We report the observation of magnetoresistance (MR) that could originate from the orbital angular momentum (OAM) transport in a permalloy (Py)/oxidized Cu (Cu^{*}) heterostructure: the orbital ...Rashba-Edelstein magnetoresistance. The angular dependence of the MR depends on the relative angle between the induced OAM and the magnetization in a similar fashion as the spin Hall magnetoresistance. Despite the absence of elements with large spin-orbit coupling, we find a sizable MR ratio, which is in contrast to the conventional spin Hall magnetoresistance which requires heavy elements. Through Py thickness-dependence studies, we conclude another mechanism beyond the conventional spin-based scenario is responsible for the MR observed in Py/Cu^{*} structures-originated in a sizable transport of OAM. Our findings not only suggest the current-induced torques without using any heavy elements via the OAM channel but also provide an important clue towards the microscopic understanding of the role that OAM transport can play for magnetization dynamics.
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Anionic redox chemistry has attracted increasing attention in research on P2-type layered oxide cathodes for sodium-ion batteries. But how to modulate the crystal or electronic structure to achieve ...high activity and reversibility of oxygen redox is extremely challenging. Herein, we propose to enhance the activity and reversibility of both cationic and anionic redox in Na0.67Mn0.75Ni0.25O2 by a synergy of Cu and Mg co-doping. The cycling stability and the rate capability were found to be largely enhanced, and the synergy mechanism of Cu and Mg co-doping was unveiled. Firstly, Cu/Mg co-doping shortens TM–O and enhances TM–O bonding energy, which improve the oxygen redox reversibility and structure stability. Secondly, Cu/Mg co-doping improves the thermal decomposition temperature and the reversible transformation from P2 to O2 phase, indicating the enhancement of anionic redox reversibility. Thirdly, Cu/Mg co-doping reduces the ratio of Mn3+/Mn4+, which alleviates the Jahn–Teller effect and enhances the layered structure stability. Moreover, the d-spacing was also enlarged by Cu/Mg co-doping, which facilitates the Na+ diffusion. This study presents some insights into simultaneously tuning the activity and reversibility of cationic and anionic redox in layered oxide cathode materials.
Current-induced spin-orbit torques (SOTs) allow for the efficient electrical manipulation of magnetism in spintronic devices. Engineering the SOT efficiency is a key goal that is pursued by ...maximizing the active interfacial spin accumulation or modulating the nonequilibrium spin density that builds up through the spin Hall and inverse spin galvanic effects. Regardless of the origin, the fundamental requirement for the generation of the current-induced torques is a net spin accumulation. We report on the large enhancement of the SOT efficiency in thulium iron garnet (TmIG)/Pt by capping with a CuOx layer. Considering the weak spin-orbit coupling (SOC) of CuOx, these surprising findings likely result from an orbital current generated at the interface between CuOx and Pt, which is injected into the Pt layer and converted into a spin current by strong SOC. The converted spin current decays across the Pt layer and exerts a "nonlocal" torque on TmIG. This additional torque leads to a maximum colossal enhancement of the SOT efficiency of a factor 16 for 1.5 nm of Pt at room temperature, thus opening a path to increase torques while at the same time offering insights into the underlying physics of orbital transport, which has so far been elusive.
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Doping some elements on Li site of LLZO is an effective method to stabilize it as cubic phase and improve Li+ conductivity. The reported possible Li site elements calculated by first principle are ...Be, B, Al, Fe, Zn, Ga and the Ga-doped LLZO shows the a higher conductivity than other LLZO. However, whether these elements all can stable LLZO as cubic phase are needed to be verified and the reason of Ga exhibits higher conductivity is not clear enough. In this work, all these elements are tried to be doped on Li site and the results show that the Al, or Fe, or Ga can stable LLZO as cubic phase while the others does not. The Ga-doped LLZO exhibits the highest conductivity of 1.31×10−3 S•cm-1 due to the transform of group space from Ia-3d to I-43d, shorter distances between different Li+, and Ga can improve the grain size.
The seven members of the signal transducer and activator of transcription （STAT） family of transcription factors are activated in response to many different cytokines and growth factors by ...phosphorylation of specific tyrosine residues. The STAT1 and STAT3 genes are specific targets of activated STATs 1 and 3, respectively, resulting in large increases in the levels of these unphosphorylated STATs （U-STATs） in response to the interferons （STAT1） or ligands that active gpl30, such as IL-6 （STAT3）. U-STATs drive gene expression by novel mechanisms distinct from those used by phosphorylated STAT （P-STAT） dimers. In this review, we discuss the roles of U-STATs in transcription and regulation of gene expression.
