Anomaly detection in the Open Supernova Catalog Pruzhinskaya, M V; Malanchev, K L; Kornilov, M V ...
Monthly notices of the Royal Astronomical Society,
08/2019, Volume:
489, Issue:
3
Journal Article
Peer reviewed
ABSTRACT
In the upcoming decade, large astronomical surveys will discover millions of transients raising unprecedented data challenges in the process. Only the use of the machine learning algorithms ...can process such large data volumes. Most of the discovered transients will belong to the known classes of astronomical objects. However, it is expected that some transients will be rare or completely new events of unknown physical nature. The task of finding them can be framed as an anomaly detection problem. In this work, we perform for the first time an automated anomaly detection analysis in the photometric data of the Open Supernova Catalog (OSC), which serves as a proof of concept for the applicability of these methods to future large-scale surveys. The analysis consists of the following steps: (1) data selection from the OSC and approximation of the pre-processed data with Gaussian processes, (2) dimensionality reduction, (3) searching for outliers with the use of the isolation forest algorithm, and (4) expert analysis of the identified outliers. The pipeline returned 81 candidate anomalies, 27 (33 per cent) of which were confirmed to be from astrophysically peculiar objects. Found anomalies correspond to a selected sample of 1.4 per cent of the initial automatically identified data sample of approximately 2000 objects. Among the identified outliers we recognized superluminous supernovae, non-classical Type Ia supernovae, unusual Type II supernovae, one active galactic nucleus and one binary microlensing event. We also found that 16 anomalies classified as supernovae in the literature are likely to be quasars or stars. Our proposed pipeline represents an effective strategy to guarantee we shall not overlook exciting new science hidden in the data we fought so hard to acquire. All code and products of this investigation are made publicly available.1
ABSTRACT
We present results from applying the SNAD anomaly detection pipeline to the third public data release of the Zwicky Transient Facility (ZTF DR3). The pipeline is composed of three stages: ...feature extraction, search of outliers with machine learning algorithms, and anomaly identification with followup by human experts. Our analysis concentrates in three ZTF fields, comprising more than 2.25 million objects. A set of four automatic learning algorithms was used to identify 277 outliers, which were subsequently scrutinized by an expert. From these, 188 (68 per cent) were found to be bogus light curves – including effects from the image subtraction pipeline as well as overlapping between a star and a known asteroid, 66 (24 per cent) were previously reported sources whereas 23 (8 per cent) correspond to non-catalogued objects, with the two latter cases of potential scientific interest (e.g. one spectroscopically confirmed RS Canum Venaticorum star, four supernovae candidates, one red dwarf flare). Moreover, using results from the expert analysis, we were able to identify a simple bi-dimensional relation that can be used to aid filtering potentially bogus light curves in future studies. We provide a complete list of objects with potential scientific application so they can be further scrutinised by the community. These results confirm the importance of combining automatic machine learning algorithms with domain knowledge in the construction of recommendation systems for astronomy. Our code is publicly available.1
•Dopamine transporter knockout rats are able to be trained in an eight-arm radial maze.•Dopamine transporter knockout rats have pronounced impairment of working memory.•Dopamine transporter knockout ...rats during training use different behavioral tactics incomparison with wild type rats.•Dopamine transporter knockout rats demonstrate pronounced perseverative patterns oflocomotor activity during training.
Understanding the role of the dopamine system in learning and memory processes is very important for uncovering central mechanisms underlying complex behavioral responses that can be impaired in patients with neuropsychiatric disorders caused by dopamine system dysfunction. One of the most useful animal models for dopaminergic dysregulation is the strain of dopamine transporter knockout (DAT-KO) rats that have no dopamine re-uptake and thus elevated extracellular dopamine levels. It is known that dopamine is involved in various cognitive processes such as learning, memory and attention. This investigation was focused on the ability of DAT-KO rats to learn and perform a behavioral task in the 8-arm radial maze test. It was found that DAT-KO rats are able to learn the behavioral task, but the level of task performance did not reach that of WT group. The behavioral tactics used by animals during training significantly differ in mutants. The behavioral tactics used by DAT-KO rats involved perseverations and resulted in worse task fulfillment in comparison to wild-type controls. The data obtained indicate that deficient dopamine reuptake results in an impairment of working memory and perseverative behavioral tactics in DAT-KO rats.
