We present the first wide area (19 deg2), deep (≈120–150 μJy beam−1), high-resolution (5.6 × 7.4 arcsec) LOFAR High Band Antenna image of the Boötes field made at 130–169 MHz. This image is at least ...an order of magnitude deeper and 3–5 times higher in angular resolution than previously achieved for this field at low frequencies. The observations and data reduction, which includes full direction-dependent calibration, are described here. We present a radio source catalogue containing 6 276 sources detected over an area of 19 deg2, with a peak flux density threshold of 5σ. As the first thorough test of the facet calibration strategy, introduced by van Weeren et al., we investigate the flux and positional accuracy of the catalogue. We present differential source counts that reach an order of magnitude deeper in flux density than previously achieved at these low frequencies, and show flattening at 150-MHz flux densities below 10 mJy associated with the rise of the low flux density star-forming galaxies and radio-quiet AGN.
With combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of ...active plaque calcification and inflammation, respectively.
The noninvasive assessment of coronary artery plaque biology would be a major advance particularly in the identification of vulnerable plaques, which are associated with specific pathological characteristics, including micro-calcification and inflammation.
We prospectively recruited 119 volunteers (72 ± 8 years of age, 68% men) with and without aortic valve disease and measured their coronary calcium score and 18F-NaF and 18F-FDG uptake. Patients with a calcium score of 0 were used as control subjects and compared with those with calcific atherosclerosis (calcium score >0).
Inter-observer repeatability of coronary 18F-NaF uptake measurements (maximum tissue/background ratio) was excellent (intra-class coefficient 0.99). Activity was higher in patients with coronary atherosclerosis (n = 106) versus control subjects (1.64 ± 0.49 vs. 1.23 ± 0.24; p = 0.003) and correlated with the calcium score (r = 0.652, p < 0.001), although 40% of those with scores >1,000 displayed normal uptake. Patients with increased coronary 18F-NaF activity (n = 40) had higher rates of prior cardiovascular events (p = 0.016) and angina (p = 0.023) and higher Framingham risk scores (p = 0.011). Quantification of coronary 18F-FDG uptake was hampered by myocardial activity and was not increased in patients with atherosclerosis versus control subjects (p = 0.498).
18F-NaF is a promising new approach for the assessment of coronary artery plaque biology. Prospective studies with clinical outcomes are now needed to assess whether coronary 18F-NaF uptake represents a novel marker of plaque vulnerability, recent plaque rupture, and future cardiovascular risk. (An Observational PET/CT Study Examining the Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis; NCT01358513).
Abstract
The relative positions of the high and low surface brightness regions of radio-loud active galaxies in the 3CR sample were found by Fanaroff and Riley to be correlated with their luminosity. ...We revisit this canonical relationship with a sample of 5805 extended radio-loud active galactic nuclei (AGN) from the LOFAR Two-Metre Sky Survey (LoTSS), compiling the most complete data set of radio-galaxy morphological information obtained to date. We demonstrate that, for this sample, radio luminosity does not reliably predict whether a source is edge-brightened (FRII) or centre-brightened (FRI). We highlight a large population of low-luminosity FRIIs, extending three orders of magnitude below the traditional FR break, and demonstrate that their host galaxies are on average systematically fainter than those of high-luminosity FRIIs and of FRIs matched in luminosity. This result supports the jet power/environment paradigm for the FR break: low-power jets may remain undisrupted and form hotspots in lower mass hosts. We also find substantial populations that appear physically distinct from the traditional FR classes, including candidate restarting sources and ‘hybrids’. We identify 459 bent-tailed sources, which we find to have a significantly higher SDSS cluster association fraction (at z < 0.4) than the general radio-galaxy population, similar to the results of previous work. The complexity of the LoTSS faint, extended radio sources not only demonstrates the need for caution in the automated classification and interpretation of extended sources in modern radio surveys, but also reveals the wealth of morphological information such surveys will provide and its value for advancing our physical understanding of radio-loud AGN.
