RESUMEN El siglo XX ha sido testigo de excepción de los grandes avances y hallazgos en la comprensión neurofisiológica y el tratamiento multidisciplicar del dolor crónico. No obstante, el interés por ...la forma diferente de expresión en la percepción dolorosa entre hombres y mujeres y los determinantes psicológicos y sociales específicos asociados a los roles de género es relativamente reciente. En este artículo se realiza una revisión no sistemática de los determinantes diferenciales psicológicos y sociales siguiendo el modelo de la neuromatriz. Por último, el conocimiento de aquellos sesgos que de forma involuntaria tenemos los profesionales es crucial para abordar las desigualdades evitables en tratamiento y la recuperación de la salud de hombres y mujeres. Finalmente se ofrecen recomendaciones desde el ámbito de la Psicología Clínica.
We present the first experimental realization of a quantum artificial life algorithm in a quantum computer. The quantum biomimetic protocol encodes tailored quantum behaviors belonging to living ...systems, namely, self-replication, mutation, interaction between individuals, and death, into the cloud quantum computer IBM ibmqx4. In this experiment, entanglement spreads throughout generations of individuals, where genuine quantum information features are inherited through genealogical networks. As a pioneering proof-of-principle, experimental data fits the ideal model with accuracy. Thereafter, these and other models of quantum artificial life, for which no classical device may predict its quantum supremacy evolution, can be further explored in novel generations of quantum computers. Quantum biomimetics, quantum machine learning, and quantum artificial intelligence will move forward hand in hand through more elaborate levels of quantum complexity.
Summary
Background
Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three cancer‐prone genodermatoses whose causal ...genetic mutations cannot fully explain, on their own, the array of associated phenotypic manifestations. Recent evidence highlights the role of the stromal microenvironment in the pathology of these disorders.
Objectives
To investigate, by means of comparative gene expression analysis, the role played by dermal fibroblasts in the pathogenesis of RDEB, KS and XPC.
Methods
We conducted RNA‐Seq analysis, which included a thorough examination of the differentially expressed genes, a functional enrichment analysis and a description of affected signalling circuits. Transcriptomic data were validated at the protein level in cell cultures, serum samples and skin biopsies.
Results
Interdisease comparisons against control fibroblasts revealed a unifying signature of 186 differentially expressed genes and four signalling pathways in the three genodermatoses. Remarkably, some of the uncovered expression changes suggest a synthetic fibroblast phenotype characterized by the aberrant expression of extracellular matrix (ECM) proteins. Western blot and immunofluorescence in situ analyses validated the RNA‐Seq data. In addition, enzyme‐linked immunosorbent assay revealed increased circulating levels of periostin in patients with RDEB.
Conclusions
Our results suggest that the different causal genetic defects converge into common changes in gene expression, possibly due to injury‐sensitive events. These, in turn, trigger a cascade of reactions involving abnormal ECM deposition and underexpression of antioxidant enzymes. The elucidated expression signature provides new potential biomarkers and common therapeutic targets in RDEB, XPC and KS.
What's already known about this topic?
Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three genodermatoses with high predisposition to cancer development.
Although their causal genetic mutations mainly affect epithelia, the dermal microenvironment likely contributes to the physiopathology of these disorders.
What does this study add?
We disclose a large overlapping transcription profile between XPC, KS and RDEB fibroblasts that points towards an activated phenotype with high matrix‐synthetic capacity.
This common signature seems to be independent of the primary causal deficiency, but reflects an underlying derangement of the extracellular matrix via transforming growth factor‐β signalling activation and oxidative state imbalance.
What is the translational message?
This study broadens the current knowledge about the pathology of these diseases and highlights new targets and biomarkers for effective therapeutic intervention.
It is suggested that high levels of circulating periostin could represent a potential biomarker in RDEB.
Linked Comment: Has. Br J Dermatol 2019; 181:440–441.
Plain language summary available online
Binary and multiple stars have long provided an effective empirical method of testing stellar formation and evolution theories. In particular, the existence of wide binary systems (separations ...>20,000 au) is particularly challenging to binary formation models as their physical separations are beyond the typical size of a collapsing cloud core (∼5000-10,000 au). We mined the recently published Gaia-DR2 catalog to identify bright comoving systems in the five-dimensional space (sky position, parallax, and proper motion). We identified 3741 comoving binary and multiple stellar candidate systems, out of which 575 have compatible radial velocities for all the members of the system. The candidate systems have separations between ∼400 and 500,000 au. We used the analysis tools of the Virtual Observatory to characterize the comoving system members and to assess their reliability. The comparison with previous comoving systems catalogs obtained from TGAS showed that these catalogs contain a large number of false systems. In addition, we were not able to confirm the ultra-wide binary population presented in these catalogs. The robustness of our methodology is demonstrated by the identification of well known comoving star clusters and by the low contamination rate for comoving binary systems with projected physical separations <50,000 au. These last constitute a reliable sample for further studies. The catalog is available online at the Spanish Virtual Observatory portal (http://svo2.cab.inta-csic.es/vocats/v2/comovingGaiaDR2/).
