In this study the computational and experimental electroporation model with human aorta tissue is made in order to examine the reduction of smooth muscle cells.
The segments in native state of the ...aorta are treated by electroporation method through a series of electrical impulses from 50 V/cm to 2500 V/cm. For each patient we analyzed one sample with and one sample without electroporation as a control. In the computational study, electrical field distribution is solved by the Laplace equation. The Pennes Bioheat equation without metabolism and blood perfusion heating is used to solve heat transfer problems. Different conductivity values are used in order to fit the experimental results.
Experimental histology has shown us that there are a smaller number of vascular smooth muscle cells (VSMC) nuclei at the tunica media, while the elastic fibre morphology is maintained 24 h after electroporation. In the computational model, heat generation coupled with electrical field is included. The fitting procedure is applied for conductivity values in order to make material properties of the aorta tissue. The fitting procedure gives tissue conductivity of 0.44 S/m for applied electrical field of 2500 V/cm.
Future studies are necessary for investigation of a new device for in-vivo ablation with electroporation of plaque stenosis. It will open up a new avenue for stenosis treatment without stent implantation.
The subject of this paper was a research of physical and mechanical
properties of LVL composed of peeled poplar veneers in core layers and only
outer layers of beech peeled veneers, so as the ...examination of window frame
glue joint strength produced of this material. LVL boards have been hot
pressed in industrial conditions, using appropriate phenol formaldehyde (PP)
adhesive. Samples for corner window frame glue joint strength testing were
glued with PVAc D4 class adhesive. Statistical analysis showed that there
were significant differences both in moisture content and density of LVL
boards regarding their thickness, while in the case of hardness this
difference did not exist. Examinations of LVL glue line shear strength
showed that both phenol formaldehyde (PP) and PVAc D4 class adhesives
fulfilled standard requirements. The results of corner window frame double
tenon glue joint strength produced from combined poplar-beech veneer LVL
indicated that such material could be used to produce window frame corner
joint, strong enough to withstand the additional load, without an increase
of the cross section.
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