HIAF (High Intensity heavy ion Accelerator Facility), a new facility planned in China for heavy ion related researches, consists of two ion sources, a high intensity Heavy Ion Superconducting Linac ...(HISCL), a 45 Tm Accumulation and Booster Ring (ABR-45) and a multifunction storage ring system. The key features of HIAF are unprecedented high pulse beam intensity and versatile operation mode. The HIAF project aims to expand nuclear and related researches into presently unreachable region and give scientists possibilities to conduct cutting-edge researches in these fields. The general description of the facility is given in this article with a focus on the accelerator design.
The microfluidic flow is typically laminar due to the dominant viscous effects. At Reynolds numbers far below 1 (Re < 1), the fluid inertia can be neglected. For the steady flow of incompressible ...Newtonian fluids, it approaches linear Stokes flow. At intermediate Re, there exists a weak-inertia flow regime where secondary flows such as Dean vortices are accessible for microfluidic manipulations. Apart from the fluid inertia, other nonlinear factors such as the non-Newtonian fluid properties, concurrent flow of dissimilar fluids, compliant fluidic structures and stimuli-responsive materials can also cause intriguing flow behaviours. Through proper designs, they can be applied for a variety of microfluidic components including mixers, valves, oscillators, stabilizers and auto-regulators
etc.
, greatly enriching the microfluidic flow control and manipulation strategies. Due to its unique working characteristics and advantages, nonlinear microfluidics has increasingly attracted extensive attention. This review presents a systematic survey on this subject. The designs of typical nonlinear microfluidic devices, their working mechanisms, key applications, and the perspective of their future developments will be discussed. The nonlinear microfluidic techniques are believed to play an essential role in the next generation of highly-integrated, automated, and intelligent microfluidics.
Nonlinear microfluidics, including the typical devices, their working mechanisms and applications are discussed.
•Provincial marginal abatement cost curves are derived.•The economic performance of interprovincial CO2 emission trading in China is modeled.•Total abatement cost could be reduced by over 40% with ...interprovincial emission trading.•CO2 emission and population criteria look fairer in allocating emission allowances.
Carbon emission reduction is a long-term strategy for China to promote its economic and social development. However, emission reduction often involves a huge amount of technological investment, which could vary substantially across different provinces due to their discrepancy in economic and technological development levels. Emission trading as a useful policy instrument may help different provinces achieve their emission reduction targets cost-effectively. This paper models the economic performance of an interprovincial emission reduction quota trading scheme in China. The marginal abatement cost curve of each province in China is first estimated. A nonlinear programming model is further developed to evaluate the economic performance of interprovincial emission reduction quota trading. Five equity criteria are used to conduct the initial allocation of emission reduction targets between different provinces. Our modeling results show that China’s total emission abatement cost could decrease by over 40% through implementing such an interprovincial emission reduction quota trading scheme. Of the five alternative criteria, the CO2 emissions and population criteria look fairer and are recommended for use in the initial allocation of CO2 emission reduction targets.
Immunity acquired from infection or vaccination protects humans from symptomatic hepatitis E. However, whether the risk of hepatitis E virus (HEV) infection is reduced by the immunity remains ...unknown. To understand this issue, a cohort with 12 409 participants randomized to receive the hepatitis E vaccine Hecolin® or placebo were serologically followed up for 2 years after vaccination. About half (47%) of participants were initially seropositive. A total of 139 infection episodes, evidenced by four-fold or greater rise of anti-HEV level or positive seroconversion, occurred in participants who received three doses of treatment. Risk of infection was highest among the baseline seronegative placebo group participants (2.04%). Pre-existing immunity and vaccine-induced immunity lower the risk significantly, to 0.52% and 0.30%, respectively. In conclusion, both vaccine-induced and naturally acquired immunity can effectively protect against HEV infection.