Abstract
Radio emission is a key indicator of star formation activity in galaxies, but the radio luminosity–star formation relation has to date been studied almost exclusively at frequencies of ...1.4 GHz or above. At lower radio frequencies, the effects of thermal radio emission are greatly reduced, and so we would expect the radio emission observed to be completely dominated by synchrotron radiation from supernova-generated cosmic rays. As part of the LOFAR Surveys Key Science project, the Herschel-ATLAS NGP field has been surveyed with LOFAR at an effective frequency of 150 MHz. We select a sample from the MPA-JHU catalogue of Sloan Digital Sky Survey galaxies in this area: the combination of Herschel, optical and mid-infrared data enable us to derive star formation rates (SFRs) for our sources using spectral energy distribution fitting, allowing a detailed study of the low-frequency radio luminosity–star formation relation in the nearby Universe. For those objects selected as star-forming galaxies (SFGs) using optical emission line diagnostics, we find a tight relationship between the 150 MHz radio luminosity (L150) and SFR. Interestingly, we find that a single power-law relationship between L150 and SFR is not a good description of all SFGs: a broken power-law model provides a better fit. This may indicate an additional mechanism for the generation of radio-emitting cosmic rays. Also, at given SFR, the radio luminosity depends on the stellar mass of the galaxy. Objects that were not classified as SFGs have higher 150-MHz radio luminosity than would be expected given their SFR, implying an important role for low-level active galactic nucleus activity.
ABSTRACT
Scaling laws of dust, H i gas, and metal mass with stellar mass, specific star formation rate, and metallicity are crucial to our understanding of the build-up of galaxies through their ...enrichment with metals and dust. In this work, we analyse how the dust and metal content varies with specific gas mass (MH i/M⋆) across a diverse sample of 423 nearby galaxies. The observed trends are interpreted with a set of Dust and Element evolUtion modelS (DEUS) – including stellar dust production, grain growth, and dust destruction – within a Bayesian framework to enable a rigorous search of the multidimensional parameter space. We find that these scaling laws for galaxies with −1.0 ≲ log MH i/M⋆ ≲ 0 can be reproduced using closed-box models with high fractions (37–89 ${{\ \rm per\ cent}}$) of supernova dust surviving a reverse shock, relatively low grain growth efficiencies (ϵ = 30–40), and long dust lifetimes (1–2 Gyr). The models have present-day dust masses with similar contributions from stellar sources (50–80 ${{\ \rm per\ cent}}$) and grain growth (20–50 ${{\ \rm per\ cent}}$). Over the entire lifetime of these galaxies, the contribution from stardust (>90 ${{\ \rm per\ cent}}$) outweighs the fraction of dust grown in the interstellar medium (<10 ${{\ \rm per\ cent}}$). Our results provide an alternative for the chemical evolution models that require extremely low supernova dust production efficiencies and short grain growth time-scales to reproduce local scaling laws, and could help solving the conundrum on whether or not grains can grow efficiently in the interstellar medium.
Radiotherapy-associated cardiac toxicity studies in patients with locally advanced non-small cell lung cancer (NSCLC) have been limited by small sample size and nonvalidated cardiac endpoints.
The ...purpose of this analysis was to ascertain whether cardiac radiation dose is a predictor of major adverse cardiac events (MACE) and all-cause mortality (ACM).
This retrospective analysis included 748 consecutive locally advanced NSCLC patients treated with thoracic radiotherapy. Fine and Gray and Cox regressions were used to identify predictors for MACE and ACM, adjusting for lung cancer and cardiovascular prognostic factors, including pre-existing coronary heart disease (CHD).
After a median follow-up of 20.4 months, 77 patients developed ≥1 MACE (2-year cumulative incidence, 5.8%; 95% confidence interval CI: 4.3% to 7.7%), and 533 died. Mean radiation dose delivered to the heart (mean heart dose) was associated with a significantly increased risk of MACE (adjusted hazard ratio HR: 1.05/Gy; 95% CI: 1.02 to 1.08/Gy; p < 0.001) and ACM (adjusted HR: 1.02/Gy; 95% CI: 1.00 to 1.03/Gy; p = 0.007). Mean heart dose (≥10 Gy vs. <10 Gy) was associated with a significantly increased risk of ACM in CHD-negative patients (178 vs. 118 deaths; HR: 1.34; 95% CI: 1.06 to 1.69; p = 0.014) with 2-year estimates of 52.2% (95% CI: 46.1% to 58.5%) versus 40.0% (95% CI: 33.5% to 47.4%); but not among CHD-positive patients (112 vs. 82 deaths; HR: 0.94; 95% CI: 0.70 to 1.25; p = 0.66) with 2-year estimates of 54.6% (95% CI: 46.8% to 62.7%) versus 50.8% (95% CI: 41.5% to 60.9%), respectively (p for interaction = 0.028).
