The phytotoxicity of alumina nanoparticles loaded with and without phenanthrene (Phen) was investigated by means of root elongation (RE) experiments in this study. Five plant species,
Zea mays ...(corn),
Cucumis sativus (cucumber),
Glycine max (soybean),
Brassica oleracea (cabbage), and
Daucus carota (carrot) were used in our study of phytotoxicity by root elongation experiments. The surface characteristics of Phen-loaded and Phen-nonloaded nanoparticles were investigated using the Fourier transformed infrared (FTIR) spectroscopy technique. It was found that when loaded with 10.0%, 100.0%, or 432.4% monomolecular layer (MML) of Phen, the degree of the root elongation inhibition caused by the particles was reduced. The loading of Phen leads to the appearance of a vibrational mode in the region of 850–1050
cm
−1, which was assigned to the surface characteristics of the particles and arises from the disappearance of free hydroxyl groups according to an earlier study. When mixed with a known free hydroxyl radical scavenger, DMSO (0.5% and 1.0%), the non-loaded particles also showed decreased inhibition of root elongations. We supposed that the surface characteristics of the particles play an important role in the phytotoxicity of alumina nanoparticles.
I offer an approach to Dreyer’s film Ordet as a contribution to the phenomenology of a certain kind of religious experience. The experience in question is one of a moment that disrupts the ...chronological flow of time and that, in the lived experience of it, is charged with eternal significance. I propose that the notoriously divisive ending of Ordet reflects an aim to provide the film’s viewers with an experience of this very sort. I draw throughout on some central ideas in Kierkegaard’s work, especially his category of ‘the moment.’
The atomic nucleus is a complex quantum-mechanical system that poses signicant challenges for theoretical physicists. The strong interaction between component nucleons (protons and neutrons) depends ...onmany quantities: the nucleons radial separation, relative kinetic energies, relative directions of intrinsic spin and relative angular momentum. There is also a strong coupling between the spin of a nucleonand its orbital motion (nuclear spinorbit coupling). Furthermore, the nucleus is one of the few systems in nature that manifests three-body forces forces that existonly when three bodies are interacting, irreducible to pair-wise interactions. To add further complexity, most nuclei are quantum many-body systems that are not amenable to a perturbative treatment, which is the approach taken, for example, when dealing with electrons in an atom.
This retrospective study aimed to assess the effects of two differing revision total knee implants designs (condylar and rotating hinge) on joint line height.
The use of distal augmentation and pre ...and post revision radiographic joint line heights were compared in 19 condylar type knee replacements (Zimmer NexGen Legacy Constrained Condylar Knee - LCCK) and 40 LINK-Endo-rotating hinge knee replacements. Joint line and patellar heights were determined for each implant using four validated methods. For comparison within a group a two tailed paired Student's t-test was used, for comparison between the groups an unpaired, two tailed Student's t-test was used. A p value of less than 0.05 was deemed statistically significant.
In 15 of 19 NexGen revision knee replacements distal augments were used. No distal augments were used in the LINK-Endo RHK group. In both systems there was no tendency to elevate the joint line relative to the tibia. The joint line was distalised relative to the femur in the NexGen group and proximalised in the rotating hinge knee group. Measurements using antero-posterior radiographs were found to be the most reliable method of assessing joint line height when compared to lateral radiographs.
Both revision knee implant systems adequately restored joint line height. In condylar type knee revision implants elevation of the joint line height may be avoided through the use of distal augmentation. We found AP radiographs to be the most reliable method of accurately assessing joint line height.
This article focuses on the reuse and recycling of end-of-life (EOL) lithium-ion batteries (LIB) in the USA in the context of the rapidly growing electric vehicle (EV) market. Due to the recent ...increase in the enactment of both current and pending regulations concerning EV battery recycling, this work focuses on the recycling aspect for lithium-ion batteries rather than emphasizing the reuse of EOL batteries (although these practices have value and utility). A comparative analysis of various recycling methods is presented, including hydrometallurgy, pyrometallurgy, direct recycling, and froth flotation. The efficiency and commercial viability of these individual methods are highlighted. This article also emphasizes the practices and capabilities of leading companies, noting their current superior annual processing capacities. The transportation complexities of lithium-ion batteries are also discussed, noting that they are classified as hazardous materials and that stringent safety standards are needed for their handling. The study underscores the importance of recycling in mitigating environmental risks associated with EOL of LIBs and facilitates comparisons among the diverse recycling processes and capacities among key players in the industry.
A Life Cycle Assessment (LCA) quantifies the environmental impacts during the life of a product from cradle to grave. It evaluates energy use, material flow, and emissions at each stage of life. This ...report addresses the challenges and potential solutions related to the surge in electric vehicle (EV) batteries in the United States amidst the EV market’s exponential growth. It focuses on the environmental and economic implications of disposal as well as the recycling of lithium-ion batteries (LIBs). With millions of EVs sold in the past decade, this research highlights the necessity of efficient recycling methods to mitigate environmental damage from battery production and disposal. Utilizing a Life Cycle Assessment (LCA) and Life Cycle Cost Assessment (LCCA), this research compares emissions and costs between new and recycled batteries by employing software tools such as SimaPro V7 and GREET V2. The findings indicate that recycling batteries produces a significantly lower environmental impact than manufacturing new units from new materials and is economically viable as well. This research also emphasizes the importance of preparing for the upcoming influx of used EV batteries and provides suggestions for future research to optimize the disposal and recycling of EV batteries.
