (2.0) No 1073174 (2.9) 0.01 Cocaine use, demographics Age (years) 18 -35 1420 (1.2) 0.02 36 -50 3535 (1.9) 0.08 51 - 65 4029 (2.9) 0.21 > 65 358 (3.6) 0.12 Sex Male 6558 (2.3) 0.01 Female 2782 (1.7) 0.05 Race Black 4076 (2.0) 0.12 Hispanics 1174 (2.8) 0.01 Asian/Pacific Islander 37 (1.8) 0.33 Native American 82 (3.4) 0.02 White 3062 (1.9) 0.01 Other races 298 (1.9) 0.23 Insurance Insured 7377 (2.0) 0.01 Medicare 1989 (2.2) 0.01 Medicaid 3607 (1.9) 0.06 Private Insurance 984 (1.7) 0.31 Other insurance 243 (2.7) 0.14 Uninsured 1963 (2.5) 0.02 Outcomes in cocaine users In-hospital mortality (%) 9.6 vs 7.7 0.01 Mortality per race Black 8.7 vs 8.7 0.06 Hispanic 10.9 vs 9.3 0.05 Asian/Pacific Islander 16.7 vs 9.3 0.23 Native American 20.0 vs 9.3 0.01 White 10.1 vs 7.3 0.09 Other races 10.7 vs 8.5 0.10 Mortality per insurance status Medicare 9.5 vs 7.4 0.01 Medicaid 9.5 vs 10.3 0.14 Private Insurance 8.8 vs 7.4 0.15 Other insurance 7.9 vs 9.5 0.06 Uninsured 10.8 vs 9.8 0.21 Hospital LOS, days 6.0 vs 5.5 0.02 Total charges, $ 51198 vs 29914 0.01 *Abbreviations: LOS: length of stay.
Introduction: Acute pancreatitis is one of the major gastrointestinal causes of hospitalization, significant user of health care costs and is widely agreed that severity of acute pancreatitis plays a ...major role in the outcomes of acute pancreatitis. In this study we aim to study the association between aspirin usage and severity, complications of acute pancreatitis in patients admitted to hospital in United States. Adjusted odds ratio (OR) and confidence intervals (CI) at 99% were reported.
