Long non coding RNA (LncRNA) urothelial carcinoma-associated 1 (UCA1) is an oncogene in breast cancer. However, the detailed mechanism has not been fully revealed. This study explored whether UCA1 ...can directly interact with miR-143, a tumor suppressor in breast cancer and whether the UCA1-miR-143 axis is involved in regulation of cancer cell growth and apoptosis.
miRNA microarray was performed to identify the most dysregulated miRNAs between tumor and adjacent normal tissues of breast cancer. QRT-PCR analysis was performed to assess the expression of UCA1 and miR-143. The binding between UCA1 and miR-143 was verified using dual luciferase and RNA binding protein immunoprecipitation (RIP) assay. MTT assay and flow cytometry analysis were performed to study the role of UCA1-miR-143 axis in cell proliferation, cell cycle and apoptosis.
UC1 was significantly upregulated, while miR-143 was significantly downregulated in the tumor tissues than in the adjacent normal tissues. There are direct interactions between miR-143 and the miRNA recognition sites of UCA1. UCA1 is present in Ago2-containing RNA-induced silencing complex (RISC), through association with miR-143. Through downregulating miR-143, UCA1 can modulate breast cancer cell growth and apoptosis.
UCA1 can directly interact with miR-143, lower its expression and affect its downstream regulation. Therefore, the UCA1-miR-143 axis constitutes a part of the oncogenic role of UCA1 in breast cancer.
Abstract
Cyclotron line scattering features are detected in a few tens of X-ray pulsars (XRPs) and used as direct indicators of a strong magnetic field at the surface of accreting neutron stars ...(NSs). In a few cases, cyclotron lines are known to be variable with the accretion luminosity of XRPs. It is accepted that the observed variations of cyclotron line scattering features are related to variations of geometry and dynamics of accretion flow above the magnetic poles of an NS. A positive correlation between the line centroid energy and luminosity is typical for subcritical XRPs, where the accretion results in hot spots at the magnetic poles. The negative correlation was proposed to be a specific feature of bright supercritical XRPs, where radiation pressure supports accretion columns above the stellar surface. The cyclotron line in the spectra of the Be-transient XRP GRO J1008-57 is detected at energies from ∼75 to 90 keV, the highest observed energy of a cyclotron line feature in XRPs. We report the peculiar relation of cyclotron line centroid energies with luminosity in GRO J1008-57 during the Type II outburst in 2017 August observed by Insight-HXMT. The cyclotron line energy was detected to be negatively correlated with the luminosity at 3.2 × 10
37
erg s
−1
<
L
< 4.2 × 10
37
erg s
−1
and positively correlated at
L
≳ 5 × 10
37
erg s
−1
. We speculate that the observed peculiar behavior of a cyclotron line would be due to variations of accretion channel geometry.
Abstract We report the phase-resolved spectral results of the first Galactic pulsating ultraluminous X-ray source (PULX) Swift J0243.6+6124, modeling its 2017–2018 outburst peak using data collected ...by the Hard X-ray Modulation Telescope (Insight-HXMT). The broad energy coverage of Insight-HXMT allows us to obtain a more accurate spectral continuum to reduce the coupling of broad iron line profiles with other components. We use three different continuum spectrum models but obtain similar iron line results. For the first time, we detect the pulse characteristics of the broad iron line in a PULX. The variation in the width and intensity of this iron line with σ ∼ 1.2–1.5 keV has a phase offset of about 0.25 from the pulse phase. We suggest that the uneven irradiation of the thick inner disk by the accretion column produces the modulated variation of the broad iron line. In addition, the nonpulsed narrow line is suggested to come from the outer disk region.