The Fusarium incarnatum-equiseti species complex (FIESC) is a phylogenetically species-rich complex that includes over 30 cryptic phylogenetic species, making identification based on phenotypic ...characters problematic. Several established Fusarium species known to reside
in the FIESC lack type material, further complicating the use of Latin binomials for this complex. To overcome this problem, an informal classification system based on a haplotype nomenclature was introduced to improve communication between researchers in various fields. However, some conflicts
in the application of this nomenclature system have arisen. To date, 16 phylo-species in the FIESC have been provided with Latin binomials with approximately 18 FIESC phylo-species still lacking Latin binomials, the majority of which reside in the Incarnatum clade. The aim of this study is
to introduce Latin binomials for the unnamed FIESC phylo-species based on phylogenetic inference supported by phenotypic characters. The three-gene (calmodulin, RNA polymerase II second largest subunit and translations elongation factor 1-alpha) phylogenetic inference resolved 47 lineages,
of which 44 belonged to the FIESC. The F. camptoceras species complex (FCAMSC) is introduced here for three lineages that are distinct from the FIESC. Epitypes are designated for F. compactum, F. incarnatum and F. scirpi, and a neotype for F. camptoceras.
Latin binomials are provided for 20 of these newly resolved phylo-species in the FIESC.
The search for genetic variants underlying major depressive disorder (MDD) has not yet provided firm leads to its underlying molecular biology. A complementary approach is to study gene expression in ...relation to MDD. We measured gene expression in peripheral blood from 1848 subjects from The Netherlands Study of Depression and Anxiety. Subjects were divided into current MDD (N=882), remitted MDD (N=635) and control (N=331) groups. MDD status and gene expression were measured again 2 years later in 414 subjects. The strongest gene expression differences were between the current MDD and control groups (129 genes at false-discovery rate, FDR<0.1). Gene expression differences across MDD status were largely unrelated to antidepressant use, inflammatory status and blood cell counts. Genes associated with MDD were enriched for interleukin-6 (IL-6)-signaling and natural killer (NK) cell pathways. We identified 13 gene expression clusters with specific clusters enriched for genes involved in NK cell activation (downregulated in current MDD, FDR=5.8 × 10(-5)) and IL-6 pathways (upregulated in current MDD, FDR=3.2 × 10(-3)). Longitudinal analyses largely confirmed results observed in the cross-sectional data. Comparisons of gene expression results to the Psychiatric Genomics Consortium (PGC) MDD genome-wide association study results revealed overlap with DVL3. In conclusion, multiple gene expression associations with MDD were identified and suggest a measurable impact of current MDD state on gene expression. Identified genes and gene clusters are enriched with immune pathways previously associated with the etiology of MDD, in line with the immune suppression and immune activation hypothesis of MDD.
The Coronavirus disease 2019 (COVID-19) which outbroke in December 2019 is highly contagious with a low cure rate. In view of this, there is an urgent need to find a more appropriate therapeutic ...scheme against COVID-19. The study aimed to investigate whether lopinavir/ritonavir (LPV/r) in combination with other pneumonia-associated adjuvant drugs has a better therapeutic effect on COVID-19.
Totally 47 patients with COVID-19 infection who were admitted to Rui'an People's Hospital between January 22 and January 29, 2020 were collected. The patients were divided into the test group and the control group according to whether they had been treated with LPV/r or not during hospitalization. Patients in the test group were treated with LPV/r combined with adjuvant medicine, while those in the control group were just treated with adjuvant medicine. The changes of body temperature, blood routine and blood biochemistry between the two groups were observed and compared.
Both groups achieved good therapeutic effect with the body temperature of patients decreased gradually from admission to the 10th day of treatment. But the body temperature of patients in the test group decreased faster than that of the control group. Blood routine indexes showed that compared with the control group, the abnormal proportion of white blood cells, lymphocytes and C-reactive protein of the test group could be reduced to some extent. Blood biochemical indexes exhibited that the proportion of patients with abnormal alanine aminotransferase and aspartate aminotransferase in the test group were lower than the control group. The number of days for nCoV-RNA turning negative after treatment was significantly decreased in the test group than that in the control group.
