DBSCAN is the most famous density based clustering algorithm which is one of the main clustering paradigms. However, there are many redundant distance computations among the process of DBSCAN ...clustering, due to brute force Range-Query used to retrieve neighbors for each point in DBSCAN, which yields high complexity (O(n 2 )) and low efficiency. Thus, it is unsuitable and not applicable for large scale data. In this paper, an improved DBSCAN based on neighbor similarity is proposed, which utilizes and Cover Tree to retrieve neighbors for each point in parallel, and the triangle inequality to filter many unnecessary distance computations. From the experiments conducted on large scale data sets, it is demonstrated that the proposed algorithm greatly speedup the original DBSCAN, and outperform the main improvements of DBSCAN. Comparing with ρ-approximate DBSCAN, which is the current fastest but approximate version of DBSCAN, the proposed algorithm has two advantages: one is faster and the other is that the result is accurate.
The Earth as a planetary system has experienced significant change since its formation c. 4.54 Gyr ago. Some of these changes have been gradual, such as secular cooling of the mantle, and some have ...been abrupt, such as the rapid increase in free oxygen in the atmosphere at the Archean–Proterozoic transition. Many of these changes have directly affected tectonic processes on Earth and are manifest by temporal trends within the sedimentary, igneous, and metamorphic rock record. Indeed, the timing of global onset of mobile-lid (subduction-driven) plate tectonics on our planet remains one of the fundamental points of debate within the geosciences today, and constraining the age and cause of this transition has profound implications for understanding our own planet's long-term evolution, and that for other rocky bodies in our solar system. Interpretations based on various sources of evidence have led different authors to propose a very wide range of ages for the onset of subduction-driven tectonics, which span almost all of Earth history from the Hadean to the Neoproterozoic, with this uncertainty stemming from the varying reliability of different proxies. Here, we review evidence for paleo-subduction preserved within the geological record, with a focus on metamorphic rocks and the geodynamic information that can be derived from them. First, we describe the different types of tectonic/geodynamic regimes that may occur on Earth or any other silicate body, and then review different models for the thermal evolution of the Earth and the geodynamic conditions necessary for plate tectonics to stabilize on a rocky planet. The community's current understanding of the petrology and structure of Archean and Proterozoic oceanic and continental crust is then discussed in comparison with modern-day equivalents, including how and why they differ. We then summarize evidence for the operation of subduction through time, including petrological (metamorphic), tectonic, and geochemical/isotopic data, and the results of petrological and geodynamical modeling. The styles of metamorphism in the Archean are then examined and we discuss how the secular distribution of metamorphic rock types can inform the type of geodynamic regime that operated at any point in time. In conclusion, we argue that most independent observations from the geological record and results of lithospheric-scale geodynamic modeling support a global-scale initiation of plate tectonics no later than c. 3 Ga, just preceding the Archean–Proterozoic transition. Evidence for subduction in Early Archean terranes is likely accounted for by localized occurrences of plume-induced subduction initiation, although these did not develop into a stable, globally connected network of plate boundaries until later in Earth history. Finally, we provide a discussion of major unresolved questions related to this review's theme and provide suggested directions for future research.
Background and aims
Microvascular invasion (MVI) is a key pathological factor that severely affects the postoperative prognosis of patients with hepatocellular carcinoma (HCC). However, no MVI ...classification schemes based on standardized gross sampling protocols of HCC are available at present.
Methods
119 HCC specimens were sampled at multiple sites (3-, 7-, and 13 points) for the optimum MVI detection rate. 16,144 resected HCCs were graded as M0, M1 or M2 by adopting three-tiered MVI grading (MVI-TTG) scheme based on the seven-point sampling protocol (SPSP). Survival analyses were performed on 2573 patients to explore the advantages of MVI-TTG.
Results
The MVI detection rate determined by SPSP was significantly higher than that determined by the 3-point sampling method (34.5% vs. 47.1%,
p
= 0.048), but was similar to that determined by the 13-point sampling method (47.1% vs. 51.3%,
p
= 0.517). Among 16,144 resected HCCs, the proportions of M0, M1 and M2 specimens according to SPSP were 53.4%, 26.2% and 20.4%, respectively. Postoperative survival analysis in 2573 HCC patients showed that the 3-year recurrence rates in M0, M1 and M2 MVI groups were 62.5%, 71.6% and 86.1%, respectively (
p
< 0.001), and the corresponding 3-year overall survival (OS) rates were 94.1%, 87.5% and 67.0%, respectively (
p
< 0.001). M1 grade was associated with early recurrence, while M2 grade was associated with both early and late recurrence. MVI-TTG had a larger area under the curve and net benefit rate than the two-tiered MVI grading scheme for predicting time to recurrence and OS.
