Background
In a previous study, we described the distribution of coronal alignment in a normal asymptomatic population and recognized the occurrence of constitutional varus in one of four ...individuals. It is important to further investigate the influence of this condition on the joint line orientation and how the latter is affected by the onset and progression of arthritis.
Questions/purposes
The purposes of this study are (1) to describe the distribution of joint line orientation in the coronal plane in the normal population; (2) to compare joint line orientation between patients with constitutional varus and neutral mechanical alignment; and (3) to compare joint line orientation between a cohort of patients with prearthritic constitutional varus and a cohort of patients with established symptomatic varus arthritis.
Methods
Full-leg standing hip-to-ankle digital radiographs were performed in 248 young healthy individuals and 532 patients with knee arthritis. Hip-knee-ankle (HKA) angle and tibial joint line angle (TJLA) were measured in the coronal plane. Patients were subdivided into varus (HKA ≤ −3°), neutral, and valgus (HKA ≥ 3°).
Results
The mean TJLA in healthy subjects was 0.3° (SD 2.0°). TJLA was parallel to the floor in healthy subgroups with neutral alignment (TJLA 0.3°, SD 1.9) and constitutional varus (TJLA 0.2°, SD 2.2°). In patients with symptomatic arthritis and varus alignment, the TJLA opened medially (mean −1.9°, SD 3.5°).
Conclusions
Constitutional varus does not affect joint line orientation. Advanced medial arthritis causes divergence of the joint line from parallel to the floor. These findings influence decision-making for osteotomy and alignment in total knee arthroplasty.
Level of Evidence
Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
The goals of lower limb reconstruction are to restore alignment, to improve function, and to reduce pain. However, it remains unclear whether alignment of the lower limb and hindfoot are associated ...because an accurate assessment of hindfoot deformities has been limited by superposition on plain radiography. Consequently, surgeons often overlook hindfoot deformity when planning orthopaedic procedures of the lower limb. Therefore, we used weight-bearing CT to quantify hindfoot deformity related to lower limb alignment in the coronal plane.
(1) Is lower-limb alignment different in varus than in valgus hindfoot deformities for patients with and without tibiotalar joint osteoarthritis? (2) Does a hindfoot deformity correlate with lower-limb alignment in patients with and without tibiotalar joint osteoarthritis? (3) Is joint line orientation different in varus than in valgus hindfoot deformities for patients with tibiotalar joint osteoarthritis? (4) Does a hindfoot deformity correlate with joint line orientation in patients with tibiotalar joint osteoarthritis?
Between January 2015 and December 2017, one foot and ankle surgeon obtained weightbearing CT scans as second-line imaging for 184 patients with ankle and hindfoot disorders. In 69% (127 of 184 patients) of this cohort, a combined weightbearing CT and full-leg radiograph was performed when symptomatic hindfoot deformities were present. Of those, 85% (109 of 127 patients) with a median (range) age of 53 years (23 to 75) were confirmed eligible based on the inclusion and exclusion criteria of this retrospective comparative study. The Takakura classification was used to divide the cohort into patients with (n = 74) and without (n = 35) osteoarthritis of the tibiotalar joint. Lower-limb measurements, obtained from the full-leg radiographs, consisted of the mechanical tibiofemoral angle, mechanical tibia angle, and proximal tibial joint line angle. Weightbearing CT images were used to determine the hindfoot's alignment (mechanical hindfoot angle), the tibiotalar joint alignment (distal tibial joint line angle and talar tilt angle) and the subtalar joint alignment (subtalar vertical angle). These values were statistically assessed with an ANOVA and a pairwise comparison was subsequently performed with Tukey's adjustment. A linear regression analysis was performed using the Pearson correlation coefficient (r). A reliability analysis was performed using the intraclass correlation coefficient.