The quantum perceptron is a fundamental building block for quantum machine learning. This is a multidisciplinary field that incorporates abilities of quantum computing, such as state superposition ...and entanglement, to classical machine learning schemes. Motivated by the techniques of shortcuts to adiabaticity, we propose a speed-up quantum perceptron where a control field on the perceptron is inversely engineered leading to a rapid nonlinear response with a sigmoid activation function. This results in faster overall perceptron performance compared to quasi-adiabatic protocols, as well as in enhanced robustness against imperfections in the controls.
•We search SDSS image archive for near-Earth (NEA) and Mars-crosser (MC) asteroids.•We report on the taxonomic classification of 206 NEA and 776 MC.•We study NEA source regions and confirm the inner ...main belt as a major source.•We develop a force model on surface grain and study planetary encounters.•The fresher surfaces have statistically more encounters with Venus and Earth.
The nature and origin of the asteroids orbiting in near-Earth space, including those on a potentially hazardous trajectory, is of both scientific interest and practical importance. We aim here at determining the taxonomy of a large sample of near-Earth and Mars-crosser asteroids and analyze the distribution of these classes with orbit. We use this distribution to identify the source regions of near-Earth objects and to study the strength of planetary encounters to refresh asteroid surfaces. We measure the photometry of these asteroids over four filters at visible wavelengths on images taken by the Sloan Digital Sky Survey (SDSS). These colors are used to classify the asteroids into a taxonomy consistent with the widely used Bus-DeMeo taxonomy (DeMeo et al. 2009. Icarus 202, 160–180) based on visible and near-infrared spectroscopy. We report here on the taxonomic classification of 206 near-Earth and 776 Mars-crosser asteroids determined from SDSS photometry, representing an increase of 40% and 663% of known taxonomy classifications in these populations. Using the source region mapper by Greenstreet et al. (Greenstreet, S., Ngo, H., Gladman, B. 2012. Icarus, 217, 355–366), we compare for the first time the taxonomic distribution among near-Earth and main-belt asteroids of similar diameters. Both distributions agree at the few percent level for the inner part of the main belt and we confirm this region as a main source of near-Earth objects. The effect of planetary encounters on asteroid surfaces are also studied by developing a simple model of forces acting on a surface grain during planetary encounter, which provides the minimum distance at which a close approach should occur to trigger resurfacing events. By integrating numerically the orbit of the 519 S-type and 46 Q-type asteroids in our sample back in time for 500,000years and monitoring their encounter distance with Venus, Earth, Mars, and Jupiter, we seek to understand the conditions for resurfacing events. The population of Q-type is found to present statistically more encounters with Venus and the Earth than S-types, although both S- and Q-types present the same amount of encounters with Mars.
Over the last few decades, quantum chemistry has progressed through the development of computational methods based on modern digital computers. However, these methods can hardly fulfill the ...exponentially-growing resource requirements when applied to large quantum systems. As pointed out by Feynman, this restriction is intrinsic to all computational models based on classical physics. Recently, the rapid advancement of trapped-ion technologies has opened new possibilities for quantum control and quantum simulations. Here, we present an efficient toolkit that exploits both the internal and motional degrees of freedom of trapped ions for solving problems in quantum chemistry, including molecular electronic structure, molecular dynamics, and vibronic coupling. We focus on applications that go beyond the capacity of classical computers, but may be realizable on state-of-the-art trapped-ion systems. These results allow us to envision a new paradigm of quantum chemistry that shifts from the current transistor to a near-future trapped-ion-based technology.
Quantum communication protocols based on nonclassical correlations can be more efficient than known classical methods and offer intrinsic security over direct state transfer. In particular, remote ...state preparation aims at the creation of a desired and known quantum state at a remote location using classical communication and quantum entanglement. We present an experimental realization of deterministic continuous-variable remote state preparation in the microwave regime over a distance of 35 cm. By employing propagating two-mode squeezed microwave states and feedforward, we achieve the remote preparation of squeezed states with up to 1.6 dB of squeezing below the vacuum level. Finally, security of remote state preparation is investigated by using the concept of the one-time pad and measuring the von Neumann entropies. We find nearly identical values for the entropy of the remotely prepared state and the respective conditional entropy given the classically communicated information and, thus, demonstrate close-to-perfect security.
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