Based on
3
×
3
irreducible representation of Duffin–Kemmer–Petiau (DKP) algebras, we obtain the bound-states energy spectrum, the wave function and the probability density of DKP oscillator with ...linear potential under the effect of Generalized Uncertainty Principle in the momentum space representation. In addition, the numerical results of the bound-states energy spectrum are discussed. It shows that the deformation parameter
β
and the linear potential parameter
λ
have non-negligible effect on the
(
1
+
1
)
dimensional DKP oscillator system.
Multi-FPGA architectures have gained great interests in accelerating large-scale graph processing with great potential on high throughput and energy efficiency. As a beneficial complement, work ...stealing functions effectively to balance the computational workload on different FPGAs dynamically. Unfortunately, existing graph partitioning schemes originally designed in distributed settings potentially mismatch the work stealing-enabled multi-FPGA situations, where the computation is balanced while the communication overhead is unprecedentedly significant. In this paper, we present a 2-dimension balanced graph partitioning for work stealing assisted graph systems on multi-FPGAs, which can reduce communication overhead while preserving the optimal performance of work stealing. Our approach is novel by 1) exploring the tradeoff between load balance dimension and communication dimension in work-stealing-enabled graph processing system for the optimal performance, and 2) optimizing the memory access sequences to improve the granularity of graph partitioning for high-throughput graph analytics. Our experimental results show that our approach achieves 1.63x<inline-formula><tex-math notation="LaTeX">\sim</tex-math> <mml:math><mml:mo>∼</mml:mo></mml:math><inline-graphic xlink:href="zheng-ieq1-3035090.gif"/> </inline-formula>2.56x speedups compared with state-of-the-art FPGA-based graph processing systems.
Objective
To explore the potential mechanism of Yishen Qutong Granules (YSQTG) for the treatment of esophageal cancer using network pharmacology and experimental research.
Methods
The effective ...components and molecular mechanism of YSQTG in treating esophageal cancer were expounded based on network pharmacology and molecular docking. The key compound was identified by high-performance liquid chromatography and mass spectrometry (HPLC-MS) to verify the malignant phenotype of the key compounds in the treatment of esophageal cancer. Then, the interaction proteins of key compounds were screened by pull-down assay combined with mass spectrometry. RNA-seq was used to screen the differential genes in the treatment of esophageal cancer by key compounds, and the potential mechanism of key compounds on the main therapeutic targets was verified.
Results
Totally 76 effective compounds of YSQTG were found, as well as 309 related targets, and 102 drug and disease interaction targets. The drug-compound-target network of YSQTG was constructed, suggesting that quercetin, luteolin, wogonin, kaempferol and baicalein may be the most important compounds, while quercetin had higher degree value and degree centrality, which might be the key compound in YSQTG. The HPLC-MS results also showed the stable presence of quercetin in YSQTG. By establishing a protein interaction network, the main therapeutic targets of YSQTG in treating esophageal cancer were Jun proto-oncogene, interleukin-6, tumor necrosis factor, and RELA proto-oncogene. The results of cell function experiments
in vitro
showed that quercetin could inhibit proliferation, invasion, and clonal formation of esophageal carcinoma cells. Quercetin mainly affected the biological processes of esophageal cancer cells, such as proliferation, cell cycle, and cell metastasis. A total of 357 quercetin interacting proteins were screened, and 531 genes were significantly changed. Further pathway enrichment analysis showed that quercetin mainly affects the metabolic pathway, MAPK signaling pathway, and nuclear factor kappa B (NF- κ B) signaling pathway, etc. Quercetin, the key compound of YSQTG, had stronger binding activity by molecular docking. Pull-down assay confirmed that NF- κ B was a quercetin-specific interaction protein, and quercetin could significantly reduce the protein level of NF- κ B, the main therapeutic target.
Conclusion
YSQTG can be multi-component, multi-target, multi-channel treatment of esophageal cancer, it is a potential drug for the treatment of esophageal cancer.
