Text recognition in nature scene is currently applied in various intelligence equipment. The first step of text recognition is to precisely locate the text. In the Pixel Link text location methods, ...there are mainly two problems: too much background information is incorporated in the text region, and the test accuracy is insufficient. Aiming at these issues, an improved text location method was proposed to precisely locate the text in the natural scene. At first, an attention mechanism was incorporated into the original network. By focusing on the weight relationship between feature channels in the generated feature map, one can improve the weight coefficient of effective feature channels, and suppress the weight of inefficient or invalid feature channels. In the second, by changing the form of data set annotation, the coordinate points can be expressed as a series of sequence forms, so that the text lines can be framed adaptively in the LSTM model. At last, the located object is rotated according to the angle
This systematic review and meta-analysis aimed to examine the risk of second primary cancers (SPCs) among retinoblastoma (Rb) patients, both hereditary and nonhereditary. Previous studies have ...reported on the long-term risk of SPCs in these patient populations, but a comprehensive synthesis of the existing evidence is lacking.
A systematic search was conducted in PubMed, EMBASE, and Cochrane Library from inception to 12 March 2023, supplemented by manual screening. Eligible studies were identified, and data were extracted. The primary outcome measure was the standardized incidence ratios (SIRs) of SPCs in Rb patients. Summary estimates were calculated using random or fixed effects models. The quality of included studies was assessed using the Newcastle-Ottawa Scale.
Ten studies, including nine high-quality studies, were included in this review. The summary estimate of SIR for SPCs among hereditary Rb patients was 17.55 (95% CI=13.10-23.51), while the pooled estimate of SIR for SPCs among nonhereditary Rb patients was 1.36 (95% CI=0.90-2.04). Significant differences in SIRs for different SPC types were observed (P=0.028), including nasal cavity tumor (SIR=591.06, 95% CI=162.79-2146.01), bone tumor (SIR=442.91, 95% CI=191.63-1023.68), soft tissue sarcoma (SIR=202.93, 95% CI=114.10-360.93), CNS (SIR=12.84, 95% CI=8.80-18.74), and female breast cancer (SIR=3.68, 95% CI=2.52-5.37). Chemotherapy and radiation therapy were associated with an increased risk of SPCs among hereditary Rb patients.
The findings of this review indicate that hereditary Rb patients have a significantly elevated risk of developing SPCs, whereas nonhereditary Rb patients do not show the same risk. Furthermore, significant differences were observed in the SIRs of different SPC types. Treatment techniques, specifically chemotherapy and radiation therapy, were associated with an increased risk of SPCs among hereditary Rb patients. These findings highlight the importance of radiation protection for Rb patients and the need for further research and tailored management strategies for this high-risk population.
Minichromosome maintenance protein 10 (MCM10) is essential for eukaryotic DNA replication. Here, we describe compound heterozygous MCM10 variants in patients with distinctive, but overlapping, ...clinical phenotypes: natural killer (NK) cell deficiency (NKD) and restrictive cardiomyopathy (RCM) with hypoplasia of the spleen and thymus. To understand the mechanism of MCM10-associated disease, we modeled these variants in human cell lines. MCM10 deficiency causes chronic replication stress that reduces cell viability due to increased genomic instability and telomere erosion. Our data suggest that loss of MCM10 function constrains telomerase activity by accumulating abnormal replication fork structures enriched with single-stranded DNA. Terminally-arrested replication forks in MCM10-deficient cells require endonucleolytic processing by MUS81, as MCM10:MUS81 double mutants display decreased viability and accelerated telomere shortening. We propose that these bi-allelic variants in MCM10 predispose specific cardiac and immune cell lineages to prematurely arrest during differentiation, causing the clinical phenotypes observed in both NKD and RCM patients.
A hysteresis space vector pulse width modulation (SVPWM) reconfigurable fault-tolerant method for single-phase voltage source multi-level inverter with current tracking is proposed. Firstly, the ...influence of single switch open circuit fault and double switches open circuit fault on the voltage vector of the inverter is analyzed, and on this basis, the equivalent replacement of the voltage vector is obtained by using the topology reconstruction of the inverter, and the redundant voltage vectors with overlapping positions are preferred for equivalent replacement. If there are no coincident non-fault vectors, the other non-fault vectors with the closest position and effect are selected. The fault-tolerant method does not need the switching operation between the main power switching device and spare power switching device of the inverter, and can directly control the on–off process of the inverter reconfiguration unit through the driving signal of insulated gate bipolar translator (IGBT), which is simple and stable. Under the conditions of single switch open circuit and most double switches open circuit, the output current of the inverter can accurately track the reference current.
The development of cathode catalysts with a porous structure is essential to design Li-O2 batteries with a high rate performance and good cycle stability. Herein, spinel-type porous cobalt-manganese ...oxide (Co-Mn-O) nanocubes derived from metal organic frameworks were employed as an electrocatalyst in a Li-O2 battery. The battery with the porous Co-Mn-O nanocubes electrode showed a low overpotential and enhanced capacity. The synergistic effects of large specific surface area, porous structure, and the high electrocatalytic activity of the porous Co-Mn-O nanocubes electrode endowed the Li-O2 battery with a good rate performance and excellent cycle stability up to 100 cycles.