ABSTRACT
High time resolution and accuracy are of critical importance in the studies of timing analysis and time delay localization of gamma-ray bursts (GRBs), soft gamma-ray repeaters (SGRs) and ...pulsars. The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) consisting of two micro-satellites, GECAM-A and GECAM-B, launched on 2020 December 10, is aimed at monitoring and locating X-ray and GRBs all over the sky. To achieve its scientific goals, GECAM is designed to have the highest time resolution (0.1 $\mu {\rm s}$) among all GRB detectors ever flown. Here, we make a comprehensive time calibration campaign including both on-ground and on-orbit tests to derive not only the relative time accuracy of GECAM satellites and detectors, but also the absolute time accuracy of GECAM-B. Using the on-ground calibration with a $\rm ^{22}Na$ radioactive source, we find that the relative time accuracy between GECAM-A and GECAM-B is about 0.15 $\mu {\rm s}$ (1σ). To measure the relative time accuracy between all detectors of a single GECAM satellite, cosmic-ray events detected on orbit are utilized since they could produce many secondary particles simultaneously record by multiple detectors. We find that the relative time accuracy among all detectors onboard GECAM-B is about 0.12 $\mu {\rm s}$ (1σ). Finally, we use the novel Li-CCF method to perform the absolute time calibration with Crab pulsar and SGR J1935+2154, both of which were jointly observed by GECAM-B and Fermi/GBM, and obtain that the time difference between GECAM-B and Fermi/GBM is 3.06 ± 6.04 $\mu {\rm s}$ (1σ).
Abstract
Using the observations of the high-energy detector of the Hard X-ray Modulation Telescope (Insight-HXMT) for Scorpius X-1 from 2017 to 2020, we search for hard X-ray tails in the X-ray ...spectra in ∼30–200 keV. The hard X-ray tails are found throughout the
Z
-track on the hardness–intensity diagram, and the detected hard X-ray tails become hard and weak from the horizontal branch (HB), through the normal branch (NB), to the flaring branch (FB). Comparing the hard X-ray spectra of Insight-HXMT between Cyg X-1 and Sco X-1, it is concluded that the hard X-ray spectrum of Cyg X-1 shows a high-energy cutoff, implying a hot corona in it, but the high-energy cutoff is not seen in the hard X-ray spectrum of Sco X-1. From fitting the broadband spectrum of Sco X-1 in ∼2–200 keV, it is proposed that the hard X-ray tails in the HB and NB can be explained by the overall Comptonization COMPTB model, suggesting that the hard X-ray tails could have resulted from the Comptonization of the photons from the neutron star (NS) surface by the thermal electrons in the region between the NS and the disk and the energetic electrons in the freefall toward the NS in the converging flow onto the NS. However, this model cannot be responsible for the hard X-ray tails in the FB. Further study on the FB hard X-ray tails is needed.
Abstract
Recent observations of Her X-1 with NuSTAR (as well as with INTEGRAL, Swift, and Astrosat) have provided evidence that the nearly 20 yr-long decay of the cyclotron line energy since ∼1994 ...has ended and that a stable value has replaced the decay. Using the observations of the Hard X-ray Modulation Telescope (Insight-HXMT) performed between 2017 July and 2020 February, we analyze the spectra of Her X-1 in its main-on state, focusing on tracing the evolution of cyclotron line energy. While our analysis of eight main-on observations with Insight-HXMT (two in coordination with NuSTAR) shows significant differences with the results of NuSTAR, two earlier findings are confirmed: the positive correlation between the cyclotron line energy and the X-ray flux (source luminosity) and the constancy of the flux-normalized cyclotron line energy during 2017–2020—albeit with significant uncertainty about the absolute value.
Abstract
We present detailed timing and spectral analyses of the transient X-ray pulsar RX J0209.6−7427 in the Small Magellanic Cloud during its 2019 giant outburst. With a better known distance than ...most galactic X-ray pulsars, its peak luminosity is determined to be (1.11 ± 0.06) × 10
39
erg s
−1
; it is thus a bona fide pulsating ultraluminous X-ray source (PULX). Owing to the broad energy band of Insight-HXMT, its pulsed X-ray emission was detected from 1 keV up to the 130–180 keV band, which is the highest energy emission detected from any PULXs outside the Milky Way. This allows us to conclude that its main pulsed X-ray emission is from the
fan beam
of the accretion column, and its luminosity is thus intrinsic. We also estimate its magnetic field of (4.8–8.6) × 10
12
or (1.7–2.2) × 10
13
G, from its spin evolution or transition in the accretion column structure during the outburst; we suggest that the two values of the magnetic field strength correspond to the dipole and multipole magnetic fields of the neutron star, similar to the recent discovery in the Galactic PULX Swift J0243.6+6124. Therefore, the nature of the neutron star and its ULX emission can be understood within the current theoretical frame of accreting neutron stars. This may have implications for understanding the nature of those farther away extragalactic PULXs.