Aims. We present the first piece of evidence that adaptive learning techniques can boost the discovery of unusual objects within astronomical light curve data sets. Methods. Our method follows an ...active learning strategy where the learning algorithm chooses objects that can potentially improve the learner if additional information about them is provided. This new information is subsequently used to update the machine learning model, allowing its accuracy to evolve with each new piece of information. For the case of anomaly detection, the algorithm aims to maximize the number of scientifically interesting anomalies presented to the expert by slightly modifying the weights of a traditional isolation forest (IF) at each iteration. In order to demonstrate the potential of such techniques, we apply the Active Anomaly Discovery algorithm to two data sets: simulated light curves from the Photometric LSST Astronomical Time-series Classification Challenge (PLAsTiCC) and real light curves from the Open Supernova Catalog. We compare the Active Anomaly Discovery results to those of a static IF. For both methods, we performed a detailed analysis for all objects with the ∼2% highest anomaly scores. Results. We show that, in the real data scenario, Active Anomaly Discovery was able to identify ∼80% more true anomalies than the IF. This result is the first piece of evidence that active anomaly detection algorithms can play a central role in the search for new physics in the era of large-scale sky surveys.
We present our observations of electromagnetic transients associated with GW170817/GRB 170817A using optical telescopes of Chilescope observatory and Big Scanning Antenna (BSA) of Pushchino Radio ...Astronomy Observatory at 110 MHz. The Chilescope observatory detected an optical transient of ∼19m on the third day in the outskirts of the galaxy NGC 4993; we continued observations following its rapid decrease. We put an upper limit of 1.5 × 104 Jy on any radio source with a duration of 10-60 s, which may be associated with GW170817/GRB 170817A. The prompt gamma-ray emission consists of two distinctive components-a hard short pulse delayed by ∼2 s with respect to the LIGO signal and softer thermal pulse with T ∼ 10 keV lasting for another ∼2 s. The appearance of a thermal component at the end of the burst is unusual for short GRBs. Both the hard and the soft components do not satisfy the Amati relation, making GRB 170817A distinctively different from other short GRBs. Based on gamma-ray and optical observations, we develop a model for the prompt high-energy emission associated with GRB 170817A. The merger of two neutron stars creates an accretion torus of ∼10−2 M , which supplies the black hole with magnetic flux and confines the Blandford-Znajek-powered jet. We associate the hard prompt spike with the quasispherical breakout of the jet from the disk wind. As the jet plows through the wind with subrelativistic velocity, it creates a radiation-dominated shock that heats the wind material to tens of kiloelectron volts, producing the soft thermal component.
We report the automatic detection of 11 transients (7 possible supernovae and 4 active galactic nuclei candidates) within the Zwicky Transient Facility fourth data release (ZTF DR4), all of them ...observed in 2018 and absent from public catalogs. Among these, three were not part of the ZTF alert stream. Our transient mining strategy employs 41 physically motivated features extracted from both real light curves and four simulated light curve models (SN Ia, SN II, TDE, SLSN-I). These features are input to a k-D tree algorithm, from which we calculate the 15 nearest neighbors. After pre-processing and selection cuts, our dataset contained approximately a million objects among which we visually inspected the 105 closest neighbors from seven of our brightest, most well-sampled simulations, comprising 89 unique ZTF DR4 sources. Our result illustrates the potential of coherently incorporating domain knowledge and automatic learning algorithms, which is one of the guiding principles directing the SNAD team. It also demonstrates that the ZTF DR is a suitable testing ground for data mining algorithms aiming to prepare for the next generation of astronomical data.
Cardiotonic steroids (CTSs), such as digoxin, are used for heart failure treatment. However, digoxin permeates the brain-blood barrier (BBB), affecting central nervous system (CNS) functions. Finding ...a CTS that does not pass through the BBB would increase CTSs' applicability in the clinic and decrease the risk of side effects on the CNS. This study aimed to investigate the tissue distribution of the CTS ouabain following intraperitoneal injection and whether ouabain passes through the BBB. After intraperitoneal injection (1.25 mg/kg), ouabain concentrations were measured at 5 min, 15 min, 30 min, 1 h, 3 h, 6 h, and 24 h using HPLC-MS in brain, heart, liver, and kidney tissues and blood plasma in C57/black mice. Ouabain was undetectable in the brain tissue. Plasma: C
= 882.88 ± 21.82 ng/g; T
= 0.08 ± 0.01 h; T
= 0.15 ± 0.02 h; MRT = 0.26 ± 0.01. Cardiac tissue: C
= 145.24 ± 44.03 ng/g (undetectable at 60 min); T
= 0.08 ± 0.02 h; T
= 0.23 ± 0.09 h; MRT = 0.38 ± 0.14 h. Kidney tissue: C
= 1072.3 ± 260.8 ng/g; T
= 0.35 ± 0.19 h; T
= 1.32 ± 0.76 h; MRT = 1.41 ± 0.71 h. Liver tissue: C
= 2558.0 ± 382.4 ng/g; T
= 0.35 ± 0.13 h; T
= 1.24 ± 0.7 h; MRT = 0.98 ± 0.33 h. Unlike digoxin, ouabain does not cross the BBB and is eliminated quicker from all the analyzed tissues, giving it a potential advantage over digoxin in systemic administration. However, the inability of ouabain to pass though the BBB necessitates intracerebral administration when used to investigate its effects on the CNS.
Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace ...amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its localization, we observed TAAR5 expression in the Purkinje cells of the cerebellum and the medial vestibular nucleus, suggesting that TAAR5 might be involved in the vestibular and motor control. Accordingly, in various behavioral tests, TAAR5-KO mice demonstrated lower endurance, but better coordination and balance compared to wild-type controls. Furthermore, we found specific changes in striatal local field potentials and motor cortex electrocorticogram, such as a decrease in delta and an increase in theta oscillations of power spectra, respectively. The obtained data indicate that TAAR5 plays a considerable role in regulation postural stability, muscle force, balance, and motor coordination during active movements, likely via modulation of monoaminergic systems at different levels of sensorimotor control involving critical brain areas such as the brainstem, cerebellum, and forebrain.
Using electrocorticogram (ECoG) analysis, we compared age-related dynamics of general neuronal activity and convulsive epileptiform responsiveness induced by intracortical microinjections of ...4-aminopyridine (4-AP) in control Wistar rats and those subjected to prenatal hypoxia (Hx; E14; 7% O2, 3 h). The studies were carried out in three age periods roughly corresponding to childhood (P20-27), adolescence (P30-45), and adulthood (P90-120). It was found that in the process of postnatal development of the control rats, the peak of the ECoG power spectrum density (PSD) of the theta rhythm during wakefulness shifted from the low to the higher frequency, while in the Hx rats this shift had the opposite direction. Moreover, the Hx rats had different frequency characteristics of the ECoG PSD and longer episodes of spike-and-wave discharges caused by 4-AP injections compared to the controls. The total ECoG PSD of slow-wave sleep (1-5 Hz) was also dramatically decreased in the process of development of the Hx rats. Such alterations in PSD could be explained by the changes in balance of the excitation and inhibition processes in the cortical networks. Analyzing protein levels of neurotransmitter transporters in the brain structures of the Hx rats, we found that the content of the glutamate transporter EAAT1 was higher in the parietal cortex in all age groups of Hx rats while in the hippocampus it decreased during postnatal development compared to controls. Furthermore, the content of the vesicular acetylcholine transporter in the parietal cortex, and of the inhibitory GABA transporter 1 in the hippocampus, was also affected by prenatal Hx. These data suggest that prenatal Hx results in a shift in the excitatory and inhibitory balance in the rat cortex towards excitation, making the rat's brain more vulnerable to the effects of proconvulsant drugs and predisposing animals to epileptogenesis during postnatal life.
Neurophotonic technology is a rapidly growing group of techniques that are based on the interactions of light with natural or genetically modified cells of the neural system. New optical technologies ...make it possible to considerably extend the tools of neurophysiological research, from the visualization of functional activity changes to control of brain tissue excitability. This opens new perspectives for studying the mechanisms underlying the development of human neurological diseases. Epilepsy is one of the most common brain disorders; it is characterized by recurrent seizures and affects >1% of the world's population. However, how seizures occur, spread, and terminate in a healthy brain is still unclear. Therefore, it is extremely important to develop appropriate models to accurately explore the causal relationship of epileptic activity. The use of neurophotonic technologies in epilepsy research falls into two broad categories: the visualization of neural epileptic activity, and the direct optical influence on neurons to induce or suppress epileptic activity. An optogenetic variant of the classical kindling model of epileptic seizures, in which activatable cells are genetically defined, is called optokindling. Research is also underway concerning the application of neurophotonic techniques for suppressing epileptic activity, aiming to bring these methods into clinical practice. This review aims to systematize and describe new approaches that use combinations of different neurophotonic methods to work with in vivo models of epilepsy. These approaches overcome many of the shortcomings associated with classical animal models of epilepsy and thus increase the effectiveness of developing new diagnostic methods and antiepileptic therapy.