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  • The JAK-STAT Pathway at Twenty The JAK-STAT Pathway at Twenty
    Stark, George R.; Darnell, James E. Immunity, 04/2012, Volume: 36, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial ...
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2.
  • The JAK-STAT pathway at 30:... The JAK-STAT pathway at 30: Much learned, much more to do
    Philips, Rachael L.; Wang, Yuxin; Cheon, HyeonJoo ... Cell, 10/2022, Volume: 185, Issue: 21
    Journal Article
    Peer reviewed
    Open access

    The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in ...
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  • Unphosphorylated STAT1 prol... Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
    Cheon, HyeonJoo; Stark, George R Proceedings of the National Academy of Sciences - PNAS, 06/2009, Volume: 106, Issue: 23
    Journal Article
    Peer reviewed
    Open access

    In normal human cells treated with interferons (IFNs), the concentration of tyrosine-phosphorylated STAT1 (YP-STAT1), which drives the expression of a large number of genes, increases quickly but ...
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  • Roles of unphosphorylated S... Roles of unphosphorylated STATs in signaling
    Yang, Jinbo; Stark, George R Cell research, 04/2008, Volume: 18, Issue: 4
    Journal Article
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    Open access

    The seven members of the signal transducer and activator of transcription (STAT) family of transcription factors are activated in response to many different cytokines and growth factors by ...
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5.
  • How cells respond to interf... How cells respond to interferons revisited: From early history to current complexity
    Stark, George R Cytokine & growth factor reviews, 10/2007, Volume: 18, Issue: 5
    Journal Article
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    Open access

    Abstract A brief account of how I became involved in interferon research is followed by recollections of key experiments that led to the discovery of the roles of the JAKs and STATs in ...
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6.
  • STAT3-driven transcription ... STAT3-driven transcription depends upon the dimethylation of K49 by EZH2
    Dasgupta, Maupali; Dermawan, Josephine Kam Tai; Willard, Belinda ... Proceedings of the National Academy of Sciences - PNAS, 03/2015, Volume: 112, Issue: 13
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    Open access

    Significance Protein lysine methyl transferases and demethylases, previously identified for histone modification, now are known to modify several nonhistone proteins as well. Their deregulation leads ...
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  • Dual Role of WISP1 in maint... Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
    Tao, Weiwei; Chu, Chengwei; Zhou, Wenchao ... Nature communications, 06/2020, Volume: 11, Issue: 1
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    The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. However, the ...
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  • Inflammation mobilizes copp... Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
    Liao, Yun; Zhao, Junjie; Bulek, Katarzyna ... Nature communications, 02/2020, Volume: 11, Issue: 1
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    Open access

    Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which ...
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  • STAT3 activation in respons... STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
    Wang, Yuxin; van Boxel-Dezaire, Anette H. H.; Cheon, HyeonJoo ... Proceedings of the National Academy of Sciences - PNAS, 10/2013, Volume: 110, Issue: 42
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    The activation of STAT3 by tyrosine phosphorylation, essential for normal development and for a normal inflammatory response to invading pathogens, is kept in check by negative regulators. Abnormal ...
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  • Interferon-beta represses c... Interferon-beta represses cancer stem cell properties in triple-negative breast cancer
    Doherty, Mary R.; Cheon, HyeonJoo; Junk, Damian J. ... Proceedings of the National Academy of Sciences - PNAS, 12/2017, Volume: 114, Issue: 52
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    Triple-negative breast cancer (TNBC), the deadliest form of this disease, lacks a targeted therapy. TNBC tumors that fail to respond to chemotherapy are characterized by a repressed IFN/signal ...
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