Lower limb alignment differed among patients with hindfoot deformity and among patients with or without tibiotalar joint osteoarthritis. In patients with tibiotalar joint osteoarthritis, we found knee valgus in presence of hindfoot varus deformity and knee varus in presence of hindfoot valgus deformity (mechanical tibiofemoral angle 0.3 ± 2.6° versus -1.8 ± 2.1°; p < 0.001; mechanical tibia angle -1.4 ± 2.2° versus -4.3 ± 1.9°; p < 0.001). Patients without tibiotalar joint osteoarthritis demonstrated knee varus in the presence of hindfoot varus deformity compared with knee valgus in presence of hindfoot valgus deformity (mechanical tibiofemoral angle -2.2 ± 2.2° versus 0.9 ± 2.4°; p < 0.001; mechanical tibia angle -1.8 ± 2.1° versus -4.3 ± 1.9°; p < 0.001). Patients with more valgus deformity in the hindfoot tended to have more tibiofemoral varus (r = -0.38) and tibial varus (r = -0.53), when tibiotalar joint osteoarthritis was present (p < 0.001). Conversely, patients with more valgus deformity in the hindfoot tended to have more tibiofemoral valgus (r = 0.4) and tibial valgus (r = 0.46), when tibiotalar joint osteoarthritis was absent (p < 0.001). The proximal joint line of the tibia had greater varus orientation in patients with a hindfoot valgus deformity compared with greater valgus orientation in patients with a hindfoot varus deformity (proximal tibial joint line angle 88.5 ± 2.0° versus 90.6 ± 2.2°; p < 0.05). Patients with more valgus deformity in the hindfoot tended to have more varus angulation of the proximal tibial joint line angle (r = 0.31; p < 0.05).
In patients with osteoarthritis of the tibiotalar joint, varus angulation of the knee was associated with hindfoot valgus deformity and valgus angulation of the knee was associated with hindfoot varus deformity. Patients without tibiotalar joint osteoarthritis exhibited the same deviation at the level of the knee and hindfoot. These distinct radiographic findings were most pronounced in the alignment of the tibia relative to the hindfoot deformity. This suggests a detailed examination of hindfoot alignment before knee deformity correction at the level of the proximal tibia, to avoid postoperative increase of pre-existing hindfoot deformity. Other differences detected between the radiographic parameters were less pronounced and varied within the subgroups. Future research could identify prospectively which of these parameters contain clinical relevance by progressing osteoarthritis or deformity and how they can be altered by corrective treatment.
Level III, prognostic study.
A core tenet of total knee arthroplasty (TKA) is that achieving more natural kinematics will lead to superior patient outcomes. Yet this relationship has not been proven for large representative ...cohorts of TKA patients because accurately measuring 3-dimensional TKA kinematics is time-consuming and expensive. But advanced imaging systems and machine learning–enhanced analysis software will soon make it practical to measure knee kinematics preoperatively and postoperatively in the clinic using radiographic methods. The purpose of this study was to assess the reported relationships between TKA kinematics and outcomes and distill those findings into a proposal for a clinically practical protocol for a clinical kinematic exam.
This study reviewed the recent literature relating TKA kinematics to patient outcomes. There were 10 studies that reported statistical associations between TKA kinematics and patient outcome scores utilizing a range of functional activities. We stratified these activities by the complexity of the radiographic examination to create a proposed examination protocol, and we generated a list of requirements and characteristics for a practical TKA clinical kinematic examination.
Given considerations for a clinically practical kinematic exam, including equipment, time and other resources, we propose 3 exam levels. With basic radiographs, we suggest studying single-leg stance in extension, lunge or squat, and kneeling. For fluoroscopic systems with X-ray pulses up to 20 ms, we propose chair-rise or stair ascent to provide additional dynamic information. For fluoroscopic systems with X-ray pulses of less than 10 ms, we propose rapid open-chain knee flexion-extension to simulate the highly dynamic swing phase of gait.
