In the face of the increasingly severe water environment, establishing an effective water environment management mechanism is a major concern of governments around the world. The River Chief System ...attempts to match water environment management to the performance of the main leaders of the local party and government and represents an institutional innovation to solve the problem of river and lake management in China. However, there is still a lack of systematic research on the performance of the River Chief System and how to promote its overall effectiveness. This paper took Chaohu Lake Basin, with a concentrated and complicated water environment, as the research object and divided it into eastern and western halves. The water ecological security before and after the implementation of the River Chief System was comprehensively evaluated, and the obstacles to ecological security were diagnosed. The implementation effect of the River Chief System and the weak links of the corresponding river chiefs’ work performance were analyzed. The results show the following: (1) Since the implementation of the River Chief System in 2013, the overall water ecological security of Chaohu Lake Basin has been raised from the lower limit to the upper limit of the generally healthy category, initially reflecting the effect of the River Chief System. (2) For the eastern half of the lake, the threat to water ecological security mainly comes from the development of industry. Industrial water use intensity is the primary obstacle to the ecological security of the eastern half of the lake in recent years. (3) For the western half of the lake, the threat to water ecological security mainly comes from the process of urbanization. The wetland area, urban domestic water use intensity, and artificial afforestation area are the main factors hindering the ecological security of the western half of the lake. The above analysis results can be used as the basis for future work to improve the performance of the relevant river chiefs in Chaohu Lake Basin.
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•The impacts of GVC position on GTIE are considered in the context of environmental regulation.•We explore the industries’ heterogeneity impacts of GVC position on GTIE.•The ...moderating effect of environmental regulation expands the impact of GVC position on GTIE.•The GVC position has a double-threshold effect of environmental regulation relationship with GTIE.•The coordination between environmental regulation and GVC position for decision-making.
Under the open economy, whereas the manufacturing industry has realized transformation and upgrading by the embedding global value chain (GVC) division system, the problems of energy consumption and environmental damage caused by the industry have attracted increasing attention from society. In this paper, the industry classification standard of Trade in Value Added (TiVA) database is used to integrate China’s manufacturing industry during 2006–2015. Based on the indicator measurement, corresponding panel data models are constructed to study the impacts of the GVC position on green technology innovation efficiency (GTIE) in the context of environmental regulation. The empirical results show that: (1) The rise of the GVC embedding position significantly promotes the GTIE, and there is industry heterogeneity characterized by pollution intensity and factor density. (2) There is a positive moderating effect and a double threshold effect of environmental regulation on the relationship between the GVC position and the GTIE. The above research findings offer a certain managerial enlightenment for the manufacturing industry of developing countries to guide adjustment of environmental regulation policies, alleviate the pressure on resources and the environment, and even cultivate a new momentum of sustainable economic growth.
To identify key regulatory genes involved in ROS scavenging in response to cadmium (Cd) exposure in pak choi, eight cDNA libraries from Cd-treated and Cd-free roots of two cultivars, Baiyewuyueman ...(high Cd accumulator) and Kuishan'aijiaoheiye (low Cd accumulator), were firstly performed by RNA-sequencing. Totally 0.443 billion clean reads and 244,190 unigenes were obtained from eight transcriptome. About 797 and 1167 unigenes encoding ROS related proteins and transcription factors were identified. Of them, 11 and 16 ROS scavenging system related DEGs, and 29 and 15 transcription factors related DEGs were found in Baiyewuyueman and Kuishan'aijiaoheiye, respectively. Ten ROS-scavenging genes (Cu/Zn-SOD, GST1, PODs, TrxR2, PrxR, FER3 and NDPK) showed higher expression levels in Cd-exposed seedings of Baiyewuyueman than those of Kuishan'aijiaoheiye. Four genes (GPX, APX, GRX and GST3) specifically expressed in Cd-free roots of Kuishan'aijiaoheiye. For transcription factors, ERF12/13/22 and WRKY31 was up-regulated by Cd in Baiyewuyueman, while in Kuishan'aijiaoheiye, Cd induced down-regulations of bZIP, NAC and ZFP families. The results indicate that the two cultivars differed in the mechanism of ROS scavenging in response to Cd stress. Fe SOD1, POD A2/44/54/62 and GST1 may be responsible for the difference of Cd tolerance between Baiyewuyueman and Kuishan'aijiaoheiye.