The neutral catalysts IrCl(H)2(NHC)(substrate)2 or IrCl(H)2(NHC)(substrate)(sulfoxide) are used to transfer polarization from para hydrogen (pH2) to 3,5-dichloropyridine and 3,5-dibromopyridine ...substrates. This is achieved in a rapid, reversible, and low-cost process that relies on ligand exchange within the active catalyst. Notably, the sulfoxide-containing catalyst systems produced NMR signal enhancements between 1 and 2 orders of magnitude larger than its unmodified counterpart. Consequently, this signal amplification by reversible exchange hyperpolarization method can boost the 1H, 13C, and 15N nuclear magnetic resonance (NMR) signal intensities by factors up to 4350, 1550, and 46,600, respectively (14.0, 1.3, and 15.4% polarization). In this paper, NMR and X-ray crystallography are used to map the evolution of catalytically important species and provide mechanistic rational for catalytic efficiency. Furthermore, applications in spontaneous radiofrequency amplification by stimulated emission and NMR reaction monitoring are also shown.
Fast-scan cyclic voltammetry (FSCV) is an effective tool for measuring dopamine release and clearance throughout the brain, especially the striatum where dopamine terminals are abundant and signals ...are heavily regulated by release machinery and the dopamine transporter (DAT). Peak height measurement is perhaps the most common method for measuring dopamine release, but it is influenced by changes in clearance. Michaelis–Menten-based modeling has been a standard in measuring dopamine clearance, but it is problematic in that it requires experimenter fitted modeling subject to experimenter bias. This study presents the use of the first derivative (velocity) of evoked dopamine signals as an alternative approach for measuring and distinguishing dopamine release from clearance. Maximal upward velocity predicts reductions in dopamine peak height due to D2 and GABAB receptor stimulation and by alterations in calcium concentrations. The Michaelis–Menten maximal velocity (V max) measure, an approximation for DAT levels, predicts maximal downward velocity in slices and in vivo. Dopamine peak height and upward velocity were similar between wild-type and DAT knock-out (DATKO) mice. In contrast, downward velocity was lower and exponential decay (tau) was higher in DATKO mice, supporting the use of both measures for extreme changes in DAT activity. In slices, the competitive DAT inhibitors cocaine, PTT, and WF23 increased peak height and upward velocity differentially across increasing concentrations, with PTT and cocaine reducing these measures at high concentrations. Downward velocity and tau values decreased and increased respectively across concentrations, with greater potency and efficacy observed with WF23 and PTT. In vivo recordings demonstrated similar effects of WF23, PTT, and cocaine on measures of release and clearance. Tau was a more sensitive measure at low concentrations, supporting its use as a surrogate for the Michaelis–Menten measure of apparent affinity (K m). Together, these results inform on the use of these various measures for dopamine release and clearance.
Introduction
Lower limb arthroplasty is performed under general anaesthesia (GA) or regional anaesthesia (RA). There is increasing evidence of the surgical and anaesthetic benefits of RA. National ...Institute for Health and Care Excellence (NICE) guidelines advise using either but highlight a lack of data comparing outcomes of RA and GA for these procedures. We conducted a service evaluation, prospectively analysing elective orthopaedic cases performed at the Nuffield Orthopaedic Centre, Oxford, UK from 19/11/2018 to 03/04/2019. We aimed to compare data on anaesthetic assessment, intra-operative parameters and patient satisfaction for RA and GA cases.
Methods
We selected elective patients, aged above 18, undergoing total hip, total knee or unilateral knee arthroplasties. Prospective quantitative and qualitative data were collected using two forms. Firstly, anaesthetists completed a case report recording demographic data, intra-operative details and reason for anaesthetic choice. Secondly a questionnaire gathered patient satisfaction data. This was analysed using descriptive statistics and presented in tables.
Results
Data for 132 patients were collected over the service evaluation period. After exclusion, 99 patients were included for final analysis; 59 underwent GA and 40 had RA. GA was used predominantly due to patient preference (74.6%). RA was used primarily due to anaesthetic preference (75%); most commonly due to speed of list and duration of operation. Overall patients had low pain scores (0.3/10) and high pre-operative anxiety levels (4.6/10) regardless of anaesthetic.
Conclusion
Our results show high patient satisfaction with GA and RA for lower limb arthroplasty; however, pre-operative anxiety was common for both. Patient preference and comfort influenced choice of anaesthesia, highlighting the importance of pre-operative counselling and education to facilitate shared decision making, leading to favourable post-operative outcomes.
PDF