It is our hope that this proposed examination protocol spurs discussion and debate so that there can be a consensus approach to clinical examination of knee and TKA kinematics when the rapidly advancing hardware and software capabilities are in place to do so.
In patients with chronic heart failure (HF), the MONITOR-HF trial demonstrated the efficacy of pulmonary artery (PA)-guided HF therapy over standard of care in improving quality of life and reducing ...HF hospitalizations and mean PA pressure. This study aimed to evaluate the consistency of these benefits in relation to clinically relevant subgroups.
The effect of PA-guided HF therapy was evaluated in the MONITOR-HF trial among predefined subgroups based on age, sex, atrial fibrillation, diabetes mellitus, left ventricular ejection fraction, HF aetiology, cardiac resynchronisation therapy, and implantable cardioverter defibrillator. Outcome measures were based upon significance in the main trial and included quality of life, clinical, and PA pressure endpoints, and were assessed for each subgroup. Differential effects in relation to the subgroups were assessed with interaction terms. Both unadjusted and multiple testing adjusted interaction terms were presented.
The effects of PA monitoring on quality of life, clinical events, and PA pressure were consistent in the predefined subgroups, without any clinically relevant heterogeneity within or across all endpoint categories (all adjusted interaction P-values were nonsignificant). In the unadjusted analysis of the primary endpoint quality-of-life change, weak trends towards a less pronounced effect in older patients (Pinteraction = 0.03; adjusted Pinteraction = 0.33) and diabetics (Pinteraction = 0.01; adjusted Pinteraction = 0.06) were observed. However, these interaction effects did not persist after adjusting for multiple testing.
This subgroup analysis confirmed the consistent benefits of PA-guided HF therapy observed in the MONITOR-HF trial across clinically relevant subgroups, highlighting its efficacy in improving quality of life, clinical, and PA pressure endpoints in chronic HF patients.
European results of assisted reproductive techniques from treatments initiated during 2001 are presented in this fifth report. Data were collected mainly from already existing national registers. ...From 23 countries, 579 clinics reported 289 690 cycles with: IVF 120 946, ICSI 114 378, frozen embryo transfer (FER) 47 195 and egg donation (ED) 7171. Overall this represents a 4% increase since the year 2000. For the first time, results on European data on intra-uterine inseminations (IUIs) were reported from 15 countries. A total of 67 124 cycles IUI husband'sperm (IUI-H) 52 949 and IUI donor sperm (IUI-D) 14 185 were included. In 12 countries where all clinics reported to the register, a total of 108 910 cycles were performed in a population of 131.4 million, corresponding to 829 cycles per million inhabitants. For IVF, the clinical pregnancy rate per aspiration and per transfer was 25.1 and 29.0%, respectively. For ICSI, the corresponding rates were 26.2 and 28.3%. These figures are similar to the results from 2000. After IUI-H, the clinical pregnancy rate was 12.8% in women <40 and 9.7% in women ≥40 years of age. After IVF and ICSI, the distribution of transfer of one, two, three and ≥4 embryos was 12.0, 51.7, 30.8 and 5.5%, respectively. Compared with the year 2000, fewer embryos were transferred, but huge differences existed between countries. The distribution of singleton, twin and triplet deliveries for IVF and ICSI combined was 74.5, 24.0 and 1.5%, respectively. This gives a total multiple delivery rate of 25.5%, compared with 26.9% in the year 2000. The range of triplet deliveries after IVF and ICSI differed from 0.0 to 8.2% between countries. After IUI-H in women <40 years of age, 10.2% were twin and 1.1% were triplet gestations.
Total Knee Arthroplasty Bellemans, Johan; Ries, Michael D; Victor, Jan M. K
2005, 2004-12-31
eBook
"Take away my knee pain and give me better motion". This is what the arthritic patient expects from a Total Knee Arthroplasty (TKA). By virtue of standardization of the TKA procedure, surgeons can ...nowadays solve the pain issue for the majority of the patients.