The extraction and separation of docosahexaenoic acid (DHA)-rich oils, proteins, and polysaccharides from microalgae is a challenge for industrial commercialization of DHA, such as drying and ...dewatering, cell wall disruption, laborious conventional extraction procedures and exploitation of large volumes of solvents. To address these concerns, a novel microwave-assisted three-liquid-phase salting-out extraction (MA-TLPSOE) was used to separate DHA-rich oils, proteins, and polysaccharides from wet cultivation broths of Schizochytrium limacinum SR21. The optimized MA-TLPSOE system was composed of 30% (w/w) n-hexane/13% (w/w) ethanol/9% (w/w) sodium carbonate and treated at high microwave power (650 W) for 30 s. Under optimized conditions, 100 ± 0.59% oil and 100 ± 0.64% DHA were partitioned in the top n-hexane phase while 93.75 ± 0.25% of polysaccharides and 92.96 ± 0.43% of proteins were distributed in the solid-phase interface. The effects of microwave power and duration, sodium carbonate, n-hexane, ethanol concentration and extraction time were studied. When the optimized system was enlarged from 20 g to 60 g, the yields of all effective components were almost the same. Thus, the MA-TLPSOE system is a promising and attractive technology, which could be used for the separation and extraction of various effective ingredients from complex natural products in a single step with significant recovery yield.
It has been established that long-chain coding RNA (lncRNA) SLC25A25-AS1 is associated with cancer progression. However, the roles and mechanisms of SLC25A25-AS1 in prostate cancer (PC) have not been ...reported in the literature. The present study explored the relationship between SLC25A25-AS1 expression and PC progression
via
comprehensive analysis. The pan-cancer expression of SLC25A25-AS1 was identified using data from The Cancer Genome Atlas (TCGA) database and tissue specimens from our hospital. The expression levels of SLC25A25-AS1 in various subgroups based on the clinical features were identified. The prognostic value of SLC25A25-AS1 and SLC25A25-AS1 co-expressed lncRNAs in PC patients was assessed by survival analysis and ROC analysis, and prognosis-related risk models of SLC25A25-AS1 were constructed. The relationship between SLC25A25-AS1 and the PC immune microenvironment was investigated using correlation analysis. SLC25A25-AS1 expression in PC was significantly increased and correlated with the T stage, clinical stage, Gleason score (GS), and dismal prognosis. SLC25A25-AS1 overexpression exhibited good performance in evaluating the prognosis of PC patients. The area under the curves (AUCs) of the 1-, 3-, and 5-year overall survival (OS) for SLC25A25-AS1 was 1, 0.876, and 0.749. Moreover, the AUCs for the 1-, 3-, and 5-year progress free interval (PFI) for SLC25A25-AS1 were 0.731, 0.701, and 0.718. SLC25A25-AS1 overexpression correlated with the infiltration of CD8 T cells, interstitial dendritic cells (IDC), macrophages and other cells. AC020558.2, ZNF32-AS2, AP4B1-AS1, AL355488.1, AC109460.3, SNHG1, C3orf35, LMNTD2-AS1, and AL365330.1 were significantly associated with SLC25A25-AS1 expression, and short OS and PFI in PC patients. The risk models of the SLC25A25-AS1-related lncRNAs were associated with a dismal prognosis in PC. Overall, SLC25A25-AS1 expression was increased in PC and related to the prognosis and PC immune microenvironment. The risk model of SLC25A25-AS1 have huge prospect for application as prognostic tools in PC.