Abstract
A double-peak X-ray burst from the Galactic magnetar SGR J1935+2154 was discovered to be associated with the two radio pulses of FRB 200428 separated by 28.97 ± 0.02 ms. Precise measurements ...of the timing and spectral properties of the X-ray bursts are helpful for understanding the physical origin of fast radio bursts. In this paper, we have reconstructed some information about the hard X-ray events, which were lost because the High Energy X-ray Telescope (HE) on board the Insight-HXMT mission was saturated by this extremely bright burst, and used the information to improve the temporal and spectral analyses of the X-ray burst. The arrival times of the two X-ray peaks by fitting the new Insight-HXMT/HE lightcurve with multi-Gaussian profiles are 2.77 ± 0.45 ms and 34.30 ± 0.56 ms after the first peak of FRB 200428, respectively, while these two parameters are 2.57 ± 0.52 ms and 32.5 ± 1.4 ms if the fitting profile is a fast-rise and exponential decay function. The spectrum of the two X-ray peaks could be described by a cutoff power law with cutoff energy ∼60 keV and photon index ∼1.4; the latter is softer than the result obtained in Li et al. when the two X-ray peaks appeared.
ABSTRACT
The High Energy (HE) X-ray telescope on board the Hard X-ray Modulation Telescope (Insight-HXMT) can serve as a wide field of view (FOV) gamma-ray monitor with high time resolution (μs) and ...large effective area (up to thousands cm2). We developed a pipeline to search for gamma-ray bursts (GRBs), using the traditional signal-to-noise ratio (SNR) method for blind search and the coherent search method for targeted search. By taking into account the location and spectrum of the burst and the detector response, the targeted coherent search is more powerful to unveil weak and sub-threshold bursts, especially those in temporal coincidence with gravitational wave (GW) events. Based on the original method in literature, we further improved the coherent search to filter out false triggers caused by spikes in light curves, which are commonly seen in gamma-ray instruments (e.g. Fermi/GBM, POLAR). We show that our improved targeted coherent search method could eliminate almost all false triggers caused by spikes. Based on the first two years of Insight-HXMT/HE data, our targeted search recovered 40 GRBs, which were detected by either Swift/BAT or Fermi/GBM but too weak to be found in our blind search. With this coherent search pipeline, the GRB detection sensitivity of Insight-HXMT/HE is increased to about 1.5E-08 erg cm−2 (200 keV–3 MeV). We also used this targeted coherent method to search Insight-HXMT/HE data for electromagnetic counterparts of LIGO-Virgo GW events (including O2 and O3a runs). However, we did not find any significant burst associated with GW events.
Abstract
In this paper, the multiwavelength data from radio to X-ray bands for 2709 blazars in the 4FGL-DR3 catalog are compiled to calculate their spectral energy distributions using a parabolic ...equation
log
(
ν
f
ν
)
=
P
1
log
ν
−
P
2
2
+
P
3
. Some important parameters including spectral curvature (
P
1
), synchrotron peak frequency (
P
2
,
log
ν
p
), and peak luminosity (
log
L
p
) are obtained. Based on those parameters, we discussed the classification of blazars using the “Bayesian classification” and investigated some mutual correlations. We came to the following results. (1) Based on the Bayesian classification of synchrotron peak frequencies, the 2709 blazars can be classified into three subclasses, i.e.,
log
(
ν
p
/
Hz
)
<
13.7
for low synchrotron peak blazars (LSPs),
13.7
<
log
(
ν
p
/
Hz
)
<
14.9
for intermediate synchrotron peak blazars (ISPs), and
log
(
ν
p
/
Hz
)
>
14.9
for high synchrotron peak blazars (HSPs), and there are 820 HSPs, 750 ISPs, and 1139 LSPs. (2) The
γ
-ray emission has the closest relationship with radio emission, followed by optical emission, while the weakest relationship is that with X-ray emission. The
γ
-ray luminosity is also correlated with the synchrotron peak luminosity. (3) There are strong positive correlations between the curvature (1/∣
P
1
∣) and the peak frequency (
log
ν
p
) for all subclasses (FSRQs, (high, intermediate, and low) BL Lacertae objects). For different subclasses, the correlation slopes are different, which implies that there are different acceleration mechanisms and emission processes for different subclasses of blazars.
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