Restoration of function is a goal of a different order and forms the scope of this book. The editors confronted today's leading knee surgeons with the limitations of current surgical techniques and technology. They challenged them to define new thresholds of functional capacity after Total Knee Arthroplasty. "A Guide to Get Better Performance in TKA" describes the cutting edge in surgical techniques, prosthetic design and achievement of excellent function for these patients.
Background Remodeling biomarkers carry high potential for predicting adverse events in chronic heart failure ( CHF ) patients. However, temporal patterns during the course of CHF , and especially the ...trajectory before an adverse event, are unknown. We studied the prognostic value of temporal patterns of 14 cardiac remodeling biomarker candidates in stable patients with CHF from the Bio-SHiFT (Serial Biomarker Measurements and New Echocardiographic Techniques in Chronic Heart Failure Patients Result in Tailored Prediction of Prognosis) study. Methods and Results In 263 CHF patients, we performed trimonthly blood sampling during a median follow-up of 2.2 years. For the analysis, we selected all baseline samples, the 2 samples closest to the primary end point ( PE ), or the last sample available for end point-free patients. Thus, in 567 samples, we measured suppression of tumorigenicity-2, galectin-3, galectin-4, growth differentiation factor-15, matrix metalloproteinase-2, 3, and 9, tissue inhibitor metalloproteinase-4, perlecan, aminopeptidase-N, caspase-3, cathepsin-D, cathepsin-Z, and cystatin-B. The PE was a composite of cardiovascular mortality, heart transplantation, left ventricular assist device implantation, and HF hospitalization. Associations between repeatedly measured biomarker candidates and the PE were investigated by joint modeling. Median age was 68 (interquartile range: 59-76) years with 72% men; 70 patients reached the PE . Repeatedly measured suppression of tumorigenicity-2, galectin-3, galectin-4, growth differentiation factor-15, matrix metalloproteinase-2 and 9, tissue inhibitor metalloproteinase-4, perlecan, cathepsin-D, and cystatin-B levels were significantly associated with the PE , and increased as the PE approached. The slopes of biomarker trajectories were also predictors of clinical outcome, independent of their absolute level. Associations persisted after adjustment for clinical characteristics and pharmacological treatment. Suppression of tumorigenicity-2 was the strongest predictor (hazard ratio: 7.55 per SD difference, 95% CI : 5.53-10.30), followed by growth differentiation factor-15 (4.06, 2.98-5.54) and matrix metalloproteinase-2 (3.59, 2.55-5.05). Conclusions Temporal patterns of remodeling biomarker candidates predict adverse clinical outcomes in CHF . Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 01851538.
The major fallout of radionuclides from the nuclear power station accident at Chernobyl on 26 April, 1986, occurred in regions of Ukraine and Belarus that are believed to be moderately deficient in ...dietary iodine. On 17 November, 2000, in conjunction with the Ukraine-Belarus-USA study of developing thyroid disease in a cohort of individuals exposed as children, a workshop was held to review what is known about iodine nutrition in the region, how this might influence the risk of thyroid tumor formation from radioiodine, and whether and how iodine nutrition should be monitored in this long-term project. This report is a summary of the workshop proceedings. Although no precise information about iodine intake in 1986 was found, the prevalence of mild goiter in the region's children suggested iodine deficiency and urinary iodine measurements begun in 1990 indicated that mild to moderate deficiency existed. Increased thyroid iodine uptake and increased thyroid size in 1986 resulting from iodine deficiency would have had counteracting influence on the thyroid radiation dose and knowledge of these parameters is required for dose reconstruction. More problematic is the possible role of iodine deficiency in the years following the accident. Theoretically, the resulting increase in thyroid cellular activity might increase the risk of tumorigenesis but experimental or clinical evidence supporting this hypothesis is meager or absent. Despite this limitation it was considered important to monitor iodine nutrition in the cohort subjects in relation to their place of residence and over time. Methods to accomplish this were discussed.
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