Formation of low-resistance metal contacts is the biggest challenge that masks the intrinsic exceptional electronic properties of two dimensional WSe2 devices. We present the first comparative study ...of the interfacial properties between monolayer/bilayer (ML/BL) WSe2 and Sc, Al, Ag, Au, Pd, and Pt contacts by using ab initio energy band calculations with inclusion of the spin-orbital coupling (SOC) effects and quantum transport simulations. The interlayer coupling tends to reduce both the electron and hole Schottky barrier heights (SBHs) and alters the polarity for the WSe2-Au contact, while the SOC chiefly reduces the hole SBH. In the absence of the SOC, the Pd contact has the smallest hole SBH. Dramatically, the Pt contact surpasses the Pd contact and becomes the p-type ohmic or quasi-ohmic contact with inclusion of the SOC. Therefore, p-type ohmic or quasi-ohmic contact exists in WSe2-metal interfaces. Our study provides a theoretical foundation for the selection of favorable metal electrodes in ML/BL WSe2 devices.
Abstract
Over the past few decades, exciton-polaritons have attracted substantial research interest due to their half-light-half-matter bosonic nature. Coupling exciton-polaritons with magnetic ...orders grants access to rich many-body phenomena, but has been limited by the availability of material systems that exhibit simultaneous exciton resonances and magnetic ordering. Here we report magnetically-dressed microcavity exciton-polaritons in the van der Waals antiferromagnetic (AFM) semiconductor CrSBr coupled to a Tamm plasmon microcavity. Using angle-resolved spectroscopy, we reveal an exceptionally high exciton-photon coupling strength, up to 169 meV, demonstrating ultrastrong coupling that persists up to room temperature. By performing temperature-dependent spectroscopy, we show the magnetic nature of the exciton-polaritons in CrSBr microcavity as the magnetic order changes from AFM to paramagnetic. By applying an out-of-plane magnetic field, we achieve effective tuning of the polariton energy while maintaining the ultrastrong exciton-photon coupling strength. We attribute this to the spin canting process that modulates the interlayer exciton interaction.
The activation of STAT3 by tyrosine phosphorylation, essential for normal development and for a normal inflammatory response to invading pathogens, is kept in check by negative regulators. Abnormal ...constitutive activation of STAT3, which contributes to the pathology of cancer and to chronic inflammatory diseases such as rheumatoid arthritis, occurs when negative regulation is not fully effective. SOCS3, the major negative regulator of STAT3, is induced by tyrosine-phosphorylated STAT3 and terminates STAT3 phosphorylation about 2 h after initial exposure of cells to members of the IL-6 family of cytokines by binding cooperatively to the common receptor subunit gp130 and JAKs 1 and 2. We show here that when the epidermal growth factor receptor (EGFR) is present and active, STAT3 is rephosphorylated about 4 h after exposure of cells to IL-6 or oncostatin M and remains active for many hours. Newly synthesized IL-6 drives association of the IL-6 receptor and gp130 with EGFR, leading to EGFR-dependent rephosphorylation of STAT3, which is not inhibited by the continued presence of SOCS3. This second wave of STAT3 activation supports sustained expression of a subset of IL-6-induced proteins, several of which play important roles in inflammation and cancer, in which both IL-6 secretion and EGFR levels are often elevated.
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive and more susceptible to ...developing cirrhosis and hepatocellular carcinoma. Currently, lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the development of fibrosis. While there are still limited appropriate drugs specifically to treat NAFL/NASH, growing progress is being seen in elucidating the pathogenesis and identifying therapeutic targets. In this review, we discussed recent developments in etiology and prospective therapeutic targets, as well as pharmacological candidates in pre/clinical trials and patents, with a focus on diabetes, hepatic lipid metabolism, inflammation, and fibrosis. Importantly, growing evidence elucidates that the disruption of the gut-liver axis and microbe-derived metabolites drive the pathogenesis of NAFL/NASH. Extracellular vesicles (EVs) act as a signaling mediator, resulting in lipid accumulation, macrophage and hepatic stellate cell activation, further promoting inflammation and liver fibrosis progression during the development of NAFL/NASH. Targeting gut microbiota or EVs may serve as new strategies for the treatment of NAFL/NASH. Finally, other mechanisms, such as cell therapy and genetic approaches, also have enormous therapeutic potential. Incorporating drugs with different mechanisms and personalized medicine may improve the efficacy to better benefit patients with NAFL/NASH.
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