Despite the competing risk of cancer-specific death in locally advanced NSCLC patients, cardiac radiation dose exposure is a modifiable cardiac risk factor for MACE and ACM, supporting the need for early recognition and treatment of cardiovascular events and more stringent avoidance of high cardiac radiotherapy dose.
Radiotherapy accelerates coronary heart disease (CHD), but the dose to critical cardiac substructures has not been systematically studied in lung cancer.
To examine independent cardiac substructure ...radiotherapy factors for major adverse cardiac events (MACE) and all-cause mortality in patients with locally advanced non-small cell lung cancer (NSCLC).
A retrospective cohort analysis of 701 patients with locally advanced NSCLC treated with thoracic radiotherapy at Harvard University-affiliated hospitals between December 1, 2003, and January 27, 2014, was performed. Data analysis was conducted between January 12, 2019, and July 22, 2020. Cardiac substructures were manually delineated. Radiotherapy dose parameters (mean, maximum, and the volume V, percentage receiving a specific Gray Gy dose in 5-Gy increments) were calculated. Receiver operating curve and cut-point analyses estimating MACE (unstable angina, heart failure hospitalization or urgent visit, myocardial infarction, coronary revascularization, and cardiac death) were performed. Fine and Gray and Cox regressions were adjusted for preexisting CHD and other prognostic factors.
MACE and all-cause mortality.
Of the 701 patients included in the analysis, 356 were men (50.8%). The median age was 65 years (interquartile range, 57-73 years). The optimal cut points for substructure and radiotherapy doses (highest C-index value) were left anterior descending (LAD) coronary artery V15 Gy greater than or equal to 10% (0.64), left circumflex coronary artery V15 Gy greater than or equal to 14% (0.64), left ventricle V15 Gy greater than or equal to 1% (0.64), and mean total coronary artery dose greater than or equal to 7 Gy (0.62). Adjusting for baseline CHD status and other prognostic factors, an LAD coronary artery V15 Gy greater than or equal to 10% was associated with increased risk of MACE (adjusted hazard ratio, 13.90; 95% CI, 1.23-157.21; P = .03) and all-cause mortality (adjusted hazard ratio, 1.58; 95% CI, 1.09-2.29; P = .02). Among patients without CHD, associations with increased 1-year MACE were noted for LAD coronary artery V15 Gy greater than or equal to 10% (4.9% vs 0%), left circumflex coronary artery V15 Gy greater than or equal to 14% (5.2% vs 0.7%), left ventricle V15 Gy greater than or equal to 1% (5.0% vs 0.4%), and mean total coronary artery dose greater than or equal to 7 Gy (4.8% vs 0%) (all P ≤ .001), but only a left ventricle V15 Gy greater than or equal to 1% increased the risk among patients with CHD (8.4% vs 4.1%; P = .046). Among patients without CHD, 2-year all-cause mortality was increased with an LAD coronary artery V15 Gy greater than or equal to 10% (51.2% vs 42.2%; P = .009) and mean total coronary artery dose greater than or equal to 7 Gy (53.2% vs 40.0%; P = .01).
The findings of this cohort study suggest that optimal cardiac dose constraints may differ based on preexisting CHD. Although the LAD coronary artery V15 Gy greater than or equal to 10% appeared to be an independent estimator of the probability of MACE and all-cause mortality, particularly in patients without CHD, left ventricle V15 Gy greater than or equal to 1% appeared to confer an increased risk of MACE among patients with CHD. These constraints are worthy of further study because there is a need for improved cardiac risk stratification and aggressive risk mitigation strategies.