Compared with the treatment of pneumonia-associated adjuvant drugs alone, the combination treatment with LPV/r and adjuvant drugs has a more evident therapeutic effect in lowering the body temperature and restoring normal physiological mechanisms with no evident toxic and side effects. In view of these conclusions, we suggested that the use of LPV/r combined with pneumonia-associated adjuvant drugs in the clinical treatment for patients with COVID-19 should be promoted.
Kinematic significance and time scales of geodynamic processes forming the Altai Orogenic Belt are addressed through structural and petrological analysis combined with zircon and monazite ...geochronology. The study area is composed of orogenic lower crust represented by a Devonian migmatite‐magmatite complex and orogenic middle and upper crust formed by an amphibolite‐facies Ordovician sedimentary sequence and a weakly to unmetamorphosed Devonian volcano‐sedimentary cover, respectively. The orogenic lower and middle crust were first affected by moderate thickening, which formed subhorizontal Barrovian metamorphic schistosity. This fabric was reworked by deep crustal melting and intrusion of granite sheets during horizontal extension at 400–380 Ma. Soon after, this horizontal fabric was affected by NW‐SE shortening generating crustal‐scale upright folding associated with subvertical flow of still partially molten orogenic lower crust. During this event, the orogenic lower and middle crust were tightly juxtaposed with upper crustal sedimentary rocks. The last event was related with a NE‐SW oriented convergence resulting in large‐scale folding and megafold interference pattern in the Permian at 280–273 Ma. Combined with existing regional data, our results allow proposing a Devonian tectonic switching from compression to extension and back to compression, as a response to variations of subduction dynamics between slab advance and retreat in a Pacific‐type suprasubduction system. The Permian folding was associated with the progressive northward exhumation of thermally softened crust. This tectonic evolution is in response to the indentation of the rigid Junggar arc domain into the weak Altai wedge.
Key Points
The Chinese Altai was affected by pre‐Devonian crustal thickening, Mid‐Devonian (400‐380 Ma) extension, and Late Devonian NW‐SE shortening
The Devonian edifice was affected by NW‐SE zones of high‐temperature deformation and upright folding in the Permian at 280‐273 Ma
Devonian events reflect suprasubduction tectonic switching, while Permian folding indicates the Junggar‐Chinese Altai collision
An elevated DNA-repair capacity in cancer cells leads to radiation resistance and severely limits the efficacy of radiation therapy. Activation of Akt is tightly associated with resistance to ...radiotherapy, and Mre11 protein has important role during the repair of DNA double-strand breaks (DSBs). In this report, our results showed that inhibition of Akt activity impaired the repair of DSBs in CNE2 cells, whereas activated Akt promoted the repair of DSBs in HeLa cells. Knockdown of Mre11 also impaired the process of DSB repair in both these two cell lines. More importantly, we found that Akt could regulate Mre11 expression. Inhibition of Akt activity by small interfering RNA or LY294002 efficiently downregulated the Mre11 expression in CNE2 cells, and transfection with myr-Akt plasmid in HeLa cells upregulated the Mre11 expression. In addition, luciferase reporter analysis revealed that Mre11 reporter activity increased after transfection with myr-Akt1 plasmids, and this myr-Akt1-induced transcriptional activity was blocked in the presence of LY294002. Further study showed GSK3β/β-catenin/LEF-1 pathway was involved in this regulation. Knockdown of β-catenin or LEF-1 led to the downregulation of Mre11, whereas overexpression of β-catenin led to upregulation of Mre11. The chromatin immunoprecipitation assay assay showed β-catenin/LEF-1 heterodimer could directly bind to the promoter of Mre11 in vivo. And the luciferase activity of the pGL3-Mre11 and pGL3-Lef increased in HeLa cells following β-catenin plasmid co-transfected, but was abolished when the LEF-1-binding conserved sequences of Mre11 promoter were mutated. These results together support Akt can upregulate the expression of Mre11 through GSK3β/ β-catenin/LEF pathway to elevate DSB-repair capacity in cancer cells.
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