For the separation problem at small and medium angles of attack, in the early stage of DDES (Delayed Detached Eddy Simulation) method, it takes some time for the flow separation region to develop, ...and usually delays the switch from RANS mode to LES mode, so as to underestimate the flow separation. An improved RANS-LES hybrid length scale method is adopted to modify the grid scale and vortex tilting measure (VTM) function in this paper. Based on open source CFD software OpenFOAM, the modified hybrid grid scale, vortex tilting measure(VTMnew) function and two-dimensional shear layer identification function FKH(VTMnew)are implanted into the S-A DDES model to study the flow around NACA0012 airfoil at high angle of attack and NACA0012 half span rectangular wing at angle of attack 12°. The vortex structure and tip vortex in the leeward region of the wing calculated by the original S-A DDES and the S-A DDES turbulence model with improved RANS-LES mixing length scale are compared. The results show that the rapid inst
Wide band gap γ-CuI is a p-type transparent semiconductor with excellent optoelectronic and thermoelectric property, which has recently attracted worldwide attention. However, as an emerging ...material, its luminescence mechanism that is impacted by defects is rarely reported and remains obscure, limiting its further applications. In this work, Cl-doped CuI film was prepared by gas-phase reaction method. Using cathodoluminescence spectroscopy, effects of Cl doping on the surface morphology and cathodoluminescence property of CuI films were investigated in detail, and main defects of Cl presence in CuI films were explored by combining first-principle calculations, revealing relationship between structure and luminescent property of Cl-doped CuI films. These data showed Cl-doped region had a smoother surface than that of the undoped region with granular morphology, which clearly demonstrated that Cl dopant altered surface structure of the undoped region. Compared with the undoped region, the Cl dopant induced dou
Covalent modification of histones is important in regulating chromatin dynamics and transcription. One example of such modification is ubiquitination, which mainly occurs on histones H2A and H2B. ...Although recent studies have uncovered the enzymes involved in histone H2B ubiquitination and a 'cross-talk' between H2B ubiquitination and histone methylation, the responsible enzymes and the functions of H2A ubiquitination are unknown. Here we report the purification and functional characterization of an E3 ubiquitin ligase complex that is specific for histone H2A. The complex, termed hPRC1L (human Polycomb repressive complex 1-like), is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2. hPRC1L monoubiquitinates nucleosomal histone H2A at lysine 119. Reducing the expression of Ring2 results in a dramatic decrease in the level of ubiquitinated H2A in HeLa cells. Chromatin immunoprecipitation analysis demonstrated colocalization of dRing with ubiquitinated H2A at the PRE and promoter regions of the Drosophila Ubx gene in wing imaginal discs. Removal of dRing in SL2 tissue culture cells by RNA interference resulted in loss of H2A ubiquitination concomitant with derepression of Ubx. Thus, our studies identify the H2A ubiquitin ligase, and link H2A ubiquitination to Polycomb silencing.
High-performance polymer dielectrics are critical for high-tech fields such as electrical insulation and aerospace. Nevertheless, it is still challenging to achieve simultaneous improvements in both ...dielectric constant and breakdown strength in polymer dielectrics. In this work, Al3+ substitution Si4+ in SiO2 by high-temperature sintering to create hole traps to obtain the acceptor-doped fillers Si1-0.75xAlxO2 (SA (x mol%)), and polyimide (PI) dielectric containing SA fillers with different contents were synthesized using in-situ polymerization. The hole traps in the fillers modulate the electrical behavior of the polymer dielectric, thereby significantly increasing the dielectric constant and breakdown strength by modulating the polarization behavior and capture carriers. Among them, the dielectric constant of the 1.25 vol% SA (1.5 mol%)/PI composite was increased to 3.60 at 1 Hz, and the breakdown strength Eb reached 581.5 kV/mm. This work provides a new synthesis strategy for simultaneously achieving high insulation and high polarization of polymer dielectric.
•The Si1-0.75xAlxO2 fillers were synthesized via ball-milling and sintering methods.•Composite achieve an incredible breakdown strength, which is 2 times of pure PI.•Regulating the content of traps in SiO2 via the acceptor-doped.•A strategy to simultaneously enhance insulation and polarization was proposed.
The diagenetic alteration of rhythmic successions remains one of the main challenges in paleoclimatology and cyclostratigraphy. To address this very important problem, thin sections and geochemical ...data of the limestone-marl alternations from Middle Permian carbonate successions in South China are examined to identify differential diagenetic effects in the petrography, organic and inorganic compositions, strontium concentrations and stable isotopic compositions of limestone beds and marl interlayers. In the Lengshuixi outcrop and the JY66-1 drill core, the most conspicuous features are that the limestone beds exhibit dense cementation, high strontium concentrations, negative oxygen isotopic values and positive carbon isotopic values. In contrast, the marl interlayers contain talc and exhibit strongly deformed and oriented bioclasts, low strontium concentrations, positive oxygen isotopic values and negative carbon isotopic values.
Although differential diagenesis has occurred, some paleoclimate proxies (e.g., computed gamma-ray values) still preserve their primary signals and thus are suitable for cyclostratigraphic research. Eccentricity rhythm and millennial-scale rhythm are obviously recorded in Middle Permian limestone-marl alternations in South China. The variations in the oxygen and carbon isotopic values of limestone-marl alternations from different basins represent responses to different processes of differential diagenesis. This knowledge assumes that differential diagenesis occurs in diagenetically closed systems under the deep sea-floor. However, this assumption may not be valid in diagenetically open systems, where exotic fluids may add unexpected disturbances. Hence, it is crucial to understand diagenetic systems by determining the variations in strontium concentrations, which are as important as variations in carbon and oxygen isotopic values.
•Although the differential diagenesis occurred, some primary signals are still preserved.•Dissolution-reprecipitation of CaCO3 occurred during the differential diagenesis.•The limestone-marl alternations result from millennial-scale rhythm.•Primary cycles of LMA differ significantly in diagenetic potential.•Organic matter decay and oxidation drive the aragonite dissolution in closed systems.
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