Conclusions
SPSP is a practical method to balance the efficacy of sampling numbers and MVI detection rates. MVI-TTG based on SPSP is a better prognostic predictor than the two-tiered MVI scheme. The combined use of SPSP and MVI-TTG is recommended for the routine pathological diagnosis of HCC.
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•Gabbro anorthosite suite of Konkanhundi emplaced at 2.6 Ga along the suture dividing Western and Eastern Dharwar blocks.•Surrounding TTG rocks were emplaced at 3.2 Ga, forming arc ...basement.•Zircon Lu-Hf isotopes suggest magma derivation for gabbro-anorthosite complex from heterogeneous source components.•Widespread Neoarchean magmatism in suprasubduction settings marks multiple converge of microblocks and cratonization.
Anorthositic rocks have attracted attention in terms of their possible role as the primordial crust of our planet, and also as markers of Archean-Paleoproterozoic plate tectonic regimes. Here we investigate the Konkanhundi gabbro-anorthosite suite from Peninsular India, adjacent to the major collisional suture between the Western and Eastern Dharwar cratonic blocks. The anorthosites display high Al2O3 contents with negative correlation against MgO, high CaO and Sr contents, and positive Eu anomalies indicating plagioclase flotation in the magma chamber. The pyroxenite and gabbroic rocks of the suite show high Ni, Cr, Co contents and geochemical features typical of pyroxene cumulation. LA-ICPMS U-Pb analyses of magmatic zircon grains yield weighted mean 207Pb/206Pb ages of 2601 ± 12 Ma for pyroxenite, 2616 ± 12 Ma for gabbro, 2615 ± 13 Ma and 2627 ± 14 Ma for anorthositic gabbro, 2594 ± 16 Ma for anorthosite, and 2605 ± 27 Ma for microgabbro. The age data from the different rock types in the anorthosite suite are broadly consistent, marking the emplacement time as ca. 2.6 Ga, and providing insights on one of the oldest anorthosite complexes in Peninsular India. Zircon grains in the surrounding TTG gneisses into which the gabbro-anorthosite suite was emplaced show weighted mean 207Pb/206Pb age of 3321 ± 11 Ma suggesting Mesoarchean basement. The zircon grains display high Th/U values and REE patterns typical of magmatic crystallization with enriched HREE, positive Ce and Sm anomalies, and negative Pr, Nd, Eu anomalies. Zircon Lu-Hf analysis yield negative εHf(t) values of −4.9–−0.7 with TDMC (two stage model ages) of 3123–3376 Ma for pyroxenite, −4.5–−1.7 and 3192–3366 Ma for gabbro, −5.3–0.9 and 3034–3410 Ma for anorthositic gabbro, and −3.9–-2.4 and 3221–3311 Ma respectively, suggesting the incorporation of Mesoarchean components within the Neoarchean magmatic suite. However, zircon grains in the TTG gneiss possess more ‘juvenile’ εHf(t) values in the range of −0.2–1.3 with TDMC in the range of 3554–3646 Ma. The zircon Hf isotopes and trace element data, together with the whole rock geochemical features suggest that the parent magma of the Konkanhundi gabbro-anorthosite suite was derived from subduction-related depleted mantle source that also incorporated continental crustal components. The time of emplacement of the gabbro-anorthosite complex broadly correlates with widespread arc magmatism and crust production as well recycling in other domains of the Dharwar Craton. We envisage multiple convergence of microblocks during craton assembly at the end of Archean in Dharwar, with the greenstone belts marking zones of paleo-ocean closure.
A new kind of nitrogen‐doped graphene/carbon nanotube nanocomposite can be synthesized by a facile hydrothermal process under mild conditions, which exhibits synergistically enhanced electrochemical ...activity for the oxygen reduction reaction. This research provides a new route to access a metal‐free electrocatalyst with high activity under mild conditions.
Precuneus responds to a wide range of cognitive processes. Here, we examined how the patterns of resting state connectivity may define functional subregions in the precuneus. Using a K-means ...algorithm to cluster the whole-brain “correlograms” of the precuneus in 225 adult individuals, we corroborated the dorsal-anterior, dorsal-posterior, and ventral subregions, each involved in spatially guided behaviors, mental imagery, and episodic memory as well as self-related processing, with the ventral precuneus being part of the default mode network, as described extensively in earlier work. Furthermore, we showed that the lateral/medial volumes of dorsal anterior and dorsal posterior precuneus are each connected with areas of motor execution/attention and motor/visual imagery, respectively. Compared to the ventral precuneus, the dorsal precuneus showed greater connectivity with occipital and posterior parietal cortices, but less connectivity with the medial superior frontal and orbitofrontal gyri, anterior cingulate cortex as well as the parahippocampus. Compared to dorsal-posterior and ventral precuneus, the dorsal-anterior precuneus showed greater connectivity with the somatomotor cortex, as well as the insula, supramarginal, Heschl's, and superior temporal gyri, but less connectivity with the angular gyrus. Compared to ventral and dorsal-anterior precuneus, dorsal-posterior precuneus showed greater connectivity with the middle frontal gyrus. Notably, the precuneus as a whole has negative connectivity with the amygdala and the lateral and inferior orbital frontal gyri. Finally, men and women differed in the connectivity of precuneus. Men and women each showed greater connectivity with the dorsal precuneus in the cuneus and medial thalamus, respectively. Women also showed greater connectivity with ventral precuneus in the hippocampus/parahippocampus, middle/anterior cingulate gyrus, and middle occipital gyrus, compared to men. Taken together, these new findings may provide a useful platform upon which to further investigate sex-specific functional neuroanatomy of the precuneus and to elucidate the pathology of many neurological illnesses.
