In normal operation, doubly-fed induction generator (DFIG) can generate certain range of reactive power and the DFIG based wind farm can participate in reactive power control of grid as a reactive ...power supply. This paper proposes one multi-objective power dispatch optimization model which considers copper loss minimization of all DFIGs in wind farm and maximization reactive power margin of every DFIG. The active power and reactive power generated by wind farm can meet the power gird requirements of both active power and reactive power. This wind farm power dispatch model will cause more economic benefit and bring more reactive power margin to every DFIG. The advantages and validity of the proposed method have been verified in the case study.
Type 2 diabetes mellitus (T2DM) is a common metabolic disease influenced by both genetic and environmental factors. In this study, we performed an in-house genotyping and meta-analysis study using ...three independent GWAS datasets of T2DM and found that rs3743121, located 1 kb downstream of AQR, was a novel susceptibility SNP associated with T2DM. The risk allele C of rs3743121 was correlated with the increased expression of AQR in white blood cells, similar to that observed in T2DM models. The knockdown of AQR in HepG2 facilitated the glucose uptake, decreased the expression level of PCK2, increased the phosphorylation of GSK-3β, and restored the insulin sensitivity. Furthermore, the suppression of AQR inhibited the mTOR pathway and the protein ubiquitination process. Our study suggests that AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism.
In this paper, a novel slot-ring coupling antenna with reconfigurable circular polarization is presented. The antenna consists of Wilkinson power divider and a slot-ring with perturbations. By ...controlling the states of the switches, the antenna can achieve right-hand circular polarization (RHCP), left-hand circular polarization (LHCP) in the same direction, respectively. The proposed antenna is designed and simulated using Ansoft HFSS. The measured results of the fabricated antenna are in good agreement with the simulated. Both measured and simulated results of the antenna are presented and discussed.
The CXC chemokine CXCL12 and its cognate receptor CXCR4 play an important role in inflammation, human immunodeficiency virus (HIV) infection and cancer metastasis. The signal transduction and ...intracellular trafficking of CXCR4 are involved in these functions, but the underlying mechanisms remain incompletely understood. In the present study, we demonstrated that the CXCR4 formed a complex with the cytolinker protein plectin in a ligand-dependent manner in HEK293 cells stably expressing CXCR4. The glutathione-
S-transferase (GST)–CXCR4 C-terminal fusion proteins co-precipitated with the full-length and the N-terminal fragments of plectin isoform 1 but not with the N-terminal deletion mutants of plectin isoform 1, thereby suggesting an interaction between the N-terminus of plectin and the C-terminus of CXCR4. This interaction was confirmed by confocal microscopic reconstructions showing co-distribution of these two proteins in the internal vesicles after ligand-induced internalization of CXCR4 in HEK293 cells stably expressing CXCR4. Knockdown of plectin with RNA interference (RNAi) significantly inhibited ligand-dependent CXCR4 internalization and attenuated CXCR4-mediated intracellular calcium mobilization and activation of extracellular signal regulated kinase 1/2 (ERK1/2). CXCL12-induced chemotaxis of HEK293 cells stably expressing CXCR4 and of Jurkat T cells was inhibited by the plectin RNAi. Moreover, CXCR4 tropic HIV-1 infection in MAGI (HeLa-CD4-LTR-Gal) cells was inhibited by the RNAi of plectin. Thus, plectin appears to interact with CXCR4 and plays an important role in CXCR4 signaling and trafficking and HIV-1 infection.
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