Bullous pemphigoid is the most frequent autoimmune blistering disease. It occurs in the elderly. The cause of this disease is unknown, but cases of bullous pemphigoid have been occasionally ...attributed to drug therapy. We conducted a multicenter prospective case-control study looking at the drugs used on a long-term basis before the onset of the disease in 116 incident cases of bullous pemphigoid and 216 control patients with malignant or benign skin tumors.
Case patients and control patients received many drugs on a long-term basis (mean +/-SD, 4.4+/-3.2 and 4.4+/-2.7 years respectively). Two classes of drugs, neuroleptics and diuretics, were used more frequently by case patients than control patients. Neuroleptics were used by 15.5% of case patients and 8.3% of control patients (adjusted odds ratios; 1.9; 95% confidence interval, 0.95 to 3.8). Diuretics were used by 36.2% of case patients and 24.5% of control patients (adjusted odds ratios, 1.8; 95% confidence interval, 1.1 to 2.9). Among neuroleptics, no specific drug emerged. The association with diuretics was only linked to aldosterone antagonists, which were taken by 12.9% of case patients and 4.6% of control patients (adjusted odds ratios, 3.1; 95% confidence interval, 1.4 to 7.1).
These results suggest that some drug therapies may be a risk factor for bullous pemphigoid. The cause of this association should be further investigated.
A 13-year-old boy presented with Seckel's syndrome, still called bird's head nanism, characterized by: --nanism, mental retardation, microcephaly, and protrusio of the middle third of the face. The ...typical facial appearance enabled a detailed study to be conducted of both clinical and radiological features, including, particularly, an architectural and structural analysis of profile teleradiographic images, providing objective data on the craniofacial deformities. Skeletal and systemic anomalies are also described, together with elements documented in the literature but absent in the present case. The etiology of this syndrome remains unknown.
Vitamin A acid has been used for 20 years in the local treatment of acne. In 1986, Kligman published a description of the efficacy of this molecule against skin ageing. In 1987, we began a study ...which is still in progress. It is intended to confirm the beneficial effects already observed in photosenescence and to demonstrate them by non-invasive methods and by standardized photographs. This study was randomized and carried out under double blind. Each patient acted as her own control. The concentration administered was 0.025 per cent for 6 months and then 0.05 per cent. The patient was followed up every month for 6 months and then every 4 months. The results demonstrated a reduction in the number and depth of the wrinkles and a regression of the pigmented spots. Safety was excellent and all the patients were highly satisfied with the treatment.
Provider: - Institution: - Data provided by Europeana Collections- Contient : Étienne de Salagnac : « Tractatus fratris Stephani de Salanhac, Lemovicensis dyocesis, de IIIIer privilegiis, quibus Deus ...ordinem Predicatorum insignivit, et primo ponitur prologus. » ; Bernard Gui : « Tractatus de tribus gradibus prelatorum in ordine Predicatorum » ; Bernard Gui : « Acta capitulorum provincialium in provincia Provincie non divise. »- Numérisation effectuée à partir d'un document original : Ms. 488.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
L'oidium americain du haricot (Erysiphe polygoni D.C.) dans la zone antillaise: recherche de geniteurs de resistance Messiaen , C.M. (INRA (France). 0386 Laboratoire de Biochimie et physiologie moléculaires des plantes); Pauvert , P. (INRA , Pointe-à-Pitre (France). UR 0979 Laboratoire de recherches en productions végétales: secteur pathologie végétale et malherbologie); Jacqua , G. (INRA , Pointe-à-Pitre (France). UR 0979 Laboratoire de recherches en productions végétales: secteur pathologie végétale et malherbologie) ...
1989
Publication
The american bean powdery mildew seems to be very virulent in the West Indian area. Resistant lines have been found in Haiti, such as "Kenscoff I", "Salagnac 86", "Salagnac 131". Borlotto nano ...Vigevano" was used as susceptible check. The study of the progeny from crosses between these cultivars allowed to distinguish two components of the resistance obtained from Haitian lines: "seedling resistance", induced by a dominant gene, and "adult plant resistance", which seems polygenic recessive.
L’oïdium américain du haricot semble particulièrement virulent dans la zone antillaise, où il attaque des variétés considérées comme résistantes aux Etats-Unis. Des géniteurs de résistance ont été trouvés en Haïti, parmi lesquels les lignées "Kenscoff I", "Salagnac 86", "Salagnac 131" ont été plus particulièrement utilisées dans les programmes de sélection. L’étude de la descendance de croisements a permis de définir une "composante précoce" (résistance des plantules) et une "composante tardive" (tolérance du feuillage adulte) dans la résistance issue des géniteurs haïtiens. La première est liée à un gène dominant, la deuxième, d’hérédité polygénique, est à tendance récessive.
