In the operation of gas turbine unit, it often come across condition changes such as acceleration, deceleration and external drag effects. This will cause transient process of gas turbine system, ...which is of great significance to the dynamic performance simulation. This paper established dynamic simulation model of different components in gas turbine unit, introduced several process methods of compressor characteristic curves, and finally the RBF neural network method is used. Through simulation test, the variation rule of each parameter can be obtained so as to improve the operation efficiency of the whole unit, which lay a foundation for further optimization study.
To tackle the debate surrounding the tension between knowledge and power in online education for adolescents and between freedom and control at large, this study examines how disciplinary power was ...exercised and resisted in a Chinese setting of online compulsory education during the COVID-19 outbreak in 2020. Overall, 60 participants, including students (from Grade 7 to 12), their parents, and teachers joined in our focus groups or individual interviews in a secondary school in Xi’an, China. By following Foucault’s concepts of three techniques of disciplinary power: hierarchical observation, normalizing judgement and examination, we identified four themes based on the data: (1) diminished discipline with the dissolving boundary, (2) reconfigured disciplinary power by teachers, (3) self-discipline as a vital skill, and (4) online compulsory education as a future trend. Interpretations from the Foucauldian perspective were presented, suggesting that most adolescents depend upon more external disciplines from schools and teachers, while only a few may achieve autonomy through self-discipline.
Small‐molecule‐based multimodal and multifunctional imaging probes play prominent roles in biomedical research and have high clinical translation ability. A novel multimodal imaging platform using ...base‐catalyzed double addition of thiols to a strained internal alkyne such as bicyclo6.1.0nonyne has been established in this study, thus allowing highly selective assembly of various functional units in a protecting‐group‐free manner. Using this molecular platform, novel dual‐modality (PET and NIRF) uPAR‐targeted imaging probe: 64Cu‐CHS1 was prepared and evaluated in U87MG cells and tumor‐bearing mice models. The excellent PET/NIRF imaging characteristics such as good tumor uptake (3.69 %ID/g at 2 h post‐injection), high tumor contrast, and specificity were achieved in the small‐animal models. These attractive imaging properties make 64Cu‐CHS1 a promising probe for clinical use.
Spitting image: The products of the base‐catalyzed addition of various functional molecules to bicyclo6.1.0nonyne‐based scaffolds provided precursors for novel dual‐modality (PET and NIRF) uPAR‐targeted imaging probes. The probes were evaluated in U87MG cells and tumor‐bearing mice models, thus demonstrating excellent imaging characteristics.
In light of the prolonged period of social distancing and
highly mediated communication patterns during the COVID-19 pandemic, this study
sought to understand how pandemic-related fear affects social ...connectedness.
Drawing from the Internet-enhanced self-disclosure and fear-eliciting
affiliation hypotheses, survey findings from a stratified sample collected among
Hong Kong university students (N = 310) revealed that
pandemic-related fear positively influences social connectedness not only
through self-disclosure but also through the combination of information seeking
and self-disclosure. Social interaction, however, does not mediate the
relationship between fear and social connectedness on its own. Overall, we argue
that fear motivated people to seek information, self-disclose, and articulate
connectedness with society. During this process, social media provided an
essential ground and self-disclosure proved a viable tool. This study
demonstrated that negative emotions aroused in crisis situations might result in
constructive behaviors, which is contingent on how people react to mitigate the
negative consequences.
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Amid the proliferation of multiplatform social media use and fake news, the ongoing debate about social media’s impact on news engagement and selective exposure remains inconclusive. Drawing on a ...representative sample of 17 countries (N = 34,633), the present study examined the association of country-level media systems, individual-level fake news concerns, and multiplatform news use with news engagement and selective exposure. The multilevel analyses revealed (a) an overall positive association between multiplatform social media use and news engagement, (b) the role of fake news concerns on the formation of echo chambers, and (c) the role of state intervention in mitigating individuals’ news engagement in a multiplatform landscape.
