People's differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found ...evidence for polygenic effects yet, to date, there are few replicated genetic associations. Here we use data from the UK Biobank sample to investigate the genetic contributions to variation in tests of three cognitive functions and in educational attainment. GWA analyses were performed for verbal-numerical reasoning (N=36 035), memory (N=112 067), reaction time (N=111 483) and for the attainment of a college or a university degree (N=111 114). We report genome-wide significant single-nucleotide polymorphism (SNP)-based associations in 20 genomic regions, and significant gene-based findings in 46 regions. These include findings in the ATXN2, CYP2DG, APBA1 and CADM2 genes. We report replication of these hits in published GWA studies of cognitive function, educational attainment and childhood intelligence. There is also replication, in UK Biobank, of SNP hits reported previously in GWA studies of educational attainment and cognitive function. GCTA-GREML analyses, using common SNPs (minor allele frequency>0.01), indicated significant SNP-based heritabilities of 31% (s.e.m.=1.8%) for verbal-numerical reasoning, 5% (s.e.m.=0.6%) for memory, 11% (s.e.m.=0.6%) for reaction time and 21% (s.e.m.=0.6%) for educational attainment. Polygenic score analyses indicate that up to 5% of the variance in cognitive test scores can be predicted in an independent cohort. The genomic regions identified include several novel loci, some of which have been associated with intracranial volume, neurodegeneration, Alzheimer's disease and schizophrenia.
We use the science demonstration field data of the Herschel Astrophysical Terahertz Large Area Survey to study how star formation, traced by the far-infrared Herschel data, is related to both the ...accretion luminosity and redshift of quasars selected from the Sloan Digital Sky Survey (SDSS) and the 2dF-SDSS luminous red galaxy (LRG) and Quasar Spectroscopic Catalogue survey. By developing a maximum-likelihood estimator to investigate the presence of correlations between the far-infrared and optical luminosities, we find evidence that the star formation in quasar hosts is correlated with both redshift and quasar accretion luminosity. Assuming a relationship of the form L
IR∝L
θ
QSO(1 +z)ζ, we find θ= 0.22 ± 0.08 and ζ= 1.6 ± 0.4, although there is substantial additional uncertainty in ζ of the order of ±1, due to uncertainties in the host galaxy dust temperature. We find evidence for a large intrinsic dispersion in the redshift dependence, but no evidence for intrinsic dispersion in the correlation between L
QSO and L
IR, suggesting that the latter may be due to a direct physical connection between star formation and black hole accretion. This is consistent with the idea that both the quasar activity and star formation are dependent on the same reservoir of cold gas, so that they are both affected by the influx of cold gas during mergers or heating of gas via feedback processes.
We present Low-Frequency Array (LOFAR) High-Band Array observations of the Herschel-ATLAS North Galactic Pole survey area. The survey we have carried out, consisting of four pointings covering around ...142 deg2 of sky in the frequency range 126–173 MHz, does not provide uniform noise coverage but otherwise is representative of the quality of data to be expected in the planned LOFAR wide-area surveys, and has been reduced using recently developed ‘facet calibration’ methods at a resolution approaching the full resolution of the data sets (∼10 × 6 arcsec) and an rms off-source noise that ranges from 100 μJy beam−1 in the centre of the best fields to around 2 mJy beam−1 at the furthest extent of our imaging. We describe the imaging, cataloguing and source identification processes, and present some initial science results based on a 5σ source catalogue. These include (i) an initial look at the radio/far-infrared correlation at 150 MHz, showing that many Herschel sources are not yet detected by LOFAR; (ii) number counts at 150 MHz, including, for the first time, observational constraints on the numbers of star-forming galaxies; (iii) the 150-MHz luminosity functions for active and star-forming galaxies, which agree well with determinations at higher frequencies at low redshift, and show strong redshift evolution of the star-forming population; and (iv) some discussion of the implications of our observations for studies of radio galaxy life cycles.