► Precuneus contains dorsal anterior, dorsal posterior, and ventral subregions. ► Precuneus is negatively connected with the amygdala and orbitofrontal cortex. ► Men and women show different patterns of precuneus connectivity.
An ultrasensitive electrochemical detection of heavy metal ions is achieved via defect- and phase-engineering of Mn-mediated MoS2 nanosheets. We find for the first time that chemical interactions ...between Pb(ii) and active S atoms in Mn–MoS2 facilitate the electron transfer and in situ catalytic redox reactions.
A potassium carbonate promoted tandem oxy-Michael addition/cyclization of α,β-unsaturated carbonyl compounds with naphthol derivatives for the synthesis of 2-substituted naphthopyrans was developed. ...Using the readily available, inexpensive potassium carbonate as the promoter, a range of different substituted naphthopyrans were prepared.
Single‐cell biophysical properties play a crucial role in regulating cellular physiological states and functions, demonstrating significant potential in the fields of life sciences and clinical ...diagnostics. Therefore, over the last few decades, researchers have developed various detection tools to explore the relationship between the biophysical changes of biological cells and human diseases. With the rapid advancement of modern microfabrication technology, microfluidic devices have quickly emerged as a promising platform for single‐cell analysis offering advantages including high‐throughput, exceptional precision, and ease of manipulation. Consequently, this paper provides an overview of the recent advances in microfluidic analysis and detection systems for single‐cell biophysical properties and their applications in the field of cancer. The working principles and latest research progress of single‐cell biophysical property detection are first analyzed, highlighting the significance of electrical and mechanical properties. The development of data acquisition and processing methods for real‐time, high‐throughput, and practical applications are then discussed. Furthermore, the differences in biophysical properties between tumor and normal cells are outlined, illustrating the potential for utilizing single‐cell biophysical properties for tumor cell identification, classification, and drug response assessment. Lastly, we summarize the limitations of existing microfluidic analysis and detection systems in single‐cell biophysical properties, while also pointing out the prospects and future directions of their applications in cancer diagnosis and treatment.
Pharmacological studies have indirectly shown that necroptosis participates in ischemic neuronal death. However, its mechanism has yet to be elucidated in the ischemic brain. TNFα-triggered RIPK1 ...kinase activation could initiate RIPK3/MLKL-mediated necroptosis under inhibition of caspase-8. In the present study, we performed middle cerebral artery occlusion (MCAO) to induce cerebral ischemia in rats and used immunoblotting and immunostaining combined with pharmacological analysis to study the mechanism of necroptosis in ischemic brains. In the ipsilateral hemisphere, we found that ischemia induced the increase of (i) RIPK1 phosphorylation at the Ser166 residue (p-RIPK1), representing active RIPK1 kinase and (ii) the number of cells that were double stained with P-RIPK1 (Ser166) (p-RIPK1
) and TUNEL, a label of DNA double-strand breaks, indicating cell death. Furthermore, ischemia induced activation of downstream signaling factors of RIPK1, RIPK3 and MLKL, as well as the formation of mature interleukin-1β (IL-1β). Treatment with necrostatin-1 (Nec-1), an inhibitor of necroptosis, significantly decreased ischemia-induced increase of p-RIPK1 expression and p-RIPK1
neurons, which showed protection from brain damage. Meanwhile, Nec-1 reduced RIPK3, MLKL and p-MLKL expression levels and mature IL-1β formation in Nec-1 treated ischemic brains. Our results clearly demonstrated that phosphorylation of RIPK1 at the Ser166 residue was involved in the pathogenesis of necroptosis in the brains after ischemic injury. Nec-1 treatment protected brains against ischemic necroptosis by reducing the activation of RIPK1 and inhibiting its downstream signaling pathways. These results provide direct
evidence that phosphorylated RIPK1 (Ser 166) plays an important role in the initiation of RIPK3/MLKL-dependent necroptosis in the pathogenesis of ischemic stroke in the rodent brain.
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