The wide occurrence and high environmental concentration of titanium dioxide nanoparticles (nano-TiO
) have raised concerns about their potential toxic effects on crops. In this study, we employed a ...GC-MS-based metabolomic approach to investigate the potential toxicity of nano-TiO
on hydroponically-cultured rice (Oryza sativa L.) after exposed to 0, 100, 250 or 500 mg/L of nano-TiO
for fourteen days. Results showed that the biomass of rice was significantly decreased and the antioxidant defense system was significantly disturbed after exposure to nano-TiO
. One hundred and five identified metabolites showed significant difference compared to the control, among which the concentrations of glucose-6-phosphate, glucose-1-phosphate, succinic and isocitric acid were increased most, while the concentrations of sucrose, isomaltulose, and glyoxylic acid were decreased most. Basic energy-generating ways including tricarboxylic acid cycle and the pentose phosphate pathway, were elevated significantly while the carbohydrate synthesis metabolism including starch and sucrose metabolism, and glyoxylate and dicarboxylate metabolism were inhibited. However, the biosynthetic formation of most of the identified fatty acids, amino acids and secondary metabolites which correlated to crop quality, were increased. The results suggest that the metabolism of rice plants is distinctly disturbed after exposure to nano-TiO
, and nano-TiO
would have a mixed effect on the yield and quality of rice.
This paper presents an unconditionally stable integration method, which introduces a linearly implicit algorithm featuring an explicit displacement expression. The technique that is being considered ...integrates one Newton iteration into the mean acceleration method. The stability of the proposed algorithm in solving equations of motion containing nonlinear restoring force and nonlinear damping force is analyzed using the root locus method. The objective of this investigation was to assess the accuracy and consistency of the proposed approach in contrast to the Chang method and the CR method. This is achieved by analyzing the dynamic response of three distinct structures: a three-layer shear structure model outfitted with viscous dampers, a three-layer shear structure model featuring metal dampers, and an eight-story planar frame structure. Empirical evidence indicates that the algorithm in question exhibits a notable degree of precision and robustness when applied to nonlinear dynamic problem-solving.
Traumatic brain injury (TBI) is the leading cause of disability and mortality globally. Melatonin (Mel) is a neuroendocrine hormone synthesized from the pineal gland that protects against TBI. Yet, ...the precise mechanism of action is not fully understood. In this study, we examined the protective effect and regulatory pathways of melatonin in the TBI mice model using transcriptomics and bioinformatics analysis. The expression profiles of mRNA, long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA) were constructed using the whole transcriptomes sequencing technique. In total, 93 differentially expressed (DE) mRNAs (DEmRNAs), 48 lncRNAs (DElncRNAs), 59 miRNAs (DEmiRNAs), and 59 circRNAs (DEcircRNAs) were identified by the TBI mice with Mel treatment compared to the group without drug intervention. The randomly selected coding RNAs and non-coding RNAs (ncRNAs) were identified by quantitative real-time polymerase chain reaction (qRT-PCR). To further detect the biological functions and potential pathways of those differentially expressed RNAs, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were executed. In our research, the regulatory network was constructed to show the relationship of lncRNA-RBPs. The lncRNA-mRNA co-expression network was established based on the Pearson coefficient to indicate the expression correlations. Moreover, the DEcircRNA–DEmiRNA–DEmRNA and DElncRNA–DEmiRNA–DEmRNA regulatory networks were constructed to demonstrate the regulatory relationship between ncRNAs and mRNA. Finally, to further verify our predicted results, cytoHubba was used to find the hub gene in the synaptic vesicle cycle pathway, and the expression level of SNAP-25 and VAMP-2 after melatonin treatment were detected by Western blotting and immunofluorescence. To sum up, these data offer a new insight regarding the molecular effect of melatonin treatment after TBI and suggest that the high-throughput sequencing and analysis of transcriptomes are useful for studying the drug mechanisms in treatment after TBI.
Reclamation of tidal flats is one of the engineering measures of expanding land area and developing the economy in coastal areas; however, this process disturbs the natural processes of the tidal ...flat system. Taking the flood-tidal dominant Oufei tidal flat at the Wenzhou coast as a study area, the influences of tidal flat reclamation on tidal and suspended sediment dynamics were comprehensively investigated
via
numerical modeling. Before the reclamation, the Eulerian residual current flows alongshore and the residual sediment transport on-shore in the tidal flat area. The reclamation reduces the tidal flat area, shifting the M4 co-phase line toward the coast and squeezing the flood-dominated area. Consequently, the tidal current is weakened and the suspended sediment concentration (SSC) is reduced, but the residual sediment transport change insignificantly. The residual sediment transport in the Feiyunjiang Estuary is controlled by the tidal pumping effect. The upper estuary shows a net sediment transport landward, while a seaward transport is observed in the lower estuary, which further splits into two circulation outside the estuary. The south Oufei dike construction interferes the northern sediment circulation, resulting in the alteration of local SSC and enhancing landward sediment transport inside the estuary. The methodology and understandings arising from this study could be a good reference for the analysis of suspended sediment transport under tidal flat reclamation effects at other sites.
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