A ratiometric fluorescent sensor（Hoe-NI） was developed by connecting a nucleus targeted Hoechst unit to a naphthalimide dye via ＂click chemistry＂. The sensor achieves high specific nucleus labeling ...with wash-free staining method in various kinds of living cells. The fluorescence ratio of the two emission bands（450 nm for Hoechst and 505 nm for naphthalimide） is changed sensitively to the variation of DNA concentrations, which provides the quantitative information in the processes of DNA damage induced by hydroxyl radicals and antitumor drug. Therefore, Hoe-NI is a recommendable sensor for the monitoring of nuclear DNA damage that reveals the health status of cells.
Muon tomography is developing as a promising system to detect high-Z (atomic number) material for ensuring homeland security. In the present work, three kinds of spatial locations of materials which ...are made of aluminum, iron, lead and uranium are simulated with GEANT4 codes, which are horizontal, diagonal and vertical objects, respectively. Two statistical algorithms are used with MATLAB software to reconstruct the image of detected objects, which are the Point of Closet Approach (PoCA) and Maximum Likelihood Scattering-Expectation Maximization iterative algorithm (MLS-EM), respectively. Two analysis methods are used to evaluate the quality of reconstruction image, which are the Receiver Operating Characteristic (ROC) and the localization ROC (LROC) curves, respectively. The reconstructed results show that, compared with PoCA algorithm, MLS-EM can achieve a better image quality in both edge preserving and noise reduction. And according to the analysis of ROC (LROC) curves, it shows that MLS-EM algorithm can discriminate and exclude the presence and location of high-Z object with a high efficiency, which is more flexible with an different EM algorithm employed than prior work. Furthermore the MLS-EM iterative algorithm will be modified and ran in parallel executive way for improving the reconstruction speed.
Few-layer black phosphorus (BP), as the most alluring graphene analogue owing to its similar structure as graphene and thickness dependent direct band-gap, has now triggered a new wave of research on ...two-dimensional (2D) materials based photonics and optoelectronics. However, a major obstacle of practical applications for few-layer BPs comes from their instabilities of laser-induced optical damage. Herein, we demonstrate that, few-layer BPs, fabricated through the liquid exfoliation approach, can be developed as a new and practical saturable absorber (SA) by depositing few-layer BPs with microfiber. The saturable absorption property of few-layer BPs had been verified through an open-aperture z-scan measurement at the telecommunication band and the microfiber-based BP device had been found to show a saturable average power of ~4.5 mW and a modulation depth of 10.9%, which is further confirmed through a balanced twin detection measurement. By further integrating this optical SA device into an erbium-doped fiber laser, it was found that it can deliver the mode-locked pulse with duration down to 940 fs with central wavelength tunable from 1532 nm to 1570 nm. The prevention of BP from oxidation through the 'lateral interaction scheme' owing to this microfiber-based few-layer BP SA device might partially mitigate the optical damage problem of BP. Our results not only demonstrate that black phosphorus might be another promising SA material for ultrafast photonics, but also provide a practical solution to solve the optical damage problem of black phosphorus by assembling with waveguide structures such as microfiber.
This review summarizes the recent advances in the catalytic syntheses of CF_3S-containing organic molecules using various nucleophilic or electrophilic trifluoromethylthiolating reagents.C-halogen ...and C—H bonds in various molecules have been transformed to C—SCF_3 bonds by transition-metal-catalyzed reactions,such as cross-coupling of aryl halides.Enantioselective reactions controlled by chiral metal complexes or chiral organocatalysts have afforded many trifluoromethylthiolated chiral architectures,such as β-ketoesters and oxindoles.Very recently,visible-light-induced photoredox trifluoromethylthiolations have been developed,providing versatile CF_3S-containing structures efficiently.
A high-energy pulse fiber laser with long-cavity length based on domain-wall theory was proposed and demonstrated. At a maximum pump power of 200 mW, 56.3 nJ pulse with 79.98 kHz repetition ration ...was efficiently generated.
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