Abstract
In order to further improve accuracy and stability of detection of combustion coal fallout propensity of cigarettes, author of the paper adopted computational fluid dynamics (CFD) technology ...for a three-dimensional numerical simulation of exhaust system of detection instrument, aiming to study characteristics of flow field near cigarettes. Moreover, a simulation model of eight-channel exhaust enclosure was established, obtaining vector diagram for flow velocity of flow field, velocity contour diagram, and pressure distribution cloud diagram. According to findings, flow field of eight channels is evenly distributed, with slow flow velocity around the instrument but furious inside channels. The wind velocity of cigarette monitoring channel is stable at about 200mm/s specified as per standard. However, there is significant change in pressure and flow velocity at the corners of channels, causing local turbulence. In experiments, average wind velocity of 8 monitoring channels was measured, and simulation results were compared with experiment data. Eventually, a conclusion is drawn that simulation result at cigarette monitoring channels changes consistently with the experimental data, with small errors as a whole. Therefore, the designed exhaust system complies with regulations on wind velocity stipulated by YC/T558-2018 Cigarettes—Determination of Combustion Coal Fallout Propensity of Burning Cigarettes. In a word, this paper is hoped to provide technical support for analogue simulation of exhaust system of cigarette detection instrument, and improve detection accuracy.
Mobile sensing based on the integration of microfluidic device and smartphone, so-called MS2 technology, has enabled many applications over recent years, and continues to stimulate growing interest ...in both research communities and industries. In particular, it has been envisioned that MS2 technology can be developed for various cell functional assays to enable basic research and clinical applications. Toward this direction, in this paper, we describe the development of a MS2-based cell functional assay for testing cell migration (the Mkit). The system is constructed as an integrated test kit, which includes microfluidic chips, a smartphone-based imaging platform, the phone apps for image capturing and data analysis, and a set of reagent and accessories for performing the cell migration assay. We demonstrated that the Mkit can effectively measure purified neutrophil and cancer cell chemotaxis. Furthermore, neutrophil chemotaxis can be tested from a drop of whole blood using the Mkit with red blood cell (RBC) lysis. The effects of chemoattractant dose and gradient profile on neutrophil chemotaxis were also tested using the Mkit. In addition to research applications, we demonstrated the effective use of the Mkit for on-site test at the hospital and for testing clinical samples from chronic obstructive pulmonary disease patient. Thus, this developed Mkit provides an easy and integrated experimental platform for cell migration related research and potential medical diagnostic applications.
•A novel cell migration assay based on microfluidic device and smartphone is developed.•Chemotaxis assay of neutrophils and cancer cells is demonstrated.•On-site test at the hospital and clinical sample test are demonstrated.
Mobile sensing based on the integration of microfluidic device and smartphone, so-called MS
technology, has enabled many applications over recent years, and continues to stimulate growing interest in ...both research communities and industries. In particular, it has been envisioned that MS
technology can be developed for various cell functional assays to enable basic research and clinical applications. Toward this direction, in this paper, we describe the development of a MS
-based cell functional assay for testing cell migration (the M
). The system is constructed as an integrated test kit, which includes microfluidic chips, a smartphone-based imaging platform, the phone apps for image capturing and data analysis, and a set of reagent and accessories for performing the cell migration assay. We demonstrated that the M
can effectively measure purified neutrophil and cancer cell chemotaxis. Furthermore, neutrophil chemotaxis can be tested from a drop of whole blood using the M
with red blood cell (RBC) lysis. The effects of chemoattractant dose and gradient profile on neutrophil chemotaxis were also tested using the M
. In addition to research applications, we demonstrated the effective use of the M
for on-site test at the hospital and for testing clinical samples from chronic obstructive pulmonary disease patient. Thus, this developed M
provides an easy and integrated experimental platform for cell migration related research and potential medical diagnostic applications.
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