Objective: Rare study of the non-coding and regulatory regions of the genome limits our ability to decode the mechanisms of fatty liver hemorrhage syndrome (FLHS) in chickens.Methods: Herein, we ...constructed the high-fat diet-induced FLHS chicken model to investigate the genome-wide active enhancers and transcriptome by H3K27ac target chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-Seq) profiles of normal and FLHS liver tissues. Concurrently, an integrative analysis combining ChIP-seq with RNA-Seq and a comparative analysis with chicken FLHS, rat non-alcoholic fatty liver disease (NAFLD) and human NAFLD at the transcriptome level revealed the enhancer and super enhancer target genes and conservative genes involved in metabolic processes.Results: In total, 56 and 199 peak-genes were identified in upregulated peak-genes positively regulated by H3K27ac (Cor (peak-gene correlation) ≥0.5 and log2(FoldChange) ≥1) (PP) and downregulated peak-genes positively regulated by H3K27ac (Cor (peak-gene correlation) ≥0.5 and log2(FoldChange)≤–1) (PN), respectively; then we screened key regulatory targets mainly distributing in lipid metabolism (PCK1, APOA4, APOA1, INHBE) and apoptosis (KIT, NTRK2) together with MAPK and PPAR signaling pathway in FLHS. Intriguingly, PCK1 was also significantly covered in up-regulated super-enhancers (SEs), which further implied the vital role of PCK1 during the development of FLHS.Conclusion: Together, our studies have identified potential therapeutic biomarkers of PCK1 and elucidated novel insights into the pathogenesis of FLHS, especially for the epigenetic perspective.
The global value chain (GVC) is a new model of international commodity manufacturing and trade that provides a unique channel to obtain innovative knowledge and technology spillover. However, the ...impact mechanism of GVC embeddedness on the internal processes of the green innovation value chain (GIVC) is not clear. This study opens the “black box” of green innovation processes, which is very important for connecting resource and industrial chains. The KPWW method and the super-efficiency network SBM-DEA model (NSBM-S) are used to measure the GVC embeddedness index and GIVC efficiency, respectively. A panel model is constructed to demonstrate the multidimensional impacts of the GVC position on GIVC. The result show that mean green technology R&D efficiency is less than mean green achievement transformation efficiency; the impact of the GVC embeddedness on the GIVC efficiency is mainly reflected in the rise of the GVC position rather than the deepening of GVC participation; and the impact of the rise of the GVC position on the green technology R&D efficiency is greater than that of green achievement transformation efficiency. Without considering the greenness characteristics of intermediate output, the impact of the GVC position on the general innovation value chain will be amplified. Our conclusions are conducive to identifying the weak links in green innovation processes and provide novel empirical evidence for formulating sustainable development countermeasures in an open economy.
Nonalcoholic fatty liver disease (NAFLD) is a stress-induced liver injury related to heredity, environmental exposure and the gut microbiome metabolism. Short-chain fatty acids (SCFAs), the ...metabolites of gut microbiota (GM), participate in the regulation of hepatic steatosis and inflammation through the gut-liver axis, which play an important role in the alleviation of NAFLD. However, little progress has been made in systematically elucidating the mechanism of how SCFAs improve NAFLD, especially the epigenetic mechanisms and the potential therapeutic application as clinical treatment for NAFLD. Herein, we adopted PubMed and Medline to search relevant keywords such as ‘SCFAs’, ‘NAFLD’, ‘gut microbiota’, ‘Epigenetic’, ‘diet’, and ‘prebiotic effect’ to review the latest research on SCFAs in NAFLD up to November 2023. In this review, firstly, we specifically discussed the production and function of SCFAs, as well as their crosstalk coordination in the gut liver axis. Secondly, we provided an updated summary and intensive discussion of how SCFAs affect hepatic steatosis to alleviate NAFLD from the perspective of genetic and epigenetic. Thirdly, we paid attention to the pharmacological and physiological characteristics of SCFAs, and proposed a promising future direction to adopt SCFAs alone or in combination with prebiotics and related clinical drugs to prevent and treat NAFLD. Together, this review aimed to elucidate the function of SCFAs and provide new insights to the prospects of SCFAs as a therapeutic target for NAFLD.