Over-activated microglia is involved in various kinds of neurodegenerative process including Parkinson, Alzheimer and HIV dementia. Suppression of microglial over activation has emerged as a novel ...strategy for treatment of neuroinflammation-based neurodegeneration. In the current study, anti-inflammatory and neuroprotective effects of the ent-kauranoid diterpenoids, which were isolated from the aerial parts of Rabdosia japonica (Burm. f.) var. glaucocalyx (Maxim.) Hara, were investigated in cultured microglia cells. Glaucocalyxin B (GLB), one of five ent-kauranoid diterpenoids, significantly decreased the generation of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-activated microglia cells. In addition, GLB inhibited activation of nuclear factor-κB (NF-κB), p38 mitogen-activated protein kinase (MAPK) and generation of reactive oxygen species (ROS) in LPS-activated microglia cells. Furthermore, GLB strongly induced the expression of heme oxygenase (HO)-1 in BV-2 microglia cells. Finally, GLB exhibited neuroprotective effect by preventing over-activated microglia induced neurotoxicity in a microglia/neuron co-culture model. Taken together, the present study demonstrated that the GLB possesses anti-nueroinflammatory activity, and might serve as a potential therapeutic agent for treating neuroinflammatory diseases.
The aim of this study is to reveal the mechanism underlying the influence of adsorbed water on the deformation of high liquid limit soils, and establish the prediction equation of compressibility ...coefficient, which is helpful for engineering application. high liquid limit clay, high liquid limit silt and clayey sand were selected for laboratory tests. The initial adsorbed water of the soil samples was controlled by different concentrations of NaCl solution, and the adsorbed water contents of three soil samples in different concentrations of salt solution were determined by thermogravimetric analysis. Meanwhile, the variations of liquid limit (LL) and plastic limit (PL) at different concentrations were also determined by the liquid-plastic limit combine tester. In order to study the effect of adsorbed water on the consolidation characteristics, saturated consolidation tests were carried out on three soil samples under different concentrations of salt solutions. The results show that as the concentration of salt solution increases, the adsorbed water content, LL and PL decrease accordingly. For saturated soil samples with the same initial void ratio, the compression index decreases with an increase in adsorbed water content. At the same modified void ratio, the compression curves of different soils tend to be consistent. Based on the results of this study and those available in the literature, the prediction equations of initial void ratio and compression index were established. Compared with the unmodified void ratio, the modified void ratio can normalize the compression behavior of different soil samples since the adsorbed water plays a skeletal role in the soil. Thus, the precision of the prediction equation of compression index can be improved using the modified void ratio.
The potential use of chromium carbide thin films has been a great interest to academia and industry due to their outstanding properties such as chemical stability, low coefficient of friction, ...adequate hardness and high wear resistance. In this study, the chromium carbide thin films were fabricated by a magnetron sputtering using different power supply systems, including direct-current (DC), pure high power impulse magnetron sputtering (HiPIMS), and superimposed HiPIMS- middle frequency (MF). The Cr target poisoning status was controlled using a plasma emission monitoring (PEM) system by adjusting the gas flow ratios of Ar and acetylene (C2H2). The morphology and microstructure of thin films were evaluated by scanning electron microscope (SEM) and transmission electron microscope (TEM). The crystallinity of films was studied using an X-ray diffractometer (XRD). The electron probe micro analyzer (EPMA) and X-ray photoelectron spectroscope were used to determine the chemical compositions and binding structures of thin films, respectively. The hardness and residual stress were explored. The results showed that the thin film sample prepared by the superimposed HiPIMS-MF power supply can obtain the maximum hardness of ~27.5 GPa at a PEM set point of 30%, i.e., the target poisoning degree of 70%. The hardening mechanism may be caused by the formation of nanoscale CrC crystallites incorporated into the amorphous CrCx matrix in the thin film, which can be attributed to the Hall-Petch strengthening effect.
•DC, pure HiPIMS and superimposed HiPIMS-MF technique are used to fabricate CrCx films.•Plasma emission monitoring system (PEM) is utilized to control reactive C2H2 gas.•Different PEM set points alter the chemical composition of CrC films.•Superimposed HiPIMS-MF PEM at set point of 30% yields the CrC film with the highest hardness of 27.5 GPa.
PDF