The Asteroid Terrestrial impact Last Alert System (ATLAS) system consists of two 0.5 m Schmidt telescopes with cameras covering 29 square degrees at plate scale of 1.86 arcsec per pixel. Working in ...tandem, the telescopes routinely survey the whole sky visible from Hawaii (above δ > − 50 ° ) every two nights, exposing four times per night, typically reaching o < 19 magnitude per exposure when the moon is illuminated and c < 19.5 magnitude per exposure in dark skies. Construction is underway of two further units to be sited in Chile and South Africa which will result in an all-sky daily cadence from 2021. Initially designed for detecting potentially hazardous near earth objects, the ATLAS data enable a range of astrophysical time domain science. To extract transients from the data stream requires a computing system to process the data, assimilate detections in time and space and associate them with known astrophysical sources. Here we describe the hardware and software infrastructure to produce a stream of clean, real, astrophysical transients in real time. This involves machine learning and boosted decision tree algorithms to identify extragalactic and Galactic transients. Typically we detect 10-15 supernova candidates per night which we immediately announce publicly. The ATLAS discoveries not only enable rapid follow-up of interesting sources but will provide complete statistical samples within the local volume of 100 Mpc. A simple comparison of the detected supernova rate within 100 Mpc, with no corrections for completeness, is already significantly higher (factor 1.5 to 2) than the current accepted rates.
The flare of radiation from the tidal disruption and accretion of a star can be used as a marker for supermassive black holes that otherwise lie dormant and undetected in the centres of distant ...galaxies. Previous candidate flares have had declining light curves in good agreement with expectations, but with poor constraints on the time of disruption and the type of star disrupted, because the rising emission was not observed. Recently, two 'relativistic' candidate tidal disruption events were discovered, each of whose extreme X-ray luminosity and synchrotron radio emission were interpreted as the onset of emission from a relativistic jet. Here we report a luminous ultraviolet-optical flare from the nuclear region of an inactive galaxy at a redshift of 0.1696. The observed continuum is cooler than expected for a simple accreting debris disk, but the well-sampled rise and decay of the light curve follow the predicted mass accretion rate and can be modelled to determine the time of disruption to an accuracy of two days. The black hole has a mass of about two million solar masses, modulo a factor dependent on the mass and radius of the star disrupted. On the basis of the spectroscopic signature of ionized helium from the unbound debris, we determine that the disrupted star was a helium-rich stellar core.
We present the greenhouse gas concentrations for the Representative Concentration Pathways (RCPs) and their extensions beyond 2100, the Extended Concentration Pathways (ECPs). These projections ...include all major anthropogenic greenhouse gases and are a result of a multi-year effort to produce new scenarios for climate change research. We combine a suite of atmospheric concentration observations and emissions estimates for greenhouse gases (GHGs) through the historical period (1750–2005) with harmonized emissions projected by four different Integrated Assessment Models for 2005–2100. As concentrations are somewhat dependent on the future climate itself (due to climate feedbacks in the carbon and other gas cycles), we emulate median response characteristics of models assessed in the IPCC Fourth Assessment Report using the reduced-complexity carbon cycle climate model MAGICC6. Projected ‘best-estimate’ global-mean surface temperature increases (using inter alia a climate sensitivity of 3°C) range from 1.5°C by 2100 for the lowest of the four RCPs, called both RCP3-PD and RCP2.6, to 4.5°C for the highest one, RCP8.5, relative to pre-industrial levels. Beyond 2100, we present the ECPs that are simple extensions of the RCPs, based on the assumption of either smoothly stabilizing concentrations or constant emissions: For example, the lower RCP2.6 pathway represents a strong mitigation scenario and is extended by assuming constant emissions after 2100 (including net negative CO
2
emissions), leading to CO
2
concentrations returning to 360 ppm by 2300. We also present the GHG concentrations for one supplementary extension, which illustrates the stringent emissions implications of attempting to go back to ECP4.5 concentration levels by 2250 after emissions during the 21
st
century followed the higher RCP6 scenario. Corresponding radiative forcing values are presented for the RCP and ECPs.
Anthropogenic increases in atmospheric greenhouse gas
concentrations are the main driver of current and future climate change. The
integrated assessment community has quantified anthropogenic ...emissions for
the shared socio-economic pathway (SSP) scenarios, each of which represents
a different future socio-economic projection and political environment.