In response to severe energy and environmental challenges, electric vehicles (EVs) have been thoroughly considered by governments. Although China has become the largest EV market, currently the ...limitations of EVs and decreasing subsidies have led to a challenging future. To promote EV diffusion, we use a complex network evolutionary game method to explore the dynamic impacts of government policies on EV diffusion in different scale networks. The results show that with the increase in manufacturers in the network, the degree of EV diffusion increases accordingly at the same government policy level. In the present network scale of manufacturers, on the supply side, the effects of tax and subsidy policies can respectively promote EV diffusion to 0.82 and 0.86. Fuel vehicle (FV) license plate restrictions and consumer purchase subsidies are effective policies on the demand side, which both can promote EV diffusion to 0.84. Compared with consumer purchase subsidies, production subsidies for manufacturers have better effects on EV diffusion. Neither the tax and subsidy policies nor the FV license plate restriction and EV purchase subsidy policies can realize full EV diffusion. Finally, combined with the current status of China's automobile industry, the corresponding policy recommendations for different periods are given.
•A complex network evolutionary game method is used to explore the dynamic impacts.•We consider the interactions among government, enterprises and consumers.•Production subsidies have better effects on EV diffusion than purchase subsidies.•None of these policies can realize the full diffusion of EV.•This study can bring important insights into EV policy making in China.
cAMP and mature promoting factor (MPF) play critical roles during the maturation of mammalian oocytes. The aim of this study was to produce the offspring from denuded oocytes (DOs) in mice by ...regulating cAMP and MPF.
In this study, we used DOs at the germinal vesicle (GV) stage in mice and regulated levels of cAMP and MPF in DOs by adding Forskolin and PD166285 during
maturation without follicle stimulating hormone and luteinizing hormone, respectively.
Combined use of 50 μM Forskolin for 3 h and 2.5 μM PD166285 for additional 21 h enhanced the developmental competence of DOs, maturation rate of DOs was 76.71%± 4.11%, blastocyst rate was 18.33%±4.44% after parthenogenetic activation (PA). The DOs could successfully be fertilized with sperm
, cleavage rate was 17.02%±5.82% and blastocyst rate was 5.65%±3.10%. Besides, 2-cell
fertilization embryos from DOs produced 4 normal live offspring (4/34).
The results confirmed that the combination of Forskolin and PD166285 can induce DOs to complete meiosis process and produce normal offspring.
Atmospheric resources provide important support for human economic and social systems through their unique ecosystem service functions. Implementing the off-office auditing of atmospheric resources ...for leading cadres holds great strategic significance for fundamentally solve air pollution problems. Exploring the compilation of an atmospheric resource balance sheet is a necessary pre-step in the implementation of outgoing audits. In this paper, atmospheric resources are innovatively divided into atmospheric capacity resources and atmospheric quality resources from the perspective of the ecosystem service functions of atmospheric resources. The value of atmospheric resource assets is calculated by combining the environmental capacity value method and the environmental loss evaluation method. This study evaluates atmospheric ecological achievements based on the atmospheric resources balance sheet and related accounts as the data carrier and opens up the key “blocking point” of the off-office auditing of atmospheric resources. This paper takes Anhui Province as an example and applies the accounting results of the prepared atmospheric resource balance sheet to evaluate the atmospheric resource ecological achievements of leading cadres from 2016 to 2020. The results clearly reflect the ecological achievements and shortcomings of local leading cadres during their tenure.
Global value chain (GVC) embeddedness is an irreversible development paradigm in China's manufacturing sector. However, the increasingly prominent problem of ecological deterioration has become a ...bottleneck restricting its further high-quality development. Green technological innovation is an effective way to realise cleaner production and an environmentally-friendly society. Most studies consider green technological innovation as a whole. The specific mechanism and path influences on GVC participation in green technological innovation require further clarification. This study subdivides green technology innovation into process innovation and product innovation, constructing an improved Utterback and Abernathy (A-U) technological innovation process model to reveal the mediation effect moderated by environmental regulation. Our innovative findings are as follows: Green process innovation completely mediates GVC participation and green product innovation nexus; and environmental regulation positively moderates green process innovation's mediating role between GVC participation and green product innovation. Cleaner production technology innovation completely mediates the relationship between GVC participation and green product innovation. Green process innovation partially mediates the relationship between GVC forward participation and green product innovation. Cleaner production technology innovation completely mediates GVC forward participation and green product innovation nexus. The research conclusions provide new theoretical evidence for improving GVC forward participation and giving full play to cleaner production process innovation to promote China's green and low-carbon transformation; we also offer some references for other developing countries and emerging economies.
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•We explore the impact of GVC participation on green technology innovation processes.•The impact of GVC participation on GPI is completely mediated by GTI.•The mediating effect model moderated by environmental regulation is verified.•CTI partially mediates the relationship between GVC participation and GPI.•GTI completely mediates the nexus between GVC forward participation and GPI.
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