An XMM–Newton study of active–inactive galaxy pairs Guainazzi, Matteo; De Rosa, Alessandra; Bianchi, Stefano ...
Monthly Notices of the Royal Astronomical Society,
06/2021, Volume:
504, Issue:
1
Journal Article
Peer reviewed
Open access
ABSTRACT
While theory and simulations indicate that galaxy mergers play an important role in the cosmological evolution of accreting black holes and their host galaxies, samples of active galactic ...nuclei (AGNs) in galaxies at close separations are still small. In order to increase the sample of AGN pairs, we undertook an archival project to investigate the X-ray properties of an SDSS-selected sample of 32 galaxy pairs with separations ≤150 kpc containing one optically identified AGN, which were serendipitously observed by XMM–Newton. We discovered only one X-ray counterpart among the optically classified non-active galaxies, with a weak X-ray luminosity (≃ 5 × 1041 erg s−1). 59 per cent (19 out of 32) of the AGNs in our galaxy pair sample exhibit an X-ray counterpart, covering a wide range in absorption-corrected X-ray luminosity (5 × 1041–2 × 1044 erg s−1). More than 79 per cent of these AGNs are obscured (column density NH > 1022 cm−2), with more than half thereof (i.e. about 47 per cent of the total AGN sample) being Compton-thick. AGN/no-AGN pairs are therefore more frequently X-ray obscured (by a factor ≃1.5) than isolated AGNs. When compared to a luminosity and redshift-matched sample of bona fide dual AGN, AGN/no-AGN pairs exhibit one order-of-magnitude lower X-ray column density in the same separation range (>10 kpc). A small sample (4 objects) of AGN/no-AGN pairs with sub-pc separation is all heavily obscured, driving a formal anticorrelation between the X-ray column density and the galaxy pair separation in these systems. These findings suggest that the galactic environment has a key influence on the triggering of nuclear activity in merging galaxies.
Abstract
The first X-ray pulsar, Cen X-3, was discovered 50 yr ago. Radiation from such objects is expected to be highly polarized due to birefringence of plasma and vacuum associated with ...propagation of photons in the presence of the strong magnetic field. Here we present results of the observations of Cen X-3 performed with the Imaging X-ray Polarimetry Explorer. The source exhibited significant flux variability and was observed in two states different by a factor of ∼20 in flux. In the low-luminosity state, no significant polarization was found in either pulse phase-averaged (with a 3
σ
upper limit of 12%) or phase-resolved (the 3
σ
upper limits are 20%–30%) data. In the bright state, the polarization degree of 5.8% ± 0.3% and polarization angle of 49.°6 ± 1.°5 with a significance of about 20
σ
were measured from the spectropolarimetric analysis of the phase-averaged data. The phase-resolved analysis showed a significant anticorrelation between the flux and the polarization degree, as well as strong variations of the polarization angle. The fit with the rotating vector model indicates a position angle of the pulsar spin axis of about 49° and a magnetic obliquity of 17°. The detected relatively low polarization can be explained if the upper layers of the neutron star surface are overheated by the accreted matter and the conversion of the polarization modes occurs within the transition region between the upper hot layer and a cooler underlying atmosphere. A fraction of polarization signal can also be produced by reflection of radiation from the neutron star surface and the accretion curtain.
The quest for binary and dual supermassive black holes (SMBHs) at the dawn of the multi-messenger era is compelling. Detecting dual active galactic nuclei (AGN) – active SMBHs at projected ...separations larger than several parsecs – and binary AGN – probing the scale where SMBHs are bound in a Keplerian binary – is an observational challenge. The study of AGN pairs (either dual or binary) also represents an overarching theoretical problem in cosmology and astrophysics. The AGN triggering calls for detailed knowledge of the hydrodynamical conditions of gas in the imminent surroundings of the SMBHs and, at the same time, their duality calls for detailed knowledge on how galaxies assemble through major and minor mergers and grow fed by matter along the filaments of the cosmic web. This review describes the techniques used across the electromagnetic spectrum to detect dual and binary AGN candidates and proposes new avenues for their search. The current observational status is compared with the state-of-the-art numerical simulations and models for formation of dual and binary AGN. Binary SMBHs are among the loudest sources of gravitational waves (GWs) in the Universe. The search for a background of GWs at nHz frequencies from inspiralling SMBHs at low redshifts, and the direct detection of signals from their coalescence by the Laser Interferometer Space Antenna in the next decade, make this a theme of major interest for multi-messenger astrophysics. This review discusses the future facilities and observational strategies that are likely to significantly advance this fascinating field.
In this study, two potentially new species of turtle blood flukes (TBFs) (Digenea: Spirorchiidae) have been recorded from South Brazil. The spirorchiid parasites infect the vascular system of ...turtles, thereby compromising their health. The life cycle of these parasites is not well studied. The larval stage of cercaria is found in intermediate gastropod hosts, with some species presenting similar morphological characteristics, which can result in misinterpretations when using only morphological taxonomy for species identification. In this study, we recorded a single morphotype belonging to the family Spirorchiidae in
Biomphalaria occidentalis
in an urban aquatic ecosystem in Brazil. However, molecular data (28S rDNA and cytochrome oxidase subunit I) confirmed the presence of two species of Spirorchiidae in the sampled environment; both phylogenetically close to genera previously studied in freshwater turtles from the Peruvian Amazon. In this study, species characterization was possible because of molecular tools. We recommend using more than one molecular marker in future studies focusing on TBFs, which need attention about their evolutionary history and ecology to understand their distribution in South America.
