To evaluate the long-term survival of visual field and visual acuity in treated glaucoma patients with end-stage glaucomatous visual field loss defined by a field constricted to a 10-degree radius or ...less.
Retrospective chart review.
Sixty-four patients with end-stage glaucoma.
Serial 10-2 Humphrey visual fields with size III stimulus were analyzed. The following data were recorded for each visual field: mean deviation (MD), pattern standard deviation, the largest horizontal and vertical diameters measured in degrees including only locations with thresholds of 10 decibels or more, and the number of points on the pattern deviation plot with a probability value of more than 5%.
Change in visual acuity and visual field.
Eighty-four eyes of 64 patients satisfied inclusion criteria with an average follow-up of 8.34+/-3.1 years. Seventy-eight percent of patients were black. During the study period, 14 eyes lost more than 3 lines of visual acuity. Of these 14, 8 eyes progressed to a visual acuity of 20/200 or worse. Seven eyes lost 3 decibels or more from the MD that could be reproduced over 2 visual fields.
In this predominantly black population, most treated patients with end-stage glaucoma did not demonstrate a decline in visual acuity or progressive loss of the central visual field during long-term follow-up.
Suppose that (
s
1,
t
1),…,(
s
k
,
t
k
) are pairs of vertices of a graph. When can one choose a path between
s
1 and
t
1 for each
i, all pairwise edge-disjoint? Menger's theorem answers this when
s
...1,…,
s
k
,
t
1,…,
t
k
take only two distinct values, but the general problem is unsolved. We settle the two next simplest cases.
1.
(i) when
k = 2, and
2.
(ii) when
s
1,…,
s
k
,
t
1,…,
t
k
take only three distinct values—the solution to this is obtained by applying a theorem of Mader.
We obtain both good characterizations and good algorithms for these problems. The analogous “vertex-disjoint” problems are also solved.
Packing Odd Paths Schrijver, A.; Seymour, P.D.
Journal of combinatorial theory. Series B,
11/1994, Volume:
62, Issue:
2
Journal Article
Peer reviewed
Open access
Let
s,
t be vertices of a graph
G, and let each edge
e have a "capacity"
c(
e) ∈
R
+. We prove a conjecture of Cook and Sebő that for every
k ∈
R
+, the following two statements are equivalent: (i) ...there is a "fractional packing" of value
k of the odd length
s -
t paths, so that no edge is used more than its capacity; (ii) for every subgraph
H of
G with
s,
t ∈
V(
H) in which there is no odd
s -
t path, formula ∑ (c(e): e ∈ E(G) − E(H), and e is incident with
v ≥ 2
k.
Advising Patients Who Use Dietary Supplements Ashar, Bimal H., MD, MBA; Rowland-Seymour, Anastasia, MD
The American journal of medicine,
02/2008, Volume:
121, Issue:
2
Journal Article
Peer reviewed
Abstract Public use of dietary supplements is quite prevalent, with an estimated 1 of 5 patients using such substances in an effort to maintain or promote their health. Despite their popularity, ...patients and physicians are often unaware of the limited regulation of these products as well as their potential risks and benefits. Lack of physician knowledge in these areas has the potential to strain the doctor-patient relationship. In this review, we present a 6-step approach to advising patients who are considering use of dietary supplements. Our framework includes a discussion of regulatory issues, efficacy and safety, potential supplement-drug interactions, and monitoring for adverse events and therapeutic effects.
The synthesis of a variety of pyrrolo1,2-cquinazolines and pyrrolo1,2-cquinazolinones is described. Several of these compounds have exhibited antihypertensive properties in the spontaneously ...hypertensive rat (SHR). Structure-activity comparisons have indicated that optimal activity is obtained in both the 2-carbethoxydihydroquinazoline series (C) and 2-carbethoxyquinazolinone series (D) when there is either a carbethoxy or cyanoethyl group at position 6 and no substitution in the benzene ring, while optimal activity is obtained in the 2-methyl-quinazolinone series (D) when both position 6 and the benzene ring are unsubstituted.
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