Here, we provide the greenhouse gas concentrations for these SSP scenarios
– using the reduced-complexity climate–carbon-cycle model MAGICC7.0. We
extend historical, observationally based concentration data with SSP
concentration projections from 2015 to 2500 for 43 greenhouse gases with monthly and latitudinal resolution. CO2 concentrations by 2100 range
from 393 to 1135 ppm for the lowest (SSP1-1.9) and highest (SSP5-8.5)
emission scenarios, respectively. We also provide the concentration
extensions beyond 2100 based on assumptions regarding the trajectories of fossil
fuels and land use change emissions, net negative emissions, and the
fraction of non-CO2 emissions. By 2150, CO2 concentrations in the
lowest emission scenario are approximately 350 ppm and approximately plateau
at that level until 2500, whereas the highest fossil-fuel-driven scenario
projects CO2 concentrations of 1737 ppm and reaches concentrations
beyond 2000 ppm by 2250. We estimate that the share of CO2 in the total
radiative forcing contribution of all considered 43 long-lived greenhouse
gases increases from 66 % for the present day to roughly 68 % to 85 % by
the time of maximum forcing in the 21st century. For this estimation,
we updated simple radiative forcing parameterizations that reflect the Oslo
Line-By-Line model results. In comparison to the representative concentration pathways (RCPs), the five main SSPs
(SSP1-1.9, SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5) are more evenly spaced
and extend to lower 2100 radiative forcing and temperatures. Performing two
pairs of six-member historical ensembles with CESM1.2.2, we estimate the
effect on surface air temperatures of applying latitudinally and seasonally
resolved GHG concentrations. We find that the ensemble differences in the
March–April–May (MAM) season provide a regional warming in higher northern
latitudes of up to 0.4 K over the historical period, latitudinally averaged
of about 0.1 K, which we estimate to be comparable to the upper bound
(∼5 % level) of natural variability. In comparison to the
comparatively straight line of the last 2000 years, the greenhouse gas
concentrations since the onset of the industrial period and this studies'
projections over the next 100 to 500 years unequivocally depict a
“hockey-stick” upwards shape. The SSP concentration time series derived in
this study provide a harmonized set of input assumptions for long-term
climate science analysis; they also provide an indication of the wide set of
futures that societal developments and policy implementations can lead to –
ranging from multiple degrees of future warming on the one side to
approximately 1.5 ∘C warming on the other.
We present the first major data release of the largest single key-project in area carried out in open time with the Herschel Space Observatory. The Herschel Astrophysical Terahertz Large Area Survey ...(H-ATLAS) is a survey of 600 deg super( 2) in five photometric bands -- 100, 160, 250, 350 and 500 mu m -- with the Photoconductor Array Camera and Spectrometer and Spectral and Photometric Imaging Receiver (SPIRE) cameras. In this paper and the companion Paper II, we present the survey of three fields on the celestial equator, covering a total area of 161.6 deg super( 2) and previously observed in the Galaxy and Mass Assembly (GAMA) spectroscopic survey. This paper describes the Herschel images and catalogues of the sources detected on the SPIRE 250 mu m images. The 1 sigma noise for source detection, including both confusion and instrumental noise, is 7.4, 9.4 and 10.2 mJy at 250, 350 and 500 mu m. Our catalogue includes 120 230 sources in total, with 113 995, 46 209 and 11 011 sources detected at >4 sigma at 250, 350 and 500 mu m. The catalogue contains detections at >3 sigma at 100 and 160 mu m for 4650 and 5685 sources, and the typical noise at these wavelengths is 44 and 49 mJy. We include estimates of the completeness of the survey and of the effects of flux bias and also describe a novel method for determining the true source counts. The H-ATLAS source counts are very similar to the source counts from the deeper HerMES survey at 250 and 350 mu m, with a small difference at 500 mu m. Appendix A provides a quick start in using the released data sets, including instructions and cautions on how to use them.
A Critical Appraisal of “Chronic Lyme Disease” Feder, Henry M; Johnson, Barbara J.B; O'Connell, Susan ...
The New England journal of medicine,
10/2007, Volume:
357, Issue:
14
Journal Article
Peer reviewed
“Chronic Lyme disease” is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, ...prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.
“Chronic Lyme disease” is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.
Lyme disease, the most common tick-borne infection in the northern hemisphere, is a serious public health problem. In North America, it is caused exclusively by
Borrelia burgdorferi
sensu stricto (hereafter referred to as
B. burgdorferi
), whereas in Europe it is caused by
B. afzelii, B. garinii, B. burgdorferi,
and occasionally by other species of borrelia.
1
This complex infection has a number of objective manifestations, including a characteristic skin lesion called erythema migrans (the most common presentation of early Lyme disease), certain neurologic and cardiac manifestations, and pauciarticular arthritis (the most common presentation of late Lyme disease), all of which . . .
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