Epigenetic events that are essential drivers of lymphocyte transformation remain incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell transformation to document the ...relevance of protein arginine methyltransferase 5 (PRMT5) to regulation of epigenetic-repressive marks during lymphomagenesis. EBV+ lymphomas and transformed cell lines exhibited abundant expression of PRMT5, a type II PRMT enzyme that promotes transcriptional silencing of target genes by methylating arginine residues on histone tails. PRMT5 expression was limited to EBV-transformed cells, not resting or activated B lymphocytes, validating it as an ideal therapeutic target. We developed a first-in-class, small-molecule PRMT5 inhibitor that blocked EBV-driven B-lymphocyte transformation and survival while leaving normal B cells unaffected. Inhibition of PRMT5 led to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation. RNA-sequencing and chromatin immunoprecipitation experiments identified several tumor suppressor genes, including the protein tyrosine phosphatase gene PTPROt, which became silenced during EBV-driven B-cell transformation. Enhanced PTPROt expression following PRMT5 inhibition led to dephosphorylation of kinases that regulate B-cell receptor signaling. We conclude that PRMT5 is critical to EBV-driven B-cell transformation and maintenance of the malignant phenotype, and that PRMT5 inhibition shows promise as a novel therapeutic approach for B-cell lymphomas.
•EBV infection leads to PRMT5 overexpression and global epigenetic changes that are essential to drive B-lymphocyte transformation.•Highly selective PRMT5 inhibitors represent a novel, first-in-class drug that restores critical regulatory checkpoints in lymphoma cells.
Chronic Obstructive Pulmonary Disease (COPD) is a syndrome that comprises several distinct and overlapping phenotypes. In addition to persistent airflow limitation and respiratory symptoms, COPD is ...also characterized by chronic systemic inflammation. Epidemiological studies have shown that dietary fibers, fruits and vegetables intake protects against the COPD development, while fructose-loading is associated with increased risk of asthma and chronic bronchitis. Since dietary factors might affect susceptibility to COPD by modulating oxidative stress and inflammatory responses, we evaluated how fructose feeding might affect the smoking-induced emphysema in mice. We found that chronic fructose intake induced destruction and remodeling of lung parenchyma and impairment of respiratory mechanics, which are associated with distinctive cytokine profiles in bronchoalveolar lavage fluid, blood plasma and skeletal muscle. The combined effects of chronic fructose intake and cigarette smoking on destruction of lung parenchyma are more pronounced than the effects of either alone. Excessive intake of fructose might directly cause pulmonary emphysema in mice rather than just altering its natural history by facilitating the installation of a low-grade systemic inflammatory milieu.
Background and aim: Osteoarthritis (OA) is characterized by pain and inflammation. Electroacupuncture (EA) and swimming (SW) are non-pharmacological interventions recommended for treating OA. The ...study evaluated the benefits of electroacupuncture (EA) and swimming (SW) association when compared with isolated protocols in an OA rodent model. Experimental. Procedures: An ankle monoarthritis model was induced in rats by applying Complete Freund's Adjuvant (CFA). After seven days of induced OA, the groups were submitted to EA (ST36 and the GB 30 Acupoint), SW, or the EA + SW protocol. The nociceptive behavior was measured by the Von Frey test, the Cold Stimulation test, and the Paw Flick Immersion test. Inflammatory activity was evaluated by measuring TNF levels, myeloperoxidase, NAGase, immunological parameters and the histology from the subcutaneous tissue. Results: Compared to CFA group, EA decreased the nociceptive scores in the cold stimulation test (p ＜ 0.05), and it also increased the latency time in thermal cold (p ＜ 0.01) and heat hyperalgesia (p ＜ 0.001). Also, EA reduced NAGase (p ＜ 0.01). SW reduced the edema (p ＜ 0.05) and did not increase the inflammatory infiltrates or congestion, neither in the histological measurements nor by analyzing the levels of TNF. The association of EA + SW decreased the neutrophils and the monocytes, MPO (p ＜ 0.05), and the glutamate levels in the cerebrospinal fluid (CSF, p ＜ 0.001). Conclusion: There were statistical differences between combination therapy and monotherapy as seen by the inflammatory parameters, which could be associate to the delay of the chronification osteoarthritis retardation. However, EA + SW did not show benefits when compared to isolated protocols in nociceptive behavior.
In this study, functionalized biscuits were prepared through the enrichment of dough with lemon peel and natural antioxidants extracted from lemon pomace. Lemon pomace extract (LPE) was analyzed for ...total phenolic content before addition, and then a known concentration of 50 mg kg−1 was used for the formulation of enriched biscuits. Three different biscuit samples were compared to a control biscuit, without the addition of functional ingredients. The main physicochemical, microbiological, and sensory aspects of doughs and biscuits enriched with LPE were investigated. The enriched biscuits showed higher phenolic content and antioxidant activity than the control one and a longer induction period (IP), which means that the enriched products had a higher intrinsic resistance to lipid oxidation, thanks to the antioxidant effect exerted by the added fresh lemon peel and the LPE. Furthermore, from a sensorial point of view, they showed suitable acceptability, in terms of appearance, flavor, and aromatic attributes. Thus, results indicated that the incorporation of lemon processing by-products allowed the production of functional enriched biscuits with improved antioxidant properties.
Peripheral oxygen saturation (SpO 2 ) monitoring is critical during surgery and in intensive care units (ICS). Over the last decades, several studies have addressed the noncontact monitoring of vital ...signs, but few reports have focused on SpO 2 . This paper presents an SpO 2 monitoring method without physical contact with the patient using imaging photoplethysmography (iPPG). Eulerian video magnification (EVM) was employed in the proposed solution to amplify the changes in skin color due to the heart cycle. The developed software operates on a widely available, low-cost hardware platform. Experiments were performed with nine healthy individuals. When comparing the experimental SpO 2 results to those obtained with a reference pulse oximeter, the proposed solution showed good accuracy, with differences of less than 2%.
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