Aims. We aim to study the far-infrared radio correlation (FIRC) at 150 MHz in the local Universe (at a median redshift ⟨z⟩∼0.05) and improve the use of the rest-frame 150 MHz luminosity, L150, as a ...star-formation rate (SFR) tracer, which is unaffected by dust extinction. Methods. We cross-match the 60 μm selected Revised IRAS Faint Source Survey Redshift (RIFSCz) catalogue and the 150 MHz selected LOFAR value-added source catalogue in the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) Spring Field. We estimate L150 for the cross-matched sources and compare it with the total infrared (IR) luminosity, LIR, and various SFR tracers. Results. We find a tight linear correlation between log L150 and log LIR for star-forming galaxies, with a slope of 1.37. The median qIR value (defined as the logarithm of the LIR to L150 ratio) and its rms scatter of our main sample are 2.14 and 0.34, respectively. We also find that log L150 correlates tightly with the logarithm of SFR derived from three different tracers, i.e., SFRHα based on the Hα line luminosity, SFR60 based on the rest-frame 60 μm luminosity and SFRIR based on LIR, with a scatter of 0.3 dex. Our best-fit relations between L150 and these SFR tracers are, log L150 (L⊙) = 1.35(±0.06) × log SFRHα (M⊙ yr−1) + 3.20(±0.06), log L150 (L⊙) = 1.31(±0.05) × log SFR60 (M⊙ yr−1) + 3.14(±0.06), and log L150 (L⊙) = 1.37 (±0.05) × log SFRIR (M⊙ yr−1) + 3.09(±0.05), which show excellent agreement with each other.
Optically luminous quasars at
z
> 5 are important probes of super-massive black hole (SMBH) formation. With new and future radio facilities, the discovery of the brightest low-frequency radio ...sources in this epoch would be an important new probe of cosmic reionization through 21-cm absorption experiments. In this work, we systematically study the low-frequency radio properties of a sample of 115 known spectroscopically confirmed
z
> 5 quasars using the second data release of the Low Frequency Array (LOFAR) Two Metre Sky survey (LoTSS-DR2), reaching noise levels of ∼80 μJy beam
−1
(at 144 MHz) over an area of ∼5720 deg
2
. We find that 41 sources (36%) are detected in LoTSS-DR2 at > 2
σ
significance and we explore the evolution of their radio properties (power, spectral index, and radio loudness) as a function of redshift and rest-frame ultra-violet properties. We obtain a median spectral index of −0.29
−0.09
+0.10
by stacking 93 quasars using LoTSS-DR2 and Faint Images of the Radio Sky at Twenty Centimetres (FIRST) data at 1.4 GHz, in line with observations of quasars at
z
< 3. We compare the radio loudness of the high-
z
quasar sample to a lower-
z
quasar sample at
z
∼ 2 and find that the two radio loudness distributions are consistent with no evolution, although the low number of high-
z
quasars means that we cannot rule out weak evolution. Furthermore, we make a first order empirical estimate of the
z
= 6 quasar radio luminosity function, which is used to derive the expected number of high-
z
sources that will be detected in the completed LoTSS survey. This work highlights the fact that new deep radio observations can be a valuable tool in selecting high-
z
quasar candidates for follow-up spectroscopic observations by decreasing contamination of stellar dwarfs and reducing possible selection biases introduced by strict colour cuts.
Empirical algorithms are developed using high‐quality GO‐SHIP hydrographic measurements of commonly measured parameters (temperature, salinity, pressure, nitrate, and oxygen) that estimate pH in the ...Pacific sector of the Southern Ocean. The coefficients of determination, R2, are 0.98 for pH from nitrate (pHN) and 0.97 for pH from oxygen (pHOx) with RMS errors of 0.010 and 0.008, respectively. These algorithms are applied to Southern Ocean Carbon and Climate Observations and Modeling (SOCCOM) biogeochemical profiling floats, which include novel sensors (pH, nitrate, oxygen, fluorescence, and backscatter). These algorithms are used to estimate pH on floats with no pH sensors and to validate and adjust pH sensor data from floats with pH sensors. The adjusted float data provide, for the first time, seasonal cycles in surface pH on weekly resolution that range from 0.05 to 0.08 on weekly resolution for the Pacific sector of the Southern Ocean.
Key Points
Algorithms are developed for estimation of pH from biogeochemical floats in the Southern Ocean
The pH algorithms can also be used to adjust pH sensor data on biogeochemical floats
The seasonal cycle in surface pH ranges from 0.05 to 0.08 for the study region
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